Detailed information for compound 1620904

Basic information

Technical information
  • TDR Targets ID: 1620904
  • Name: [(6S)-2-chloro-6,6a,7,11b-tetrahydro-5H-inden o[2,1-c]quinolin-6-yl]-phenylmethanone
  • MW: 359.848 | Formula: C23H18ClNO
  • H donors: 1 H acceptors: 1 LogP: 5.76 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C1C([C@H](N2)C(=O)c2ccccc2)Cc2c1cccc2
  • InChi: 1S/C23H18ClNO/c24-16-10-11-20-18(13-16)21-17-9-5-4-8-15(17)12-19(21)22(25-20)23(26)14-6-2-1-3-7-14/h1-11,13,19,21-22,25H,12H2/t19?,21?,22-/m0/s1
  • InChiKey: XUTQDVBWBVTKPY-VTLFHKLASA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(6S)-2-chloro-6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolin-6-yl]-phenyl-methanone
  • NCI60_014524

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0139 0.0132
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.009 0.0083
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.009 0.0083
Brugia malayi MH1 domain containing protein 0.0009 0.009 0.0157
Echinococcus multilocularis Smad4 0.0009 0.009 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0166 0.3418 0.5503
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0779 0.0335
Giardia lamblia Fructose-bisphosphate aldolase 0.034 0.7114 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0139 0.0242
Brugia malayi hypothetical protein 0.0006 0.0007 0.0012
Echinococcus multilocularis muscleblind protein 0.0174 0.3581 0.3577
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0139 0.1228
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.009 0.0157
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0065 0.0059
Brugia malayi Smad1 0.0009 0.009 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0139 0.0242
Brugia malayi beta-lactamase family protein 0.0042 0.0779 0.1358
Onchocerca volvulus 0.0042 0.0779 0.7187
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0139 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0139 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Schistosoma mansoni cpg binding protein 0.0035 0.0639 0.0633
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0779 0.0773
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0108 0.0102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0779 0.0773
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.5734 0.5732
Onchocerca volvulus 0.0012 0.0139 0.1228
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.1148 0.1143
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1148 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0753 0.0996
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0139 0.0132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.034 0.7114 1
Echinococcus granulosus smad 0.0009 0.009 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0139 0.0242
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0753 0.1313
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0021 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0779 0.1032
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0007 0.0012
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.1307 0.2279
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0139 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0021 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0139 0.0242
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0007 0.0012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.1521 0.2652
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0139 0.0132
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0021 0.0014
Echinococcus granulosus Smad4 0.0009 0.009 0.0083
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0139 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0139 0.0132
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.1148 0.515
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Echinococcus multilocularis transcription factor btf3 0.0041 0.0753 0.0747
Schistosoma mansoni transcription factor btf3 0.0041 0.0753 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0753 0.0996
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0139 0.0132
Brugia malayi ecdysteroid receptor 0.0012 0.0139 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.009 0.0083
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0083
Brugia malayi tailless protein 0.0006 0.0007 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.5575 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0139 0.0132
Trypanosoma brucei protein kinase, putative 0.0059 0.1148 0.515
Brugia malayi MH1 domain containing protein 0.0009 0.009 0.0157
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0779 0.0335
Brugia malayi Muscleblind-like protein 0.0174 0.3581 0.6246
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0779 0.1032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0139 0.0242
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0007 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0139 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0139 0.0242
Echinococcus granulosus cpg binding protein 0.0035 0.0639 0.0633
Brugia malayi MH2 domain containing protein 0.0139 0.284 0.4953
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0139 0.0242
Onchocerca volvulus 0.0056 0.1081 1
Schistosoma mansoni cpg binding protein 0.0033 0.0599 0.0592
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0139 0.1228
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1395 0.1389
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.1148 0.8223
Loa Loa (eye worm) DR-78 0.0006 0.0007 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0166 0.3418 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0007 0.0012
Echinococcus multilocularis smad 0.0009 0.009 0.0083
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0083
Trichomonas vaginalis esterase, putative 0.0042 0.0779 0.1032
Brugia malayi beta-NAC-like protein 0.0041 0.0753 0.1313
Echinococcus granulosus transcription factor btf3 0.0041 0.0753 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0139 0.0242
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.1307 0.1301
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0139 0.0242
Brugia malayi hypothetical protein 0.0006 0.0021 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0139 0.0242
Schistosoma mansoni Smad4 0.0009 0.009 0.0083
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0779 0.1358
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.1307 0.2001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.1307 0.1101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0599 0.1044
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Brugia malayi CXXC zinc finger family protein 0.0033 0.0599 0.1044
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0779 0.0335
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0166 0.3418 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.1148 0.2003
Loa Loa (eye worm) histone methyltransferase 0.001 0.0108 0.0189
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0007 0.0012
Brugia malayi nuclear hormone receptor 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Brugia malayi nuclear receptor NHR-88 0.0012 0.0139 0.0242
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.1081 0.1885
Treponema pallidum fructose-bisphosphate aldolase 0.034 0.7114 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0139 0.0132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0021 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0139 0.0132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0139 0.0132
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.1521 0.1515
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0139 0.0132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0139 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0139 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.1521 0.1515
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0139 0.1228
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1148 0.1555
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0139 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1234 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0139 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1148 0.1555
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0108 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0021 0.0036
Brugia malayi steroid hormone receptor 0.0012 0.0139 0.0242
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.1148 0.515
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.009 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0139 0.0132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0139 0.0132
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.1307 0.1301
Onchocerca volvulus 0.0042 0.0779 0.7187
Schistosoma mansoni smad 0.0009 0.009 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.284 0.4953
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0139 0.0132
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.1148 0.515
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0779 0.1032
Echinococcus multilocularis muscleblind protein 1 0.0174 0.3581 0.3577
Leishmania major hypothetical protein, conserved 0.0042 0.0779 0.0335
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0139 0.0132
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0036
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0139 0.0242
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Schistosoma mansoni cpg binding protein 0.0035 0.0639 0.0633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0036
Brugia malayi conserved hypotetical protein 0.0006 0.0007 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0139 0.0132
Brugia malayi MAP kinase sur-1 0.0059 0.1148 0.2003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.1521 0.1207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0065 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0139 0.0242
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0779 0.1032
Brugia malayi nuclear hormone receptor 0.0012 0.0139 0.0242
Brugia malayi MH2 domain containing protein 0.0009 0.009 0.0157
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0106 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0139 0.0242
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Loa Loa (eye worm) hypothetical protein 0.0174 0.3581 0.6246
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Brugia malayi nuclear receptor NHR-67 0.0006 0.0007 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.1148 0.1143
Loa Loa (eye worm) hypothetical protein 0.0275 0.5734 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0753 0.0996
Echinococcus multilocularis cpg binding protein 0.0035 0.0639 0.0633
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0065 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0779 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0139 0.0242
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0139 0.0242
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.1148 0.515
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.1521 0.1515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0139 0.0132
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0139 0.0242
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0139 0.0132
Loa Loa (eye worm) hypothetical protein 0.0174 0.3581 0.6246
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0833 0.0827
Schistosoma mansoni coup transcription factor 0.0012 0.0139 0.0132
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0779 0.1032
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1148 0.515
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.1521 0.2652
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.1307 0.1301
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.1148 0.1143
Brugia malayi nuclear receptor RXR 0.0006 0.0007 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0007 0.0012
Brugia malayi ecdysone receptor 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0139 0.0242
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.1148 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0139 0.0242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0779 0.0773
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.1521 1
Brugia malayi hypothetical protein 0.0275 0.5734 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.009 0.0083
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1521 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0021 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.034 0.7114 1
Loa Loa (eye worm) beta-lactamase 0.0042 0.0779 0.1358
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0779 1
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.1148 0.1143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Brugia malayi hypothetical protein 0.0006 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.009 0.0083
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Brugia malayi nuclear receptor NHR-88 0.0006 0.0007 0.0012
Brugia malayi nuclear receptor RXR 0.0006 0.0021 0.0036
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0139 0.0132
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.1307 0.2001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0139 0.0242
Loa Loa (eye worm) hypothetical protein 0.0042 0.0779 0.1358
Onchocerca volvulus 0.0033 0.0599 0.5511
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1521 1
Brugia malayi MH2 domain containing protein 0.0009 0.009 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0065 0.0059
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.1148 0.515
Brugia malayi beta-lactamase family protein 0.0042 0.0779 0.1358
Brugia malayi hypothetical protein 0.0006 0.0021 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0139 0.0242
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.284 0.4953
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0779 0.1358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0139 0.0132
Onchocerca volvulus 0.0042 0.0779 0.7187
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1148 0.1555
Brugia malayi beta-lactamase 0.0042 0.0779 0.1358
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0139 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0139 0.0132
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.1211 0.2113
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0007 0.0012
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0753 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Loa Loa (eye worm) Smad1 0.0009 0.009 0.0157
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.5734 0.5732
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0833 0.0827
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.7114 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0139 0.0132
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0139 0.0132
Schistosoma mansoni survival motor neuron protein 0.0056 0.1081 0.1075
Echinococcus granulosus muscleblind protein 0.0174 0.3581 0.3577
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0139 0.0242
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1521 1
Schistosoma mansoni hypothetical protein 0.0056 0.1081 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0139 0.0242
Toxoplasma gondii ABC1 family protein 0.0042 0.0779 0.0535
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0065 0.0059
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1148 0.515
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0012
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.1307 0.7216

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.671 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.345 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.22 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.08 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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