Detailed information for compound 1515310

Basic information

Technical information
  • TDR Targets ID: 1515310
  • Name: N-(4-ethoxyphenyl)-4-propylpiperazine-1-carbo xamide
  • MW: 291.389 | Formula: C16H25N3O2
  • H donors: 1 H acceptors: 1 LogP: 2.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCN(CC1)C(=O)Nc1ccc(cc1)OCC
  • InChi: 1S/C16H25N3O2/c1-3-9-18-10-12-19(13-11-18)16(20)17-14-5-7-15(8-6-14)21-4-2/h5-8H,3-4,9-13H2,1-2H3,(H,17,20)
  • InChiKey: ZNPQLUKXHSZNIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-ethoxyphenyl)-4-propyl-piperazine-1-carboxamide
  • N-(4-ethoxyphenyl)-4-propyl-1-piperazinecarboxamide
  • MLS000679313
  • IVK/0018973
  • SMR000297723

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0547 0.189
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0066 0.0253
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0066 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0066 0.0091
Trypanosoma brucei polo-like protein kinase 0.0115 0.261 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0945 0.3621
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.3872 0.3864
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0547 0.189
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0318 0.0775
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0306 0.05
Brugia malayi hypothetical protein 0.0141 0.3313 0.5622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.3872 0.6573
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.4368 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.2675 0.8837
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0027 0.0015
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0945 0.0934
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0945 0.3621
Brugia malayi Smad1 0.0016 0.0027 0.0025
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0027 0.0027
Mycobacterium tuberculosis Probable reductase 0.0117 0.2675 0.8837
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.261 0.2601
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0945 0.3455
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1165 0.1154
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0945 0.3455
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.2675 0.8837
Onchocerca volvulus 0.0094 0.207 0.4343
Brugia malayi MH1 domain containing protein 0.0016 0.0027 0.0025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0066 0.0253
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.261 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Brugia malayi PHD-finger family protein 0.0025 0.0252 0.0408
Echinococcus multilocularis lamin dm0 0.0027 0.0306 0.0294
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0945 0.1588
Plasmodium falciparum glutathione reductase 0.0051 0.0948 0.2714
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0948 0.2985
Echinococcus multilocularis RUN 0.0141 0.3313 0.3305
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0027 0.0015
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.3019 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0547 0.189
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0541 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1095 0.4046
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0945 0.3621
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0318 0.0775
Echinococcus granulosus lamin 0.0027 0.0306 0.0294
Brugia malayi glutathione reductase 0.0051 0.0948 0.1593
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0547 0.2096
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0547 0.0535
Schistosoma mansoni kinase 0.0058 0.1135 0.1135
Brugia malayi Thioredoxin reductase 0.0051 0.0948 0.1593
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0046 0.0034
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.019 0.0178
Brugia malayi Bromodomain containing protein 0.0038 0.0603 0.1006
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0046 0.0034
Trypanosoma brucei protein kinase, putative 0.0051 0.0945 0.3621
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0945 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1095 0.4046
Echinococcus multilocularis Smad4 0.0016 0.0027 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0318 0.052
Loa Loa (eye worm) hypothetical protein 0.0141 0.3313 0.5622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0945 0.3621
Brugia malayi hypothetical protein 0.0141 0.3313 0.5622
Echinococcus granulosus zinc finger protein 0.002 0.0112 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0547 0.189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.2675 0.8837
Loa Loa (eye worm) hypothetical protein 0.0034 0.0493 0.0818
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0547 0.2096
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0062 0.0085
Echinococcus granulosus smad 0.0016 0.0027 0.0015
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.261 0.2601
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0948 0.0936
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Brugia malayi intermediate filament protein 0.0027 0.0306 0.05
Schistosoma mansoni lamin 0.0027 0.0306 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.5884 1
Brugia malayi hypothetical protein 0.0018 0.0063 0.0086
Schistosoma mansoni loxhd1 0.0141 0.3313 0.3313
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.3872 0.6573
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0066 0.0054
Schistosoma mansoni bromodomain containing protein 0.0063 0.1258 0.1258
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3872 0.3864
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.3019 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.261 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1927 0.326
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0066 0.5
Echinococcus multilocularis Polycystic kidney disease protein 0.0141 0.3313 0.3305
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0547 0.0535
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0306 0.05
Echinococcus granulosus Polycystic kidney disease protein 0.0141 0.3313 0.3305
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0945 0.3621
Loa Loa (eye worm) hypothetical protein 0.0043 0.0717 0.12
Schistosoma mansoni smad 0.0016 0.0027 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0948 0.1593
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0066 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.2675 0.8837
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0906 0.1522
Treponema pallidum NADH oxidase 0.0018 0.0066 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0318 0.2855
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.261 0.5671
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0046
Brugia malayi MH2 domain containing protein 0.0016 0.0027 0.0025
Schistosoma mansoni rab6-interacting 0.0141 0.3313 0.3313
Brugia malayi MH2 domain containing protein 0.0016 0.0027 0.0025
Echinococcus granulosus RUN 0.0141 0.3313 0.3305
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0306 0.05
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0066 0.0253
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.261 1
Giardia lamblia Kinase, PLK 0.0115 0.261 1
Brugia malayi Bromodomain containing protein 0.0075 0.1566 0.2646
Trypanosoma brucei glucosidase, putative 0.0036 0.0547 0.2096
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0547 0.189
Echinococcus multilocularis smad 0.0016 0.0027 0.0015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0541 0.0529
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0066 0.5
Leishmania major hypothetical protein, conserved 0.0027 0.0318 0.1218
Toxoplasma gondii thioredoxin reductase 0.0051 0.0948 1
Schistosoma mansoni hypothetical protein 0.0034 0.0493 0.0493
Trypanosoma brucei trypanothione reductase 0.0051 0.0948 0.3631
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0027 0.0025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0141 0.3313 0.3305
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.019 0.019
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0948 0.2714
Loa Loa (eye worm) glutathione reductase 0.0051 0.0948 0.1593
Echinococcus multilocularis zinc finger protein 0.002 0.0112 0.01
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Echinococcus granulosus lipoxygenase domain containing protein 0.0141 0.3313 0.3305
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0066 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 0.1927 0.326
Loa Loa (eye worm) Smad1 0.0016 0.0027 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0948 0.0936
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Schistosoma mansoni lipoxygenase 0.0141 0.3313 0.3313
Schistosoma mansoni alpha-glucosidase 0.014 0.3277 0.3277
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0605 0.1009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0906 0.1522
Brugia malayi MH2 domain containing protein 0.0239 0.5884 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0066 0.0253
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0547 0.189
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0945 0.3455
Echinococcus granulosus Smad4 0.0016 0.0027 0.0015
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.261 0.4424
Plasmodium vivax glutathione reductase, putative 0.0051 0.0948 0.2714
Brugia malayi MH1 domain containing protein 0.0016 0.0027 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Schistosoma mansoni alpha glucosidase 0.0036 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.005 0.0906 0.1522
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0046 0.0034
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0066 0.5
Schistosoma mansoni rab6-interacting 0.0141 0.3313 0.3313
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0906 0.1522
Schistosoma mansoni Smad4 0.0016 0.0027 0.0027
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0945 0.3621
Echinococcus multilocularis musashi 0.0027 0.0306 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0547 0.2096
Echinococcus multilocularis lipoxygenase domain containing protein 0.0141 0.3313 0.3305
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.3019 1
Schistosoma mansoni zinc finger protein 0.002 0.0112 0.0112
Onchocerca volvulus 0.0141 0.3313 0.7404
Schistosoma mansoni lamin 0.0027 0.0306 0.0306
Echinococcus multilocularis lamin 0.0027 0.0306 0.0294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Echinococcus granulosus lamin dm0 0.0027 0.0306 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0945 0.0945
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0945 0.0934
Brugia malayi MAP kinase sur-1 0.0051 0.0945 0.1588
Loa Loa (eye worm) hypothetical protein 0.0071 0.1454 0.2454
Brugia malayi N-terminal motif family protein 0.0181 0.4368 0.7418
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0945 0.3621
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0066 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0547 0.091
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.261 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0046 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0066 0.0253
Schistosoma mansoni intermediate filament proteins 0.0027 0.0306 0.0306
Brugia malayi Doublecortin family protein 0.0141 0.3313 0.5622
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0066 0.0253
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0945 0.9971
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0318 0.0775
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0066 0.0253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1165 0.1154
Schistosoma mansoni hypothetical protein 0.0141 0.3313 0.3313
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3872 0.3864
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0318 0.1218
Echinococcus granulosus lipoxygenase domain containing protein 0.0141 0.3313 0.3305
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0027 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0066 0.0054
Schistosoma mansoni polycystin 1-related 0.0141 0.3313 0.3313
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0318 0.1218
Brugia malayi hypothetical protein 0.0089 0.1927 0.326
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.019 0.0178
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0027 0.0015
Brugia malayi hypothetical protein 0.0027 0.0318 0.052
Schistosoma mansoni eyes absent homolog 0.0089 0.1927 0.1927
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0547 0.189
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.5884 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0478
Leishmania major trypanothione reductase 0.0051 0.0948 0.3631
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0945 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.261 1
Schistosoma mansoni hypothetical protein 0.0021 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0306 0.05
Onchocerca volvulus 0.0141 0.3313 0.7404
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.014 0.0217
Echinococcus granulosus intermediate filament protein 0.0027 0.0306 0.0294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0066 0.0253
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.3019 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0141 0.3313 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0547 0.091
Loa Loa (eye worm) hypothetical protein 0.0041 0.0667 0.1115
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0493 0.0818
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0547 0.189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0547 0.189
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.261 0.4424
Plasmodium falciparum thioredoxin reductase 0.0051 0.0948 0.2714
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.261 0.261
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0945 0.3455
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0948 0.3631
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0046
Schistosoma mansoni alpha-glucosidase 0.014 0.3277 0.3277
Loa Loa (eye worm) doublecortin family protein 0.0141 0.3313 0.5622
Loa Loa (eye worm) hypothetical protein 0.0181 0.4368 0.7418
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0318 0.1218
Plasmodium falciparum LCCL domain-containing protein 0.0141 0.3313 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.3313 0.5622
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0547 0.5455
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.2675 0.8837
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0066 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0945 0.3455
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0066 0.0253
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0027 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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