TDR Targets

Basic information

Technical information

TDR Targets ID: 1516963
Name: N-[2-(4-chlorophenyl)ethyl]-3-methyl-2-[(1-pr opanoyl-2,3-dihydroindol-5-yl)sulfonylamino]b utanamide
MW: 492.031 | Formula: C24H30ClN3O4S
H donors: 2 H acceptors: 4 LogP: 4.05 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)N1CCc2c1ccc(c2)S(=O)(=O)NC(C(=O)NCCc1ccc(cc1)Cl)C(C)C
InChi: 1S/C24H30ClN3O4S/c1-4-22(29)28-14-12-18-15-20(9-10-21(18)28)33(31,32)27-23(16(2)3)24(30)26-13-11-17-5-7-19(25)8-6-17/h5-10,15-16,23,27H,4,11-14H2,1-3H3,(H,26,30)
InChiKey: XBBHDLVLGYUHJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(4-chlorophenyl)ethyl]-3-methyl-2-[(1-propanoylindolin-5-yl)sulfonylamino]butanamide
N-[2-(4-chlorophenyl)ethyl]-3-methyl-2-[[1-(1-oxopropyl)-5-indolinyl]sulfonylamino]butanamide
N-[2-(4-chlorophenyl)ethyl]-3-methyl-2-[(1-propionylindolin-5-yl)sulfonylamino]butyramide
C464-0653
NCGC00108973-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0026	0.0913	0.2648
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1529	0.1529
Plasmodium vivax	vivapain-1	0.0027	0.1006	0.262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Entamoeba histolytica	hypothetical protein	0.0043	0.2219	0.4592
Echinococcus granulosus	cathepsin l1	0.0049	0.265	0.2432
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.3013	0.2966
Echinococcus multilocularis	lamin dm0	0.0026	0.0913	0.0644
Giardia lamblia	Histone deacetylase	0.0062	0.3649	1
Plasmodium vivax	vivapain-3	0.0027	0.1006	0.262
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.0738
Plasmodium vivax	unspecified product	0.0027	0.1006	0.262
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0062	0.3649	1
Plasmodium vivax	histone deacetylase 2, putative	0.0018	0.0288	0.0616
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.1006	0.1006
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.265	0.2432
Onchocerca volvulus		0.0049	0.265	1
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Leishmania major	cysteine peptidase A (CPA)	0.0049	0.265	0.7027
Brugia malayi	hypothetical protein	0.0016	0.0143	0.0143
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.265	0.2432
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.265	0.26
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0054	0.3013	0.2966
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.1006	0.0945
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.265	0.26
Echinococcus granulosus	lamin	0.0026	0.0913	0.0644
Echinococcus multilocularis	cysteine protease	0.0049	0.265	0.2432
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.265	0.2432
Loa Loa (eye worm)	histone deacetylase	0.0018	0.0288	0.0288
Brugia malayi	Histone deacetylase family protein	0.0018	0.0288	0.0288
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0062	0.3649	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0913	0.0644
Schistosoma mansoni	histone deacetylase hda2	0.0018	0.0288	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0049	0.265	0.265
Entamoeba histolytica	hypothetical protein	0.0043	0.2219	0.4592
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1529	0.1529
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0027	0.1006	0.0945
Brugia malayi	Histone deacetylase 1	0.0062	0.3649	0.3649
Onchocerca volvulus		0.0026	0.0913	0.2648
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Brugia malayi	hypothetical protein	0.0025	0.08	0.08
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.265	0.265
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.265	0.265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.08	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Onchocerca volvulus		0.0049	0.265	1
Brugia malayi	histone deacetylase 3 (HD3)	0.0062	0.3649	0.3649
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0034	0.1529	0.1471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.1006	0.0945
Echinococcus granulosus	histone deacetylase 1	0.0062	0.3649	0.3461
Schistosoma mansoni	histone deacetylase	0.0062	0.3649	0.3606
Trypanosoma cruzi	histone deacetylase, putative	0.0018	0.0288	0.0222
Schistosoma mansoni	hypothetical protein	0.0043	0.2219	0.2167
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0288	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1529	0.1529
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0015	0.0067	0.0067
Toxoplasma gondii	cathepsin CPL	0.0049	0.265	0.7027
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0913	0.0913
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.265	0.26
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.1006	0.0945
Brugia malayi	cathepsin L-like precursor	0.0034	0.1529	0.1529
Brugia malayi	cathepsin F-like cysteine proteinase	0.0015	0.0067	0.0067
Brugia malayi	histone deacetylase 11	0.0018	0.0288	0.0288
Echinococcus multilocularis	cathepsin L	0.0027	0.1006	0.0739
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.265	0.26
Trypanosoma cruzi	histone deacetylase, putative	0.0018	0.0288	0.0222
Loa Loa (eye worm)	histone deacetylase 11	0.0018	0.0288	0.0288
Plasmodium vivax	histone deacetylase, putative	0.0018	0.0288	0.0616
Brugia malayi	intermediate filament protein	0.0026	0.0913	0.0913
Echinococcus granulosus	cathepsin l1	0.0034	0.1529	0.1278
Entamoeba histolytica	cysteine protease, putative	0.0049	0.265	0.6219
Leishmania major	hypothetical protein, conserved	0.0025	0.08	0.1524
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.0738
Brugia malayi	histone deacetylase 1 (HD1)	0.0062	0.3649	0.3649
Toxoplasma gondii	histone deacetylase HDAC2	0.0062	0.3649	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0054	0.3013	0.8109
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0062	0.3649	0.3606
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0067	0.0067
Schistosoma mansoni	lamin	0.0026	0.0913	0.0852
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.1006	0.0945
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.265	1
Trypanosoma cruzi	histone deacetylase, putative	0.0018	0.0288	0.0222
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1529	0.1529
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.265	0.26
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Plasmodium vivax	histone deacetylase 1, putative	0.0062	0.3649	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Leishmania major	histone deacetylase, putative	0.0062	0.3649	1
Echinococcus granulosus	cathepsin L	0.0027	0.1006	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.265	0.7027
Entamoeba histolytica	hypothetical protein	0.0043	0.2219	0.4592
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.265	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.265	0.7027
Trypanosoma brucei	histone deacetylase 1	0.0062	0.3649	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.08	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1529	0.1979
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Plasmodium vivax	histone deacetylase, putative	0.0018	0.0288	0.0616
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.2219	0.2167
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1524
Loa Loa (eye worm)	histone deacetylase 3	0.0062	0.3649	0.3649
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.2219	0.1989
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trypanosoma cruzi	histone deacetylase, putative	0.0018	0.0288	0.0222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.265	0.6219
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.265	0.2432
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0034	0.1529	0.1529
Loa Loa (eye worm)	fibroinase	0.0049	0.265	0.265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Echinococcus multilocularis	histone deacetylase 1	0.0062	0.3649	0.3461
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.265	0.6219
Toxoplasma gondii	histone deacetylase HDAC3	0.0062	0.3649	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0913	0.0852
Trypanosoma cruzi	cruzipain precursor, putative	0.0049	0.265	0.26
Onchocerca volvulus		0.0049	0.265	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.265	0.2432
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0913	0.0913
Schistosoma mansoni	cathepsin F (C01 family)	0.0034	0.1529	0.1471
Loa Loa (eye worm)	hypothetical protein	0.0062	0.3649	0.3649
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.08	0.1524
Toxoplasma gondii	cathepsin B	0.0054	0.3013	0.8109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.1006	0.2136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.265	0.26
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0067	0.0067
Onchocerca volvulus		0.0049	0.265	1
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1529	0.1979
Echinococcus multilocularis	cysteine protease	0.0049	0.265	0.2432
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.265	0.2432
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0027	0.1006	0.2136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Loa Loa (eye worm)	hypothetical protein	0.0025	0.08	0.08
Echinococcus granulosus	cysteine protease	0.0027	0.1006	0.0739
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Onchocerca volvulus		0.0034	0.1529	0.5254
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0913	0.0913
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.1529	0.1979
Echinococcus multilocularis	musashi	0.0026	0.0913	0.0644
Leishmania major	histone deacetylase, putative	0.0062	0.3649	1
Echinococcus granulosus	lamin dm0	0.0026	0.0913	0.0644
Echinococcus multilocularis	lamin	0.0026	0.0913	0.0644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Loa Loa (eye worm)	cathepsin B	0.0054	0.3013	0.3013
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Plasmodium falciparum	histone deacetylase 1	0.0062	0.3649	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.1006	0.1006
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0062	0.3649	1
Loa Loa (eye worm)	cysteine protease	0.0049	0.265	0.265
Entamoeba histolytica	histone deacetylase, putative	0.0062	0.3649	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.265	0.7027
Trypanosoma cruzi	cysteine protease, putative	0.0027	0.1006	0.0945
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.265	0.265
Schistosoma mansoni	histone deacetylase 4 5	0.0018	0.0288	0.0222
Echinococcus multilocularis	histone deacetylase 3	0.0062	0.3649	0.3461
Leishmania major	cathepsin L-like protease	0.0049	0.265	0.7027
Loa Loa (eye worm)	histone deacetylase 1	0.0062	0.3649	0.3649
Onchocerca volvulus		0.0049	0.265	1
Loa Loa (eye worm)	ctsf protein	0.0049	0.265	0.265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.265	0.6219
Echinococcus granulosus	histone deacetylase 3	0.0062	0.3649	0.3461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.265	0.6219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Schistosoma mansoni	histone deacetylase	0.0062	0.3649	0.3606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0913	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Echinococcus granulosus	cathepsin L cysteine protease	0.0027	0.1006	0.0739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.2219	0.1989
Schistosoma mansoni	lamin	0.0026	0.0913	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1529	0.1529
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.1006	0.2136
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.3013	0.7595
Plasmodium vivax	vivapain-2	0.0049	0.265	0.721
Trichomonas vaginalis	histone deacetylase, putative	0.0062	0.3649	1
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.265	0.6219
Brugia malayi	Cathepsin L-like precursor	0.0049	0.265	0.265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Entamoeba histolytica	hypothetical protein	0.0043	0.2219	0.4592
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Plasmodium vivax	vivapain-2	0.0049	0.265	0.721
Onchocerca volvulus		0.0049	0.265	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.265	0.7027
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.1006	0.0945
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0054	0.3013	0.8109
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0877	0.0877
Schistosoma mansoni	histone deacetylase hda2	0.0018	0.0288	0.0222
Brugia malayi	Histone deacetylase family protein	0.0018	0.0288	0.0288
Onchocerca volvulus		0.0049	0.265	1
Schistosoma mansoni	histone deacetylase 1 2 3	0.0018	0.0288	0.0222
Trypanosoma cruzi	histone deacetylase 1, putative	0.0062	0.3649	0.3606
Loa Loa (eye worm)	histone deacetylase 7A	0.0018	0.0288	0.0288
Trypanosoma cruzi	histone deacetylase, putative	0.0018	0.0288	0.0222
Schistosoma mansoni	histone deacetylase 4 5	0.0018	0.0288	0.0222
Brugia malayi	hypothetical protein	0.0043	0.2219	0.2219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.265	0.6219
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.1006	0.0945

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.3096 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1706404

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1516963