Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.05 | 0.4361 | 0.4361 |
Giardia lamblia | Aurora kinase | 0.0905 | 0.9446 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0532 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0905 | 0.9446 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0468 | 0.3948 | 0.528 |
Toxoplasma gondii | aurora kinase | 0.0905 | 0.9446 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0532 | 0.4752 | 0.6337 |
Brugia malayi | serine/threonine kinase 12 | 0.0905 | 0.9446 | 0.9446 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Leishmania major | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0172 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0285 | 0.1644 | 0.2199 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0468 | 0.3948 | 0.3948 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0905 | 0.9446 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0905 | 0.9446 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0905 | 0.9446 | 0.9446 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0403 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0485 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | polyketide synthase | 0.0532 | 0.4752 | 0.6357 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.05 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0331 | 0.2228 | 0.2981 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0403 | 0.3131 | 0.4155 |
Onchocerca volvulus | 0.0871 | 0.9025 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.036 | 0.2588 | 0.3461 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.1592 | 0.0745 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0905 | 0.9446 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.0494 | 0.4277 | 0.391 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0331 | 0.2228 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0331 | 0.2228 | 0.2981 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0356 | 0.2547 | 0.1586 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0905 | 0.9446 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0417 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0403 | 0.3131 | 0.4188 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0905 | 0.9446 | 0.9446 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0532 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.8643 | 0.9054 |
Echinococcus granulosus | aurora kinase A | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0409 | 0.3214 | 0.4299 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0748 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | thioesterase | 0.0417 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.05 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0417 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0157 | 0.0042 | 0.0056 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0905 | 0.9446 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.05 | 0.4361 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0532 | 0.4752 | 0.4276 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0468 | 0.3948 | 0.3521 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0157 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0532 | 0.4752 | 0.6337 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0202 | 0.061 | 0.0817 |
Mycobacterium ulcerans | thioesterase TesA | 0.0417 | 0.3311 | 0.443 |
Trypanosoma brucei | aurora B kinase | 0.0905 | 0.9446 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0905 | 0.9446 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0902 | 0.9416 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.05 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0485 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0325 | 0.2149 | 0.1101 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.874 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.805 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.801 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.653 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.545 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.409 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.35 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.331 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.168 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.112 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.046 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.847 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.