TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 273.107 | Formula: C8H5BrN2O2S
H donors: 2 H acceptors: 2 LogP: 1.49 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)/C(=C/c2sccc2Br)/N1
InChi: 1S/C8H5BrN2O2S/c9-4-1-2-14-6(4)3-5-7(12)11-8(13)10-5/h1-3H,(H2,10,11,12,13)/b5-3-
InChiKey: SXWBWYKEMLNJES-HYXAFXHYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0031	0.0287	0.0287
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0158	0.4346	0.4346
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1782	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0287	0.0287
Echinococcus granulosus	peregrin	0.0028	0.02	0.02
Brugia malayi	ecdysone receptor	0.0158	0.4346	0.4346
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0287	0.0089
Onchocerca volvulus		0.0033	0.0347	0.0347
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0158	0.4346	0.4346
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0347	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4951	0.4951
Leishmania major	cathepsin L-like protease	0.0125	0.3301	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0287	0.0287
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0158	0.4346	0.423
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0158	0.4346	0.423
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0158	0.4346	0.4346
Onchocerca volvulus		0.0033	0.0347	0.0347
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.039	0.039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4951	0.4951
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.1435	0.1435
Brugia malayi	hypothetical protein	0.0158	0.4346	0.4346
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0347	0.0151
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0287	0.0287
Brugia malayi	MH2 domain containing protein	0.0116	0.2995	0.2995
Loa Loa (eye worm)	nuclear hormone receptor	0.0158	0.4346	0.4346
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0287	0.0089
Schistosoma mansoni	hypothetical protein	0.0028	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4951	0.4951
Brugia malayi	nuclear receptor NHR-88	0.0158	0.4346	0.4346
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0177	0.4951	0.4951
Schistosoma mansoni	nuclear hormone receptor	0.0158	0.4346	0.4346
Brugia malayi	conserved hypotetical protein	0.0158	0.4346	0.4346
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.3301	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2995	0.2995
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Schistosoma mansoni	nuclear receptor nhr-48	0.0158	0.4346	0.4346
Schistosoma mansoni	hypothetical protein	0.0031	0.0287	0.0287
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.2255	0.2097
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4951	0.4951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Echinococcus granulosus	cathepsin l1	0.0033	0.0347	0.0347
Plasmodium vivax	vivapain-2	0.0033	0.0347	0.1195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Plasmodium vivax	vivapain-2	0.0033	0.0347	0.1195
Brugia malayi	Nuclear hormone receptor E75	0.0158	0.4346	0.4346
Schistosoma mansoni	nuclear hormone receptor	0.0158	0.4346	0.4346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0347	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	nuclear receptor RXR	0.0158	0.4346	0.4346
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.1782	0.1614
Echinococcus multilocularis	cysteine protease	0.0033	0.0347	0.0151
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0287	0.0089
Brugia malayi	jmjC domain containing protein	0.0093	0.2255	0.2255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0347	0.0347
Onchocerca volvulus		0.0033	0.0347	0.0347
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0287	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1162	0.1162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Brugia malayi	nuclear receptor NHR-67	0.0158	0.4346	0.4346
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0158	0.4346	0.4346
Loa Loa (eye worm)	ctsf protein	0.0033	0.0347	0.0347
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.0347	0.1195
Brugia malayi	Bromodomain containing protein	0.0028	0.02	0.02
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0158	0.4346	0.4346
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.2425	0.2425
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0926	0.4744
Schistosoma mansoni	zinc finger protein	0.0158	0.4346	0.4346
Loa Loa (eye worm)	fibroinase	0.0033	0.0347	0.0347
Leishmania major	cathepsin L-like protease	0.0125	0.3301	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0158	0.4346	0.4346
Brugia malayi	hypothetical protein	0.0177	0.4951	0.4951
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0177	0.4951	0.4951
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0287	0.0287
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0158	0.4346	0.4346
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.02	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Trypanosoma cruzi	major cysteine proteinase, putative	0.0098	0.2444	0.7098
Loa Loa (eye worm)	hypothetical protein	0.0028	0.02	0.02
Brugia malayi	tailless protein	0.0158	0.4346	0.4346
Schistosoma mansoni	nuclear receptor	0.0158	0.4346	0.4346
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.3301	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.2425	0.2425
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0347	1
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0347	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0158	0.4346	0.4346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Onchocerca volvulus		0.0158	0.4346	0.4346
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0347	0.0347
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0347	0.0347
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0926	0.0741
Brugia malayi	hypothetical protein	0.0177	0.4951	0.4951
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0114	0.2953	0.8824
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0845	0.0845
Toxoplasma gondii	cathepsin CPL	0.0033	0.0347	0.1195
Schistosoma mansoni	hypothetical protein	0.0067	0.1435	0.1435
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0554	0.0361
Loa Loa (eye worm)	DR-78	0.0158	0.4346	0.4346
Trypanosoma cruzi	cruzipain precursor, putative	0.0125	0.3301	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0158	0.4346	0.4346
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0158	0.4346	0.4346
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0926	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0287	0.0287
Leishmania major	cathepsin L-like protease	0.0125	0.3301	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Giardia lamblia	PHD finger protein 15	0.0028	0.02	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.1782	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0158	0.4346	0.4346
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0926	0.0926
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0177	0.4951	0.4951
Schistosoma mansoni	nuclear receptor	0.0158	0.4346	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Brugia malayi	orphan nuclear receptor NR2E1	0.0158	0.4346	0.4346
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0177	0.4951	0.4848
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.0347	0.0347
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0554	0.0554
Brugia malayi	nuclear receptor RXR	0.0177	0.4951	0.4951
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Loa Loa (eye worm)	cysteine protease	0.0033	0.0347	0.0347
Echinococcus multilocularis	nuclear receptor nhr 48	0.0158	0.4346	0.423
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.0347	0.0347
Brugia malayi	Nuclear hormone receptor E75	0.0158	0.4346	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2425	0.2425
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	0.5
Onchocerca volvulus		0.0033	0.0347	0.0347
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0347	0.0151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0158	0.4346	0.423
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Echinococcus granulosus	GPCR family 2	0.0031	0.0287	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.0347	0.1195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.02	0.0288
Brugia malayi	Nuclear hormone receptor-like 1	0.0177	0.4951	0.4951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Onchocerca volvulus		0.0033	0.0347	0.0347
Brugia malayi	Nuclear hormone receptor-like 1	0.0177	0.4951	0.4951
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4951	0.4951
Brugia malayi	hypothetical protein	0.0158	0.4346	0.4346
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Brugia malayi	Probable ClpP-like protease	0.0078	0.1782	0.1782
Echinococcus multilocularis	cysteine protease	0.0033	0.0347	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Onchocerca volvulus	Alhambra homolog	0.0028	0.02	0.02
Onchocerca volvulus		0.0033	0.0347	0.0347
Brugia malayi	nuclear hormone receptor	0.0158	0.4346	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0347	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0347	0.0347
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.0347	0.1195
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0347	0.0347
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2995	0.2995
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1782	0.1782
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.2425	0.2425
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0287	0.0287
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0158	0.4346	0.423
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0347	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0158	0.4346	0.4346
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.039	0.0194
Onchocerca volvulus		0.0033	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.02	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1435	0.1435
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0158	0.4346	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Brugia malayi	PHD-finger family protein	0.0028	0.02	0.02
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0926	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0177	0.4951	0.4951
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.1782	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.0347	0.0347
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.039	0.039
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1647	0.1647
Plasmodium falciparum	phd finger protein, putative	0.0028	0.02	0.0288
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1782	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0158	0.4346	0.4346
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.1782	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0158	0.4346	0.4346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0347	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.2255	0.2255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.3301	0.5
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.02	0.02
Onchocerca volvulus		0.0158	0.4346	0.4346
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.3301	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0158	0.4346	0.423
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0158	0.4346	0.4346
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0287	0.0287
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.039	0.039
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.039	0.039
Brugia malayi	jmjC domain containing protein	0.0034	0.039	0.039
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0347	0.0151
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0347	0.0347
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.1782	0.1782
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0347	1
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.02	0.02
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1782	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 16 %	Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay	ChEMBL.	22077389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1957786

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1616748