Detailed information for compound 1620693

Basic information

Technical information
  • TDR Targets ID: 1620693
  • Name: ethyl (2Z)-2-[(5Z)-5-[(6-methoxynaphthalen-2- yl)methylidene]-4-oxo-3-[2-oxo-2-(oxolan-2-yl methylamino)ethyl]-1,3-thiazolidin-2-ylidene] acetate
  • MW: 496.575 | Formula: C26H28N2O6S
  • H donors: 1 H acceptors: 3 LogP: 3.71 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C=c/1\s/c(=C\c2ccc3c(c2)ccc(c3)OC)/c(=O)n1CC(=O)NCC1CCCO1
  • InChi: 1S/C26H28N2O6S/c1-3-33-25(30)14-24-28(16-23(29)27-15-21-5-4-10-34-21)26(31)22(35-24)12-17-6-7-19-13-20(32-2)9-8-18(19)11-17/h6-9,11-14,21H,3-5,10,15-16H2,1-2H3,(H,27,29)/b22-12-,24-14-
  • InChiKey: NEWSIJKERMBALI-GCHCWRHXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl (2Z)-2-[(5Z)-5-[(6-methoxy-2-naphthyl)methylene]-4-oxo-3-[2-oxo-2-(tetrahydrofuran-2-ylmethylamino)ethyl]thiazolidin-2-ylidene]acetate
  • (2Z)-2-[(5Z)-5-[(6-methoxy-2-naphthyl)methylene]-4-oxo-3-[2-oxo-2-(2-tetrahydrofuranylmethylamino)ethyl]-2-thiazolidinylidene]acetic acid ethyl ester
  • (2Z)-2-[(5Z)-4-keto-3-[2-keto-2-(tetrahydrofurfurylamino)ethyl]-5-[(6-methoxy-2-naphthyl)methylene]thiazolidin-2-ylidene]acetic acid ethyl ester
  • ethyl (2Z)-2-[(5Z)-5-[(6-methoxynaphthalen-2-yl)methylidene]-4-oxo-3-[2-oxo-2-(oxolan-2-ylmethylamino)ethyl]-1,3-thiazolidin-2-ylidene]ethanoate
  • T5296361
  • MLS000567764
  • SMR000154339

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens neurotensin receptor 1 (high affinity) Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0181 0.4457 0.4437
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.4457 0.4348
Brugia malayi voltage-dependent calcium channel 0.0181 0.4457 0.4437
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0181 0.4457 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0477 0.029
Echinococcus multilocularis potassium voltage gated channel protein 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0181 0.4457 0.4348
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0181 0.4457 0.4348
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0477 0.0668
Schistosoma mansoni voltage-gated ion channel 0.0181 0.4457 0.4348
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0477 0.029
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0181 0.4457 0.4348
Schistosoma mansoni vesicular amine transporter 0.0181 0.4457 0.4348
Echinococcus multilocularis voltage dependent calcium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Trichomonas vaginalis rotamase, putative 0.004 0.0352 0.079
Echinococcus multilocularis potassium large conductance calcium activated 0.0181 0.4457 0.4348
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0181 0.4457 0.4348
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Echinococcus multilocularis transient receptor potential gamma protein 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.0188
Loa Loa (eye worm) hypothetical protein 0.0245 0.6322 0.625
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel protein 0.0181 0.4457 0.4348
Schistosoma mansoni lipoxygenase 0.01 0.2077 0.1922
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus multilocularis hyperpolarization activated cyclic 0.0181 0.4457 0.4348
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0376 0.0192
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0181 0.4457 0.4348
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0325 0.0728
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0181 0.4457 1
Echinococcus granulosus sodium leak channel non selective protein 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel protein 0.0181 0.4457 0.4348
Schistosoma mansoni hypothetical protein 0.0041 0.0376 0.0188
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Echinococcus granulosus two pore calcium channel protein 2 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0181 0.4457 0.4348
Echinococcus multilocularis ryanodine receptor 44f 0.0181 0.4457 0.4348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0477 0.1069
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0181 0.4457 0.4437
Echinococcus multilocularis geminin 0.0205 0.5135 0.504
Echinococcus multilocularis transfer RNA-Gly 0.0181 0.4457 0.4348
Echinococcus granulosus sodium channel protein 0.0181 0.4457 0.4348
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0181 0.4457 0.4348
Echinococcus granulosus geminin 0.0205 0.5135 0.504
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0352 0.079
Echinococcus granulosus voltage gated hydrogen channel 1 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.4457 0.4348
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Brugia malayi ion channel NompC 0.0181 0.4457 0.4437
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.4457 0.4348
Echinococcus granulosus short transient receptor potential channel 6 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0181 0.4457 0.4437
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.4457 1
Schistosoma mansoni voltage-gated cation channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0931 0.0753
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0325 0.0312
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Leishmania major hypothetical protein, conserved 0.0181 0.4457 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) voltage-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) ryanodine receptor 0.0181 0.4457 0.4348
Echinococcus multilocularis voltage dependent calcium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0931 0.0769
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0181 0.4457 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0477 0.1069
Schistosoma mansoni transient receptor potential channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0477 0.1069
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0477 0.1069
Loa Loa (eye worm) hypothetical protein 0.0365 0.9803 0.9799
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis short transient receptor potential channel 6 0.0181 0.4457 0.4348
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0477 0.5
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0181 0.4457 0.4437
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0477 0.0668
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0181 0.4457 0.4437
Echinococcus multilocularis expressed protein 0.004 0.0352 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0181 0.4457 0.4437
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus multilocularis voltage gated potassium channel 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0181 0.4457 0.4437
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0477 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Toxoplasma gondii hypothetical protein 0.0181 0.4457 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0181 0.4457 0.4348
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0325 0.0728
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus granulosus TRP transient receptor potential channel 0.0181 0.4457 0.4348
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2082 1
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) voltage-gated calcium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0325 0.1559
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0325 0.0312
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0181 0.4457 0.4348
Echinococcus multilocularis short transient receptor potential channel 6 0.0181 0.4457 0.4348
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0181 0.4457 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0181 0.4457 0.4437
Brugia malayi Cyclic-nucleotide gated cation channel 0.0181 0.4457 0.4437
Schistosoma mansoni transient receptor potential channel 0.0181 0.4457 0.4348
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0181 0.4457 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0181 0.4457 0.4437
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0181 0.4457 0.4348
Schistosoma mansoni hypothetical protein 0.0181 0.4457 0.4348
Onchocerca volvulus 0.0365 0.9803 1
Brugia malayi olfactory channel protein osm-9 0.0181 0.4457 0.4437
Echinococcus multilocularis potassium voltage gated channel protein 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential channel 4 0.0181 0.4457 0.4348
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0181 0.4457 0.4437
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.5124 0.5029
Loa Loa (eye worm) voltage-dependent calcium channel 0.0181 0.4457 0.4348
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0181 0.4457 0.4437
Schistosoma mansoni lipoxygenase 0.0142 0.3324 0.3194
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0181 0.4457 0.4437
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni hypothetical protein 0.0205 0.5135 0.504
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0181 0.4457 0.4348
Schistosoma mansoni ryanodine receptor related 0.0181 0.4457 0.4348
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0181 0.4457 0.4348
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0181 0.4457 1
Echinococcus granulosus ryanodine receptor 44f 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0181 0.4457 0.4348
Schistosoma mansoni rotamase 0.004 0.0352 0.0164
Brugia malayi hypothetical protein 0.0181 0.4457 0.4437
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0181 0.4457 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis sodium channel protein 0.0181 0.4457 0.4348
Loa Loa (eye worm) voltage-gated potassium channel 0.0181 0.4457 0.4348
Echinococcus granulosus shaker cognate 0.0181 0.4457 0.4348
Plasmodium vivax importin-beta 2, putative 0.0035 0.0192 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0181 0.4457 0.4348
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0477 0.029
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0181 0.4457 0.4348
Echinococcus granulosus hypothetical protein 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0181 0.4457 0.4437
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0181 0.4457 0.4348
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0477 0.1069
Echinococcus granulosus transcription factor eb 0.013 0.2973 0.2835
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Echinococcus granulosus calcium activated potassium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis two pore calcium channel protein 2 0.0181 0.4457 0.4348
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0181 0.4457 0.4348
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0181 0.4457 0.4348
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.5124 0.5029
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.034 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0325 0.0728
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.4457 1
Schistosoma mansoni hypothetical protein 0.0205 0.5135 0.504
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni calcium-activated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni two-pore calcium channel 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0181 0.4457 0.4437
Echinococcus multilocularis transcription factor eb 0.013 0.2973 0.2835
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential channel 0.0181 0.4457 0.4348
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.3324 0.3194
Brugia malayi Inositol-1 0.0045 0.0477 0.0296
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.4457 0.4348
Trichomonas vaginalis rotamase, putative 0.0039 0.0325 0.0728
Toxoplasma gondii hypothetical protein 0.0181 0.4457 1
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0181 0.4457 1
Echinococcus multilocularis voltage gated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis sodium leak channel non selective protein 0.0181 0.4457 0.4348
Echinococcus granulosus hyperpolarization activated cyclic 0.0181 0.4457 0.4348
Echinococcus multilocularis two pore calcium channel protein 1 0.0181 0.4457 0.4348
Echinococcus granulosus voltage dependent calcium channel 0.0181 0.4457 0.4348
Brugia malayi hypothetical protein 0.0365 0.9803 1
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Echinococcus granulosus hyperpolarization activated cyclic 0.0181 0.4457 0.4348
Echinococcus granulosus two pore calcium channel protein 1 0.0181 0.4457 0.4348
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.4457 0.4348
Echinococcus multilocularis shaker cognate 0.0181 0.4457 0.4348
Brugia malayi RNA, U transporter 1 0.0099 0.2061 0.1945
Echinococcus granulosus voltage gated potassium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.3324 0.3194
Brugia malayi Transient-receptor-potential like protein 0.0181 0.4457 0.4437
Echinococcus granulosus potassium large conductance calcium activated 0.0181 0.4457 0.4348
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0181 0.4457 0.4437
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.034 0.5
Loa Loa (eye worm) ion channel NompC 0.0181 0.4457 0.4348
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.2973 0.2894
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.4457 0.4348
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.013 0.2954 0.2817
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.01 0.2082 0.1927
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.4457 0.4348
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Echinococcus multilocularis calcium activated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.2954 0.2817
Schistosoma mansoni voltage-dependent calcium channel 0.0181 0.4457 0.4348
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0477 0.2289
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.4457 1
Echinococcus granulosus voltage dependent calcium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0181 0.4457 0.4348
Brugia malayi cation channel family protein 0.0181 0.4457 0.4437
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0181 0.4457 0.4348
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0181 0.4457 0.4348
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.6322 0.6378
Echinococcus granulosus short transient receptor potential channel 6 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.4457 0.4348
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0352 0.0164
Echinococcus granulosus transient receptor potential gamma protein 0.0181 0.4457 0.4348
Plasmodium falciparum importin beta, putative 0.0035 0.0192 0.5
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0181 0.4457 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0181 0.4457 0.4348
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.4457 0.4348
Loa Loa (eye worm) inositol-1 0.0045 0.0477 0.029
Brugia malayi cation channel family protein 0.0181 0.4457 0.4437
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0181 0.4457 0.4348
Echinococcus granulosus voltage gated potassium channel 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2082 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0181 0.4457 0.4348
Loa Loa (eye worm) hypothetical protein 0.0181 0.4457 0.4348
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0181 0.4457 0.4348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0477 0.1069
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.4457 0.4348
Schistosoma mansoni 60S ribosomal protein L21 0.0181 0.4457 0.4348
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.4457 0.4348
Leishmania major hypothetical protein, unknown function 0.0181 0.4457 1
Echinococcus granulosus expressed protein 0.004 0.0352 0.0164
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0352 0.0167
Schistosoma mansoni inositol monophosphatase 0.0045 0.0477 0.029
Loa Loa (eye worm) calcium channel 0.0181 0.4457 0.4348
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0181 0.4457 0.4348
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0181 0.4457 0.4348

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.729 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 5.729 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 5.729 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
EC50 (functional) = 7.15 uM PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055] ChEMBL. No reference
EC50 (binding) = 90.417 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) > 300 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.0126 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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