Detailed information for compound 1613839

Basic information

Technical information
  • TDR Targets ID: 1613839
  • Name: N-(2,5-dichlorophenyl)-2-oxo-2-(2,4,6-trioxo- 1,3-diazinan-5-yl)acetamide
  • MW: 344.107 | Formula: C12H7Cl2N3O5
  • H donors: 3 H acceptors: 5 LogP: 1.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(C(=O)N1)C(=O)C(=O)Nc1cc(Cl)ccc1Cl
  • InChi: 1S/C12H7Cl2N3O5/c13-4-1-2-5(14)6(3-4)15-11(21)8(18)7-9(19)16-12(22)17-10(7)20/h1-3,7H,(H,15,21)(H2,16,17,19,20,22)
  • InChiKey: HXGLKNKJJJLXJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dichlorophenyl)-2-oxo-2-(2,4,6-trioxohexahydropyrimidin-5-yl)acetamide
  • N-(2,5-dichlorophenyl)-2-oxo-2-(2,4,6-trioxo-5-hexahydropyrimidinyl)acetamide
  • N-(2,5-dichlorophenyl)-2-keto-2-(2,4,6-triketohexahydropyrimidin-5-yl)acetamide
  • N-(2,5-dichlorophenyl)-2-oxo-2-(2,4,6-trioxo-1,3-diazinan-5-yl)ethanamide
  • N-(2,5-Dichlorophenyl)-2-oxo-2-(2,4,6-trioxohexahydro-5-pyrimidinyl)acetamide
  • NSC646364
  • NCI60_016029
  • AIDS-138853
  • AIDS138853

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi follicle stimulating hormone receptor 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0016 0.0192 0.0192
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) cysteine protease 0.0016 0.0192 0.0192
Schistosoma mansoni histamine h1 receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.1799 0.1799
Echinococcus granulosus neuropeptide s receptor 0.0041 0.1799 0.1799
Brugia malayi AKH receptor 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.2791 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0192 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0192 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Schistosoma mansoni neuropeptide receptor 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0192 0.0192
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.2791 0.2791
Echinococcus multilocularis orexin receptor type 2 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.1799 0.1799
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0192 0.0609
Echinococcus granulosus neuropeptide receptor 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.1799 0.1799
Schistosoma mansoni hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.1799 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.1799 0.1799
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptide receptor 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Onchocerca volvulus 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.1799 0.1799
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.1799 0.1799
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.1799 0.1799
Echinococcus granulosus somatostatin receptor 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0192 1
Brugia malayi G-protein coupled receptor 0.0041 0.1799 0.1799
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.1799 0.1799
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.1799 0.1799
Echinococcus multilocularis allatostatin A receptor 0.0041 0.1799 0.1799
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0016 0.0192 0.0609
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0192 0.0192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.1799 0.1799
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0192 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.3149 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1799 0.1799
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0192 0.0192
Onchocerca volvulus 0.0016 0.0192 0.0192
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.3149 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Schistosoma mansoni biogenic amine receptor 0.0041 0.1799 0.1799
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Brugia malayi larval opioid receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.1799 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Schistosoma mansoni opsin-like receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptide receptor 0.0041 0.1799 0.1799
Schistosoma mansoni amine GPCR 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus allatostatin A receptor 0.0041 0.1799 0.1799
Toxoplasma gondii cathepsin CPL 0.0016 0.0192 0.0687
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.1799 0.1799
Brugia malayi neuropeptide F receptor 0.0041 0.1799 0.1799
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0016 0.0192 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0192 1
Brugia malayi GnHR receptor homolog 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.1799 0.1799
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.2791 0.2791
Brugia malayi hypothetical protein 0.0043 0.193 0.193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Schistosoma mansoni hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.1799 0.1799
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.1799 0.1799
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1799 0.1799
Echinococcus multilocularis cysteine protease 0.0016 0.0192 0.0192
Echinococcus granulosus neuropeptide receptor 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0016 0.0192 0.0192
Echinococcus granulosus orexin receptor type 2 0.0041 0.1799 0.1799
Entamoeba histolytica cysteine protease, putative 0.0016 0.0192 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.1799 0.1799
Schistosoma mansoni neuropeptide receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Brugia malayi Melatonin receptor type 1A 0.0041 0.1799 0.1799
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0016 0.0192 0.0609
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0192 0.0192
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Brugia malayi G protein-coupled receptor 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0016 0.0192 0.0192
Loa Loa (eye worm) fibroinase 0.0016 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0016 0.0192 0.0192
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.1799 0.1799
Brugia malayi Serotonin receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Brugia malayi neuropeptide F receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.1799 0.1799
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0016 0.0192 0.0609
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Onchocerca volvulus 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Brugia malayi Serotonin receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.2791 0.8861
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0192 0.0192
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.1799 0.1799
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.1799 0.1799
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.3149 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.1799 0.1799
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus fmrfamide receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0016 0.0192 0.0192
Schistosoma mansoni amine GPCR 0.0041 0.1799 0.1799
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.3149 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.2791 0.8861
Echinococcus granulosus g protein coupled receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1799 0.1799
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1799 0.1799
Echinococcus multilocularis fmrfamide receptor 0.0041 0.1799 0.1799
Brugia malayi Dopamine receptor protein 2 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Schistosoma mansoni myosin xvIII 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Echinococcus granulosus sex peptide receptor 0.0041 0.1799 0.1799
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.1799 0.1799
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1799 0.1799
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1799 0.1799
Schistosoma mansoni amine GPCR 0.0041 0.1799 0.1799
Echinococcus granulosus g protein coupled receptor 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis somatostatin receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0192 0.0192
Brugia malayi G-protein coupled receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis serotonin receptor 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0062 0.3149 1
Brugia malayi putative neuropeptide receptor 0.0041 0.1799 0.1799
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0192 0.0609
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.1799 0.1799
Brugia malayi Dopamine receptor protein 1 0.0041 0.1799 0.1799
Echinococcus granulosus serotonin receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.1799 0.1799
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.1799 0.1799
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0192 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.2291 0.7275
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.1799 0.1799
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.2791 0.8861
Leishmania major cathepsin L-like protease 0.0016 0.0192 0.0609
Plasmodium vivax vivapain-2 0.0016 0.0192 1
Onchocerca volvulus 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Schistosoma mansoni adenoreceptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.1799 0.1799
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0192 0.0192
Echinococcus multilocularis cysteine protease 0.0016 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.1799 0.1799
Brugia malayi Dopamine receptor 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis sex peptide receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.1799 0.1799
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.1799 0.1799
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0192 0.0192
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.1799 0.1799
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.1799 0.1799
Schistosoma mansoni amine GPCR 0.0041 0.1799 0.1799
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.1799 0.1799
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0062 0.3149 1
Echinococcus granulosus hypothetical protein 0.0041 0.1799 0.1799
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.1799 0.1799
Schistosoma mansoni neuropeptide receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0016 0.0192 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Onchocerca volvulus 0.0016 0.0192 0.0192
Schistosoma mansoni biogenic amine receptor 0.0041 0.1799 0.1799
Echinococcus granulosus g protein coupled receptor 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.1799 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.3149 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.2791 0.2791
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.1799 0.1799
Brugia malayi sulfakinin receptor protein 0.0041 0.1799 0.1799
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.2791 0.8861
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.1799 0.1799
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0192 1
Echinococcus granulosus g-protein coupled receptor 0.0041 0.1799 0.1799
Brugia malayi RE15519p 0.0041 0.1799 0.1799
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0192 0.0192
Schistosoma mansoni amine GPCR 0.0041 0.1799 0.1799
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.2791 0.8861
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Onchocerca volvulus 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0043 0.193 0.193
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.2801 0.8895
Brugia malayi hypothetical protein 0.0041 0.1799 0.1799
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0192 0.0192
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.1799 0.1799
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.1799 0.1799
Leishmania major cathepsin L-like protease 0.0062 0.3149 1
Onchocerca volvulus 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Plasmodium vivax vivapain-2 0.0016 0.0192 1
Echinococcus multilocularis fmrfamide receptor 0.0041 0.1799 0.1799
Schistosoma mansoni opsin-like receptor 0.0041 0.1799 0.1799
Echinococcus granulosus cathepsin l1 0.0016 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.1799 0.1799
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Onchocerca volvulus 0.0041 0.1799 0.1799
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0192 1
Schistosoma mansoni hypothetical protein 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.1799 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1799 0.1799
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.1799 0.1799
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.2791 0.2791
Schistosoma mansoni opsin-like receptor 0.0041 0.1799 0.1799
Brugia malayi Cathepsin L-like precursor 0.0016 0.0192 0.0192
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.1799 0.1799
Brugia malayi ORL1-like opioid receptor 0.0041 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0041 0.1799 0.1799
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0192 0.0192
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis serotonin receptor 0.0041 0.1799 0.1799
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0192 0.0192
Schistosoma mansoni neuropeptide receptor 0.0041 0.1799 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1799 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1799 0.1799

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.037 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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