Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3877 | 0.4244 | 0.5704 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0037 | 0.0037 |
Brugia malayi | Protein kinase domain containing protein | 0.0193 | 0.0159 | 0.0159 |
Echinococcus granulosus | twitchin | 0.0101 | 0.0058 | 0.0058 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.578 | 0.6355 | 0.6355 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.105 | 0.111 | 0.111 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.105 | 0.111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Schistosoma mansoni | vesicular amine transporter | 0.0052 | 0.0003 | 0.0003 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hhat protein | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.1269 | 0.1353 | 0.1353 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.105 | 0.111 | 0.111 |
Trichomonas vaginalis | conserved hypothetical protein | 0.105 | 0.111 | 0.2484 |
Brugia malayi | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Trichomonas vaginalis | porcupine, putative | 0.105 | 0.111 | 0.2484 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.1269 | 0.1353 | 0.1353 |
Brugia malayi | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Trypanosoma cruzi | GUP1, putative | 0.105 | 0.111 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.1269 | 0.1353 | 0.1353 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.671 | 0.7386 | 1 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.578 | 0.6355 | 0.8575 |
Loa Loa (eye worm) | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0193 | 0.0159 | 0.0159 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2523 | 0.2744 | 0.2744 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0152 | 0.0114 | 0.0114 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3877 | 0.4244 | 0.4244 |
Leishmania major | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Brugia malayi | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Toxoplasma gondii | hypothetical protein | 0.105 | 0.111 | 0.1324 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0115 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 0.0007 | 0.0007 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.105 | 0.111 | 0.111 |
Entamoeba histolytica | hypothetical protein | 0.105 | 0.111 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.105 | 0.111 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.0189 | 0.0189 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0052 | 0.0003 | 0.0003 |
Brugia malayi | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.105 | 0.111 | 0.2484 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.0107 | 0.0107 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0186 | 0.0152 | 0.0152 |
Echinococcus granulosus | caspase 2 | 0.0081 | 0.0035 | 0.0035 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0847 | 0.0885 | 0.0885 |
Echinococcus multilocularis | neuroglian | 0.0065 | 0.0018 | 0.0018 |
Schistosoma mansoni | zinc finger protein | 0.105 | 0.111 | 0.111 |
Entamoeba histolytica | hypothetical protein, conserved | 0.105 | 0.111 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0152 | 0.0114 | 0.0114 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0052 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.105 | 0.111 | 0.111 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.0107 | 0.0107 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.12 | 0.1277 | 0.1646 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0186 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3877 | 0.4244 | 0.5704 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0069 | 0.0022 | 0.0022 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3877 | 0.4244 | 0.5657 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.105 | 0.111 | 0.111 |
Leishmania major | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.105 | 0.111 | 0.111 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.578 | 0.6355 | 0.8575 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3877 | 0.4244 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.671 | 0.7386 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.105 | 0.111 | 0.2484 |
Brugia malayi | Cell death protein 3 precursor | 0.0081 | 0.0035 | 0.0035 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0115 | 0.0074 | 0.0074 |
Brugia malayi | hypothetical protein | 0.12 | 0.1277 | 0.1277 |
Trypanosoma cruzi | GUP1, putative | 0.105 | 0.111 | 0.1417 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.105 | 0.111 | 0.111 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0224 | 0.0194 | 0.0194 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.105 | 0.111 | 0.111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3877 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0037 | 0.0037 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0186 | 0.0152 | 0.0107 |
Brugia malayi | diacylglycerol acyltransferase | 0.578 | 0.6355 | 0.6355 |
Loa Loa (eye worm) | hypothetical protein | 0.105 | 0.111 | 0.111 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.105 | 0.111 | 0.5 |
Onchocerca volvulus | 0.2523 | 0.2744 | 1 | |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.578 | 0.6355 | 0.6355 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Schistosoma mansoni | cell adhesion molecule | 0.0069 | 0.0022 | 0.0022 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3877 | 0.4244 | 0.4244 |
Brugia malayi | MAP kinase sur-1 | 0.3877 | 0.4244 | 0.4244 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.105 | 0.111 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0082 | 0.0037 | 0.0037 |
Schistosoma mansoni | tyrosine kinase | 0.0224 | 0.0194 | 0.0194 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.1269 | 0.1353 | 0.1353 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0115 | 0.0074 | 0.0074 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0791 | 0.0823 | 0.2999 |
Schistosoma mansoni | nephrin | 0.0065 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.0186 | 0.0152 | 0.0553 | |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0186 | 0.0152 | 0.0107 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0186 | 0.0152 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.105 | 0.111 | 0.111 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.105 | 0.111 | 0.111 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Loa Loa (eye worm) | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Trypanosoma brucei | protein kinase, putative | 0.3877 | 0.4244 | 0.5704 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0052 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Brugia malayi | Hhat protein | 0.105 | 0.111 | 0.111 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0847 | 0.0885 | 0.0885 |
Echinococcus granulosus | Immunoglobulin | 0.0052 | 0.0003 | 0.0003 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3877 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0186 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0224 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.12 | 0.1277 | 0.2885 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.105 | 0.111 | 0.111 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0152 | 0.0114 | 0.0114 |
Echinococcus granulosus | insulin receptor | 0.0193 | 0.0159 | 0.0159 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.671 | 0.7386 | 1 |
Onchocerca volvulus | 0.0771 | 0.0801 | 0.2918 | |
Echinococcus multilocularis | thymidylate synthase | 0.2523 | 0.2744 | 0.2744 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3877 | 0.4244 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Brugia malayi | thymidylate synthase | 0.2523 | 0.2744 | 0.2744 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0186 | 0.0152 | 0.0107 |
Echinococcus granulosus | roundabout 2 | 0.0082 | 0.0037 | 0.0037 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3877 | 0.4244 | 0.5704 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0224 | 0.0194 | 0.0194 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3877 | 0.4244 | 1 |
Leishmania major | hypothetical protein, conserved | 0.105 | 0.111 | 0.1417 |
Leishmania major | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Brugia malayi | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0003 | 0.0003 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0115 | 0.0074 | 0.0074 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0081 | 0.0035 | 0.0128 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3877 | 0.4244 | 0.5704 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3877 | 0.4244 | 0.4244 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3877 | 0.4244 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0081 | 0.0035 | 0.0035 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.578 | 0.6355 | 0.6355 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3877 | 0.4244 | 0.5704 |
Trichomonas vaginalis | conserved hypothetical protein | 0.105 | 0.111 | 0.2484 |
Leishmania major | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0035 | 0.0035 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0052 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.4731 | 0.5191 | 0.5191 |
Schistosoma mansoni | protein kinase | 0.0115 | 0.0074 | 0.0074 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.105 | 0.111 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.105 | 0.111 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.105 | 0.111 | 0.111 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.105 | 0.111 | 0.111 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.671 | 0.7386 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.2523 | 0.2744 | 0.2744 |
Echinococcus multilocularis | Immunoglobulin | 0.0052 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Immunoglobulin | 0.0052 | 0.0003 | 0.0003 |
Echinococcus multilocularis | 0.0067 | 0.002 | 0.002 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3877 | 0.4244 | 0.4244 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0052 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0029 | 0.0029 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.105 | 0.111 | 0.111 |
Leishmania major | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.105 | 0.111 | 0.1417 |
Echinococcus granulosus | neuroglian | 0.0065 | 0.0018 | 0.0018 |
Echinococcus multilocularis | insulin receptor | 0.0193 | 0.0159 | 0.0159 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.671 | 0.7386 | 1 |
Loa Loa (eye worm) | hhat protein | 0.105 | 0.111 | 0.111 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0066 | 0.0019 | 0.0019 |
Echinococcus granulosus | defective proboscis extension response | 0.0052 | 0.0003 | 0.0003 |
Brugia malayi | Protein kinase domain containing protein | 0.0082 | 0.0037 | 0.0037 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.105 | 0.111 | 0.111 |
Schistosoma mansoni | hypothetical protein | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | caspase 2 | 0.0081 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | thymidylate synthase | 0.2523 | 0.2744 | 0.2744 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3877 | 0.4244 | 0.5704 |
Schistosoma mansoni | tyrosine kinase | 0.0193 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.578 | 0.6355 | 0.6355 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3877 | 0.4244 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.671 | 0.7386 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2523 | 0.2744 | 0.1682 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.105 | 0.111 | 0.111 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.105 | 0.111 | 0.111 |
Loa Loa (eye worm) | MBOAT family protein | 0.105 | 0.111 | 0.111 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.105 | 0.111 | 0.111 |
Onchocerca volvulus | 0.105 | 0.111 | 0.4044 | |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0193 | 0.0159 | 0.0159 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.0107 | 0.0107 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0224 | 0.0194 | 0.0194 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0193 | 0.0159 | 0.0159 |
Schistosoma mansoni | tyrosine kinase | 0.0193 | 0.0159 | 0.0159 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3877 | 0.4244 | 0.5704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.