Detailed information for compound 1618676

Basic information

Technical information
  • TDR Targets ID: 1618676
  • Name: NCI60_040679
  • MW: 359.378 | Formula: C21H17N3O3
  • H donors: 1 H acceptors: 3 LogP: 4.02 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)OC2=C(C1c1ccc(cc1)[N+](=O)[O-])CCCc1c2cccc1
  • InChi: 1S/C21H17N3O3/c22-12-18-19(14-8-10-15(11-9-14)24(25)26)17-7-3-5-13-4-1-2-6-16(13)20(17)27-21(18)23/h1-2,4,6,8-11,19H,3,5,7,23H2
  • InChiKey: HPGKMOIISNROJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC717896

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0103 0.0187
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0001 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0103 0.0755
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.068 0.068
Echinococcus multilocularis peregrin 0.0111 0.0206 0.0206
Onchocerca volvulus 0.0113 0.0211 0.0459
Loa Loa (eye worm) Smad1 0.0142 0.0289 0.0522
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0103 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0007 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0139 0.0279 0.1232
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0139 0.0279 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0177 0.0384 0.0642
Schistosoma mansoni hypothetical protein 0.0079 0.012 0.02
Brugia malayi hypothetical protein 0.0116 0.022 0.0396
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0036 0.0002 0.0015
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0134 0.0981
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Echinococcus granulosus transient receptor potential gamma protein 0.0082 0.0127 0.0139
Echinococcus granulosus expressed conserved protein 0.0189 0.0414 0.0453
Mycobacterium tuberculosis Conserved protein 0.0139 0.0279 0.1218
Brugia malayi beta-lactamase family protein 0.0139 0.0279 0.0504
Echinococcus multilocularis isocitrate dehydrogenase 0.0085 0.0134 0.0134
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.0447 0.0489
Mycobacterium tuberculosis Probable hydrolase 0.0139 0.0279 0.1218
Loa Loa (eye worm) hypothetical protein 0.012 0.023 0.0415
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0182 0.0397 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.107 0.4722
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0289 0.0522
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0085 0.0134 0.0981
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0066 0.0083 0.0149
Echinococcus granulosus peregrin 0.0111 0.0206 0.0225
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0056 0.0056 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0696 0.3071
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.011 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0103 0.0183 0.1332
Schistosoma mansoni hypothetical protein 0.0083 0.013 0.0216
Onchocerca volvulus Cathepsin F homolog 0.0073 0.0103 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0397 0.175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Schistosoma mansoni hypothetical protein 0.0177 0.0382 0.0638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.011 0.08
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.011 0.0483
Echinococcus granulosus beta LACTamase domain containing family member 0.0139 0.0279 0.0305
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0007 0.0055
Brugia malayi F/Y-rich N-terminus family protein 0.009 0.0147 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Onchocerca volvulus Huntingtin homolog 0.0116 0.022 0.0477
Echinococcus granulosus PHD finger protein rhinoceros 0.0109 0.0201 0.022
Loa Loa (eye worm) RNA binding protein 0.0177 0.0384 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.032 0.2334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Echinococcus multilocularis short transient receptor potential channel 6 0.0054 0.0052 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0154 0.032 0.2334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.0291 0.0486
Trichomonas vaginalis helicase, putative 0.0036 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0088 0.0159
Onchocerca volvulus 0.0876 0.2267 0.4928
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0073 0.0103 0.3235
Loa Loa (eye worm) cysteine protease 0.0073 0.0103 0.0187
Echinococcus multilocularis tumor protein p63 0.3426 0.9146 0.9146
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0183 0.0805
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0073 0.0103 0.0755
Brugia malayi RNA binding protein 0.0177 0.0384 0.0693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0007 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0088 0.0642
Echinococcus multilocularis geminin 0.0957 0.2487 0.2487
Echinococcus granulosus jumonji domain containing protein 0.0152 0.0316 0.0346
Echinococcus multilocularis short transient receptor potential channel 6 0.0054 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.0298 0.1317
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0142 0.0289 0.0289
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0182 0.0397 0.2895
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.028 0.066 0.4815
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0085 0.0134 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Schistosoma mansoni hypothetical protein 0.2255 0.5987 1
Toxoplasma gondii LsmAD domain-containing protein 0.0154 0.032 0.3215
Brugia malayi hypothetical protein 0.0364 0.0887 0.16
Mycobacterium ulcerans esterase/lipase LipP 0.0139 0.0279 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0201 0.2018
Schistosoma mansoni hypothetical protein 0.0083 0.013 0.0216
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0007 0.0012
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0073 0.0103 0.0187
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0001 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.011 0.08
Echinococcus granulosus lamin 0.0123 0.0236 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.0211 0.0353
Echinococcus granulosus cysteine protease 0.0038 0.0007 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0079 0.012 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0876 0.2267 1
Onchocerca volvulus 0.0073 0.0103 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Echinococcus multilocularis cathepsin L 0.0038 0.0007 0.0007
Trypanosoma cruzi cysteine protease, putative 0.0038 0.0007 0.0055
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0064 0.0077 0.0168
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Onchocerca volvulus 0.0502 0.1258 0.2734
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0247 0.0247
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0134 0.0134
Onchocerca volvulus 0.0073 0.0103 0.0225
Mycobacterium tuberculosis Probable lipase LipE 0.0139 0.0279 0.1218
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0085 0.0134 0.0586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Mycobacterium ulcerans lipase LipD 0.0139 0.0279 1
Plasmodium vivax hypothetical protein, conserved 0.0139 0.0279 0.8733
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0103 0.0103
Onchocerca volvulus Alhambra homolog 0.0109 0.0201 0.0436
Echinococcus multilocularis mothers against decapentaplegic 2 0.0064 0.0077 0.0077
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0085 0.0134 0.0134
Echinococcus multilocularis expressed conserved protein 0.0189 0.0414 0.0414
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0103 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0007 0.0055
Onchocerca volvulus 0.0177 0.0382 0.083
Loa Loa (eye worm) isocitrate dehydrogenase 0.0085 0.0134 0.0243
Loa Loa (eye worm) phosphatidylinositol 3 0.0543 0.137 0.2473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.011 0.08
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0543 0.137 0.137
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.066 0.4815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Loa Loa (eye worm) hypothetical protein 0.0116 0.022 0.0396
Schistosoma mansoni transient receptor potential channel 0.0082 0.0127 0.0212
Loa Loa (eye worm) jmjC domain-containing protein 0.0226 0.0515 0.093
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0201 0.6277
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0134 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0781 0.3443
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0029 0.0029
Onchocerca volvulus 0.0073 0.0103 0.0225
Echinococcus multilocularis cpg binding protein 0.0169 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0046 0.003 0.0055
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0255 0.0594 0.4337
Echinococcus multilocularis survival motor neuron protein 1 0.0866 0.2241 0.2241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Toxoplasma gondii ABC1 family protein 0.0139 0.0279 0.2807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Mycobacterium tuberculosis Probable esterase LipL 0.0139 0.0279 0.1218
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0043 0.0022 0.0025
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0085 0.0134 0.4205
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0109 0.0201 0.0335
Brugia malayi MH2 domain containing protein 0.0142 0.0289 0.0522
Brugia malayi MH2 domain containing protein 0.0142 0.0289 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0001 0.0006
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0007 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0007 0.0013
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Entamoeba histolytica hypothetical protein 0.0364 0.0887 0.6471
Loa Loa (eye worm) hypothetical protein 0.0055 0.0055 0.0099
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0073 0.0103 0.3235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0086 0.0138 0.0249
Trypanosoma cruzi cruzipain precursor, putative 0.028 0.066 0.4815
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0182 0.0397 0.2895
Brugia malayi MH1 domain containing protein 0.0079 0.0118 0.0213
Brugia malayi RNA recognition motif domain containing protein 0.0177 0.0384 0.0693
Schistosoma mansoni hypothetical protein 0.0069 0.0091 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Schistosoma mansoni transient receptor potential channel 0.0054 0.0052 0.0087
Plasmodium vivax vivapain-2 0.0073 0.0103 0.3235
Brugia malayi PHD-finger family protein 0.0109 0.0201 0.0362
Schistosoma mansoni smad1 5 8 and 0.0142 0.0289 0.0483
Brugia malayi hypothetical protein 0.1741 0.4601 0.8304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0138 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Brugia malayi Intermediate filament tail domain containing protein 0.0123 0.0236 0.0426
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0247 0.027
Echinococcus multilocularis tar DNA binding protein 0.0177 0.0384 0.0384
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.011 0.0483
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0045 0.0028 0.0877
Echinococcus granulosus mothers against decapentaplegic 5 0.0142 0.0289 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.066 0.4815
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0085 0.0134 0.0225
Echinococcus multilocularis PHD finger protein rhinoceros 0.0109 0.0201 0.0201
Echinococcus granulosus tar DNA binding protein 0.0177 0.0384 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0088 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0247 0.0413
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0053 0.0049 0.0053
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0139 0.0279 0.1218
Echinococcus multilocularis cysteine protease 0.0073 0.0103 0.0103
Plasmodium falciparum cysteine proteinase falcipain 1 0.0038 0.0007 0.0234
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0038 0.0277
Schistosoma mansoni hypothetical protein 0.0388 0.0951 0.1589
Brugia malayi cytoplasmic intermediate filament protein 0.0066 0.0083 0.0149
Entamoeba histolytica hypothetical protein 0.0364 0.0887 0.6471
Schistosoma mansoni fkbp-rapamycin associated protein 0.0103 0.0183 0.0305
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.077 0.1982 0.3577
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0543 0.137 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0113 0.0211 0.2124
Echinococcus granulosus cathepsin l1 0.0049 0.0038 0.0042
Echinococcus multilocularis lamin dm0 0.0123 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Brugia malayi jmjC domain containing protein 0.0143 0.0291 0.0526
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0397 0.0716
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0001 0.0025
Brugia malayi TAR-binding protein 0.0177 0.0384 0.0693
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.0447 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0695 0.3066
Brugia malayi intermediate filament protein 0.0123 0.0236 0.0426
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.032 1
Schistosoma mansoni hypothetical protein 0.0109 0.0201 0.0335
Loa Loa (eye worm) hypothetical protein 0.0127 0.0247 0.0446
Echinococcus granulosus cpg binding protein 0.0169 0.0361 0.0395
Onchocerca volvulus 0.0139 0.0279 0.0607
Brugia malayi Latrophilin receptor protein 2 0.0388 0.0951 0.1717
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0257 0.0598 0.4366
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0088 0.0384
Echinococcus granulosus geminin 0.0957 0.2487 0.2719
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0182 0.0397 0.0397
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Loa Loa (eye worm) hypothetical protein 0.0073 0.0103 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Echinococcus granulosus tumor protein p63 0.3426 0.9146 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0142 0.0289 0.0483
Plasmodium vivax vivapain-2 0.0073 0.0103 0.3235
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Onchocerca volvulus 0.0073 0.0103 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.0109 0.0201 0.0362
Giardia lamblia PHD finger protein 15 0.0109 0.0201 0.1465
Brugia malayi Inositol-1 0.0076 0.011 0.0198
Echinococcus multilocularis cysteine protease 0.0073 0.0103 0.0103
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0139 0.0279 0.1218
Schistosoma mansoni cpg binding protein 0.0169 0.0361 0.0603
Echinococcus multilocularis protein dispatched 1 0.0098 0.0171 0.0171
Echinococcus granulosus mothers against decapentaplegic 2 0.0064 0.0077 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0888 0.3917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0397 0.175
Loa Loa (eye worm) CXXC zinc finger family protein 0.0158 0.0333 0.06
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0001 0.0001
Onchocerca volvulus Huntingtin homolog 0.0116 0.022 0.0477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.026 0.0607 0.1013
Echinococcus granulosus phd:f box containing protein 0.0035 0.0001 0.0001
Onchocerca volvulus 0.0123 0.0236 0.0513
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0056 0.0056 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.0183 0.0329
Schistosoma mansoni hypothetical protein 0.0957 0.2487 0.4153
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.066 0.4815
Loa Loa (eye worm) hypothetical protein 0.0201 0.0447 0.0807
Loa Loa (eye worm) MH1 domain-containing protein 0.0064 0.0077 0.0139
Leishmania major cysteine peptidase A (CPA) 0.0073 0.0103 0.0755
Echinococcus granulosus cathepsin L 0.0038 0.0007 0.0008
Loa Loa (eye worm) beta-lactamase 0.0139 0.0279 0.0504
Loa Loa (eye worm) hypothetical protein 0.0079 0.012 0.0216
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.107 0.4722
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0002 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0543 0.137 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0696 0.3071
Entamoeba histolytica cysteine protease, putative 0.0073 0.0103 0.0755
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0085 0.0134 0.4205
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0088 0.3158
Schistosoma mansoni bromodomain containing protein 0.0059 0.0064 0.0106
Onchocerca volvulus 0.0139 0.0279 0.0607
Echinococcus multilocularis musashi 0.0123 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Toxoplasma gondii cathepsin CPL 0.0073 0.0103 0.104
Onchocerca volvulus 0.1741 0.4601 1
Toxoplasma gondii FATC domain-containing protein 0.0103 0.0183 0.1835
Brugia malayi Cathepsin L-like precursor 0.0049 0.0038 0.0069
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0388 0.0951 0.0951
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0001 0.0001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0001 0.0008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0073 0.0103 0.3235
Brugia malayi MH2 domain containing protein 0.209 0.5541 1
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0138 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0177 0.0384 0.0642
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0177 0.0384 0.0693
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0103 0.0183 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0103 0.0225
Echinococcus granulosus transient receptor potential ion channel A 0.0079 0.012 0.0131
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0106 0.0191 0.0209
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0001 0.0006
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0182 0.0397 0.2895
Loa Loa (eye worm) hypothetical protein 0.0082 0.0127 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.034 0.0822 0.1373
Schistosoma mansoni hypothetical protein 0.0036 0.0002 0.0003
Brugia malayi mothers against decapentaplegic homolog 3 0.0064 0.0077 0.0139
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Mycobacterium tuberculosis Conserved protein 0.0139 0.0279 0.1218
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0543 0.137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0007 0.0033
Onchocerca volvulus 0.0123 0.0236 0.0513
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0059 0.0065 0.0071
Brugia malayi MH1 domain containing protein 0.0142 0.0289 0.0522
Brugia malayi beta-lactamase family protein 0.0139 0.0279 0.0504
Schistosoma mansoni lamin 0.0123 0.0236 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.0279 0.1232
Schistosoma mansoni survival motor neuron protein 0.0177 0.0382 0.0638
Schistosoma mansoni smad 0.0064 0.0077 0.0129
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0028 0.0877
Brugia malayi Pre-SET motif family protein 0.0113 0.0211 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0138 0.0609
Entamoeba histolytica cysteine proteinase 1, putative 0.0038 0.0007 0.0055
Brugia malayi Pre-SET motif family protein 0.077 0.1982 0.3577
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1225 0.321 0.5794
Schistosoma mansoni hypothetical protein 0.0838 0.2164 0.3615
Echinococcus granulosus mothers against decapentaplegic 6 0.0064 0.0077 0.0084
Schistosoma mansoni Smad4 0.0142 0.0289 0.0483
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0106
Schistosoma mansoni inositol monophosphatase 0.0076 0.011 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0772 0.3405
Brugia malayi jmjC domain containing protein 0.0035 0.0001 0.0001
Toxoplasma gondii target of rapamycin (TOR), putative 0.0404 0.0995 1
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0007 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.209 0.5541 1
Leishmania major cathepsin L-like protease 0.0073 0.0103 0.0755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.026 0.0607 0.0663
Loa Loa (eye worm) hypothetical protein 0.0106 0.019 0.0343
Echinococcus multilocularis jumonji domain containing protein 0.0152 0.0316 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0139 0.0279 0.2038
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.0279 0.2038
Mycobacterium ulcerans hypothetical protein 0.0139 0.0279 1
Brugia malayi FAT domain containing protein 0.0079 0.012 0.0216
Loa Loa (eye worm) hypothetical protein 0.0188 0.0412 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.137 0.6043
Schistosoma mansoni transient receptor potential channel 4 0.0082 0.0127 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0038 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Plasmodium vivax vivapain-3 0.0038 0.0007 0.0234
Plasmodium vivax vivapain-1 0.0038 0.0007 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.032 0.2334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0177 0.0384 0.0642
Echinococcus multilocularis dnaJ subfamily B 0.2255 0.5987 0.5987
Loa Loa (eye worm) hypothetical protein 0.0049 0.0038 0.0069
Brugia malayi hypothetical protein 0.0154 0.032 0.0577
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0182 0.0397 0.2895
Loa Loa (eye worm) intermediate filament protein 0.0123 0.0236 0.0426
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0388 0.0951 0.0951
Echinococcus granulosus smad 0.0142 0.0289 0.0316
Echinococcus granulosus cathepsin L cysteine protease 0.0038 0.0007 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0103 0.0173
Brugia malayi jmjC domain containing protein 0.0035 0.0001 0.0001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0543 0.137 1
Onchocerca volvulus 0.0049 0.0038 0.0083
Brugia malayi PHD-finger family protein 0.0046 0.003 0.0055
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.0447 0.3264
Leishmania major hypothetical protein, conserved 0.0035 0.0001 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0053 0.0049 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0139 0.0279 0.1218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0183 0.0805
Brugia malayi latrophilin 2 splice variant baaae 0.0838 0.2164 0.3907
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0359 0.0873 0.0954
Echinococcus granulosus short transient receptor potential channel 6 0.0054 0.0052 0.0057
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.011 0.1101
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.032 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0085 0.0134 0.0981
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0036 0.0002 0.002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0085 0.0134 0.0981
Brugia malayi jmjC domain containing protein 0.0035 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0073 0.0103 0.0755
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.068 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0695 0.3066
Echinococcus granulosus Smad4 0.0142 0.0289 0.0316
Echinococcus granulosus lysine specific demethylase 5A 0.0143 0.0291 0.0318
Schistosoma mansoni microtubule-associated protein tau 0.1782 0.471 0.7868
Brugia malayi Calcitonin receptor-like protein seb-1 0.1225 0.321 0.5794
Brugia malayi jmjC domain containing protein 0.0035 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0085 0.0134 0.1352
Trypanosoma cruzi major cysteine proteinase, putative 0.022 0.0498 0.3637
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0154 0.032 0.0577
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0043 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0103 0.0183 0.1332
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.011 0.08
Loa Loa (eye worm) hypothetical protein 0.1741 0.4601 0.8304
Plasmodium vivax ataxin-2 like protein, putative 0.0154 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0038 0.0069
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0306 0.073 0.7342
Schistosoma mansoni hypothetical protein 0.0364 0.0887 0.1481
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.011 0.0483
Onchocerca volvulus 0.0073 0.0103 0.0225
Leishmania major hypothetical protein, conserved 0.0139 0.0279 0.2038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.026 0.0607 0.0607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.026 0.0607 0.0663
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0359 0.0873 0.0873
Brugia malayi jmjC domain containing protein 0.0359 0.0873 0.1575
Leishmania major cathepsin L-like protease 0.0073 0.0103 0.0755
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Brugia malayi isocitrate dehydrogenase 0.0085 0.0134 0.0243
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0029 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0007 0.0033
Entamoeba histolytica hypothetical protein 0.0364 0.0887 0.6471
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0069 0.0091 0.01
Loa Loa (eye worm) inositol-1 0.0076 0.011 0.0198
Loa Loa (eye worm) hypothetical protein 0.1225 0.321 0.5794
Echinococcus granulosus microtubule associated protein 2 0.1782 0.471 0.515
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0432 0.1072 0.7822
Loa Loa (eye worm) hypothetical protein 0.0109 0.0201 0.0362
Brugia malayi MH2 domain containing protein 0.0064 0.0077 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.107 0.4722
Plasmodium falciparum phd finger protein, putative 0.0109 0.0201 0.6277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0695 0.3066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0388 0.0951 0.104
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0543 0.137 0.2289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.137 0.6043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.028 0.066 0.4815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0772 0.3405
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0007 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.0211 0.0353
Brugia malayi CHE-14 protein 0.0086 0.0138 0.0249
Schistosoma mansoni cpg binding protein 0.0158 0.0333 0.0555
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.026 0.0607 0.1095
Loa Loa (eye worm) hypothetical protein 0.0103 0.0183 0.0329
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0038 0.0007 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.012 0.0528
Echinococcus multilocularis transient receptor potential ion channel A 0.0079 0.012 0.012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0139 0.0279 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0182 0.0397 0.0663
Echinococcus multilocularis GPCR, family 2 0.0388 0.0951 0.0951
Echinococcus granulosus dnaJ subfamily B 0.2255 0.5987 0.6546
Echinococcus multilocularis smad 0.0142 0.0289 0.0289
Loa Loa (eye worm) TAR-binding protein 0.0177 0.0384 0.0693
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Echinococcus granulosus cathepsin L cysteine proteinase 0.0073 0.0103 0.0113
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0043 0.0022 0.0022
Schistosoma mansoni lamin 0.0123 0.0236 0.0394
Onchocerca volvulus 0.0073 0.0103 0.0225
Echinococcus granulosus lamin dm0 0.0123 0.0236 0.0258
Entamoeba histolytica cysteine proteinase 2 0.0038 0.0007 0.0055
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0038 0.0069
Echinococcus multilocularis microtubule associated protein 2 0.1782 0.471 0.471
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0456 0.0761
Schistosoma mansoni cpg binding protein 0.0169 0.0361 0.0603
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0106
Entamoeba histolytica protein kinase rad3, putative 0.0103 0.0183 0.1332
Echinococcus granulosus short transient receptor potential channel 6 0.0054 0.0052 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.0077 0.0139
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0543 0.137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0397 0.175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.0279 0.1232
Brugia malayi CXXC zinc finger family protein 0.0158 0.0333 0.06
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0103 0.0755
Schistosoma mansoni hypothetical protein 0.0957 0.2487 0.4153
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0388 0.0951 0.1717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.026 0.0607 0.1013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0064 0.0077 0.0139
Brugia malayi hypothetical protein 0.0099 0.0173 0.0312
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0397 0.175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0038 0.0069
Leishmania major cathepsin L-like protease 0.028 0.066 0.4815
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0038 0.0063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0182 0.0397 0.0434
Brugia malayi Cathepsin L-like precursor 0.0049 0.0038 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0543 0.137 1
Leishmania major cathepsin L-like protease 0.028 0.066 0.4815
Giardia lamblia GTOR 0.0543 0.137 1
Echinococcus granulosus survival motor neuron protein 1 0.0866 0.2241 0.245
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0059 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0696 0.3071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0696 0.3071
Loa Loa (eye worm) hypothetical protein 0.0111 0.0204 0.0368
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0543 0.137 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Echinococcus multilocularis Smad4 0.0142 0.0289 0.0289
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.0291 0.0486
Echinococcus multilocularis mothers against decapentaplegic 6 0.0064 0.0077 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0364 0.0887 0.0887
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0123 0.0236 0.0258
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Mycobacterium ulcerans beta-lactamase 0.0139 0.0279 1
Schistosoma mansoni Smad4 0.0064 0.0077 0.0129
Echinococcus multilocularis protein patched 0.0086 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0502 0.1258 0.227
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0103 0.0103
Brugia malayi Bromodomain containing protein 0.0068 0.0088 0.016
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0201 0.2018
Echinococcus granulosus serine protein kinase ATM 0.0103 0.0183 0.02
Schistosoma mansoni jumonji domain containing protein 0.0285 0.0674 0.1125
Schistosoma mansoni smad1 5 8 and 0.0142 0.0289 0.0483
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0002 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0397 0.175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0388 0.0951 0.1717
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0007 0.0055
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0138 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.026 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.107 0.4722
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0543 0.137 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0247 0.0413
Schistosoma mansoni hypothetical protein 0.0083 0.013 0.0216
Schistosoma mansoni Smad4 0.0064 0.0077 0.0129
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0103 0.0183 0.02
Brugia malayi Isocitrate dehydrogenase 0.0085 0.0134 0.0243
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0036 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0114 0.0214 0.0387
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0001 0.0001
Onchocerca volvulus 0.0073 0.0103 0.0225
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1225 0.321 0.5794
Schistosoma mansoni hypothetical protein 0.0388 0.0951 0.1589
Onchocerca volvulus 0.0158 0.0333 0.0723
Brugia malayi cathepsin L-like precursor 0.0049 0.0038 0.0069
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0007 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.0183 0.0329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0388 0.0951 0.104
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0079 0.012 0.012
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0103 0.0183 0.0305
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0103 0.0103
Trichomonas vaginalis esterase, putative 0.0139 0.0279 0.1232
Echinococcus multilocularis serine protein kinase ATM 0.0103 0.0183 0.0183
Brugia malayi MH1 domain containing protein 0.0142 0.0289 0.0522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0002 0.001
Trypanosoma cruzi target of rapamycin kinase 3 0.0432 0.1072 0.7822
Schistosoma mansoni inositol monophosphatase 0.0076 0.011 0.0183
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0114 0.0214 0.2153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0007 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.137 0.6043
Echinococcus granulosus cathepsin l1 0.0073 0.0103 0.0113
Loa Loa (eye worm) hypothetical protein 0.0866 0.2241 0.4044
Toxoplasma gondii isocitrate dehydrogenase 0.0085 0.0134 0.1352
Brugia malayi MH1 domain containing protein 0.0079 0.0118 0.0213
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0432 0.1072 0.7822
Loa Loa (eye worm) nuclear factor I 0.0079 0.0118 0.0213
Echinococcus multilocularis beta LACTamase domain containing family member 0.0139 0.0279 0.0279
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.011 0.012
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0781 0.3443
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.011 0.08
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0214 0.0945
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0177 0.0382 0.0689
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0103 0.0225
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0069 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Echinococcus granulosus TGF beta signal transducer SmadC 0.0142 0.0289 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Loa Loa (eye worm) ctsf protein 0.0073 0.0103 0.0187
Loa Loa (eye worm) hypothetical protein 0.0123 0.0236 0.0426
Schistosoma mansoni smad1 5 8 and 0.0142 0.0289 0.0483
Echinococcus granulosus mixed lineage leukemia protein mll 0.0043 0.0022 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0088 0.0388
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0139 0.0279 0.0504
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0123 0.0236 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.026 0.0607 0.1013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.1156 0.5099
Schistosoma mansoni intermediate filament proteins 0.0123 0.0236 0.0394
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0543 0.137 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0139 0.0279 0.1218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Brugia malayi Smad1 0.0142 0.0289 0.0522
Leishmania major hypothetical protein, conserved 0.0154 0.032 0.2334
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.0279 0.1232
Echinococcus granulosus cathepsin l cysteine peptidase 0.0073 0.0103 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Leishmania major cathepsin L-like protease 0.0073 0.0103 0.0755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0079 0.0119 0.0199
Brugia malayi Bromodomain containing protein 0.0111 0.0206 0.0371
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.011 0.011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0007 0.0012
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0103 0.0183 0.1332
Loa Loa (eye worm) MH1 domain-containing protein 0.0142 0.0289 0.0522
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0103 0.0183 0.1332
Onchocerca volvulus 0.0139 0.0279 0.0607
Schistosoma mansoni hypothetical protein 0.0388 0.0951 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0995 0.4388
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0001 0.0001
Brugia malayi hypothetical protein 0.0866 0.2241 0.4044
Mycobacterium leprae conserved hypothetical protein 0.0139 0.0279 1
Schistosoma mansoni transcription factor LCR-F1 0.0364 0.0887 0.1481
Schistosoma mansoni tar DNA-binding protein 0.0177 0.0384 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0781 0.3443
Mycobacterium tuberculosis Conserved protein 0.0139 0.0279 0.1218
Echinococcus multilocularis transient receptor potential gamma protein 0.0082 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0353 0.0856 0.3777
Schistosoma mansoni tar DNA-binding protein 0.0177 0.0384 0.0642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0103 0.0456
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0226 0.0514 0.375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0139 0.0279 0.0466
Echinococcus multilocularis mothers against decapentaplegic 5 0.0142 0.0289 0.0289
Brugia malayi Cathepsin L-like precursor 0.0073 0.0103 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0103 0.0755
Loa Loa (eye worm) hypothetical protein 0.0059 0.0065 0.0117
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.0447 0.0447
Brugia malayi AF-10 protein 0.0036 0.0002 0.0004
Plasmodium vivax SET domain protein, putative 0.0113 0.0211 0.6606
Loa Loa (eye worm) hypothetical protein 0.0388 0.0951 0.1717
Loa Loa (eye worm) hypothetical protein 0.0116 0.022 0.0396
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0886 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.0838 0.2164 0.3907
Schistosoma mansoni hypothetical protein 0.0388 0.0951 0.1589
Loa Loa (eye worm) hypothetical protein 0.0139 0.0279 0.0504
Schistosoma mansoni transient receptor potential channel 0.0054 0.0052 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0397 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.107 0.4722
Schistosoma mansoni smad 0.0142 0.0289 0.0483
Loa Loa (eye worm) hypothetical protein 0.0079 0.0118 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0103 0.0456
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0007 0.0012
Mycobacterium leprae Probable lipase LipE 0.0139 0.0279 1
Schistosoma mansoni hypothetical protein 0.0083 0.013 0.0216
Schistosoma mansoni patched 1 0.0086 0.0138 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0001 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.0502 0.1258 0.2101
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0103 0.0183 0.1332
Echinococcus granulosus GPCR family 2 0.0388 0.0951 0.104
Leishmania major phosphatidylinositol 3-kinase, putative 0.0182 0.0397 0.2895
Trichomonas vaginalis penicillin-binding protein, putative 0.0139 0.0279 0.1232
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Loa Loa (eye worm) fibroinase 0.0073 0.0103 0.0187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0085 0.0134 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.0291 0.0526
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0113 0.0211 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0038 0.0168
Entamoeba histolytica cysteine protease, putative 0.0038 0.0007 0.0055
Plasmodium vivax JmjC domain containing protein 0.0035 0.0001 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.209 0.5541 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0364 0.0887 0.097
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0103 0.0187
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0001 0.0001
Plasmodium vivax unspecified product 0.0038 0.0007 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.0279 0.2038
Brugia malayi beta-lactamase 0.0139 0.0279 0.0504
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0139 0.0279 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0103 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0183 0.0805
Echinococcus multilocularis lysine specific demethylase 5A 0.0133 0.0263 0.0263
Entamoeba histolytica hypothetical protein 0.0364 0.0887 0.6471
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.026 0.0607 0.1095
Toxoplasma gondii PHD-finger domain-containing protein 0.0036 0.0002 0.002
Loa Loa (eye worm) histone methyltransferase 0.0053 0.0049 0.0088
Echinococcus multilocularis lamin 0.0123 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0543 0.137 0.2473
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0002 0.001

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.227 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.997 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.929 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.846 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.82 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.818 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.798 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.787 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.747 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.718 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.716 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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