Detailed information for compound 1516728

Basic information

Technical information
  • TDR Targets ID: 1516728
  • Name: (4Z)-4-[(4-dimethylaminophenyl)methylidene]-1 -methyl-2-phenylpyrazolo[1,5-a]indol-1-ium-6- ol; trifluoromethanesulfonate
  • MW: 543.557 | Formula: C27H24F3N3O4S
  • H donors: 2 H acceptors: 4 LogP: 5.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC(S(=O)(=O)[O-])(F)F.Oc1ccc2c(c1)c(=Cc1ccc(cc1)N(C)C)c1n2[n+](C)c(c1)c1ccccc1
  • InChi: 1S/C26H23N3O.CHF3O3S/c1-27(2)20-11-9-18(10-12-20)15-22-23-16-21(30)13-14-24(23)29-26(22)17-25(28(29)3)19-7-5-4-6-8-19;2-1(3,4)8(5,6)7/h4-17H,1-3H3;(H,5,6,7)
  • InChiKey: FCWQEEIPUGZKHR-UHFFFAOYSA-N  


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Synonyms

  • (4Z)-4-[(4-dimethylaminophenyl)methylene]-1-methyl-2-phenyl-pyrazolo[1,5-a]indol-1-ium-6-ol; trifluoromethanesulfonate
  • (4Z)-4-[(4-dimethylaminophenyl)methylene]-1-methyl-2-phenyl-6-pyrazolo[1,5-a]indol-1-iumol; trifluoromethanesulfonate
  • (4Z)-4-(4-dimethylaminobenzylidene)-1-methyl-2-phenyl-pyrazolo[1,5-a]indol-1-ium-6-ol; trifluoromethanesulfonate
  • (4Z)-4-[(4-dimethylaminophenyl)methylidene]-1-methyl-2-phenyl-pyrazolo[1,5-a]indol-1-ium-6-ol; trifluoromethanesulfonate
  • NSC693573

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.077 0.2298
Loa Loa (eye worm) hypothetical protein 0.0075 0.2148 0.2615
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0151 0.041
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0009 0.0051 0.0016
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.3351 1
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0051 0.0152
Leishmania major hydrolase-like protein,esterase-like protein 0.0009 0.0051 0.0152
Echinococcus multilocularis flap endonuclease 1 0.0031 0.077 0.2217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Treponema pallidum DNA ligase (lig) 0.0012 0.0148 0.0342
Brugia malayi alpha/beta hydrolase 0.0009 0.0051 0.0062
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.367 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0173 0.0211
Echinococcus granulosus flap endonuclease 1 0.0031 0.077 0.2217
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0062
Trichomonas vaginalis hydrolase, putative 0.0009 0.0051 0.0044
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0009 0.0051 0.0051
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0008 0.0035 0.0042
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1489 0.4444
Brugia malayi MH2 domain containing protein 0.001 0.0082 0.01
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0035 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1152 0.3368
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0148 0.0442
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0013 0.0173 0.0211
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0008 0.0035 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0312
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0511 0.0511
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0978 0.2666
Trypanosoma cruzi glycosyl hydrolase, putative 0.0008 0.0035 0.0103
Giardia lamblia DINP protein human, muc B family 0.0023 0.0511 0.1393
Echinococcus granulosus Smad4 0.001 0.0082 0.0144
Giardia lamblia Phosphoglycolate phosphatase 0.0008 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Mycobacterium ulcerans oxidoreductase 0.0009 0.0051 0.0051
Onchocerca volvulus Lipase homolog 0.0009 0.0051 0.1424
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0511 0.1311
Brugia malayi Ets-domain containing protein 0.0087 0.2551 0.3106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0173 0.0211
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0692 0.1982
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0036 0.0922 0.2752
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0082 0.0144
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0009 0.0051 0.0144
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0148 0.0442
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0262 0.0783
Entamoeba histolytica hypothetical protein 0.0009 0.0051 0.0144
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.367 1
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0009 0.0051 0.0062
Schistosoma mansoni topbp1 0.0012 0.0148 0.018
Echinococcus multilocularis smad 0.001 0.0082 0.0144
Brugia malayi MH2 domain containing protein 0.001 0.0082 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0511 0.1525
Plasmodium vivax alpha/beta hydrolase, putative 0.0009 0.0051 0.0138
Echinococcus multilocularis dna polymerase eta 0.0054 0.1489 0.4386
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0173 0.0418
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0173 0.0211
Leishmania major hydrolase-like protein 0.0009 0.0051 0.0152
Brugia malayi 6-phosphogluconolactonase family protein 0.001 0.0089 0.0108
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0265
Mycobacterium ulcerans hydrolase 0.0009 0.0051 0.0051
Echinococcus multilocularis Smad4 0.001 0.0082 0.0144
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0148 0.018
Mycobacterium tuberculosis Conserved protein 0.0009 0.0051 0.0016
Echinococcus multilocularis protein C ets 2 0.0013 0.0173 0.0418
Schistosoma mansoni smad1 5 8 and 0.001 0.0082 0.01
Leishmania major 6-phosphogluconolactonase 0.001 0.0089 0.0265
Brugia malayi MH2 domain containing protein 0.0144 0.4355 0.5302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0151 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1859
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0051 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0511 0.1525
Echinococcus granulosus protein C ets 2 0.0013 0.0173 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1527 0.4499
Mycobacterium ulcerans epoxide hydrolase EphB 0.0009 0.0051 0.0051
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0035 0.0042
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.3351 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0074 0.2109 0.5746
Mycobacterium ulcerans peroxidase BpoB 0.0009 0.0051 0.0051
Mycobacterium leprae Probable exported protease 0.0009 0.0051 0.1424
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0148 0.0312
Echinococcus granulosus abhydrolase domain containing protein 3 0.0009 0.0051 0.0049
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0692 0.1808
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0148 0.0148
Brugia malayi hypothetical protein 0.0043 0.1152 0.1402
Brugia malayi MH1 domain containing protein 0.001 0.0082 0.01
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0009 0.0051 0.0016
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0009 0.0051 0.0051
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0265
Brugia malayi Smad1 0.001 0.0082 0.01
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0978 0.2919
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0511 0.1437
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4355 0.5302
Loa Loa (eye worm) 6-phosphogluconolactonase 0.001 0.0089 0.0108
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.2551 0.7588
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0009 0.0051 0.0152
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0151 0.0183
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0035 0.0042
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0692 0.0842
Echinococcus granulosus smad 0.001 0.0082 0.0144
Entamoeba histolytica Flap nuclease, putative 0.0031 0.077 0.6584
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0051 0.0152
Mycobacterium ulcerans exported protease 0.0009 0.0051 0.0051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0151 0.041
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.077 0.2298
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.3351 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0148 0.0312
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0051 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0051 0.0138
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0262 0.0783
Mycobacterium ulcerans hypothetical protein 0.0009 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0051 0.0152
Schistosoma mansoni smad 0.001 0.0082 0.01
Schistosoma mansoni smad1 5 8 and 0.001 0.0082 0.01
Plasmodium falciparum flap endonuclease 1 0.0031 0.077 0.2098
Leishmania major DNA polymerase eta, putative 0.0054 0.1489 0.4444
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0074 0.2109 0.2109
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0009 0.0051 0.0049
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0009 0.0051 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.077 0.0938
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0312
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Loa Loa (eye worm) hydrolase 0.0009 0.0051 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0511 0.1525
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0009 0.0051 0.0138
Plasmodium falciparum epoxide hydrolase 1 0.0009 0.0051 0.0138
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.367 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1152 0.3368
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0149
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0062
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.001 0.0089 0.0265
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0082 0.0144
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0009 0.0051 0.0016
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0051 0.0051
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0051 0.0152
Loa Loa (eye worm) Smad1 0.001 0.0082 0.01
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0035 0.0042
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0009 0.0051 0.0144
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0148 0.0312
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0035 0.0042
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0009 0.0051 0.0016
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0009 0.0051 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1527 0.4499
Entamoeba histolytica hypothetical protein 0.0043 0.1152 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0262 0.0783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.077 0.2098
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0148 0.0442
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0051 0.0051
Mycobacterium ulcerans hydrolase 0.0009 0.0051 0.0051
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0051 0.0016
Schistosoma mansoni hypothetical protein 0.0043 0.1152 0.1402
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0051 0.0062
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0173 0.0418
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0051 0.0049
Schistosoma mansoni topbp1 0.0012 0.0148 0.018
Leishmania major glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0265
Schistosoma mansoni ets-related 0.0265 0.8214 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0082 0.0144
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0051 0.0049
Schistosoma mansoni smad1 5 8 and 0.001 0.0082 0.01
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.3351 0.408
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0009 0.0051 0.1424
Mycobacterium tuberculosis Probable exported protease 0.0009 0.0051 0.0016
Schistosoma mansoni elf1 0.0013 0.0173 0.0211
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.001 0.0089 0.4774
Mycobacterium ulcerans lipase/esterase 0.0009 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0281 0.0839
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0009 0.0051 0.0138
Brugia malayi DKFZp564C0469 protein 0.0012 0.0148 0.018
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0173 0.0418
Schistosoma mansoni flap endonuclease-1 0.0028 0.0674 0.0821
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0148 0.018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0151 0.041
Onchocerca volvulus Lipase homolog 0.0009 0.0051 0.1424
Mycobacterium ulcerans hypothetical protein 0.0009 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1527 0.1859
Mycobacterium ulcerans lignin peroxidase LipJ 0.0009 0.0051 0.0051
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0008 0.0035 0.0094
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0051 0.0062
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.2551 0.7588
Brugia malayi topoisomerase 0.0012 0.0148 0.018
Mycobacterium ulcerans lipase/esterase 0.0009 0.0051 0.0051
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0511 0.1437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1859
Brugia malayi Ets-domain containing protein 0.0013 0.0173 0.0211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0051 0.0152
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0151 0.0349
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0148 0.0312
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1152 0.1402
Schistosoma mansoni DNA ligase IV 0.0012 0.0148 0.018
Leishmania major hydrolase-like protein,esterase-like protein 0.0009 0.0051 0.0152
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0082 0.01
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0173 0.0418
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0151 0.0349
Trypanosoma cruzi hydrolase-like protein 0.0009 0.0051 0.0152
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0511 0.1437
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0113 0.3351 1
Schistosoma mansoni ets-related 0.0013 0.0173 0.0211
Echinococcus granulosus bloom syndrome protein 0.0029 0.0692 0.1982
Echinococcus multilocularis abhydrolase domain containing 3 0.0009 0.0051 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0082 0.01
Mycobacterium ulcerans hypothetical protein 0.0008 0.0035 0.0035
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0039 0.1012 0.0981
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0148 0.0403
Mycobacterium ulcerans exported protease 0.0009 0.0051 0.0051
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0393 0.1072
Echinococcus multilocularis abhydrolase domain containing protein 0.0009 0.0051 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1859
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0035 0.0042
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0148 0.0442
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0082 0.01
Echinococcus granulosus nibrin 0.0012 0.0148 0.0342
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0173 0.0418
Plasmodium falciparum alpha/beta hydrolase, putative 0.0009 0.0051 0.0138
Loa Loa (eye worm) hypothetical protein 0.0146 0.4411 0.537
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.077 0.2098
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0173 0.0211
Brugia malayi hypothetical protein 0.0012 0.0148 0.018
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0009 0.0051 0.1424
Brugia malayi Flap endonuclease-1 0.0031 0.077 0.0938
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0173 0.0211
Echinococcus granulosus abhydrolase domain containing protein 11 0.0009 0.0051 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1489 0.1813
Schistosoma mansoni hypothetical protein 0.0013 0.0173 0.0211
Mycobacterium leprae Probable exported protease 0.0009 0.0051 0.1424
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0035 0.0042
Mycobacterium ulcerans hypothetical protein 0.0009 0.0051 0.0051
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0037 0.0957 0.2855
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0009 0.0051 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0281 0.0839
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1527 0.4499
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0148 0.0403
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0173 0.0418
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.367 1
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0051 0.0152
Entamoeba histolytica hypothetical protein 0.0043 0.1152 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.3351 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0511 0.0622
Leishmania major DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1527 0.4499
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1489 0.4444
Loa Loa (eye worm) RecQ helicase 0.0029 0.0692 0.0842
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0511 0.0478
Brugia malayi Alpha/beta hydrolase 0.0009 0.0051 0.0062
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.0051 0.0016
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0485
Schistosoma mansoni 6-phosphogluconolactonase 0.001 0.0089 0.0108
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.001 0.0089 0.0163
Giardia lamblia Phosphoglycolate phosphatase 0.0008 0.0035 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0051 0.0138
Giardia lamblia Hydrolase, putative 0.0008 0.0035 0.0094
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0009 0.0051 0.0049
Echinococcus granulosus abhydrolase domain containing protein 0.0009 0.0051 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0151 0.041
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0173 0.0418
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0035 0.0042
Mycobacterium ulcerans bromoperoxidase BpoC 0.0009 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0009 0.0051 0.0152
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.058 0.158
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0148 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0312
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0051 0.0016
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.0035 0.0042
Trypanosoma brucei unspecified product 0.0023 0.0511 0.1525
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0151 0.0183
Schistosoma mansoni DNA helicase recq1 0.0012 0.0151 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0312
Echinococcus granulosus 6 phosphogluconolactonase 0.001 0.0089 0.0163
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0173 0.0418
Echinococcus granulosus dna polymerase eta 0.0054 0.1489 0.4386
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0262 0.204
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0009 0.0051 0.1424
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0009 0.0051 0.0062
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0511 0.1525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Schistosoma mansoni hypothetical protein 0.0013 0.0173 0.0211
Schistosoma mansoni Smad4 0.001 0.0082 0.01
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0173 0.0211
Mycobacterium ulcerans hydrolase 0.0008 0.0035 0.0035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0151 0.0183
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0173 0.0418
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.077 0.2023
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.3351 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0511 0.4265
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.001 0.0089 0.0108
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.001 0.0089 0.0265
Schistosoma mansoni gabp alpha 0.0087 0.2551 0.3106
Loa Loa (eye worm) hypothetical protein 0.0054 0.1489 0.1813
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0281 0.0839
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1527 0.1859
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.077 0.2098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Brugia malayi Ets-domain containing protein 0.0087 0.2551 0.3106
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0008 0.0035 0.0094
Toxoplasma gondii alpha/beta hydrolase, putative 0.0009 0.0051 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0009 0.0051 0.1424
Mycobacterium ulcerans hypothetical protein 0.0008 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.0042
Chlamydia trachomatis 6-phosphogluconolactonase 0.001 0.0089 0.0163
Schistosoma mansoni choline dehydrogenase 0.0008 0.0035 0.0042
Entamoeba histolytica hypothetical protein 0.0043 0.1152 1
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0173 0.0211
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0173 0.0418
Mycobacterium ulcerans epoxide hydrolase EphF 0.0009 0.0051 0.0051
Mycobacterium ulcerans proline iminopeptidase PIP 0.0009 0.0051 0.0051
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0148 0.1015
Brugia malayi hypothetical protein 0.0012 0.0148 0.018
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.077 0.2298
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.0035 0.0042
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0009 0.0051 0.0016
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.3351 0.408
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.367 1
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0009 0.0051 0.0062
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0051 0.0044
Schistosoma mansoni 6-phosphogluconolactonase 0.001 0.0089 0.0108
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0151 0.0349
Schistosoma mansoni DNA helicase recq5 0.0012 0.0151 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0386 0.1052
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0312
Brugia malayi transcription factor E74 isoform 0.0013 0.0173 0.0211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Schistosoma mansoni DNA polymerase eta 0.0054 0.1489 0.1813
Trypanosoma brucei 6-phosphogluconolactonase 0.001 0.0089 0.0265
Echinococcus multilocularis 6 phosphogluconolactonase 0.001 0.0089 0.0163
Brugia malayi UPF0017 protein CG3488 0.0009 0.0051 0.0062
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.0051 0.1424
Giardia lamblia Glucosamine-6-phosphate deaminase 0.001 0.0089 0.0242
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0692 0.1808
Mycobacterium ulcerans hypothetical protein 0.0009 0.0051 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0511 0.0478
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0148 0.0312
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0148 0.0342
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4355 0.5302
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0148 0.0403
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0148 1
Mycobacterium ulcerans epoxide hydrolase EphE 0.0009 0.0051 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0051 0.0138
Mycobacterium ulcerans 6-phosphogluconolactonase 0.001 0.0089 0.0089
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0511 0.1311
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.2551 0.3106
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0008 0.0035 0.0094
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0173 0.0418
Leishmania major hydrolase, alpha/beta fold family, putative 0.0009 0.0051 0.0152
Giardia lamblia Glucosamine-6-phosphate deaminase 0.001 0.0089 0.0242
Trypanosoma brucei hypothetical protein, conserved 0.0008 0.0035 0.0103
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0009 0.0051 0.0049
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0173 0.0418
Brugia malayi MH1 domain containing protein 0.001 0.0082 0.01
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0151 0.0349
Onchocerca volvulus 0.0012 0.0148 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0511 0.0622
Loa Loa (eye worm) fli-1 protein 0.0265 0.8214 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0008 0.0035 0.0042
Trypanosoma brucei unspecified product 0.0016 0.0281 0.0839
Schistosoma mansoni hydrolase 0.0009 0.0051 0.0062
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0148 0.0342
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0498 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Leishmania major hypothetical protein, conserved 0.0009 0.0051 0.0152
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0009 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.1152 1
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0009 0.0051 0.0016
Leishmania major DNA polymerase eta, putative 0.0038 0.0978 0.2919
Trypanosoma brucei unspecified product 0.0016 0.0281 0.0839
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.3351 0.3351
Mycobacterium ulcerans hydrolase 0.0008 0.0035 0.0035
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.367 1
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0009 0.0051 0.0152
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.001 0.0089 0.0265
Echinococcus granulosus dna polymerase kappa 0.0023 0.0511 0.1437
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.3351 0.408
Giardia lamblia ENC6 protein 0.0009 0.0051 0.0138
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.367 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0148 0.0403
Echinococcus multilocularis nibrin 0.0012 0.0148 0.0342
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0148 1
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0148 0.018
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0009 0.0051 0.0044
Schistosoma mansoni ets 0.0013 0.0173 0.0211
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0511 0.0622
Chlamydia trachomatis DNA ligase 0.0012 0.0148 0.0342
Echinococcus multilocularis ets variant gene 4 0.0013 0.0173 0.0418
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.018
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0262 0.0627
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0082 0.0144
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.3351 1
Entamoeba histolytica hypothetical protein 0.0012 0.0148 0.1015
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0051 0.0152
Brugia malayi Fli-1 protein 0.0265 0.8214 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0511 0.1525
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0511 0.0622

Activities

Activity type Activity value Assay description Source Reference
AbsAC1000_uM (functional) = 2.877 uM PUBCHEM_BIOASSAY: In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504552] ChEMBL. No reference
AbsAC35 (functional) = 0.127 uM PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AbsAC35 (functional) = 0.247 uM PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) = 44.611 uM PUBCHEM_BIOASSAY: Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504435] ChEMBL. No reference
EC50 (functional) > 103.859 uM PUBCHEM_BIOASSAY: Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.595 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.481 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.174 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.108 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.968 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.948 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.533 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.109 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 3.757 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
IC50 (functional) = 9.89 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) 20.13 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.3089 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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