Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0229 | 0.0229 |
Brugia malayi | hypothetical protein | 0.0182 | 0.8806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1191 | 0.1353 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0229 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0229 | 0.0229 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0229 | 0.0229 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1191 | 0.1353 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1315 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0229 | 0.0229 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1315 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0614 | 0.0697 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6742 | 0.7656 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6742 | 0.7656 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2218 | 0.2518 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2218 | 0.2518 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2218 | 0.2518 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0229 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1191 | 0.1191 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0229 | 0.372 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1315 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0229 | 0.0229 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1315 | 0.1315 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0614 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0229 | 0.372 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0229 | 0.372 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0229 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1315 | 0.1493 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0229 | 0.372 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0229 | 0.0229 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0229 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0229 | 0.0229 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0229 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0229 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0229 | 0.026 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0614 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0229 | 0.372 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1315 | 0.1315 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0229 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0229 | 0.026 |
Onchocerca volvulus | 0.0182 | 0.8806 | 0.5 | |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0229 | 0.026 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6742 | 0.7656 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0229 | 0.372 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2218 | 0.2518 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.8806 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.003 | 0.0614 | 0.0697 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0229 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0229 | 0.0229 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0229 | 0.026 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0229 | 0.372 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1315 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1315 | 0.1315 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1315 | 0.1315 |
Brugia malayi | hypothetical protein | 0.002 | 0.0032 | 0.0037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.