Detailed information for compound 15828

Basic information

Technical information
  • TDR Targets ID: 15828
  • Name: 7-hydroxy-2-phenyl-1H-quinolin-4-one
  • MW: 237.253 | Formula: C15H11NO2
  • H donors: 2 H acceptors: 3 LogP: 3.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)nc(cc2O)c1ccccc1
  • InChi: 1S/C15H11NO2/c17-11-6-7-12-14(8-11)16-13(9-15(12)18)10-4-2-1-3-5-10/h1-9,17H,(H,16,18)
  • InChiKey: AHVIMHDOWFUQIV-UHFFFAOYSA-N  


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Synonyms

  • 7-hydroxy-2-phenyl-4-quinolone
  • NCI60_015272
  • NSC644948

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin beta chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.003 0 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Trypanosoma brucei beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0238 1 1
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis tubulin beta 1 chain 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.3934 0.3934
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.003 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5
Entamoeba histolytica tubulin family protein 0.003 0 0.5
Trypanosoma brucei beta tubulin 0.003 0 0.5
Toxoplasma gondii beta-1 tubulin, putative 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus granulosus beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin, putative 0.003 0 0.5
Echinococcus granulosus tubulin beta 1 chain 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.3934 0.3934
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Echinococcus multilocularis beta tubulin 0.003 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0 0.5
Trypanosoma cruzi beta tubulin, putative 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Toxoplasma gondii beta-tubulin, putative 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis tubulin subunit beta 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.003 0 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.003 0 0.5
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Toxoplasma gondii beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi Fibroblast growth factor family protein 0.0112 0.3934 0.3934
Entamoeba histolytica tubulin family protein 0.003 0 0.5
Plasmodium falciparum tubulin beta chain 0.003 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0 0.5
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.003 0 0.5
Echinococcus multilocularis beta tubulin 0.003 0 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.003 0 0.5
Echinococcus multilocularis tubulin, beta 4A class IVa 0.003 0 0.5
Plasmodium vivax tubulin beta chain, putative 0.003 0 0.5
Giardia lamblia Hypothetical protein 0.0112 0.3934 1
Echinococcus granulosus tubulin subunit beta 0.003 0 0.5
Schistosoma mansoni tubulin subunit beta 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi Fibroblast growth factor family protein 0.0112 0.3934 0.3934
Trypanosoma brucei beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Trypanosoma brucei beta tubulin 0.003 0 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.003 0 0.5
Echinococcus granulosus beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.45 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in murine leukemia L-1210 cell line ChEMBL. 8387598
EC50 (functional) = 0.52 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human melanoma RPMI-7951 cell line ChEMBL. 8387598
EC50 (functional) = 0.52 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human melanoma RPMI-7951 cell line ChEMBL. 8387598
EC50 (functional) = 0.55 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human epidermoid carcinoma KB cell line ChEMBL. 8387598
EC50 (functional) = 0.55 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human epidermoid carcinoma KB cell line ChEMBL. 8387598
EC50 (functional) = 0.81 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human lung carcinoma A-549 cell line ChEMBL. 8387598
EC50 (functional) = 0.81 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in murine leukemia P-388 cell line ChEMBL. 8387598
EC50 (functional) = 0.8100000000000002 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human lung carcinoma A-549 cell line ChEMBL. 8387598
EC50 (functional) = 0.8100000000000002 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in murine leukemia P-388 cell line ChEMBL. 8387598
EC50 (functional) > 10 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human ileocecal carcinoma HCT-8 cell line ChEMBL. 8387598
EC50 (functional) > 10 ug ml-1 Cytotoxicity in vitro expressed as 50% reduction in cell number after a 3-day incubation, in human ileocecal carcinoma HCT-8 cell line ChEMBL. 8387598
GI50 (functional) -4.715 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.669 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.667 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.614 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.533 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.522 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.464 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.439 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.429 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 3.4 uM Inhibition of tubulin polymerization ChEMBL. 8387598
IC50 (functional) = 3.4 uM Inhibition of tubulin polymerization ChEMBL. 8387598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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