Detailed information for compound 1722777

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.455 | Formula: C25H24Cl2N4O2S
  • H donors: 1 H acceptors: 2 LogP: 4.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCc1c(sc2=N[C@H]([C@H](n12)c1ccc(cc1)Cl)c1ccc(cc1)Cl)C(=O)N1CCNC(=O)C1
  • InChi: 1S/C25H24Cl2N4O2S/c1-2-3-19-23(24(33)30-13-12-28-20(32)14-30)34-25-29-21(15-4-8-17(26)9-5-15)22(31(19)25)16-6-10-18(27)11-7-16/h4-11,21-22H,2-3,12-14H2,1H3,(H,28,32)/t21-,22+/m0/s1
  • InChiKey: SOGIBWNBMKLYDX-FCHUYYIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.04 0.1392 0.1392
Plasmodium falciparum glutathione reductase 0.0037 0.0051 0.131
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0019 0.0118
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 0.402
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0393 1
Schistosoma mansoni hypothetical protein 0.0273 0.0925 0.1235
Schistosoma mansoni smad1 5 8 and 0.0067 0.0163 0.0218
Giardia lamblia PHD finger protein 15 0.0086 0.0234 0.2282
Entamoeba histolytica acetyltransferase, GNAT family 0.0118 0.035 0.3411
Trypanosoma brucei trypanothione reductase 0.0037 0.0051 0.0888
Mycobacterium tuberculosis Conserved protein 0.018 0.058 0.1365
Brugia malayi beta-lactamase family protein 0.018 0.058 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Loa Loa (eye worm) hypothetical protein 0.0087 0.0238 0.0238
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0039 0.006
Schistosoma mansoni hypothetical protein 0.1715 0.6244 0.8339
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0019 0.002
Echinococcus multilocularis smad 0.0067 0.0163 0.0176
Echinococcus granulosus mixed lineage leukemia protein mll 0.0057 0.0128 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.026 0.0347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.035 0.0468
Schistosoma mansoni cpg binding protein 0.0244 0.0817 0.1092
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 1
Echinococcus granulosus GPCR family 2 0.0127 0.0383 0.0511
Trichomonas vaginalis hypothetical protein 0.0028 0.0019 0.0189
Loa Loa (eye worm) pax transcription factor protein 2 0.0722 0.2582 0.2582
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.058 1
Schistosoma mansoni myst-related protein 0.0027 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0039
Schistosoma mansoni smad 0.0067 0.0163 0.0218
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0019 0.0472
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0028 0.0709
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.018 0.058 0.1365
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0241 0.0322
Mycobacterium leprae conserved hypothetical protein 0.018 0.058 1
Leishmania major pyruvate kinase 0.0033 0.0039 0.0669
Leishmania major importin beta-1 subunit, putative 0.0025 0.0009 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.018 0.058 1
Toxoplasma gondii sporozoite developmental protein 0.0051 0.0102 0.0652
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.013 0.014
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0086 0.0234 0.0313
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0028 0.0247
Entamoeba histolytica hypothetical protein 0.0025 0.0009 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Echinococcus multilocularis expressed protein 0.0027 0.0014 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.058 0.5642
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 0.402
Mycobacterium tuberculosis Conserved protein 0.018 0.058 0.1365
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.035 0.0468
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.018 0.058 0.058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0283 0.0959 0.1037
Giardia lamblia Pyruvate kinase 0.0033 0.0039 0.0378
Brugia malayi MH2 domain containing protein 0.0067 0.0163 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.018 0.058 0.0774
Trypanosoma brucei hypothetical protein, conserved 0.018 0.058 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0163 0.0218
Echinococcus multilocularis nardilysin 0.0051 0.0102 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.058 0.5642
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0225 0.051
Plasmodium falciparum phd finger protein, putative 0.0086 0.0234 0.5968
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0026 0.0035
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0026 0.0028
Echinococcus granulosus 3'partial|nardilysin 0.0051 0.0102 0.0137
Schistosoma mansoni importin beta-1 0.0031 0.003 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0393 0.6776
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0045 0.006
Schistosoma mansoni kinase 0.0047 0.0088 0.0118
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0163 0.0218
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0086 0.0234 0.0313
Mycobacterium tuberculosis Probable hydrolase 0.018 0.058 0.1365
Brugia malayi Smad1 0.0067 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0223 0.074 0.074
Mycobacterium tuberculosis Probable lipase LipD 0.018 0.058 0.1365
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0128 0.039 0.6728
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0052 0.0109 0.1061
Echinococcus multilocularis dnaJ subfamily B 0.2052 0.7488 0.8095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.026 0.0594
Echinococcus multilocularis ferritin 0.0027 0.0014 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0084 0.0815
Schistosoma mansoni ferritin 0.0027 0.0014 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.026 0.435
Schistosoma mansoni apoferritin-2 0.0027 0.0014 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.058 0.5642
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Plasmodium vivax JmjC domain containing protein 0.0028 0.0019 0.032
Brugia malayi MH2 domain containing protein 0.0984 0.3547 0.3547
Mycobacterium leprae Probable lipase LipE 0.018 0.058 1
Echinococcus granulosus peregrin 0.0097 0.0274 0.0366
Echinococcus granulosus expressed protein 0.0027 0.0014 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.04 0.1392 0.1392
Schistosoma mansoni apoferritin-2 0.0027 0.0014 0.0019
Brugia malayi Bromodomain containing protein 0.0097 0.0274 0.0274
Echinococcus multilocularis cpg binding protein 0.0244 0.0817 0.0884
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0255 0.0229
Mycobacterium ulcerans beta-lactamase 0.018 0.058 1
Schistosoma mansoni hypothetical protein 0.1715 0.6244 0.8339
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0255 0.0341
Onchocerca volvulus 0.0722 0.2582 0.2562
Brugia malayi jmjC domain containing protein 0.0028 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.026 0.0347
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0019 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0019 0.002
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.018 0.058 0.0626
Loa Loa (eye worm) hypothetical protein 0.0129 0.0393 0.0393
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0053 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0072 0.018 0.0194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0166 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Echinococcus multilocularis GPCR, family 2 0.0127 0.0383 0.0414
Trichomonas vaginalis helicase, putative 0.0052 0.0109 0.1061
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0255 0.4402
Schistosoma mansoni nardilysin (M16 family) 0.0051 0.0102 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0221
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0051 0.0102 0.1768
Echinococcus multilocularis nardilysin 0.0031 0.0029 0.0031
Loa Loa (eye worm) hypothetical protein 0.0088 0.0241 0.0241
Plasmodium vivax ataxin-2 like protein, putative 0.0129 0.0393 0.6776
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2529 0.925 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0084 0.0815
Echinococcus granulosus Smad4 0.0067 0.0163 0.0218
Echinococcus granulosus pyruvate kinase 0.0033 0.0039 0.0052
Schistosoma mansoni hypothetical protein 0.0331 0.1139 0.1521
Leishmania major poly(A)-binding protein 3 0.0027 0.0016 0.028
Trichomonas vaginalis ferritin, putative 0.0027 0.0014 0.0135
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0255 0.4402
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0163 0.0218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0086 0.0232 0.031
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0255 0.0276
Schistosoma mansoni ferritin 0.0027 0.0014 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0459 0.7863
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0039 0.0039
Plasmodium falciparum pyruvate kinase 0.0033 0.0039 0.0988
Schistosoma mansoni hypothetical protein 0.0127 0.0383 0.0511
Trypanosoma brucei ISWI complex protein 0.0024 0.0005 0.0091
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0039 0.0669
Brugia malayi MH1 domain containing protein 0.0037 0.0052 0.0052
Echinococcus multilocularis nardilysin 0.0051 0.0102 0.0111
Echinococcus granulosus importin subunit beta 1 0.0031 0.003 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.0234 0.1491
Plasmodium falciparum importin beta, putative 0.0031 0.003 0.077
Brugia malayi RNA, U transporter 1 0.0088 0.0242 0.0242
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0002 0.0015
Brugia malayi hypothetical protein 0.0129 0.0393 0.0393
Echinococcus granulosus histone acetyltransferase KAT2B 0.0425 0.1483 0.1981
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0028 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Mycobacterium ulcerans lipase LipD 0.018 0.058 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.002 0.0126
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0026 0.0026
Plasmodium vivax importin-beta 2, putative 0.0031 0.003 0.0522
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0039
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0019 0.0118
Echinococcus multilocularis polyadenylate binding protein 0.0027 0.0016 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.018 0.058 0.1365
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 0.6145
Schistosoma mansoni hypothetical protein 0.2052 0.7488 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0039 0.0669
Brugia malayi beta-lactamase family protein 0.018 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0273 0.0925 0.0925
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.058 0.5642
Brugia malayi glutathione reductase 0.0037 0.0051 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0449 0.1571 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0039 0.044
Loa Loa (eye worm) PHD-finger family protein 0.0086 0.0234 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.058 0.0774
Schistosoma mansoni eyes absent homolog 0.0087 0.0238 0.0318
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0393 1
Mycobacterium tuberculosis Conserved protein 0.018 0.058 0.1365
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0019 0.032
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0129 0.014
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0459 0.7863
Leishmania major hypothetical protein, conserved 0.0028 0.0019 0.032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0057 0.0128 0.017
Brugia malayi beta-lactamase 0.018 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.0024 0.0004 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0128 0.039 0.0521
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.026 0.0594
Schistosoma mansoni cpg binding protein 0.0231 0.0769 0.1027
Echinococcus multilocularis pyruvate kinase 0.0033 0.0039 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0038 0.0051
Toxoplasma gondii ABC1 family protein 0.018 0.058 0.3688
Loa Loa (eye worm) MH2 domain-containing protein 0.0984 0.3547 0.3547
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0019
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0241 0.1536
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Schistosoma mansoni hypothetical protein 0.0058 0.013 0.0173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Brugia malayi jmjC domain containing protein 0.0028 0.0019 0.0019
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0019 0.032
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0051 0.0051
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0241 0.1536
Loa Loa (eye worm) transcription factor SMAD2 0.0984 0.3547 0.3547
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0437 0.1528 0.1652
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0127 0.0383 0.0383
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0019 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.026 0.026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.049 0.1725 0.2304
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1027 1
Brugia malayi Importin beta-1 subunit 0.0031 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.018 0.058 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0221
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0301 0.0326
Schistosoma mansoni Smad4 0.003 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0009 0.0084
Toxoplasma gondii insulysin, putative 0.0048 0.0093 0.0593
Brugia malayi hypothetical protein 0.0083 0.0224 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0522
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0166 0.0179
Mycobacterium tuberculosis Probable conserved lipoprotein 0.018 0.058 0.1365
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0051 0.0091
Schistosoma mansoni smad1 5 8 and 0.0067 0.0163 0.0218
Echinococcus multilocularis Smad4 0.0067 0.0163 0.0176
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0035 0.0045 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.1027 1
Brugia malayi PHD-finger family protein 0.0086 0.0234 0.0234
Schistosoma mansoni ferritin light chain 0.0027 0.0014 0.0019
Echinococcus granulosus ferritin 0.0027 0.0014 0.0019
Brugia malayi insulin-degrading enzyme 0.0051 0.0102 0.0102
Echinococcus granulosus pyruvate kinase 0.0033 0.0039 0.0052
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0067 0.0073
Toxoplasma gondii LsmAD domain-containing protein 0.0129 0.0393 0.2499
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.1027 1
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0436
Toxoplasma gondii thioredoxin reductase 0.0037 0.0051 0.0327
Brugia malayi polyadenylate-binding protein 1 0.0027 0.0016 0.0016
Echinococcus multilocularis insulin degrading enzyme 0.0051 0.0102 0.0111
Trypanosoma cruzi ISWI complex protein 0.0024 0.0005 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.058 0.5642
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0024 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.018 0.058 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0051 0.0051
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0019 0.0025
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0051 0.0888
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0052 0.0109 0.1061
Echinococcus granulosus jumonji domain containing protein 0.012 0.0359 0.048
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0459 0.1073
Brugia malayi Probable ClpP-like protease 0.0088 0.0241 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0005 0.0051
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0223 0.074 0.074
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0241 0.0261
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.002 0.0126
Echinococcus multilocularis pyruvate kinase 0.0033 0.0039 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0166 0.0166
Brugia malayi MH1 domain containing protein 0.0037 0.0052 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0163 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0005 0.0051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0024 0.0004 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0051 0.0888
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0436
Echinococcus granulosus cpg binding protein 0.0244 0.0817 0.1092
Plasmodium vivax polyadenylate-binding protein, putative 0.0027 0.0016 0.028
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.003 0.0193
Echinococcus granulosus tar DNA binding protein 0.0068 0.0166 0.0221
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1149 0.4157 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0028 0.0138
Echinococcus multilocularis transcription factor eb 0.0225 0.0744 0.0805
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0039 0.0669
Plasmodium falciparum zinc finger protein, putative 0.0027 0.0016 0.0415
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0437 0.1528 0.2041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0009 0.0084
Schistosoma mansoni ferritin light chain 0.0027 0.0014 0.0019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0231 0.0769 0.0769
Schistosoma mansoni myst-related protein 0.0027 0.0016 0.0022
Brugia malayi PHD-finger family protein 0.0041 0.0068 0.0068
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0255 0.4402
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0166 0.0166
Schistosoma mansoni pyruvate kinase 0.0033 0.0039 0.0052
Echinococcus multilocularis jumonji domain containing protein 0.012 0.0359 0.0388
Schistosoma mansoni bromodomain containing protein 0.0024 0.0004 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.026 0.0594
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0039 0.0039
Toxoplasma gondii polyadenylate binding protein, putative 0.0027 0.0016 0.0103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0127 0.0383 0.0414
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0255 0.0341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.026 0.0281
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0019 0.0025
Echinococcus granulosus polyadenylate binding protein 0.0027 0.0016 0.0022
Schistosoma mansoni Smad4 0.0067 0.0163 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.026 0.0347
Schistosoma mansoni polyadenylate binding protein 0.0027 0.0016 0.0022
Leishmania major pyruvate kinase 0.0033 0.0039 0.0669
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0127 0.0383 0.0511
Brugia malayi RNA binding protein 0.0068 0.0166 0.0166
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1027 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) RNA binding protein 0.0068 0.0166 0.0166
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.002 0.0342
Mycobacterium tuberculosis Probable lipase LipE 0.018 0.058 0.1365
Echinococcus multilocularis pyruvate kinase 0.0026 0.0013 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0072 0.124
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0026 0.0035
Schistosoma mansoni zinc finger protein 0.0024 0.0004 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0013
Echinococcus granulosus dnaJ subfamily B 0.2052 0.7488 1
Schistosoma mansoni cpg binding protein 0.0244 0.0817 0.1092
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0057 0.0128 0.0138
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.1139 0.1139
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0039 0.0378
Brugia malayi PHD-finger family protein 0.0024 0.0004 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0053 0.0071
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0129 0.0172
Onchocerca volvulus 0.018 0.058 0.0555
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0067 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0072 0.018 0.024
Leishmania major hypothetical protein, conserved 0.018 0.058 1
Trypanosoma brucei PAB1-binding protein , putative 0.0129 0.0393 0.6776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Leishmania major hypothetical protein, conserved 0.0129 0.0393 0.6776
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0128 0.039 0.3796
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Echinococcus granulosus snurportin 1 0.0331 0.1139 0.1521
Plasmodium falciparum thioredoxin reductase 0.0037 0.0051 0.131
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.013 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.026 0.0347
Trypanosoma brucei polo-like protein kinase 0.0092 0.0255 0.4402
Trichomonas vaginalis bromodomain-containing protein, putative 0.0128 0.039 0.3796
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.018 0.058 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Schistosoma mansoni insulysin (M16 family) 0.0028 0.002 0.0026
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0019 0.0025
Echinococcus multilocularis snurportin 1 0.0331 0.1139 0.1231
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 1
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0031 0.0029 0.0183
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0086 0.0234 0.0234
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0241 0.4164
Schistosoma mansoni hypothetical protein 0.0127 0.0383 0.0511
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.0234 0.1491
Echinococcus granulosus insulin degrading enzyme 0.0051 0.0102 0.0137
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0039
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0051 0.0102 0.0652
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0057 0.0128 0.0138
Brugia malayi AF-10 protein 0.0028 0.002 0.002
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0019 0.0025
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0051 0.0102 0.0137
Mycobacterium tuberculosis Probable esterase LipL 0.018 0.058 0.1365
Loa Loa (eye worm) jmjC domain-containing protein 0.0178 0.0574 0.0574
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0163 0.0163
Brugia malayi jmjC domain containing protein 0.0118 0.035 0.035
Brugia malayi acetyltransferase, GNAT family protein 0.0437 0.1528 0.1528
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 1
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0019 0.0025
Toxoplasma gondii hypothetical protein 0.003 0.0028 0.0177
Schistosoma mansoni pyruvate kinase 0.0033 0.0039 0.0052
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0027 0.0016 0.028
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0128 0.039 0.2481
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0027 0.0016 0.028
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0129 0.0278
Brugia malayi hypothetical protein 0.0087 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0019 0.0189
Schistosoma mansoni ferritin 0.0027 0.0014 0.0019
Echinococcus granulosus phd:f box containing protein 0.0028 0.0019 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0127 0.0383 0.0414
Trichomonas vaginalis esterase, putative 0.018 0.058 0.5642
Loa Loa (eye worm) acetyltransferase 0.0437 0.1528 0.1528
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0039 0.0669
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0221
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0019
Chlamydia trachomatis insulinase family protease III 0.0051 0.0102 0.3142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0009 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.026 0.0281
Echinococcus multilocularis zinc finger protein 0.0024 0.0004 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0019 0.0025
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.0026
Brugia malayi MH1 domain containing protein 0.0067 0.0163 0.0163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.018 0.058 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0009 0.0148
Schistosoma mansoni ferritin 0.0027 0.0014 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.04 0.1392 0.1392
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0225 0.051
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0039 0.0378
Leishmania major trypanothione reductase 0.0037 0.0051 0.0888
Loa Loa (eye worm) hypothetical protein 0.0087 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.0068 0.0068
Schistosoma mansoni smad1 5 8 and 0.0067 0.0163 0.0218
Plasmodium falciparum histone acetyltransferase GCN5 0.0118 0.035 0.8923
Echinococcus granulosus smad 0.0067 0.0163 0.0218
Schistosoma mansoni Smad4 0.003 0.0026 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0127 0.0383 0.0383
Brugia malayi Pax transcription factor protein 2 0.0722 0.2582 0.2582
Loa Loa (eye worm) beta-lactamase 0.018 0.058 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0019 0.0019
Leishmania major poly(A)-binding protein 2 0.0027 0.0016 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Echinococcus granulosus nardilysin 0.0051 0.0102 0.0137
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0019 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0013
Plasmodium falciparum polyadenylate-binding protein, putative 0.0027 0.0016 0.0414
Echinococcus multilocularis PHD finger protein rhinoceros 0.0086 0.0234 0.0253
Schistosoma mansoni jumonji domain containing protein 0.0225 0.0745 0.0995
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0241 0.0322
Schistosoma mansoni hypothetical protein 0.0127 0.0383 0.0511
Schistosoma mansoni polyadenylate binding protein 0.0027 0.0016 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0255 0.2484
Echinococcus multilocularis importin subunit beta 1 0.0031 0.003 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Loa Loa (eye worm) histone methyltransferase 0.0072 0.018 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.058 0.0774
Trypanosoma cruzi peptidase, putative 0.0051 0.0102 0.1768
Brugia malayi Latrophilin receptor protein 2 0.0127 0.0383 0.0383
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0039 0.0669
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0436
Brugia malayi jmjC domain containing protein 0.0028 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0221
Brugia malayi MH2 domain containing protein 0.003 0.0026 0.0026
Brugia malayi jmjC domain containing protein 0.0028 0.0019 0.0019
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0225 0.0744 0.0744
Trypanosoma brucei polyadenylate-binding protein 1 0.0027 0.0016 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0005 0.0051
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0225 0.051
Brugia malayi TAR-binding protein 0.0068 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0436
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0234 0.4044
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0283 0.0959 0.1281
Onchocerca volvulus 0.018 0.058 0.0555
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Brugia malayi jmjC domain containing protein 0.0283 0.0959 0.0959
Loa Loa (eye worm) Smad1 0.0067 0.0163 0.0163
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0163 0.0176
Trypanosoma brucei polyadenylate-binding protein 2 0.0027 0.0016 0.028
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0051 0.0102 0.0137
Schistosoma mansoni bromodomain containing protein 0.0024 0.0004 0.0005
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0042 0.0072 0.183
Echinococcus granulosus lysine specific demethylase 5A 0.0118 0.035 0.0468
Giardia lamblia Histone acetyltransferase GCN5 0.0118 0.035 0.3411
Echinococcus multilocularis geminin 0.1715 0.6244 0.675
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0052
Onchocerca volvulus 0.018 0.058 0.0555
Loa Loa (eye worm) hypothetical protein 0.0127 0.0383 0.0383
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0026 0.0028
Giardia lamblia Kinase, PLK 0.0092 0.0255 0.2484
Loa Loa (eye worm) insulin-degrading enzyme 0.0051 0.0102 0.0102
Onchocerca volvulus Alhambra homolog 0.0086 0.0234 0.0209
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0039 0.044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0109 0.1061
Echinococcus granulosus zinc finger protein 0.0024 0.0004 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0241 0.2244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Echinococcus multilocularis peregrin 0.0097 0.0274 0.0296
Echinococcus granulosus geminin 0.1715 0.6244 0.8339
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0128 0.039 0.2481
Schistosoma mansoni polyadenylate binding protein 0.0027 0.0016 0.0022
Brugia malayi MH1 domain containing protein 0.0067 0.0163 0.0163
Echinococcus granulosus transcription factor eb 0.0225 0.0744 0.0994
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0129 0.2037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0129 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0045 0.006
Brugia malayi CXXC zinc finger family protein 0.0231 0.0769 0.0769
Plasmodium vivax glutathione reductase, putative 0.0037 0.0051 0.0888
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.058 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0019 0.032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.04 0.1392 0.1392
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0241 0.402
Onchocerca volvulus 0.0231 0.0769 0.0744
Echinococcus granulosus PHD finger protein rhinoceros 0.0086 0.0234 0.0313
Brugia malayi hypothetical protein 0.0035 0.0045 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.035 0.035
Brugia malayi MH2 domain containing protein 0.0067 0.0163 0.0163
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.002 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.026 0.0347
Brugia malayi Thioredoxin reductase 0.0037 0.0051 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1027 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0255 0.2484
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0255 0.0255
Brugia malayi F/Y-rich N-terminus family protein 0.0099 0.028 0.028
Trypanosoma cruzi peptidase, putative 0.0051 0.0102 0.1768
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0163 0.0176
Loa Loa (eye worm) hypothetical protein 0.0148 0.0462 0.0462
Schistosoma mansoni smad 0.003 0.0026 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0225 0.3739
Brugia malayi latrophilin 2 splice variant baaae 0.0273 0.0925 0.0925
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0225 0.051
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0393 0.6776
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0109 0.1061
Mycobacterium tuberculosis Probable reductase 0.0084 0.0225 0.051
Loa Loa (eye worm) hypothetical protein 0.018 0.058 0.058
Schistosoma mansoni nardilysin (M16 family) 0.0051 0.0102 0.0137
Loa Loa (eye worm) nuclear factor I 0.0037 0.0052 0.0052
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0225 0.051
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0039 0.0247
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0045 0.0048
Trypanosoma brucei peptidase, putative 0.0051 0.0102 0.1768
Schistosoma mansoni hypothetical protein 0.0127 0.0383 0.0511
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0019 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0127 0.0383 0.0511

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.1 uM Inhibition of GST-tagged MDM2 binding to p53 by ELISA ChEMBL. 22995624

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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