Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.2013 | 0.1579 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0057 | 0.4131 | 0.4131 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0044 | 0.2013 | 0.1579 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0069 | 0.5869 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4548 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0044 | 0.2013 | 0.2013 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0057 | 0.4131 | 0.4131 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.2013 | 0.1579 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0069 | 0.5869 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4548 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4548 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0069 | 0.5869 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4548 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0069 | 0.5869 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0057 | 0.4131 | 0.4131 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0069 | 0.5869 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0044 | 0.2013 | 0.2013 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0044 | 0.2013 | 0.1354 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0044 | 0.2013 | 0.2013 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0044 | 0.2013 | 0.1354 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0044 | 0.2013 | 0.1579 |
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.2013 | 0.1579 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0069 | 0.5869 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0057 | 0.4131 | 0.4131 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0044 | 0.2013 | 0.1354 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0057 | 0.4131 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0044 | 0.2013 | 0.1354 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0057 | 0.4131 | 0.4131 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0044 | 0.2013 | 0.1579 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0044 | 0.2013 | 0.1579 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.