Detailed information for compound 1515364

Basic information

Technical information
  • TDR Targets ID: 1515364
  • Name: 5-(1,3-benzodioxol-5-yl)-5-methyl-3-[2-oxo-2- (1H-pyrrol-2-yl)ethyl]imidazolidine-2,4-dione
  • MW: 341.318 | Formula: C17H15N3O5
  • H donors: 2 H acceptors: 3 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(C(=O)N1CC(=O)c1ccc[nH]1)(C)c1ccc2c(c1)OCO2
  • InChi: 1S/C17H15N3O5/c1-17(10-4-5-13-14(7-10)25-9-24-13)15(22)20(16(23)19-17)8-12(21)11-3-2-6-18-11/h2-7,18H,8-9H2,1H3,(H,19,23)
  • InChiKey: OVBACNKESQLJGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(1,3-benzodioxol-5-yl)-3-[2-keto-2-(1H-pyrrol-2-yl)ethyl]-5-methyl-hydantoin
  • T5439986

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0788 0.0818
Onchocerca volvulus 0.0012 0.0084 0.006
Onchocerca volvulus Tyrosine kinase homolog 0.0016 0.0244 0.0237
Trichomonas vaginalis set domain proteins, putative 0.0235 0.9092 0.9275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0224 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Schistosoma mansoni tyrosine kinase 0.0029 0.0754 0.0783
Brugia malayi RNA binding protein 0.0062 0.2095 0.2094
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0495 0.0513
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Brugia malayi Pre-SET motif family protein 0.003 0.0788 0.0787
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1399 0.1398
Onchocerca volvulus 0.0012 0.0084 0.006
Loa Loa (eye worm) hypothetical protein 0.0039 0.1155 0.1154
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0495 0.0514
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.8955 0.9135
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0231 0.8955 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0248 0.9632 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.113 0.1129
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0029 0.0754 0.0782
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2095 0.2174
Brugia malayi Bromodomain containing protein 0.0038 0.1127 0.1126
Echinococcus granulosus titin 0.0011 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0044 0.1364 0.1416
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0318 0.0129
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0016 0.0239 0.0248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0057 0.1895 0.1966
Brugia malayi protein-tyrosine kinase 0.0052 0.1692 0.1691
Schistosoma mansoni hypothetical protein 0.0011 0.0043 0.0045
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0316 0.1661
Schistosoma mansoni growth factor receptor-bound protein 0.001 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0012 0.0084 0.0087
Echinococcus multilocularis muscleblind protein 1 0.0148 0.5583 0.5796
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2095 0.2175
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0316 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2095 0.2175
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0316 0.0327
Loa Loa (eye worm) TK protein kinase 0.0047 0.1485 0.1484
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.1472 0.1528
Loa Loa (eye worm) hypothetical protein 0.0048 0.1523 0.1522
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Echinococcus granulosus mitogen activated protein kinase 0.0231 0.8955 0.9298
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0286 0.0297
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0587 0.0586
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0052 0.1692 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0231 0.8955 0.8955
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.8955 0.9135
Entamoeba histolytica protein kinase, putative 0.0047 0.1485 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0016 0.0244 0.0252
Echinococcus granulosus tar DNA binding protein 0.0062 0.2095 0.2174
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0016 0.0239 0.0232
Loa Loa (eye worm) SRC-1 0.0057 0.1895 0.1894
Brugia malayi Plexin repeat family protein 0.0011 0.0029 0.0028
Schistosoma mansoni adapter molecule crk 0.001 0.0001 0.0001
Onchocerca volvulus 0.0012 0.0084 0.006
Echinococcus multilocularis peroxidasin 0.0016 0.0239 0.0248
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1472 0.1529
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Echinococcus multilocularis epidermal growth factor receptor 0.0076 0.2659 0.276
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0032 0.0874 0.0908
Echinococcus granulosus hemicentin 1 0.0016 0.0239 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0958 0.0957
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0788 0.0818
Brugia malayi SH2 domain containing protein 0.0012 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0874 0.0873
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0316 0.0328
Schistosoma mansoni tyrosine kinase 0.0037 0.1079 0.112
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0052 0.1692 0.1756
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0231 0.8955 1
Brugia malayi hypothetical protein 0.0032 0.0874 0.0873
Schistosoma mansoni tyrosine kinase 0.0023 0.0524 0.0545
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0316 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Brugia malayi Fibronectin type III domain containing protein 0.0032 0.0874 0.0873
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0231 0.8955 1
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.0212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0316 0.0303
Schistosoma mansoni growth factor receptor-bound protein 0.001 0.0001 0.0001
Echinococcus granulosus defective proboscis extension response 0.0032 0.0874 0.0907
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.144 0.1439
Loa Loa (eye worm) plexin A 0.0013 0.011 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2095 0.2175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi Furin-like cysteine rich region family protein 0.0076 0.2659 0.2658
Brugia malayi hypothetical protein 0.0016 0.0242 0.0241
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0316 0.0128
Echinococcus multilocularis titin 0.0011 0.0044 0.0044
Echinococcus granulosus tyrosine kinase 0.0052 0.1692 0.1756
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0275 0.0285
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0043 0.0044
Brugia malayi protein unc-22 0.0011 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Entamoeba histolytica hypothetical protein 0.0025 0.0587 0.3595
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0316 0.0328
Echinococcus granulosus tyrosine protein kinase otk 0.0016 0.0239 0.0248
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0046 0.144 0.1439
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0231 0.8955 1
Schistosoma mansoni titin 0.0011 0.0044 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.159 0.159
Echinococcus granulosus tyrosine protein kinase Blk 0.0052 0.1692 0.1756
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0231 0.8955 1
Onchocerca volvulus 0.003 0.0788 0.0837
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Echinococcus granulosus plexin a4 0.0013 0.011 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0044 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Onchocerca volvulus 0.0012 0.0084 0.006
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0239 0.0238
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.159 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0029 0.0754 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) TK/ROR protein kinase 0.0016 0.0244 0.0243
Brugia malayi MAP kinase sur-1 0.0231 0.8955 0.8955
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1472 0.1529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0224 0.0223
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Echinococcus multilocularis Immunoglobulin 0.0032 0.0874 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Schistosoma mansoni nck2/grb4 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1399 0.1452
Loa Loa (eye worm) hypothetical protein 0.0025 0.06 0.0599
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Schistosoma mansoni tyrosine kinase 0.0037 0.1079 0.112
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0316 0.0327
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Echinococcus multilocularis epidermal growth factor receptor 0.0044 0.1364 0.1415
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0316 0.0128
Schistosoma mansoni zinc finger protein 0.0015 0.0205 0.0212
Echinococcus granulosus mitogen activated protein kinase 3 0.0231 0.8955 0.9298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Echinococcus multilocularis plexin a4 0.0013 0.011 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1032 0.1071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0587 0.0437
Schistosoma mansoni tyrosine kinase 0.0057 0.1895 0.1967
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0078 0.0081
Echinococcus multilocularis twitchin 0.0011 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus granulosus epidermal growth factor receptor 0.0044 0.1364 0.1415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1399 0.1452
Onchocerca volvulus 0.0235 0.9092 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0057 0.1895 0.1966
Echinococcus multilocularis Immunoglobulin 0.0032 0.0874 0.0907
Schistosoma mansoni cell adhesion molecule 0.0016 0.0239 0.0249
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.6289 0.6907
Brugia malayi hypothetical protein 0.0025 0.06 0.0599
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.06 0.0621
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0016 0.0239 0.0248
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0316 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.159 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.665 0.677
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1032 0.1071
Echinococcus granulosus lachesin 0.0016 0.0239 0.0248
Trypanosoma brucei protein kinase, putative 0.0231 0.8955 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0316 0.1661
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.06 0.0621
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0012 0.0084 0.0086
Trypanosoma brucei ISWI complex protein 0.0015 0.0205 0.0177
Echinococcus granulosus muscleblind protein 0.0148 0.5583 0.5796
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2095 0.2175
Echinococcus granulosus fibroblast growth factor receptor 4 0.0248 0.9632 1
Schistosoma mansoni vesicular amine transporter 0.0032 0.0874 0.0908
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0016 0.0239 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2095 0.2094
Echinococcus granulosus neuroglian 0.0041 0.1242 0.1289
Onchocerca volvulus 0.0012 0.0084 0.006
Echinococcus granulosus tyrosine protein kinase ABL1 0.0012 0.0084 0.0086
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0275 0.0284
Schistosoma mansoni tyrosine kinase 0.0057 0.1895 0.1967
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.06 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0316 0.0303
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2095 0.2094
Echinococcus granulosus geminin 0.0205 0.788 0.8181
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0239 0.0238
Schistosoma mansoni tyrosine kinase 0.0076 0.2659 0.2761
Echinococcus granulosus tyrosine protein kinase Src42A 0.0057 0.1895 0.1966
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0316 0.0315
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0043 0.0044
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0316 0.0303
Brugia malayi plexin A 0.0013 0.011 0.0109
Echinococcus granulosus tyrosine protein kinase HCK 0.0047 0.1485 0.154
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.8955 0.9135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Echinococcus multilocularis roundabout 2 0.0016 0.0239 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Echinococcus multilocularis lachesin 0.0016 0.0239 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi Protein kinase domain containing protein 0.0012 0.0084 0.0082
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0316 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.0224 0.0232
Schistosoma mansoni tyrosine kinase 0.0037 0.1079 0.112
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0324 0.0323
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Echinococcus multilocularis GPCR, family 2 0.0016 0.0224 0.0231
Brugia malayi Muscleblind-like protein 0.0148 0.5583 0.5582
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2095 0.2094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1399 0.1452
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0224 0.0223
Echinococcus multilocularis hemicentin 1 0.0016 0.0239 0.0248
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.1986 0.2061
Echinococcus granulosus twitchin 0.0043 0.1327 0.1377
Echinococcus granulosus tyrosine kinase 0.0012 0.0084 0.0086
Schistosoma mansoni tyrosine kinase 0.0012 0.0084 0.0087
Loa Loa (eye worm) TK/INSR protein kinase 0.0029 0.0754 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1407 0.146
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.7939 0.7939
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0316 0.0303
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.8955 0.9135
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0587 0.0609
Echinococcus granulosus tyrosine protein kinase shark 0.0012 0.0084 0.0086
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0286 0.0296
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0057 0.1895 0.1966
Schistosoma mansoni tyrosine kinase 0.0017 0.0286 0.0297
Schistosoma mansoni tyrosine kinase 0.0044 0.1364 0.1416
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0224 0.0231
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0587 0.0607
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Schistosoma mansoni titin 0.0016 0.0239 0.0249
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.1979 0.2054
Brugia malayi SH2 domain containing protein 0.0012 0.0084 0.0082
Echinococcus multilocularis insulin receptor 0.0029 0.0754 0.0782
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.8955 0.9298
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0012 0.0084 0.0086
Schistosoma mansoni cell adhesion molecule 0.0016 0.0239 0.0249
Brugia malayi SRC-1 0.0057 0.1895 0.1894
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0316 0.0315
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0016 0.0239 0.0248
Plasmodium vivax SET domain protein, putative 0.003 0.0788 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0788 0.0817
Schistosoma mansoni hypothetical protein 0.0016 0.0224 0.0232
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0231 0.8955 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0316 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0224 0.0231
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0316 0.0128
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0316 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0958 0.0957
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0318 0.0129
Loa Loa (eye worm) hypothetical protein 0.0148 0.5583 0.5582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1399 0.1452
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.1472 0.1528
Echinococcus granulosus titin 0.0011 0.0044 0.0044
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0587 0.0609
Giardia lamblia Kinase, CMGC MAPK 0.0231 0.8955 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.9799 0.9799
Echinococcus granulosus insulin receptor 0.0029 0.0754 0.0782
Schistosoma mansoni cell adhesion molecule 0.0039 0.1155 0.1199
Echinococcus multilocularis geminin 0.0205 0.788 0.8181
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0248 0.9632 1
Echinococcus granulosus roundabout 2 0.0016 0.0239 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0587 0.0554
Onchocerca volvulus 0.0011 0.0044 0.0016
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0299 0.0298
Echinococcus granulosus contactin 0.0016 0.0239 0.0248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Schistosoma mansoni cell adhesion molecule 0.0016 0.0239 0.0249
Mycobacterium ulcerans epoxide hydrolase EphA 0.016 0.6052 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Brugia malayi Bromodomain containing protein 0.0074 0.2599 0.2598
Loa Loa (eye worm) hypothetical protein 0.004 0.1225 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0275 0.0285
Brugia malayi Pre-SET motif family protein 0.0206 0.7939 0.7939
Brugia malayi Protein kinase domain containing protein 0.0012 0.0084 0.0082
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0231 0.8955 1
Schistosoma mansoni hypothetical protein 0.0034 0.0958 0.0994
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0316 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Schistosoma mansoni hypothetical protein 0.0016 0.0224 0.0232
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0239 0.0249
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0286 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0224 0.0231
Schistosoma mansoni bromodomain containing protein 0.0063 0.2129 0.2211
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0057 0.1895 0.1966
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0057 0.1895 0.1966
Schistosoma mansoni zinc finger protein 0.0019 0.0376 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1399 0.1452
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0239 0.0238
Loa Loa (eye worm) hypothetical protein 0.0046 0.1472 0.1471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0011 0.0044 0.0043
Echinococcus multilocularis muscleblind protein 0.0148 0.5583 0.5796
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0587 0.061
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0016 0.0239 0.0249
Echinococcus granulosus zinc finger protein 0.0019 0.0376 0.0389
Echinococcus granulosus neuroglian 0.0016 0.0239 0.0248
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Echinococcus multilocularis tyrosine protein kinase Blk 0.0052 0.1692 0.1756
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0044 0.1364 0.1415
Brugia malayi Protein kinase domain containing protein 0.0029 0.0754 0.0753
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0316 0.0315
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0039 0.1155 0.1198
Schistosoma mansoni memapsin-2 (A01 family) 0.0226 0.8759 0.9094
Echinococcus granulosus Immunoglobulin 0.0032 0.0874 0.0907
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0448 0.0278
Echinococcus multilocularis roundabout 2 0.0016 0.0239 0.0248
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0286 0.0296
Echinococcus multilocularis roundabout 2 0.0048 0.1523 0.158
Brugia malayi follicle stimulating hormone receptor 0.0226 0.8746 0.8746
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0418 0.0417
Brugia malayi Peroxidasin 0.0016 0.0239 0.0238
Schistosoma mansoni septate junction protein 0.0016 0.0239 0.0249
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.159 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Schistosoma mansoni hypothetical protein 0.002 0.0418 0.0434
Echinococcus granulosus roundabout 2 0.0016 0.0239 0.0248
Echinococcus multilocularis tyrosine protein kinase Srms 0.0052 0.1692 0.1756
Echinococcus multilocularis hemicentin 1 0.0016 0.0239 0.0248
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.9799 0.9799
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.06 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.5583 0.5582
Leishmania major hypothetical protein, conserved 0.0025 0.06 0.0452
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0057 0.1895 0.1966
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0012 0.0084 0.0086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Schistosoma mansoni nephrin 0.0016 0.0239 0.0249
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Echinococcus multilocularis tyrosine kinase 0.0012 0.0084 0.0086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0231 0.8955 0.9298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0316 0.0315
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0016 0.0244 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2095 0.2175
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0275 0.0284
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0032 0.0874 0.0908
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1399 0.1452
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.06 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.665 0.677
Echinococcus multilocularis tyrosine protein kinase shark 0.0012 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Loa Loa (eye worm) TK/EGFR protein kinase 0.0076 0.2659 0.2658
Brugia malayi Protein kinase domain containing protein 0.0012 0.0084 0.0082
Echinococcus multilocularis neuroglian 0.0041 0.1242 0.1289
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0316 0.0128
Brugia malayi Protein kinase domain containing protein 0.0012 0.0084 0.0082
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0316 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0448 0.0447
Echinococcus multilocularis tyrosine protein kinase otk 0.0016 0.0239 0.0248
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0286 0.0285
Brugia malayi PHD-finger family protein 0.0025 0.059 0.0589
Brugia malayi Prion-like- 0.0016 0.0239 0.0238
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0239 0.0238
Echinococcus multilocularis mitogen activated protein kinase 0.0231 0.8955 0.9298
Onchocerca volvulus 0.0012 0.0084 0.006
Schistosoma mansoni neuroglian 0.0016 0.0239 0.0249
Echinococcus multilocularis zinc finger protein 0.0019 0.0376 0.0389
Loa Loa (eye worm) hypothetical protein 0.007 0.2428 0.2427
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0239 0.0248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.8746 0.8746
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0286 0.0296
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0286 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0084 0.0082
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0231 0.8955 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0044 0.0043
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0316 0.0327
Echinococcus granulosus roundabout 2 0.0048 0.1523 0.158
Schistosoma mansoni tyrosine kinase 0.0029 0.0754 0.0783
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0248 0.9632 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1407 0.146
Loa Loa (eye worm) TK/ABL protein kinase 0.0012 0.0084 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Brugia malayi hypothetical protein 0.0012 0.0084 0.0082
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0316 0.0128
Schistosoma mansoni tyrosine kinase 0.0248 0.9632 1
Schistosoma mansoni hypothetical protein 0.0205 0.788 0.8181
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0495 0.0513
Echinococcus granulosus epidermal growth factor receptor 0.0076 0.2659 0.276
Schistosoma mansoni hypothetical protein 0.0205 0.788 0.8181
Schistosoma mansoni septate junction protein 0.0016 0.0239 0.0249
Schistosoma mansoni hypothetical protein 0.0016 0.0224 0.0232
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.1895 0.1966
Brugia malayi TAR-binding protein 0.0062 0.2095 0.2094
Echinococcus multilocularis 0.0021 0.0457 0.0474
Echinococcus granulosus GPCR family 2 0.0016 0.0224 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0032 0.0874 0.0907
Schistosoma mansoni tyrosine kinase 0.0017 0.0286 0.0297
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Schistosoma mansoni plexin 0.0011 0.0029 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1399 0.1398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0788 0.0832
Loa Loa (eye worm) hypothetical protein 0.0042 0.1301 0.1301
Schistosoma mansoni nephrin 0.0041 0.1242 0.129
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0239 0.0248
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0057 0.1895 0.1966
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0224 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.9799 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0238
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0044 0.0046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0744 0.0772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Echinococcus granulosus tyrosine protein kinase Srms 0.0012 0.0084 0.0086
Loa Loa (eye worm) TK protein kinase 0.0052 0.1692 0.1691
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.1986 0.2061
Schistosoma mansoni roundabout 0.0016 0.0239 0.0249
Brugia malayi Protein kinase domain containing protein 0.0012 0.0084 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.06 0.0452
Echinococcus granulosus peroxidasin 0.0016 0.0239 0.0248
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0057 0.1895 0.1966
Loa Loa (eye worm) hypothetical protein 0.0048 0.1523 0.1522
Echinococcus multilocularis neuroglian 0.0016 0.0239 0.0248
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0057 0.1895 0.1966
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0587 0.0607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1399 0.1452
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.016 0.6052 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0874 0.0873
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6289 0.6401
Loa Loa (eye worm) RNA binding protein 0.0062 0.2095 0.2094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0316 0.0276
Loa Loa (eye worm) CAMK protein kinase 0.0011 0.0044 0.0043
Echinococcus multilocularis tyrosine protein kinase HCK 0.0047 0.1485 0.154
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0084 0.0082

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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