Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Fatty acid synthase homolog | 0.05 | 0.9416 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0231 | 0.3311 | 0.443 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.8643 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0231 | 0.3311 | 0.4398 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0278 | 0.4361 | 0.4361 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0087 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0223 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0223 | 0.3131 | 0.4188 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.018 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | thioesterase | 0.0231 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0095 | 0.0229 | 0.0306 |
Loa Loa (eye worm) | fatty acid synthase | 0.0274 | 0.4277 | 0.4318 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0184 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0227 | 0.3214 | 0.4299 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0269 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | polyketide synthase | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0223 | 0.3131 | 0.4188 |
Brugia malayi | AMP-binding enzyme family protein | 0.0259 | 0.3948 | 0.3948 |
Mycobacterium ulcerans | thioesterase TesA | 0.0231 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0278 | 0.4361 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0295 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0259 | 0.3948 | 0.3889 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0269 | 0.4168 | 0.5576 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0184 | 0.2228 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0295 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.0483 | 0.9025 | 0.9285 | |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0087 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0112 | 0.061 | 0.0817 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0259 | 0.3948 | 0.528 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0184 | 0.2228 | 0.2941 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0415 | 0.7476 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0295 | 0.4752 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0158 | 0.1644 | 0.2199 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0198 | 0.2547 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0278 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0199 | 0.2588 | 0.3461 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.