Detailed information for compound 1621786

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 260.292 | Formula: C13H16N4O2
  • H donors: 1 H acceptors: 2 LogP: 1.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1)/C=N/NC1=NCCCCC1
  • InChi: 1S/C13H16N4O2/c18-17(19)12-6-4-5-11(9-12)10-15-16-13-7-2-1-3-8-14-13/h4-6,9-10H,1-3,7-8H2,(H,14,16)/b15-10+
  • InChiKey: MELRKOJMXILROJ-XNTDXEJSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.018 0.1083 0.1319
Mycobacterium ulcerans acyl carrier protein 0.0072 0.027 0.0271
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0596 0.4241 0.5384
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0072 0.027 0.0223
Onchocerca volvulus 0.0668 0.4788 0.5011
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.018 0.1083 0.1516
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.018 0.1083 0.1168
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.011 0.0554 0.0637
Toxoplasma gondii acyl carrier protein ACP 0.0072 0.027 0.0389
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0044 0.0059 0.0462
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0225 0.1425 0.1759
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0361 0.2463 0.4433
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.011 0.0554 0.0637
Schistosoma mansoni zinc binding dehydrogenase 0.0044 0.0059 0.0434
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0072 0.027 0.0271
Loa Loa (eye worm) hypothetical protein 0.011 0.0554 0.0564
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.018 0.1083 1
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.027 0.0271
Brugia malayi Phosphopantetheine attachment site family protein 0.0072 0.027 0.0212
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0072 0.027 0.2059
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0045 0.0064 0.0007
Toxoplasma gondii acyl transferase domain-containing protein 0.0045 0.0064 0.001
Loa Loa (eye worm) hypothetical protein 0.018 0.109 0.1175
Mycobacterium tuberculosis Hypothetical protein 0.0215 0.1356 0.1669
Loa Loa (eye worm) fatty acid synthase 0.0706 0.5072 0.5715
Schistosoma mansoni hypothetical protein 0.0072 0.027 0.199
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0072 0.027 0.0271
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0072 0.027 0.0271
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7146 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.018 0.1083 0.799
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0464 0.324 0.5866
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0072 0.027 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0575 0.4085 0.5183
Schistosoma mansoni methyltransferase-related 0.0215 0.1356 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.018 0.1083 1
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.018 0.1083 0.1319
Toxoplasma gondii type I fatty acid synthase 0.011 0.0554 0.0913
Giardia lamblia Methyltransferase like 2 0.0215 0.1356 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0575 0.4085 0.5183
Echinococcus granulosus muscleblind protein 0.018 0.109 0.8557
Echinococcus multilocularis muscleblind protein 1 0.018 0.109 0.1525
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0514 0.3617 0.4581
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1069 0.7826 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.076 0.5481 0.6981
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0499 0.4269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.027 1
Brugia malayi Muscleblind-like protein 0.018 0.109 0.1037
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0715 0.5145 0.6547
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0072 0.027 0.0212
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0072 0.027 0.0271
Mycobacterium tuberculosis Polyketide synthase Pks12 0.076 0.5481 0.6981
Schistosoma mansoni hypothetical protein 0.0205 0.1273 0.9394
Brugia malayi AMP-binding enzyme family protein 0.022 0.1389 0.1338
Mycobacterium ulcerans thioesterase TesA 0.0596 0.4241 0.5384
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.076 0.5481 0.6981
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.018 0.1083 0.7899
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0045 0.0064 0.009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0715 0.5145 0.6547
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0715 0.5145 0.5116
Loa Loa (eye worm) hypothetical protein 0.0401 0.276 0.3079
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0072 0.027 0.2059
Treponema pallidum acyl carrier protein 0.0072 0.027 0.5
Toxoplasma gondii type I fatty acid synthase, putative 0.0509 0.3582 0.6497
Plasmodium falciparum acyl carrier protein 0.0072 0.027 0.2016
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0072 0.027 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.1356 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0473 0.3308 0.4183
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0072 0.027 0.0271
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.011 0.0554 0.0637
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.076 0.5481 0.6981
Toxoplasma gondii type I fatty acid synthase, putative 0.076 0.5481 1
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0045 0.0064 0.0005
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.018 0.1083 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.018 0.1083 0.8505
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0289 0.1915 0.2389
Mycobacterium leprae Polyketide synthase Pks13 0.1069 0.7826 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0715 0.5145 0.6547
Mycobacterium ulcerans fatty acid synthase Fas 0.0225 0.1425 0.1759
Onchocerca volvulus 0.1245 0.916 0.9643
Schistosoma mansoni [ACP] S-malonyltransferase 0.0045 0.0064 0.0475
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0072 0.027 0.2059
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.018 0.1083 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0473 0.3308 0.4183
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0072 0.027 0.0271
Leishmania major acyl carrier protein, putative 0.0072 0.027 0.1626
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0473 0.3308 0.4183
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0499 0.4269
Echinococcus multilocularis AMP dependent ligase 0.0072 0.027 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.027 0.0271
Onchocerca volvulus 0.0072 0.027 0.0223
Onchocerca volvulus Fatty acid synthase homolog 0.1289 0.9497 1
Echinococcus granulosus acyl carrier protein mitochondrial 0.0072 0.027 0.2118
Mycobacterium ulcerans thioesterase 0.0596 0.4241 0.5384
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0715 0.5145 0.6547
Mycobacterium tuberculosis Probable thioesterase TesA 0.0596 0.4241 0.5384
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.022 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.027 0.0271
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0693 0.4978 0.6333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.028 0.2064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.027 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0715 0.5145 0.6547
Echinococcus granulosus NADH dehydrogenase 0.0072 0.027 0.2118
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0072 0.027 0.024
Echinococcus multilocularis NADH dehydrogenase 0.0072 0.027 0.0377
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0045 0.0064 0.0053
Mycobacterium ulcerans acyl carrier protein 0.0072 0.027 0.0271
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0072 0.027 0.0271
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0072 0.027 0.0212
Echinococcus multilocularis geminin 0.0205 0.1273 0.1782
Mycobacterium ulcerans polyketide synthase MbtD 0.022 0.1389 0.1713
Mycobacterium tuberculosis Conserved protein 0.0215 0.1356 0.1669
Echinococcus multilocularis muscleblind protein 0.018 0.109 0.1525
Schistosoma mansoni hypothetical protein 0.0205 0.1273 0.9394
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0715 0.5145 0.6547
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.011 0.0554 0.0637
Echinococcus granulosus AMP dependent ligase 0.0072 0.027 0.2118
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0044 0.0059 0.0082
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0668 0.4788 0.5391
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0585 0.4157 0.5275
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0045 0.0064 0.0505
Mycobacterium leprae Probable polyketide synthase Pks1 0.076 0.5481 0.6981
Leishmania major hypothetical protein, conserved 0.0045 0.0064 0.0042
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0246 0.1586 0.1966
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.018 0.1083 0.1889
Loa Loa (eye worm) hypothetical protein 0.011 0.0554 0.0564
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0072 0.027 0.0271
Loa Loa (eye worm) hypothetical protein 0.1201 0.8831 1
Schistosoma mansoni alcohol dehydrogenase 0.0044 0.0059 0.0434
Leishmania major hypothetical protein, conserved 0.0215 0.1356 1
Trypanosoma brucei acyl transferase-like protein 0.0045 0.0064 0.0053
Mycobacterium ulcerans hypothetical protein 0.0072 0.027 0.0271
Brugia malayi Methyltransferase-like protein 4 0.0215 0.1356 0.1304
Plasmodium vivax acyl carrier protein, putative 0.0072 0.027 0.2016
Brugia malayi AMP-binding enzyme family protein 0.0668 0.4788 0.4757
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0575 0.4085 0.5183
Mycobacterium ulcerans polyketide synthase 0.076 0.5481 0.6981
Loa Loa (eye worm) hypothetical protein 0.0045 0.0064 0.0006
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0072 0.027 0.0271
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.076 0.5481 0.6981
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0668 0.4788 0.6089
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1069 0.7826 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.018 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.018 0.109 0.1175
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.018 0.1083 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.022 0.1389 0.1713
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0225 0.1425 0.1759
Schistosoma mansoni acyl carrier protein 0.0072 0.027 0.199
Mycobacterium leprae conserved hypothetical protein 0.0072 0.027 0.0271
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0072 0.027 0.0271
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0072 0.027 0.0271
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.027 0.0271
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0715 0.5145 0.6547
Mycobacterium ulcerans polyketide synthase MbtC 0.018 0.1083 0.1319
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0072 0.027 0.0377
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0175 0.1047 0.1272
Trypanosoma cruzi acyl transferase-like protein 0.0045 0.0064 0.0053
Chlamydia trachomatis acyl carrier protein 0.0072 0.027 0.2016
Trypanosoma cruzi acyl transferase-like protein, putative 0.0045 0.0064 0.0053
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0693 0.4978 0.6333
Mycobacterium ulcerans Type I modular polyketide synthase 0.0715 0.5145 0.6547
Mycobacterium ulcerans polyketide synthase 0.0715 0.5145 0.6547
Schistosoma mansoni [ACP] S-malonyltransferase 0.0045 0.0064 0.0475
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.076 0.5481 0.6981
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0715 0.5145 0.6547
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.018 0.1083 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0045 0.0064 0.0475
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.011 0.0554 0.0637
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.076 0.5481 0.6981
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0072 0.027 0.0271
Loa Loa (eye worm) acyl carrier protein 0.0329 0.2216 0.2458
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0407 0.2805 0.3535
Loa Loa (eye worm) acyl carrier protein 0.0072 0.027 0.024
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.018 0.1083 0.103
Echinococcus granulosus geminin 0.0205 0.1273 1
Mycobacterium ulcerans polyketide synthase Pks13 0.1069 0.7826 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 47.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 2.5119 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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