Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.4022 | 0.4022 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1709 | 0.1709 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0121 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0974 | 0.0974 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1709 | 0.1709 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0121 | 0.0121 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.4022 | 0.4022 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0121 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0121 | 0.0121 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0121 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1709 | 0.1709 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0121 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.4022 | 0.4022 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0974 | 0.0974 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0121 | 0.0121 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0121 | 0.0121 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0121 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0121 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0121 | 0.0121 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0121 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.