Detailed information for compound 1515296

Basic information

Technical information
  • TDR Targets ID: 1515296
  • Name: 3-[(4-chlorobenzoyl)amino]-N-(4-methylpyridin -2-yl)benzamide
  • MW: 365.813 | Formula: C20H16ClN3O2
  • H donors: 2 H acceptors: 3 LogP: 3.85 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1nccc(c1)C
  • InChi: 1S/C20H16ClN3O2/c1-13-9-10-22-18(11-13)24-20(26)15-3-2-4-17(12-15)23-19(25)14-5-7-16(21)8-6-14/h2-12H,1H3,(H,23,25)(H,22,24,26)
  • InChiKey: SQCQHDWUHBHROG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(4-chlorobenzoyl)amino]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4-chlorophenyl)-oxomethyl]amino]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[(4-chlorophenyl)carbonylamino]-N-(4-methylpyridin-2-yl)benzamide
  • ZINC01006550
  • 3-[(4-chlorobenzoyl)amino]-N-(4-methyl-2-pyridinyl)benzamide
  • MLS001182539
  • SMR000477363
  • AN-652/43162699

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, AGC PKA 0.0261 0.6855 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0261 0.6855 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0261 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0627 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.6855 0.6855
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Brugia malayi Hr1 repeat family protein 0.0112 0.2645 0.2986
Echinococcus granulosus protein kinase C gamma type 0.0112 0.2645 0.2645
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0447 0.0301
Schistosoma mansoni hypothetical protein 0.0041 0.0627 0.0627
Echinococcus granulosus protein kinase c iota type 0.0112 0.2645 0.2645
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Leishmania major protein kinase A catalytic subunit isoform 2 0.0261 0.6855 1
Toxoplasma gondii AGC kinase 0.0261 0.6855 0.7933
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0112 0.2645 0.2645
Brugia malayi Protein kinase domain containing protein 0.0112 0.2645 0.2986
Entamoeba histolytica protein kinase, putative 0.0331 0.8858 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Entamoeba histolytica protein kinase, putative 0.0112 0.2645 0.2835
Echinococcus multilocularis serine:threonine protein kinase N2 0.0112 0.2645 0.2645
Echinococcus multilocularis nervana 2 0.021 0.5408 0.5408
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Brugia malayi Protein kinase domain containing protein 0.0112 0.2645 0.2986
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0323 0.0205
Echinococcus granulosus NDR protein kinase 0.0112 0.2645 0.2645
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Echinococcus granulosus nervana 2 0.021 0.5408 0.5408
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0215 0.5559 0.5559
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0215 0.5559 0.8056
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0447 0.031
Schistosoma mansoni importin beta-1 0.0035 0.0447 0.0447
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0447 0.0447
Trichomonas vaginalis AGC family protein kinase 0.0122 0.2909 0.314
Schistosoma mansoni serine/threonine kinase 0.0112 0.2645 0.2645
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Brugia malayi RNA, U transporter 1 0.0099 0.2268 0.256
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Schistosoma mansoni ran 0.0026 0.0187 0.0187
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0261 0.6855 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.027 0.712 0.7996
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0261 0.6855 0.7691
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Brugia malayi hypothetical protein 0.003 0.0323 0.0365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1167 0.1317
Echinococcus granulosus serine:threonine protein kinase N2 0.0112 0.2645 0.2645
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0261 0.6855 0.6855
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0112 0.2645 0.2645
Entamoeba histolytica protein kinase 2, putative 0.0215 0.5559 0.6196
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0112 0.2645 0.2645
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1167 0.1317
Schistosoma mansoni serine/threonine-protein kinase 0.0224 0.5823 0.5823
Entamoeba histolytica protein kinase, putative 0.0322 0.8593 0.9695
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0187 0.0187
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0261 0.6855 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0627 0.0708
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Echinococcus granulosus nervana 2 0.021 0.5408 0.5408
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0261 0.0085
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.021 0.5408 0.5408
Echinococcus multilocularis rac serine:threonine kinase 0.0224 0.5823 0.5823
Echinococcus multilocularis protein kinase c iota type 0.0112 0.2645 0.2645
Echinococcus granulosus protein kinase c epsilon type 0.0112 0.2645 0.2645
Brugia malayi Protein kinase domain containing protein 0.0331 0.8858 1
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.6855 0.6855
Echinococcus multilocularis Glutaredoxin protein 5 0.021 0.5408 0.5408
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0187 0.0187
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0261 0.6855 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0261 0.0085
Loa Loa (eye worm) AGC/PKA protein kinase 0.0261 0.6855 0.6855
Entamoeba histolytica PH domain containing protein kinase, putative 0.0224 0.5823 0.6501
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0255 0.6704 0.6704
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0447 0.0301
Echinococcus multilocularis nervana 2 0.021 0.5408 0.5408
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0112 0.2645 0.2645
Toxoplasma gondii AGC kinase 0.0322 0.8593 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0323 0.0205
Trichomonas vaginalis AGC family protein kinase 0.0112 0.2645 0.2835
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Loa Loa (eye worm) AGC/NDR protein kinase 0.0112 0.2645 0.2645
Trichomonas vaginalis AGC family protein kinase 0.0261 0.6855 0.7691
Schistosoma mansoni ran 0.0026 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0323 0.0323
Brugia malayi protein kinase C II. 0.0112 0.2645 0.2986
Echinococcus multilocularis geminin 0.0205 0.5262 0.5262
Brugia malayi Importin beta-1 subunit 0.0035 0.0447 0.0505
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0323 0.0205
Echinococcus granulosus Protein kinase C brain isozyme 0.0112 0.2645 0.2645
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0112 0.2645 0.2645
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0112 0.2645 0.2645
Giardia lamblia Kinase, AGC PKA 0.0215 0.5559 0.8056
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0187 0.0211
Schistosoma mansoni atypical protein kinase C 0.0112 0.2645 0.2645
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0112 0.2645 0.2645
Schistosoma mansoni hypothetical protein 0.0205 0.5262 0.5262
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0261 0.6855 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.006 0.1167 0.1167
Schistosoma mansoni serine/threonine-protein kinase 0.0224 0.5823 0.5823
Entamoeba histolytica PH domain containing protein kinase, putative 0.0224 0.5823 0.6501
Loa Loa (eye worm) hypothetical protein 0.0112 0.2645 0.2645
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0323 0.0162
Echinococcus granulosus serine threonine protein kinase nrc 0.0215 0.5559 0.5559
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0261 0.6855 0.7691
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0112 0.2645 0.2645
Leishmania major protein kinase A catalytic subunit isoform 1 0.0261 0.6855 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0215 0.5559 0.8056
Echinococcus granulosus geminin 0.0205 0.5262 0.5262
Echinococcus multilocularis serine threonine protein kinase 0.0112 0.2645 0.2645
Echinococcus multilocularis serine:threonine protein kinase 38 0.0112 0.2645 0.2645
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0112 0.2645 0.2645
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Loa Loa (eye worm) AGC/AKT protein kinase 0.0331 0.8858 0.8858
Entamoeba histolytica protein kinase, putative 0.0331 0.8858 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0255 0.6704 0.6704
Loa Loa (eye worm) AGC/PKA protein kinase 0.0261 0.6855 0.6855
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0323 0.0205
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0261 0.0111
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0107 0.2494 0.2661
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0112 0.2645 0.2645
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0323 0.0157
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0261 0.6855 0.7739
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.6855 0.6855
Brugia malayi hypothetical protein 0.002 0.0017 0.0019
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0261 0.6855 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0112 0.2645 0.2645
Echinococcus granulosus serine/threonine protein kinase 0.0224 0.5823 0.5823
Entamoeba histolytica hypothetical protein 0.0028 0.0261 0.0085
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0261 0.0085
Echinococcus granulosus importin subunit beta 1 0.0035 0.0447 0.0447
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0322 0.8593 0.8593
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.2645 0.2645
Echinococcus multilocularis protein kinase c epsilon type 0.0112 0.2645 0.2645
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0112 0.2645 0.2645
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0261 0.6855 0.7933
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.021 0.5408 0.5408
Echinococcus granulosus Glutaredoxin protein 5 0.021 0.5408 0.5408
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0215 0.5559 0.5559
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0261 0.6855 0.7691
Trypanosoma brucei rac serine-threonine kinase, putative 0.0331 0.8858 1
Toxoplasma gondii AGC kinase 0.0261 0.6855 0.7933
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0224 0.5823 0.8453
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0187 0.0187
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0323 0.0205
Leishmania major protein kinase A catalytic subunit 0.0261 0.6855 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0112 0.2645 0.2645
Trichomonas vaginalis AGC family protein kinase 0.0331 0.8858 1
Trypanosoma cruzi Protein kinase B 0.0224 0.5823 0.8453
Plasmodium vivax importin-beta 2, putative 0.0035 0.0447 0.0391
Brugia malayi p70 ribosomal S6 kinase beta 0.0322 0.8593 0.9701
Trichomonas vaginalis AGC family protein kinase 0.0112 0.2645 0.2835
Plasmodium falciparum importin beta, putative 0.0035 0.0447 0.0391
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0215 0.5559 0.8056
Leishmania major hypothetical protein, conserved 0.003 0.0323 0.0205
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0261 0.6855 0.6855
Schistosoma mansoni hypothetical protein 0.0205 0.5262 0.5262
Trichomonas vaginalis AGC family protein kinase 0.0112 0.2645 0.2835
Entamoeba histolytica PH domain containing protein kinase, putative 0.027 0.712 0.7996

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0082 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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