Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0497 | 0.1939 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2356 | 0.2356 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.001 | 0.0146 | 0.0572 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0146 | 0.0572 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0497 | 0.1939 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0716 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0716 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 0.2562 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0716 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 0.2562 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0123 | 0.048 |
Schistosoma mansoni | dep domain containing protein | 0.001 | 0.0146 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0497 | 0.1939 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1495 | 0.1495 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0716 | 0.2795 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0497 | 0.0497 |
Brugia malayi | DIX domain containing protein | 0.001 | 0.0146 | 0.0146 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0497 | 0.1939 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.2562 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0497 | 0.0497 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0497 | 0.1939 |
Onchocerca volvulus | 0.001 | 0.0146 | 0.0146 | |
Schistosoma mansoni | ferritin | 0.001 | 0.0123 | 0.048 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.001 | 0.0146 | 0.0146 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2356 | 0.2356 |
Schistosoma mansoni | regulator of G protein signaling | 0.001 | 0.0146 | 0.0572 |
Schistosoma mansoni | ferritin | 0.001 | 0.0123 | 0.048 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.2562 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.001 | 0.0146 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1495 | 0.5837 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 0.2562 | 1 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0123 | 0.048 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0716 | 0.0716 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0716 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0497 | 0.1939 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0716 | 0.2795 |
Schistosoma mansoni | ferritin | 0.001 | 0.0123 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0146 | 0.0146 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0123 | 0.048 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 0.2562 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0058 | 0.2562 | 0.2562 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0123 | 0.048 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 0.2562 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1495 | 0.1495 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0716 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0497 | 0.1939 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 0.2562 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0123 | 0.048 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0497 | 0.1939 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0123 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0716 | 0.2358 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.2562 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0146 | 0.0146 |
Schistosoma mansoni | z-protein (S1r protein) | 0.001 | 0.0146 | 0.0572 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0497 | 0.1939 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0716 | 1 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0146 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0146 | 0.0146 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0123 | 0.048 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0123 | 0.048 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0146 | 0.0572 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.001 | 0.0146 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0146 | 0.0572 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0716 | 0.2795 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2356 | 0.2356 |
Brugia malayi | hypothetical protein | 0.001 | 0.0146 | 0.0146 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.001 | 0.0146 | 0.0572 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.2562 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0716 | 0.2795 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0716 | 0.2795 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 0.2562 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0716 | 0.2795 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2356 | 0.2356 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 0.2562 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0146 | 0.0572 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.2562 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.001 | 0.0146 | 0.0146 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0123 | 0.048 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0146 | 0.0572 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0146 | 0.0572 |
Echinococcus granulosus | ferritin | 0.001 | 0.0123 | 0.048 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0123 | 0.048 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0497 | 0.0497 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.2562 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0497 | 0.1939 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.001 | 0.0146 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0146 | 0.0572 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0716 | 0.2795 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0146 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 0.2562 | 0.2562 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 0.2562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.2562 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0058 | 0.2562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.2562 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0497 | 0.0497 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0146 | 0.0572 |
Brugia malayi | hypothetical protein | 0.001 | 0.0146 | 0.0146 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 0.2562 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0716 | 0.2795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.