Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transmembrane protease, serine 15 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | _UBC13, UbcH-ben, UbcH13 | Starlite/ChEMBL | No references |
Mus musculus | B cell leukemia/lymphoma 2 related protein A1a | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2, putative | _UBC13, UbcH-ben, UbcH13 | 152 aa | 153 aa | 32.0 % |
Plasmodium falciparum | ubiquitin specific protease, putative | ubiquitin specific peptidase 2 | 362 aa | 378 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.1697 | 0.222 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.4521 | 0.4521 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0045 | 0.1623 | 0.9381 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0505 | 0.2411 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.1623 | 0.9381 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0303 | 0.0108 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6834 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.156 | 0.156 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.01 | 0.4521 | 0.4521 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.008 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.1623 | 0.9381 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0283 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.144 | 0.183 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.1566 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2437 | 0.3341 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0046 | 0.1697 | 0.1697 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0046 | 0.1697 | 0.1697 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0505 | 0.2411 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1623 | 0.2108 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.1623 | 0.9478 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.01 | 0.4521 | 0.4521 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0283 | 0.0077 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.1697 | 0.222 |
Onchocerca volvulus | 0.0019 | 0.0303 | 1 | |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0505 | 0.0505 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0505 | 0.0505 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0879 | 0.479 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.01 | 0.4521 | 0.4521 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.1623 | 0.1623 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.156 | 0.8849 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0879 | 0.4209 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0505 | 0.0415 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.1623 | 0.953 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.144 | 0.144 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0505 | 0.1566 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0879 | 0.4209 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.144 | 0.183 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.1623 | 0.1623 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.01 | 0.4521 | 0.6497 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0045 | 0.1623 | 0.1623 |
Schistosoma mansoni | apoptosis regulator bax | 0.01 | 0.4521 | 0.4521 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.1623 | 0.9381 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0505 | 0.0415 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.01 | 0.4521 | 0.4521 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0284 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0283 | 0.0077 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0046 | 0.1697 | 1 |
Echinococcus granulosus | MAM | 0.0019 | 0.0303 | 0.0303 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0283 | 0.0283 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.0303 | 0.0108 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0879 | 0.4209 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0505 | 0.0415 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.156 | 0.8849 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0505 | 0.2411 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0505 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.1697 | 1 |
Echinococcus multilocularis | MAM | 0.0019 | 0.0303 | 0.0303 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0045 | 0.1623 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0303 | 0.0303 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.1566 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.1623 | 0.2108 |
Brugia malayi | hypothetical protein | 0.0043 | 0.156 | 0.2012 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.1566 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0505 | 0.1566 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0879 | 0.4209 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.1697 | 0.222 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4521 | 0.6497 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0046 | 0.1697 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0046 | 0.1697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.4521 | 0.4521 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0505 | 0.2411 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0879 | 0.4209 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.1623 | 0.9478 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0045 | 0.1623 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.4521 | 0.4521 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0303 | 0.0108 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0505 | 0.0415 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0046 | 0.1697 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0303 | 0.0108 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.2411 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2437 | 0.3341 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.01 | 0.4521 | 0.6497 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0046 | 0.1697 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.1697 | 0.222 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0045 | 0.1623 | 0.1623 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0284 | 0.0284 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.01 | 0.4521 | 0.4521 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0505 | 0.0505 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.1697 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0283 | 0.0283 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0284 | 0.1003 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.156 | 0.156 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0505 | 0.1566 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.156 | 0.156 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.1566 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2437 | 0.3341 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.1623 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0879 | 0.0981 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0879 | 0.4209 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6834 | 1 |
Onchocerca volvulus | 0.0019 | 0.0303 | 1 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0505 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0505 | 0.0505 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.156 | 0.156 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0505 | 0.1566 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.1697 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0879 | 0.4209 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0505 | 0.0505 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0046 | 0.1697 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0505 | 0.0505 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0019 | 0.0303 | 0.0108 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0505 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.156 | 0.8849 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.156 | 0.8849 |
Brugia malayi | hypothetical protein | 0.003 | 0.0879 | 0.0981 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0303 | 0.0108 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0283 | 0.0283 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.008 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.1697 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.0284 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0505 | 0.0505 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0232 | 0.0232 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0046 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0284 | 0.008 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.1623 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0283 | 0.0283 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0505 | 0.0505 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0045 | 0.1623 | 0.9478 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0505 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0283 | 0.0077 |
Brugia malayi | hypothetical protein | 0.002 | 0.0314 | 0.0125 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2437 | 0.3341 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0045 | 0.1623 | 0.1623 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6834 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0283 | 0.0283 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0505 | 0.2411 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 54.688 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588439, AID588440, AID588442] | ChEMBL. | No reference |
EC50 (functional) | > 54.688 uM | PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
EC50 (functional) | > 55.924 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescent artifacts and/or optically active compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
IC50 (functional) | = 4.773 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493155] | ChEMBL. | No reference |
IC50 (functional) | = 9.149 uM | PUBCHEM_BIOASSAY: Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
IC50 (functional) | = 10.567 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] | ChEMBL. | No reference |
IC50 (functional) | = 18.5 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343] | ChEMBL. | No reference |
IC50 (functional) | = 38.4 uM | PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] | ChEMBL. | No reference |
Potency (functional) | 0.6513 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.6681 uM | PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.6858 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.