Detailed information for compound 1722436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.419 | Formula: C22H20N4O3
  • H donors: 2 H acceptors: 3 LogP: 2.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1C1CCCCN1C2=O)Nc1noc(c1)c1ccccc1
  • InChi: 1S/C22H20N4O3/c27-21-15-9-6-10-16(20(15)17-11-4-5-12-26(17)21)23-22(28)24-19-13-18(29-25-19)14-7-2-1-3-8-14/h1-3,6-10,13,17H,4-5,11-12H2,(H2,23,24,25,28)
  • InChiKey: UYYVTWAESUFHHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1426 0.4088
Loa Loa (eye worm) hypothetical protein 0.0177 0.5566 0.5504
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.002 0.0322 0.0187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0832 0.0832
Echinococcus multilocularis SWI:SNF matrix associated 0.002 0.0322 0.0322
Brugia malayi brahma associated protein 60 kDa 0.002 0.0322 0.034
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.5566 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0653 0.0523
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0426 0.2235
Echinococcus granulosus GPCR family 2 0.003 0.0653 0.0653
Entamoeba histolytica protein kinase, putative 0.0109 0.329 1
Schistosoma mansoni hypothetical protein 0.002 0.0322 0.0322
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0138 0.0138
Echinococcus granulosus cyclin dependent kinase 0.0053 0.1426 0.1426
Schistosoma mansoni hypothetical protein 0.002 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0052 0.138 0.1259
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1426 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.1123 0.3541
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0088 0.2583 0.2583
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.329 0.329
Brugia malayi hypothetical protein 0.0148 0.4607 0.8233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0094 0.2813 0.2712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.329 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0138 0.0138
Giardia lamblia Kinase, PLK 0.0088 0.2583 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.3563 0.3474
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0653 0.0653
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.0138 0.5
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.003 0.0653 0.0523
Chlamydia trachomatis SWIB complex protein 0.002 0.0322 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0109 0.329 1
Schistosoma mansoni hypothetical protein 0.003 0.0653 0.0653
Brugia malayi hypothetical protein 0.0015 0.0152 0.0027
Plasmodium falciparum protein kinase 5 0.0053 0.1426 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0138 0.0138
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.329 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0832 0.0832
Schistosoma mansoni hypothetical protein 0.003 0.0653 0.0653
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.1426 0.1426
Brugia malayi N-terminal motif family protein 0.0177 0.5566 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1426 0.1426
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0426 0.2235
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0426 0.0914
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.1426 0.4088
Chlamydia trachomatis DNA topoisomerase I 0.002 0.0322 0.5
Brugia malayi Protein kinase domain containing protein 0.0109 0.329 0.5808
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.1426 0.1426
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.1426 0.4088
Echinococcus granulosus dual specificity 0.0109 0.329 0.329
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.0148 0.4607 0.4531
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.002 0.0322 0.1432
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0088 0.2583 0.248
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1426 0.4883
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0426 0.0914
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1426 0.2417
Brugia malayi Latrophilin receptor protein 2 0.003 0.0653 0.095
Entamoeba histolytica serine/threonine protein kinase, putative 0.0088 0.2583 0.7125
Brugia malayi hypothetical protein 0.0023 0.0426 0.0531
Schistosoma mansoni brg-1 associated factor 0.002 0.0322 0.0322
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0088 0.2583 0.7758
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.1426 0.4088
Loa Loa (eye worm) hypothetical protein 0.0065 0.1813 0.1699
Brugia malayi MH2 domain containing protein 0.0117 0.3563 0.6311
Loa Loa (eye worm) hypothetical protein 0.0023 0.0426 0.0292
Schistosoma mansoni hypothetical protein 0.0166 0.5203 0.5203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0094 0.2813 0.4928
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0653 0.095
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1426 0.4088
Brugia malayi brahma associated protein 60 kDa 0.002 0.0322 0.034
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1426 0.1426
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Schistosoma mansoni kinase 0.0045 0.1161 0.1161
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.002 0.0322 0.1432
Echinococcus granulosus geminin 0.0166 0.5203 0.5203
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0832 0.0832
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.2583 0.7758
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Echinococcus multilocularis SWI:SNF matrix associated 0.002 0.0322 0.0322
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0426 0.2235
Plasmodium vivax hypothetical protein, conserved 0.002 0.0322 0.1432
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0426 0.0914
Schistosoma mansoni hypothetical protein 0.0035 0.0832 0.0832
Brugia malayi SWIB/MDM2 domain containing protein 0.002 0.0322 0.034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0138 0.0138
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0088 0.2583 0.2583
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0109 0.329 0.3196
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0426 0.2235
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.1426 1
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.1813 0.3087
Plasmodium vivax protein kinase Crk2 0.0053 0.1426 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.002 0.0322 0.1432
Entamoeba histolytica protein kinase, putative 0.0109 0.329 1
Echinococcus multilocularis GPCR, family 2 0.003 0.0653 0.0653
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0653 0.0653
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1426 0.1307
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0109 0.329 1
Schistosoma mansoni hypothetical protein 0.0166 0.5203 0.5203
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.1123 0.3541
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.2583 0.2583
Schistosoma mansoni hypothetical protein 0.002 0.0322 0.0322
Onchocerca volvulus Serine\/threonine kinase homolog 0.0088 0.2583 0.4312
Loa Loa (eye worm) hypothetical protein 0.0107 0.3243 0.3149
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1426 0.4883
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.002 0.0322 0.0322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0094 0.2813 0.4928
Echinococcus multilocularis SWI:SNF matrix associated 0.002 0.0322 0.0322
Echinococcus multilocularis dual specificity 0.0109 0.329 0.329
Loa Loa (eye worm) hypothetical protein 0.0094 0.2813 0.2712
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1426 0.4088
Brugia malayi Protein kinase domain containing protein 0.0053 0.1426 0.2374
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.4607 0.4531
Brugia malayi cell division control protein 2 homolog 0.0053 0.1426 0.2374
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.1426 0.4088
Echinococcus multilocularis geminin 0.0166 0.5203 0.5203
Brugia malayi serine/threonine-protein kinase plk-2 0.0088 0.2583 0.4506
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.1426 0.1426
Trypanosoma brucei polo-like protein kinase 0.0088 0.2583 0.7758
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1426 0.2417
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1426 0.1426
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0138 0.0138
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0138 0.0138
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.3563 0.3474
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Echinococcus granulosus SWI:SNF matrix associated 0.002 0.0322 0.0322
Schistosoma mansoni hypothetical protein 0.003 0.0653 0.0653
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1426 0.4883
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0653 0.0653
Schistosoma mansoni hypothetical protein 0.0065 0.1813 0.1813
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0109 0.329 1
Schistosoma mansoni hypothetical protein 0.003 0.0653 0.0653
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1426 0.4088
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.1426 0.1307
Loa Loa (eye worm) hypothetical protein 0.0107 0.3243 0.3149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0653 0.0653
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.002 0.0322 0.1432
Brugia malayi hypothetical protein 0.0035 0.0832 0.1279
Loa Loa (eye worm) brahma associated protein 0.002 0.0322 0.0187
Echinococcus granulosus Upstream activation factor subunit UAF30 0.002 0.0322 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1426 0.1426
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.2583 0.7758
Entamoeba histolytica hypothetical protein 0.0109 0.329 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.002 0.0322 0.1432
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0138 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.2583 1
Leishmania major hypothetical protein, conserved 0.0023 0.0426 0.0914

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 uM Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma-33P]-ATP after 30 mins by scintillation counting ChEMBL. 23083119
IC50 (binding) > 10 uM Inhibition of human recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate and [gamma-33P]-ATP after 30 mins by scintillation counting ChEMBL. 23083119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.