Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0073 | 0.4659 | 0.4659 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0034 | 0.1322 | 0.0958 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0073 | 0.4659 | 0.4501 |
Onchocerca volvulus | 0.0073 | 0.4659 | 0.1438 | |
Onchocerca volvulus | 0.0073 | 0.4659 | 0.1438 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0034 | 0.1322 | 0.0958 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.011 | 0.7772 | 1 |
Brugia malayi | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0073 | 0.4659 | 0.4501 |
Echinococcus multilocularis | nAChR subunit | 0.0073 | 0.4659 | 0.4436 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0034 | 0.1322 | 0.0958 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0118 | 0.843 | 0.8383 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0402 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0129 | 0.9349 | 0.9349 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0073 | 0.4659 | 0.4659 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0023 | 0.0402 | 0.0402 |
Schistosoma mansoni | nAChR subunit | 0.0063 | 0.3763 | 0.3763 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0034 | 0.1322 | 0.1065 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0118 | 0.843 | 0.8383 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.7108 | 0.7023 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0063 | 0.3763 | 0.3501 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0063 | 0.3763 | 0.3763 |
Brugia malayi | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.4659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0023 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0118 | 0.843 | 0.8364 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0063 | 0.3763 | 0.3501 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0073 | 0.4659 | 0.4659 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0073 | 0.4659 | 0.4501 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0023 | 0.0402 | 0.0118 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0023 | 0.0402 | 0.0402 |
Brugia malayi | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Brugia malayi | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.011 | 0.7772 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0063 | 0.3763 | 0.3578 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.1322 | 0.1322 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0063 | 0.3763 | 0.3763 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0063 | 0.3763 | 0.3763 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0073 | 0.4659 | 0.4501 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0063 | 0.3763 | 0.3501 |
Schistosoma mansoni | nAChR subunit | 0.0063 | 0.3763 | 0.3763 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0402 | 0.0402 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.1322 | 0.1322 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0023 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0023 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0118 | 0.843 | 0.8364 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0063 | 0.3763 | 0.3578 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0063 | 0.3763 | 0.3501 |
Echinococcus granulosus | voltage gated potassium channel | 0.0034 | 0.1322 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0063 | 0.3763 | 0.3501 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0063 | 0.3763 | 0.3578 |
Echinococcus granulosus | nAChR subunit | 0.0073 | 0.4659 | 0.4436 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0063 | 0.3763 | 0.3763 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0023 | 0.0402 | 0.0118 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0129 | 0.9349 | 0.9349 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1322 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4659 | 0.4501 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0073 | 0.4659 | 0.4501 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3763 | 0.3578 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0023 | 0.0402 | 0.0118 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0063 | 0.3763 | 0.3578 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 ug ml-1 | Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay | ChEMBL. | 21546250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.