TDR Targets

Basic information

Technical information

TDR Targets ID: 1722327
Name: 3-[[(4-chlorophenyl)methyl-(phenylmethyl)amin o]-(1-cyclopentyltetrazol-5-yl)methyl]-6-meth yl-1H-quinolin-2-one
MW: 539.07 | Formula: C31H31ClN6O
H donors: 1 H acceptors: 4 LogP: 5.7 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)CN(C(c1nnnn1C1CCCC1)c1cc2cc(C)ccc2[nH]c1=O)Cc1ccccc1
InChi: 1S/C31H31ClN6O/c1-21-11-16-28-24(17-21)18-27(31(39)33-28)29(30-34-35-36-38(30)26-9-5-6-10-26)37(19-22-7-3-2-4-8-22)20-23-12-14-25(32)15-13-23/h2-4,7-8,11-18,26,29H,5-6,9-10,19-20H2,1H3,(H,33,39)
InChiKey: LGJADEQXWGFEMC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[[(4-chlorophenyl)methyl-(phenylmethyl)amino]-(1-cyclopentyl-5-tetrazolyl)methyl]-6-methyl-1H-quinolin-2-one
3-[[benzyl-(4-chlorobenzyl)amino]-(1-cyclopentyltetrazol-5-yl)methyl]-6-methyl-carbostyril
3-[[(4-chlorophenyl)methyl-(phenylmethyl)amino]-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)methyl]-6-methyl-1H-quinolin-2-one
BAS 04417658

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_141408	All targets in OG5_141408

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cAMP response protein 1	0.0041	0.0137	0.1976
Leishmania major	hypothetical protein, conserved	0.0041	0.0137	0.1976
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0041	0.0137	0.0299
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.009	0.0866	0.0866
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0137	0.4103
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.033	0.4413	0.965
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0665	0.1506
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0007	0.0016
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0041	0.0137	0.031
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0007	0.0016
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0062	0.0441	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0743	0.1683
Trypanosoma brucei	cAMP binding protein, putative	0.0041	0.0137	0.1976
Echinococcus granulosus	hyperpolarization activated cyclic	0.0062	0.0441	0.0441
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0062	0.0441	0.0441
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.0743	0.0743
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0062	0.0441	0.0999
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0041	0.0137	0.031
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0324	1
Brugia malayi	Pip kinase protein 2	0.033	0.4413	1
Echinococcus granulosus	phosphatidylinositol 5 phosphate 4 kinase type 2	0.033	0.4413	0.4413
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0062	0.0441	0.082
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0041	0.0137	0.031
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0041	0.0137	0.1767
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.0743	1
Trypanosoma brucei	Flagellar Member 6	0.0041	0.0137	0.1976
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0324	0.0734
Leishmania major	protein kinase, putative	0.0041	0.0137	0.1976
Trypanosoma cruzi	cAMP response protein 1, putative	0.0041	0.0137	0.1976
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0665	0.894
Trypanosoma cruzi	cAMP binding protein, putative	0.0041	0.0137	0.1976
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.0665	1
Plasmodium falciparum	cGMP-dependent protein kinase	0.0041	0.0137	0.1767
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0041	0.0137	0.1976
Trypanosoma cruzi	Flagellar Member 6	0.0041	0.0137	0.1976
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0062	0.0441	0.082
Leishmania major	hypothetical protein, conserved	0.0041	0.0137	0.1976
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0041	0.0137	0.031
Schistosoma mansoni	hypothetical protein	0.0041	0.0137	0.0299
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0041	0.0137	0.0137
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0137	0.4103
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0324	0.0324
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0041	0.0137	0.0299
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0062	0.0441	0.0999
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0007	0.0015
Brugia malayi	Egg laying defective protein 4	0.0041	0.0137	0.031
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	0.5
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0062	0.0441	0.0964
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0041	0.0137	0.1767
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0041	0.0137	0.0299
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0007	0.0016
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0292	0.3844	1
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0041	0.0137	0.031
Loa Loa (eye worm)	hypothetical protein	0.0271	0.3538	0.8017
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0041	0.0137	0.0137
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0062	0.0441	0.0441
Schistosoma mansoni	60S ribosomal protein L21	0.0049	0.0255	0.0558
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0665	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1023	0.2318
Loa Loa (eye worm)	hypothetical protein	0.033	0.4413	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.0665	0.894
Schistosoma mansoni	voltage-gated potassium channel	0.0341	0.4573	1
Leishmania major	hypothetical protein, unknown function	0.0041	0.0137	0.1976
Brugia malayi	hypothetical protein	0.005	0.0261	0.0592
Leishmania major	hypothetical protein, conserved	0.0077	0.0665	1
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0041	0.0137	0.1767
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0041	0.0137	0.1976
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1023	0.2318
Trypanosoma brucei	cAMP response protein 1, putative	0.0041	0.0137	0.1976
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0062	0.0441	0.0999
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0137	0.1976
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0312	0.4148	0.9401
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0041	0.0137	0.0299
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0062	0.0441	0.0964
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Schistosoma mansoni	hypothetical protein	0.0069	0.0549	0.1202
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0062	0.0441	0.0999
Echinococcus multilocularis	phosphatidylinositol 5 phosphate 4 kinase type 2	0.033	0.4413	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0007	0.0007
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1023	0.2318
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.009	0.0866	0.1961
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0137	0.0299
Brugia malayi	hypothetical protein	0.0077	0.0665	0.1506
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0041	0.0137	0.031
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.0743	1
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0041	0.0137	0.031
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0041	0.0137	0.0299
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0041	0.0137	0.1976
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0041	0.0137	0.1767
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0041	0.0137	0.0299
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0041	0.0137	0.031
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0041	0.0137	0.0299
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0549	0.1245
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0062	0.0441	0.0964
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0062	0.0441	0.0441
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0062	0.0441	0.0999
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0324	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.009	0.0866	0.1961
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0007	0.0016
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0041	0.0137	0.1976
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.0037	0.0084
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0041	0.0137	0.4103
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.0743	0.1683
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0041	0.0137	0.0299
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0041	0.0137	0.4103
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0137	0.0299
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0041	0.0137	0.031
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0007	0.0016
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0041	0.0137	0.4103
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0041	0.0137	0.0299
Schistosoma mansoni	voltage-gated potassium channel	0.0341	0.4573	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0041	0.0137	0.4103
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.031
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0743	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0242	0.3115	0.706
Echinococcus granulosus	voltage gated potassium channel	0.009	0.0866	0.0866
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0041	0.0137	0.0299
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0041	0.0137	0.0137
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0007	0.0016
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0041	0.0137	0.1767
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0137	0.4103
Loa Loa (eye worm)	transcription factor SMAD2	0.0242	0.3115	0.706
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0041	0.0137	0.031
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.031
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0255	0.0558
Leishmania major	protein kinase, putative	0.0041	0.0137	0.1976
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0137	0.0299
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0041	0.0137	0.1767
Schistosoma mansoni	voltage-gated potassium channel	0.009	0.0866	0.1893
Loa Loa (eye worm)	hypothetical protein	0.009	0.0866	0.1961
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0041	0.0137	0.1976
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1023	0.2318
Schistosoma mansoni	voltage-gated potassium channel	0.009	0.0866	0.1893
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0312	0.4148	0.4148
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0041	0.0137	0.031
Echinococcus granulosus	cGMP dependent protein kinase	0.0041	0.0137	0.0137
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0062	0.0441	0.0999
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0007	0.0016
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0312	0.4148	0.9401
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0041	0.0137	0.1767
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0665	0.894
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.0665	0.894
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0324	0.3084
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.033	0.4413	0.965
Schistosoma mansoni	voltage-gated potassium channel	0.0062	0.0441	0.0964
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0041	0.0137	0.1767
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.0743	0.1624
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0007	0.0016
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0292	0.3844	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0041	0.0137	0.0137
Schistosoma mansoni	hypothetical protein	0.0034	0.0037	0.0081
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.0037	0.0037
Leishmania major	protein kinase A regulatory subunit, putative	0.0041	0.0137	0.1976
Echinococcus multilocularis	expressed conserved protein	0.0041	0.0137	0.031
Leishmania major	hypothetical protein, conserved	0.0041	0.0137	0.1976
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0665	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0062	0.0441	0.0999
Loa Loa (eye worm)	pip kinase 2	0.033	0.4413	1
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0041	0.0137	0.0299
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0041	0.0137	0.0299
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0062	0.0441	0.0964
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0041	0.0137	0.1976
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0041	0.0137	0.0137
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0041	0.0137	0.1767
Trypanosoma brucei	protein kinase A regulatory subunit	0.0041	0.0137	0.1976
Brugia malayi	MH2 domain containing protein	0.0242	0.3115	0.706
Onchocerca volvulus		0.033	0.4413	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0743	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0312	0.4148	0.9401
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0041	0.0137	0.031
Brugia malayi	Probable ClpP-like protease	0.0082	0.0743	0.1683
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0743	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0041	0.0137	0.0137
Echinococcus granulosus	hyperpolarization activated cyclic	0.0062	0.0441	0.0441
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0062	0.0441	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0441	0.0999
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0062	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0549	0.1245
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0041	0.0137	0.5
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0041	0.0137	0.1976
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0041	0.0137	0.031
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0041	0.0137	0.1976
Brugia malayi	N-terminal motif family protein	0.0041	0.0137	0.031
Echinococcus multilocularis	voltage gated potassium channel	0.009	0.0866	0.1961

Activities

Activity type	Activity value	Assay description	Source	Reference
FC (binding)	> 1	Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Src Y416 phosphorylation at 50 uM by Western blotting relative to untreated control	ChEMBL.	21341673
IC50 (binding)	= 9.19 uM	Inhibition of LYP expressed in Escherichia coli BL21 using pNPP substrate	ChEMBL.	21341673
Ki (binding)	= 8.07 uM	Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrate	ChEMBL.	21341673
Ki (binding)	= 23.89 uM	Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrate	ChEMBL.	21341673

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2159940

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1722327