Detailed information for compound 1515707

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 240.214 | Formula: C13H8N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON=C1c2ccc(cc2c2c1cccc2)[N+](=O)[O-]
  • InChi: 1S/C13H8N2O3/c16-14-13-10-4-2-1-3-9(10)12-7-8(15(17)18)5-6-11(12)13/h1-7,16H
  • InChiKey: LMHSTOFRBYSVEQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL No references
Homo sapiens nuclear receptor coactivator 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear receptor coactivator 3 Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax heat shock protein, putative 0.021 0.5496 1
Onchocerca volvulus Protein cycle homolog 0.0045 0.0713 0.3378
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0086 0.0337
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0582 0.0153
Echinococcus granulosus heat shock protein 0.0055 0.1019 0.061
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0787 0.308
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0435 0.0266
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3595 0.3399
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0435 0.0266
Loa Loa (eye worm) hypothetical protein 0.0064 0.1257 0.099
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0435 0.0266
Schistosoma mansoni hypothetical protein 0.0036 0.0452 0.0018
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0941 0.0529
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1343 0.1078
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.1019 0.3987
Loa Loa (eye worm) hypothetical protein 0.0044 0.0704 0.0419
Giardia lamblia Grp94/Hsp90 0.0052 0.092 0.8311
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0941 0.0529
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0835 0.0418
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1343 0.0949
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0045 0.0713 0.0429
Loa Loa (eye worm) hypothetical protein 0.0052 0.0932 0.0655
Loa Loa (eye worm) hypothetical protein 0.0107 0.2524 0.2295
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Brugia malayi Bromodomain containing protein 0.0035 0.0435 0.0142
Schistosoma mansoni sodium/solute symporter 0.004 0.0582 0.0153
Echinococcus granulosus endoplasmin 0.0052 0.092 0.0507
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0941 0.3683
Toxoplasma gondii heat shock protein HSP90 0.0055 0.1019 0.1389
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.2556 1
Echinococcus multilocularis endoplasmin 0.0052 0.092 0.0507
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0045 0.0713 0.0429
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0297 0.1162
Trichomonas vaginalis endoplasmin, putative 0.004 0.0579 0.345
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1016 0.0607
Echinococcus multilocularis heat shock protein 90 0.0055 0.1019 0.061
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1016 0.0607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1016 0.0741
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1522 0.1263
Brugia malayi jmjC domain containing protein 0.0043 0.065 0.0364
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0941 0.8672
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.092 0.5
Schistosoma mansoni heat shock protein 0.0055 0.1019 0.061
Brugia malayi hypothetical protein 0.0064 0.1257 0.099
Brugia malayi Hsp90 protein 0.0037 0.048 0.0189
Loa Loa (eye worm) heat shock protein 75 0.0037 0.048 0.0189
Brugia malayi hypothetical protein 0.0148 0.3705 0.3512
Entamoeba histolytica protein kinase, putative 0.0108 0.2556 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1016 0.0607
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0582 0.0153
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.065 0.0225
Loa Loa (eye worm) hypothetical protein 0.0035 0.0435 0.0142
Plasmodium vivax protein kinase Crk2 0.0053 0.0941 0.124
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.048 0.0047
Echinococcus granulosus heat shock protein 90 0.0047 0.0787 0.0368
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Trypanosoma cruzi heat shock protein, putative 0.0037 0.048 0.1879
Trichomonas vaginalis heat shock protein, putative 0.004 0.0579 0.345
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0582 0.0153
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.092 0.3601
Loa Loa (eye worm) RNA binding protein 0.0067 0.1343 0.1078
Brugia malayi hypothetical protein 0.0044 0.0704 0.0419
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0582 0.0153
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0582 0.0153
Echinococcus multilocularis heat shock protein 0.0055 0.1019 0.061
Brugia malayi MH2 domain containing protein 0.0144 0.3595 0.3399
Brugia malayi Protein kinase domain containing protein 0.0108 0.2556 0.2328
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.2556 1
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.8377 0.8303
Echinococcus granulosus heat shock protein 90 0.0055 0.1019 0.061
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1019 0.2595
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1019 0.3196
Loa Loa (eye worm) hypothetical protein 0.004 0.0582 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0941 0.0529
Plasmodium vivax endoplasmin, putative 0.0055 0.1019 0.1389
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.2556 0.2217
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0787 0.308
Entamoeba histolytica protein kinase, putative 0.0108 0.2556 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.0941 0.0664
Schistosoma mansoni inositol transporter 0.004 0.0582 0.0153
Echinococcus granulosus solute carrier family 5 0.004 0.0582 0.0153
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0941 0.2853
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0452 0.016
Brugia malayi heat shock protein 90 0.0055 0.1019 0.0744
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Brugia malayi hypothetical protein 0.0045 0.0713 0.0429
Leishmania major hypothetical protein, conserved 0.003 0.0297 0.1162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0909 0.0631
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0941 0.2222
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0347 0.0096
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.8377 0.8303
Echinococcus multilocularis heat shock protein 90 0.0047 0.0787 0.0368
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0941 0.2222
Plasmodium falciparum phd finger protein, putative 0.0035 0.0435 0.0266
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0941 0.3683
Loa Loa (eye worm) hypothetical protein 0.0309 0.8377 0.8327
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0941 0.8846
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Echinococcus multilocularis solute carrier family 5 0.004 0.0582 0.0153
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Echinococcus granulosus tar DNA binding protein 0.0067 0.1343 0.0949
Loa Loa (eye worm) hypothetical protein 0.0148 0.3705 0.3512
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2758 0.2429
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0941 0.0529
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.065 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0435 0.0142
Treponema pallidum heat shock protein 90 0.0052 0.092 0.5
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1019 0.3196
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1019 1
Plasmodium falciparum protein kinase 5 0.0053 0.0941 0.124
Brugia malayi Sodium:solute symporter family protein 0.004 0.0582 0.0293
Onchocerca volvulus 0.004 0.0582 0.1783
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0941 0.3683
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.1019 1
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.2556 1
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0941 0.2853
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0941 0.8672
Plasmodium vivax heat shock protein 90, putative 0.0037 0.048 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1343 0.0949
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0064 0.1266 0.0999
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0941 0.0529
Brugia malayi Endoplasmin precursor 0.0055 0.1019 0.0744
Echinococcus multilocularis dual specificity 0.0108 0.2556 0.2217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1016 0.0607
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Trichomonas vaginalis heat shock protein, putative 0.0052 0.092 0.8533
Loa Loa (eye worm) heat shock protein 90 0.0055 0.1019 0.0744
Loa Loa (eye worm) hypothetical protein 0.0044 0.0704 0.0419
Entamoeba histolytica hypothetical protein 0.0108 0.2556 1
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.1019 0.3987
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0045 0.0713 0.0429
Loa Loa (eye worm) hypothetical protein 0.006 0.1165 0.0894
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0941 0.0529
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1019 0.3987
Echinococcus granulosus aryl hydrocarbon receptor 0.0064 0.1266 0.0869
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0941 0.0529
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0582 0.0548
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.048 0.0047
Brugia malayi jmjC domain containing protein 0.0115 0.2758 0.2537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1016 0.0607
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.1019 0.1389
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.092 0.5
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.8377 0.8303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0932 0.0655
Brugia malayi PHD-finger family protein 0.0035 0.0435 0.0142
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.092 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.065 0.0225
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.065 0.0225
Loa Loa (eye worm) hypothetical protein 0.0148 0.3705 0.3512
Loa Loa (eye worm) hypothetical protein 0.0044 0.0704 0.0419
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0044 0.0704 0.0419
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1343 0.0949
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.2556 1
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0941 0.0529
Schistosoma mansoni endoplasmin 0.0055 0.1019 0.061
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0787 0.6028
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2071 0.171
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1343 0.1078
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3595 0.3399
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0941 0.0664
Schistosoma mansoni inositol transporter 0.004 0.0582 0.0153
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0941 0.0529
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0932 0.0655
Plasmodium vivax heat shock protein 86, putative 0.0055 0.1019 0.1389
Trypanosoma brucei heat shock protein, putative 0.0055 0.1019 0.3196
Loa Loa (eye worm) hypothetical protein 0.0036 0.0452 0.016
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0941 0.0664
Onchocerca volvulus 0.0064 0.1257 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1343 0.0949
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0582 0.0153
Schistosoma mansoni heat shock protein 0.0055 0.1019 0.061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0932 0.0655
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0297 0.1162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1016 0.0741
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.2556 0.2328
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0045 0.0713 0.029
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1019 0.3987
Plasmodium falciparum heat shock protein 90 0.0055 0.1019 0.1389
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.0787 0.0368
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0941 0.3683
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.065 0.0364
Brugia malayi TAR-binding protein 0.0067 0.1343 0.1078
Mycobacterium ulcerans heat shock protein 90 0.0052 0.092 0.5
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0941 0.0529
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0941 0.0664
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2758 0.2429
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0787 0.655
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.048 0.0548
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0941 0.8846
Schistosoma mansoni endoplasmin 0.0055 0.1019 0.061
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.2556 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.2524 0.2295
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.02 0.5
Echinococcus multilocularis aryl hydrocarbon receptor 0.0064 0.1266 0.0869
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0941 0.124
Plasmodium falciparum heat shock protein 90, putative 0.021 0.5496 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1343 0.0949
Echinococcus granulosus dual specificity 0.0108 0.2556 0.2217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1016 0.0607
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1019 0.2595
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.5496 1
Schistosoma mansoni heat shock protein 0.0037 0.048 0.0047
Toxoplasma gondii heat shock protein 75, putative 0.0037 0.048 0.0353
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0941 0.3683
Plasmodium falciparum endoplasmin, putative 0.004 0.0579 0.0542
Leishmania major heat shock protein 83-1 0.0055 0.1019 0.3987
Trichomonas vaginalis heat shock protein, putative 0.0052 0.092 0.8533
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1019 0.3987
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1343 0.1078
Loa Loa (eye worm) endoplasmin 0.0055 0.1019 0.0744
Brugia malayi cell division control protein 2 homolog 0.0053 0.0941 0.0664
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1016 0.0607
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0941 0.3683
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0835 0.0418
Brugia malayi RNA binding protein 0.0067 0.1343 0.1078
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0941 0.8846
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1343 0.0949
Loa Loa (eye worm) hypothetical protein 0.0044 0.0704 0.0419
Leishmania major heat shock protein, putative 0.0037 0.048 0.1879
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.048 0.0812
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0582 0.0153
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.1019 0.3196

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 2.721 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 3.931 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (binding) = 6.875 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
AC50 (binding) = 8.404 uM PUBCHEM_BIOASSAY: Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488916] ChEMBL. No reference
IC50 (functional) = 3.343 uM PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 12.584 uM PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 35.878 uM PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0027 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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