Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.5098 | 0.5098 |
Echinococcus multilocularis | cathepsin L | 0.0498 | 0.281 | 0.2608 |
Echinococcus granulosus | cathepsin L | 0.0498 | 0.281 | 0.2608 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0334 | 0.0273 | 0.0273 |
Brugia malayi | Cathepsin L-like precursor | 0.0646 | 0.5098 | 0.5098 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0498 | 0.281 | 0.281 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0646 | 0.5098 | 0.3182 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0334 | 0.0273 | 0.0273 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0334 | 0.0273 | 0.0273 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0334 | 0.0273 | 0.0273 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0498 | 0.281 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.5098 | 0.5098 |
Echinococcus granulosus | cysteine protease | 0.0498 | 0.281 | 0.2608 |
Brugia malayi | Cathepsin L-like precursor | 0.0646 | 0.5098 | 0.5098 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0646 | 0.5098 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.0646 | 0.5098 | 0.5098 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0646 | 0.5098 | 0.3182 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0498 | 0.281 | 0.2608 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0498 | 0.281 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.0273 | 0.0273 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0498 | 0.281 | 0.281 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0498 | 0.281 | 0.281 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0498 | 0.281 | 0.281 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0646 | 0.5098 | 0.5098 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0646 | 0.5098 | 0.5098 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0334 | 0.0273 | 0.0273 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0498 | 0.281 | 0.281 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0646 | 0.5098 | 0.5098 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0498 | 0.281 | 0.281 |
Echinococcus granulosus | cathepsin l1 | 0.0646 | 0.5098 | 0.496 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0498 | 0.281 | 0.281 |
Plasmodium vivax | vivapain-3 | 0.0498 | 0.281 | 0.281 |
Trypanosoma cruzi | cysteine protease, putative | 0.0498 | 0.281 | 0.281 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0334 | 0.0273 | 0.0273 |
Plasmodium vivax | unspecified product | 0.0498 | 0.281 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.5098 | 0.5098 |
Plasmodium vivax | vivapain-1 | 0.0498 | 0.281 | 0.281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.133 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.969 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.954 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.662 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.621 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.594 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.581 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.434 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.412 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.