Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.4325 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.4325 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.4325 | 0.5894 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.2931 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.4325 | 0.1972 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.4325 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.4325 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.4325 | 0.4325 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.2547 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.4325 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.4325 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.4325 | 0.4325 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.4325 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.2931 | 0.2931 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.4325 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.4325 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.4325 | 0.4325 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.4325 | 0.4325 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.5296 | 0.5296 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.5296 | 0.5296 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.4325 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.4325 | 0.5894 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.4325 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.4325 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.2931 | 0.2931 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.4325 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.2931 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.5296 | 0.3345 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5296 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.4325 | 0.1972 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.34 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.761 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.759 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.748 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.707 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.523 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.403 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.328 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.