Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Plasmodium vivax | unspecified product | 0.0169 | 0.1304 | 0.2757 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | 0.022 | 0.218 | 0.2452 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0329 | 0.4058 | 0.3167 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.022 | 0.218 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.022 | 0.218 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.157 | 0.157 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0185 | 0.157 | 0.0306 |
Giardia lamblia | Kinase, PLK | 0.0185 | 0.157 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0169 | 0.1304 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0329 | 0.4058 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.157 | 0.3457 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0169 | 0.1304 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | cathepsin s | 0.0109 | 0.0255 | 0.0255 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.022 | 0.218 | 0.218 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0329 | 0.4058 | 0.3167 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0185 | 0.157 | 0.0306 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0329 | 0.4058 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Entamoeba histolytica | cysteine proteinase, putative | 0.022 | 0.218 | 0.3182 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0185 | 0.157 | 0.3457 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0169 | 0.1304 | 0.2757 |
Entamoeba histolytica | cysteine protease, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0329 | 0.4058 | 0.4058 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Plasmodium vivax | vivapain-2 | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.157 | 0.3457 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0329 | 0.4058 | 0.4058 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0329 | 0.4058 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0329 | 0.4058 | 0.5 |
Plasmodium vivax | vivapain-1 | 0.0169 | 0.1304 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Echinococcus multilocularis | cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Plasmodium vivax | vivapain-3 | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0185 | 0.157 | 0.0967 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0185 | 0.157 | 0.0967 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0169 | 0.1304 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.022 | 0.218 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Plasmodium vivax | vivapain-2 | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0185 | 0.157 | 0.3457 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.022 | 0.218 | 0.5061 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.022 | 0.218 | 0.1008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | Cathepsin F homolog | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0169 | 0.1304 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Brugia malayi | Cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.