Detailed information for compound 1615564

Basic information

Technical information
  • TDR Targets ID: 1615564
  • Name: [[8-(4-hydroxy-3,5-dimethoxyphenyl)-7-methyl- 7,8-dihydro-6H-pyrano[6,5-f][1,3]benzodioxol- 6-yl]amino]urea
  • MW: 417.413 | Formula: C20H23N3O7
  • H donors: 4 H acceptors: 2 LogP: 2.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1O)OC)C1C(C)C(NNC(=O)N)Oc2c1cc1OCOc1c2
  • InChi: 1S/C20H23N3O7/c1-9-17(10-4-15(26-2)18(24)16(5-10)27-3)11-6-13-14(29-8-28-13)7-12(11)30-19(9)22-23-20(21)25/h4-7,9,17,19,22,24H,8H2,1-3H3,(H3,21,23,25)
  • InChiKey: YVEINCOWHHHOCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [[8-(4-hydroxy-3,5-dimethoxy-phenyl)-7-methyl-7,8-dihydro-6H-pyrano[6,5-f][1,3]benzodioxol-6-yl]amino]urea
  • NCI60_025123
  • Neuro_000410
  • 2-(8-(4-Hydroxy-3,5-dimethoxyphenyl)-7-methyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl)hydrazinecarboxamide
  • AIDS-145766
  • AIDS145766
  • NSC671172

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Echinococcus multilocularis lysine specific demethylase 5A 0.0119 0.0239 0.0239
Echinococcus multilocularis protein dispatched 1 0.0109 0.0214 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0037 0.0253
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0033 0.023
Echinococcus granulosus Niemann Pick C1 protein 0.0317 0.0702 0.0702
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.0354 0.2437
Echinococcus multilocularis dna polymerase eta 0.0022 0.001 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0051 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0048 0.0139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0037 0.0037
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0033 0.0936
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0119 0.0239 0.0239
Plasmodium vivax JmjC domain containing protein 0.0032 0.0033 0.0936
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0037 0.0253
Leishmania major GTP-binding protein, putative 0.0026 0.0019 0.0275
Echinococcus multilocularis protein patched 0.0095 0.0182 0.0182
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0377 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Schistosoma mansoni ran 0.0026 0.0019 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0222 0.0479 0.0479
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0037 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0041 0.2845
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0119 0.04
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0173 0.0173
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0035 0.0238
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0297 0.2047
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0138 0.0138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0037 0.0037
Leishmania major importin beta-1 subunit, putative 0.0028 0.0025 0.0453
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0041 0.0041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0037 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0359 0.2468
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0119 0.3172
Schistosoma mansoni hypothetical protein 0.0353 0.0787 0.0787
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0048 0.0327
Plasmodium vivax SET domain protein, putative 0.0091 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.023
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.0229 0.1577
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0037 0.0253
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0831 0.5724
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0051 0.1205
Echinococcus granulosus dna polymerase kappa 0.0022 0.001 0.001
Echinococcus granulosus dna polymerase eta 0.0022 0.001 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.014 0.014
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.0727
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0104 0.0203 0.1399
Schistosoma mansoni hypothetical protein 0.0053 0.0084 0.0084
Brugia malayi Importin beta-1 subunit 0.0035 0.0041 0.028
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0037 0.0037
Echinococcus multilocularis expressed conserved protein 0.0208 0.0447 0.0447
Trichomonas vaginalis glutaminase, putative 0.0597 0.1359 0.4951
Treponema pallidum fructose-bisphosphate aldolase 0.1183 0.2736 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0019 0.0868
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0033 0.2188
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0051 0.0152
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0225 0.0487 0.0487
Entamoeba histolytica hypothetical protein 0.0077 0.014 0.048
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0138 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0037 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0173 0.0173
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0033 0.0033
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0033 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0048 0.0139
Echinococcus granulosus troponin i 0.0104 0.0203 0.0203
Loa Loa (eye worm) troponin T 0.0062 0.0104 0.0715
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0173 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0278
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0051 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0138 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.0239 0.1642
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0019 0.0131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0037 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0033 0.2188
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0138 0.0138
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0578 0.1316 0.336
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0037 0.0253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0222 0.0479 0.1722
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0051 0.38
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0033 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0037 0.0037
Brugia malayi hypothetical protein 0.0244 0.0532 0.366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0188 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0051 0.0152
Brugia malayi jmjC domain containing protein 0.0119 0.0239 0.1642
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0035
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0048 0.1852
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0019 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.014 0.014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0019 0.0131
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0359 0.0359
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0051 0.0152
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.001 0.0066
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0062 0.0104 0.0414
Schistosoma mansoni alpha-glucosidase 0.0147 0.0303 0.0303
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1183 0.2736 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0037 0.0253
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0051 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0037 0.0253
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 1
Entamoeba histolytica hypothetical protein 0.0028 0.0025 0.0057
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0578 0.1316 0.9675
Loa Loa (eye worm) troponin 0.0062 0.0104 0.0715
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0188 0.0188
Schistosoma mansoni Replicative DNA helicase 0.0377 0.0843 0.0843
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0119 0.0119
Brugia malayi Troponin family protein 0.0104 0.0203 0.1399
Plasmodium falciparum importin beta, putative 0.0035 0.0041 0.6741
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0037 0.0253
Schistosoma mansoni hypothetical protein 0.0092 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0037 0.0253
Echinococcus granulosus phd:f box containing protein 0.0032 0.0033 0.0033
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0359 0.0359
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0278
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0168 0.0354 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0188 0.0188
Brugia malayi Troponin I 0.0104 0.0203 0.1399
Chlamydia trachomatis replicative DNA helicase 0.0377 0.0843 0.5
Schistosoma mansoni hypothetical protein 0.0092 0.0174 0.0174
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.002 0.095
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.095
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0037 0.0037
Loa Loa (eye worm) glutaminase 2 0.0597 0.1359 0.936
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0084 0.0578
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0048 0.0139
Schistosoma mansoni ap endonuclease 0.0039 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0037 0.0253
Leishmania major hypothetical protein, conserved 0.0032 0.0033 0.0694
Onchocerca volvulus Troponin I homolog 0.0104 0.0203 0.1027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0037 0.0253
Brugia malayi hypothetical protein 0.0062 0.0104 0.0715
Brugia malayi nuclear receptor NHR-88 0.0033 0.0037 0.0253
Schistosoma mansoni hypothetical protein 0.0092 0.0174 0.0174
Onchocerca volvulus 0.0091 0.0173 0.0841
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0037 0.0037
Schistosoma mansoni alpha glucosidase 0.0038 0.0048 0.0048
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0048 0.0048
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0033 0.4503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0084 0.0578
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0041 0.1401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0188 0.1292
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1689 0.3923 0.3923
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.002 0.0058
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0033 0.0936
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0636 0.1452 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0048 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0037 0.0037
Loa Loa (eye worm) glutaminase 0.0597 0.1359 0.936
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0051 0.0051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0138 0.0953
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.001 0.0066
Brugia malayi hypothetical protein 0.0026 0.002 0.0137
Echinococcus granulosus tar DNA binding protein 0.0076 0.0138 0.0138
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0297 0.2047
Echinococcus multilocularis GPCR, family 2 0.0053 0.0084 0.0084
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0578 0.1316 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1183 0.2736 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0037 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0026 0.002 0.0301
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0037 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0051 0.38
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Schistosoma mansoni alpha-glucosidase 0.0147 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0578
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0173 0.0173
Echinococcus multilocularis Niemann Pick C1 protein 0.0222 0.0479 0.0479
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0084 0.0084
Loa Loa (eye worm) twinkle helicase 0.0108 0.0212 0.1456
Brugia malayi RNA, U transporter 1 0.0099 0.0191 0.1317
Loa Loa (eye worm) hypothetical protein 0.0116 0.0232 0.1599
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0037 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0037 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.014 0.014
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0037 0.0253
Echinococcus multilocularis snurportin 1 0.0372 0.0831 0.0831
Treponema pallidum replicative DNA helicase (dnaB) 0.0377 0.0843 0.295
Echinococcus granulosus sterol regulatory element binding protein 0.0095 0.0182 0.0182
Echinococcus multilocularis troponin i 0.0104 0.0203 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0051 0.38
Schistosoma mansoni DNA polymerase eta 0.0022 0.001 0.001
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0048 0.1104
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0129 0.0262 0.0262
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0035 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0037 0.0253
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0033 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0095 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0037 0.0037
Echinococcus granulosus oncosphere protein Tso22e 0.0129 0.0262 0.0262
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0359 0.2468
Brugia malayi jmjC domain containing protein 0.0119 0.0239 0.1642
Brugia malayi jmjC domain containing protein 0.0032 0.0033 0.023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0037 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.0494 0.1118 0.5811
Brugia malayi CHE-14 protein 0.0095 0.0182 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0188 0.0188
Brugia malayi Troponin T 0.0062 0.0104 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0037 0.0253
Brugia malayi TAR-binding protein 0.0076 0.0138 0.0953
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0119 0.0119
Entamoeba histolytica Ran family GTPase 0.0026 0.0019 0.0035
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0119 0.0817
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0019 0.0868
Schistosoma mansoni hypothetical protein 0.0115 0.0229 0.0229
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 1
Echinococcus multilocularis sodium channel protein 0.0168 0.0354 0.0354
Brugia malayi RNA binding protein 0.0076 0.0138 0.0953
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0033 0.0033
Brugia malayi jmjC domain containing protein 0.0032 0.0033 0.023
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0095 0.0182 0.1254
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1301 0.3013 0.7725
Schistosoma mansoni troponin I 0.0104 0.0203 0.0203
Brugia malayi MH2 domain containing protein 0.0144 0.0297 0.2047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.0354 0.2437
Echinococcus multilocularis Niemann Pick C1 protein 0.0317 0.0702 0.0702
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0051 0.0107
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0033 0.0033
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0035
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0048 0.0048
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0048 0.0139
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0025 0.0057
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0019 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0037 0.0253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0037 0.0037
Giardia lamblia Fructose-bisphosphate aldolase 0.1183 0.2736 1
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0115 0.0229 0.1577
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Brugia malayi jmjC domain containing protein 0.0032 0.0033 0.023
Entamoeba histolytica hypothetical protein 0.0077 0.014 0.048
Schistosoma mansoni hypothetical protein 0.0077 0.014 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.005 0.0076 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0037 0.0253
Brugia malayi Troponin T 0.0062 0.0104 0.0715
Echinococcus multilocularis dna polymerase kappa 0.0022 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0037 0.0253
Brugia malayi Pre-SET motif family protein 0.0091 0.0173 0.1192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0037 0.0253
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0084 0.0084
Schistosoma mansoni patched 1 0.0095 0.0182 0.0182
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0051 0.0307
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0035 0.101
Schistosoma mansoni troponin I 0.0104 0.0203 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0173 1
Brugia malayi ecdysteroid receptor 0.0033 0.0037 0.0253
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0051 0.0051
Schistosoma mansoni troponin I 0.0104 0.0203 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0188 0.0188
Plasmodium vivax importin-beta 2, putative 0.0035 0.0041 0.1401
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0119 0.0239 0.0239
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0033 0.023
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.001 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0182 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0037 0.0253
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0129 0.0262 0.1389
Brugia malayi Niemann-Pick C1 protein precursor 0.0222 0.0479 0.3298
Onchocerca volvulus 0.0182 0.0387 0.2161
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0119 0.0817
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0033 0.0033
Trichomonas vaginalis ran, putative 0.0026 0.0019 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0033 0.023
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1678 0.3897 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0387 0.2666
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0051 0.0351
Onchocerca volvulus 0.005 0.0076 0.024
Echinococcus granulosus lysine specific demethylase 5A 0.0119 0.0239 0.0239
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.095
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0532 0.0532
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0035 0.101
Loa Loa (eye worm) hypothetical protein 0.0168 0.0354 0.2437
Brugia malayi Troponin T 0.0062 0.0104 0.0715
Schistosoma mansoni survival motor neuron protein 0.005 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0173 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0048 0.0139
Onchocerca volvulus 0.0724 0.1659 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0033 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0037 0.0253
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0035 0.2294
Schistosoma mansoni troponin t invertebrate 0.0129 0.0262 0.0262
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0035 0.0238
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0057
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0033 0.2188
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0048 0.0327
Schistosoma mansoni glutaminase 0.0597 0.1359 0.1359
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0019 0.0868
Schistosoma mansoni ran 0.0026 0.0019 0.0019
Schistosoma mansoni importin beta-1 0.0035 0.0041 0.0041
Brugia malayi hypothetical protein 0.0077 0.014 0.0967
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0037 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0048 0.0139
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.2294
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0019 0.0035
Schistosoma mansoni ap endonuclease 0.0039 0.0051 0.0051
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0037 0.0037
Brugia malayi glutaminase DH11.1 0.0597 0.1359 0.936
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0188 0.0188
Schistosoma mansoni troponin I 0.0104 0.0203 0.0203
Schistosoma mansoni hypothetical protein 0.0053 0.0084 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0173 0.0173
Echinococcus granulosus snurportin 1 0.0372 0.0831 0.0831
Echinococcus granulosus sodium channel protein 0.0168 0.0354 0.0354
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0066
Schistosoma mansoni coup transcription factor 0.0033 0.0037 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0037 0.0037
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0033 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.0354 0.2437
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0037 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0239 0.0239
Loa Loa (eye worm) troponin I 0.0104 0.0203 0.1399
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0048 0.3481
Brugia malayi nuclear hormone receptor 0.0033 0.0037 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0037 0.0253
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0035 0.4862
Brugia malayi isocitrate dehydrogenase 0.0032 0.0035 0.0238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0037 0.0037
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0033 0.0033
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0035 0.101
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0048 0.0139
Schistosoma mansoni hypothetical protein 0.0053 0.0084 0.0084
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0188 0.1292
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0091 0.0173 0.1192
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0048 0.0139
Schistosoma mansoni hypothetical protein 0.0092 0.0174 0.0174
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0033 0.0033
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0051 0.0051
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0359 0.0359
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0051 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0037 0.0037
Loa Loa (eye worm) RNA binding protein 0.0076 0.0138 0.0953
Loa Loa (eye worm) hypothetical protein 0.0062 0.0104 0.0715
Echinococcus granulosus geminin 0.0353 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0244 0.0532 0.366
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0048 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0188 0.0188
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.001 0.001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0035 0.2294
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0057
Onchocerca volvulus 0.0098 0.019 0.0945
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0095 0.0182 0.1254
Brugia malayi steroid hormone receptor 0.0033 0.0037 0.0253
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0048 0.0139
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0035 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0372 0.0831 0.0831
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0084 0.0578
Mycobacterium ulcerans glutaminase 0.0597 0.1359 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0048 0.3481
Schistosoma mansoni hypothetical protein 0.0104 0.0203 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0037 0.0037
Brugia malayi jmjC domain containing protein 0.0032 0.0033 0.023
Entamoeba histolytica hypothetical protein 0.0077 0.014 0.048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.2294
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0037 0.0037
Schistosoma mansoni jumonji domain containing protein 0.0119 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0137
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0035 0.0035
Echinococcus granulosus importin subunit beta 1 0.0035 0.0041 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0051 0.2078
Loa Loa (eye worm) hypothetical protein 0.0222 0.0479 0.3298
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0041 0.2845
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0033 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0138 0.0953
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0037 0.0253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0084 0.0084
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0033 0.0033
Echinococcus granulosus GPCR family 2 0.0053 0.0084 0.0084
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0377 0.0843 0.6176
Brugia malayi Pre-SET motif family protein 0.0636 0.1452 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Echinococcus multilocularis geminin 0.0353 0.0787 0.0787
Schistosoma mansoni hypothetical protein 0.0053 0.0084 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1183 0.2736 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0138 0.0138
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0076 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0037 0.0253
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0033 0.0033
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0025 0.1429
Toxoplasma gondii exonuclease III APE 0.0039 0.0051 0.2078
Brugia malayi hypothetical protein 0.0182 0.0387 0.2666
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0173 0.0173
Echinococcus granulosus Protein patched homolog 1 0.0095 0.0182 0.0182
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.002 0.0058
Schistosoma mansoni hypothetical protein 0.0353 0.0787 0.0787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0037 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0724 0.1659 0.6048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0104 0.0203 0.1399
Echinococcus granulosus expressed conserved protein 0.0208 0.0447 0.0447
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.023
Entamoeba histolytica hypothetical protein 0.0077 0.014 0.048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0037 0.0037
Trypanosoma brucei glucosidase, putative 0.0038 0.0048 0.3481
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0168 0.0354 0.0354

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.211 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.062 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.041 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.03 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.402 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.31 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.308 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.227 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.095 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.814 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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