Detailed information for compound 1617208

Basic information

Technical information
  • TDR Targets ID: 1617208
  • Name: 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a -[3-[4-[3,4-dihydroxy-4-(hydroxymethyl)oxolan -2-yl]oxy-3-hydroxy-6-methyl-5-(3,4,5-trihydr oxyoxan-2-yl)oxyoxan-2-yl]oxy-4,5-dihydroxyox an-2-yl]oxycarbonyl-8-hydroxy-4,4,6a,6b,11,11 ,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a ,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-t rihydroxyoxane-2-carboxylic acid
  • MW: 1191.31 | Formula: C57H90O26
  • H donors: 14 H acceptors: 16 LogP: -0.05 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC1(O)COC(C1O)OC1C(O)C(OC2C(OCC(C2O)O)OC(=O)[C@@]23CCC(C[C@H]3C3=CC[C@H]4[C@@]([C@@]3(C[C@H]2O)C)(C)CC[C@@H]2[C@]4(C)CC[C@@H](C2(C)C)OC2OC(C(=O)O)C(C(C2O)O)O)(C)C)OC(C1OC1OCC(C(C1O)O)O)C
  • InChi: 1S/C57H90O26/c1-23-39(79-45-36(66)32(62)26(59)19-74-45)40(80-49-43(69)56(73,21-58)22-76-49)38(68)47(77-23)82-42-33(63)27(60)20-75-48(42)83-50(72)57-16-15-51(2,3)17-25(57)24-9-10-29-53(6)13-12-31(78-46-37(67)34(64)35(65)41(81-46)44(70)71)52(4,5)28(53)11-14-54(29,7)55(24,8)18-30(57)61/h9,23,25-43,45-49,58-69,73H,10-22H2,1-8H3,(H,70,71)/t23?,25-,26?,27?,28-,29+,30+,31-,32?,33?,34?,35?,36?,37?,38?,39?,40?,41?,42?,43?,45?,46?,47?,48?,49?,53-,54+,55+,56?,57+/m0/s1
  • InChiKey: KFMPGQMSTZEBPT-XXMPYFHQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[3-[4-[3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-6-methyl-5-(3,4,5-trihydroxytetrahydropyran-2-yl)oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxycarbonyl-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
  • 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[[3-[[4-[[3,4-dihydroxy-4-(hydroxymethyl)-2-tetrahydrofuranyl]oxy]-3-hydroxy-6-methyl-5-[(3,4,5-trihydroxy-2-tetrahydropyranyl)oxy]-2-tetrahydropyranyl]oxy]-4,5-dihydroxy-2-tetrahydropyranyl]oxy-oxomethyl]-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxy-2-tetrahydropyrancarboxylic acid
  • 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[3-[4-(3,4-dihydroxy-4-methylol-tetrahydrofuran-2-yl)oxy-3-hydroxy-6-methyl-5-(3,4,5-trihydroxytetrahydropyran-2-yl)oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxycarbonyl-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
  • 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[3-[4-[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-6-methyl-5-(3,4,5-trihydroxyoxan-2-yl)oxy-oxan-2-yl]oxy-4,5-dihydroxy-oxan-2-yl]oxycarbonyl-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxy-oxane-2-carboxylic acid
  • NSC676793
  • NCI60_027251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0217 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.1726 0.1726
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1676 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0289 1
Echinococcus granulosus cathepsin l1 0.0017 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0016 0.0217 0.0444
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.1726 0.1726
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0045 0.0092
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.1726 0.1726
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.1726 1
Brugia malayi RE15519p 0.0068 0.1726 0.5132
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1726 0.5066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0134
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1726 0.1726
Brugia malayi putative neuropeptide receptor 0.0068 0.1726 0.5132
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.1726 0.5132
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus multilocularis sodium channel protein 0.0075 0.1932 0.1932
Mycobacterium ulcerans hypothetical protein 0.0019 0.0289 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0247 0.0733
Schistosoma mansoni neuropeptide receptor 0.0068 0.1726 0.3535
Brugia malayi Dopamine receptor protein 1 0.0068 0.1726 0.5132
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0078 0.3182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.1726 0.1726
Brugia malayi G-protein coupled receptor 0.0068 0.1726 0.5132
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.3364 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1676 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0134
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0045 0.0134
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.1726 0.5132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0289 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.1726 0.3535
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0289 1
Schistosoma mansoni myosin xvIII 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0315
Schistosoma mansoni neuropeptide receptor 0.0068 0.1726 0.3535
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.1726 0.3535
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1261 0.7525
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0247 0.1199
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1726 0.3535
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0078 0.2716
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0247 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1726 0.1726
Brugia malayi ecdysteroid receptor 0.001 0.0045 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.1726 0.5132
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.1726 0.1726
Onchocerca volvulus 0.0068 0.1726 1
Schistosoma mansoni hypothetical protein 0.0175 0.4884 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0247 1
Onchocerca volvulus 0.0068 0.1726 1
Onchocerca volvulus 0.0017 0.0247 0.1199
Echinococcus granulosus g protein coupled receptor 0.0068 0.1726 0.1726
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0045 0.0092
Onchocerca volvulus 0.0068 0.1726 1
Schistosoma mansoni hypothetical protein 0.0016 0.0217 0.0444
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0075 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0247 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.1726 0.5132
Echinococcus granulosus orexin receptor type 2 0.0068 0.1726 0.1726
Schistosoma mansoni coup transcription factor 0.001 0.0045 0.0092
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.1726 0.1726
Onchocerca volvulus 0.0017 0.0247 0.1199
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.1726 0.1726
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0078 0.3182
Brugia malayi sulfakinin receptor protein 0.0068 0.1726 0.5132
Schistosoma mansoni amine GPCR 0.0068 0.1726 0.3535
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.1726 0.3535
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0247 0.1199
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.1726 0.5066
Schistosoma mansoni hypothetical protein 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) cysteine protease 0.0017 0.0247 0.0607
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0078 0.0233
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0134
Echinococcus multilocularis allatostatin A receptor 0.0068 0.1726 0.1726
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0045 0.0045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0247 0.1472
Schistosoma mansoni hypothetical protein 0.0175 0.4884 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0045 0.0092
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1726 0.1726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus multilocularis sex peptide receptor 0.0068 0.1726 0.1726
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Onchocerca volvulus 0.0068 0.1726 1
Schistosoma mansoni opsin-like receptor 0.0068 0.1726 0.3535
Brugia malayi steroid hormone receptor 0.001 0.0045 0.0134
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Echinococcus multilocularis geminin 0.0175 0.4884 0.4884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus neuropeptide receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi Cathepsin L-like precursor 0.0012 0.0078 0.0233
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0773 0.2298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0045
Onchocerca volvulus 0.0068 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0289 0.0735
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0045 0.0045
Echinococcus granulosus GPCR family 2 0.0016 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0217 0.0217
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0289 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0247 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1726 0.3535
Onchocerca volvulus 0.0068 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus granulosus sodium channel protein 0.0075 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.1726 0.3535
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.1726 0.3535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1726 0.1726
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Onchocerca volvulus 0.0068 0.1726 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0315
Onchocerca volvulus 0.0068 0.1726 1
Echinococcus granulosus somatostatin receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0289 0.5
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0092
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0092
Onchocerca volvulus 0.0017 0.0247 0.1199
Brugia malayi G-protein coupled receptor 0.0068 0.1726 0.5132
Schistosoma mansoni hypothetical protein 0.0016 0.0217 0.0444
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1252 0.3722
Toxoplasma gondii cathepsin CPL 0.0017 0.0247 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0045 0.0092
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.1726 0.3535
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1676 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.1726 0.3535
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0014 0.015 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Plasmodium falciparum acyl-CoA synthetase 0.0014 0.015 0.6067
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) ctsf protein 0.0017 0.0247 0.0607
Brugia malayi Serotonin receptor 0.0068 0.1726 0.5132
Schistosoma mansoni hypothetical protein 0.0016 0.0217 0.0444
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1726 0.1726
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0045
Onchocerca volvulus 0.0068 0.1726 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0247 0.0505
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0247 0.0607
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.1726 0.1726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0134
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1726 0.1726
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.1726 0.1726
Brugia malayi AKH receptor 0.0068 0.1726 0.5132
Brugia malayi G protein-coupled receptor 0.0068 0.1726 0.5132
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.1726 0.5132
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0078 0.0161
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.1726 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1726 0.5066
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1726 0.1726
Onchocerca volvulus 0.0068 0.1726 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) fibroinase 0.0017 0.0247 0.0607
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0217 0.0217
Brugia malayi follicle stimulating hormone receptor 0.0068 0.1726 0.5132
Schistosoma mansoni amine GPCR 0.0068 0.1726 0.3535
Onchocerca volvulus 0.0068 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Onchocerca volvulus 0.0068 0.1726 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1726 0.1726
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.1726 0.5066
Schistosoma mansoni hypothetical protein 0.0068 0.1726 0.3535
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1252 0.3722
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.1726 0.5132
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1726 0.1726
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1726 0.1726
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Onchocerca volvulus 0.0017 0.0247 0.1199
Onchocerca volvulus 0.0068 0.1726 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0045 0.0134
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.015 0.139
Echinococcus granulosus allatostatin A receptor 0.0068 0.1726 0.1726
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1676 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.1726 0.1726
Entamoeba histolytica cysteine protease, putative 0.0017 0.0247 0.8537
Echinococcus granulosus g-protein coupled receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0134
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.1726 0.5066
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0247 0.0247
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0247 0.8537
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.1726 0.1726
Echinococcus granulosus sex peptide receptor 0.0068 0.1726 0.1726
Schistosoma mansoni hypothetical protein 0.0035 0.0773 0.1583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0289 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0045 0.0092
Brugia malayi Dopamine receptor 0.0068 0.1726 0.5132
Plasmodium vivax vivapain-2 0.0017 0.0247 1
Schistosoma mansoni biogenic amine receptor 0.0068 0.1726 0.3535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1726 0.3535
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0045 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0289 0.0859
Onchocerca volvulus 0.0068 0.1726 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.1726 0.1726
Plasmodium vivax vivapain-2 0.0017 0.0247 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0247 0.0247
Echinococcus multilocularis cysteine protease 0.0017 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus granulosus neuropeptide receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.124 0.2539
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.1726 0.1726
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.1726 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0247 0.0607
Echinococcus granulosus g protein coupled receptor 0.0068 0.1726 0.1726
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.1726 0.1726
Onchocerca volvulus 0.0019 0.0289 0.145
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0289 0.0859
Schistosoma mansoni neuropeptide receptor 0.0068 0.1726 0.3535
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0247 0.0505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0045 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1726 0.1726
Echinococcus multilocularis GPCR, family 2 0.0016 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0051 0.1252 0.3637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Echinococcus granulosus geminin 0.0175 0.4884 0.4884
Onchocerca volvulus 0.0068 0.1726 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0134
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1726 0.3535
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0289 0.0251
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0045 0.0134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1726 0.3535
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0289 0.0251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Brugia malayi Cathepsin L-like precursor 0.0012 0.0078 0.0233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0289 0.0735
Brugia malayi nuclear receptor NHR-88 0.001 0.0045 0.0134
Brugia malayi Serotonin receptor 0.0068 0.1726 0.5132
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1726 0.1726
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0247 0.0607
Brugia malayi neuropeptide F receptor 0.0068 0.1726 0.5132
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.1726 0.5132
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.1507 0.8997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0045 0.0092
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0045 0.0045
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0101
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.015 0.6067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0134
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.2194
Schistosoma mansoni opsin-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0289 0.0735
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1726 0.1726
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Brugia malayi ORL1-like opioid receptor 0.0068 0.1726 0.5132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0289 0.5
Brugia malayi cathepsin L-like precursor 0.0012 0.0078 0.0233
Echinococcus granulosus g protein coupled receptor 0.0068 0.1726 0.1726
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Echinococcus multilocularis somatostatin receptor 0.0068 0.1726 0.1726
Brugia malayi Dopamine receptor protein 2 0.0068 0.1726 0.5132
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0051 0.124 0.3601
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni amine GPCR 0.0068 0.1726 0.3535
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0045 0.0045
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.1726 0.1726
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi neuropeptide F receptor 0.0068 0.1726 0.5132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0134
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Leishmania major cathepsin L-like protease 0.0066 0.1676 0.8479
Schistosoma mansoni adenoreceptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0315
Echinococcus granulosus neuropeptide s receptor 0.0068 0.1726 0.1726
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.1726 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1726 0.1726
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0045 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0289 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.1726 0.1726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0134
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.1726 0.1726
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.1726 0.5066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0075 0.1932 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0247 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1726 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Onchocerca volvulus 0.0012 0.0078 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0289 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0045
Echinococcus granulosus serotonin receptor 0.0068 0.1726 0.1726
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0247 0.8537
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0315
Echinococcus granulosus fmrfamide receptor 0.0068 0.1726 0.1726
Brugia malayi larval opioid receptor 0.0068 0.1726 0.5132
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1726 0.1726
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1726 0.1726
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0217 0.0645
Leishmania major cathepsin L-like protease 0.0066 0.1676 0.8479
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0289 1
Onchocerca volvulus 0.0017 0.0247 0.1199
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0217 0.0519
Schistosoma mansoni amine GPCR 0.0068 0.1726 0.3535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.1726 0.1726
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1726 0.1726
Echinococcus granulosus hypothetical protein 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Schistosoma mansoni biogenic amine receptor 0.0068 0.1726 0.3535
Onchocerca volvulus 0.0017 0.0247 0.1199
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.1726 0.3535
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0247 1
Onchocerca volvulus 0.0068 0.1726 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1726 0.1726
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.1726 0.1726
Schistosoma mansoni histamine h1 receptor 0.0068 0.1726 0.3535
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0217 0.0217
Echinococcus multilocularis orexin receptor type 2 0.0068 0.1726 0.1726
Schistosoma mansoni hypothetical protein 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0315
Brugia malayi hypothetical protein 0.0068 0.1726 0.5132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0289 0.0859
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Brugia malayi Melatonin receptor type 1A 0.0068 0.1726 0.5132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0045
Echinococcus multilocularis serotonin receptor 0.0068 0.1726 0.1726
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0247 0.1199
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.1726 0.3535
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.1726 0.1726
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.1726 0.5066
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0045 0.0092
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0247 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.1726 0.5066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0045
Brugia malayi GnHR receptor homolog 0.0068 0.1726 0.5132
Schistosoma mansoni opsin-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1726 0.5066
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0247 0.0247
Schistosoma mansoni biogenic amine receptor 0.0068 0.1726 0.3535
Brugia malayi nuclear hormone receptor 0.001 0.0045 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.3364 1
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.1726 0.5066
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Echinococcus granulosus cathepsin l1 0.0012 0.0078 0.0078
Schistosoma mansoni amine GPCR 0.0068 0.1726 0.3535
Schistosoma mansoni neuropeptide receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1252 0.3637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Onchocerca volvulus 0.0051 0.124 0.7108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0217 0.0519
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Onchocerca volvulus 0.0068 0.1726 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0289 1
Leishmania major cathepsin L-like protease 0.0066 0.1676 0.8479
Brugia malayi Cathepsin L-like precursor 0.0017 0.0247 0.0733
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1726 0.1726
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.1726 0.1726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0247 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1676 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1726 0.1726
Echinococcus multilocularis serotonin receptor 0.0068 0.1726 0.1726
Echinococcus multilocularis cysteine protease 0.0017 0.0247 0.0247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0289 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1726 0.3535
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.1726 0.5132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0045 0.0045
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1726 0.5066
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0045 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1726 0.1726
Brugia malayi MH2 domain containing protein 0.0123 0.3364 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.1726 0.3535
Loa Loa (eye worm) hypothetical protein 0.0068 0.1726 0.5066
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0289 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1726 0.3535
Onchocerca volvulus 0.0017 0.0247 0.1199
Schistosoma mansoni hypothetical protein 0.0068 0.1726 0.3535
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1726 0.1726
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0045 0.0134

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.587 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.534 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.496 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.472 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.366 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.288 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.934 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.916 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.888 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.83 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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