Detailed information for compound 1722924

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 583.671 | Formula: C31H54INO
  • H donors: 0 H acceptors: 1 LogP: 10.98 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCC(=O)c1ccc(cc1)[C@@H]1CC[C@H](CC1)[N+](CCC)(C)C.[I-]
  • InChi: 1S/C31H54NO.HI/c1-5-7-8-9-10-11-12-13-14-15-16-17-31(33)29-20-18-27(19-21-29)28-22-24-30(25-23-28)32(3,4)26-6-2;/h18-21,28,30H,5-17,22-26H2,1-4H3;1H/q+1;/p-1/t28-,30-;
  • InChiKey: LBXIIAICGVDXGK-OPQWPWDLSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0012 0.0012
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Brugia malayi Cation transporter family protein 0.0013 0.0012 0.0012
Echinococcus granulosus tubulin alpha 3 chain 0.102 0.5949 0.5949
Echinococcus granulosus Tubulin alpha 1 chain 0.102 0.5949 0.5949
Echinococcus multilocularis tubulin delta chain 0.0353 0.2014 0.2014
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0092 0.0092
Echinococcus multilocularis Tubulin alpha 1 chain 0.102 0.5949 0.5949
Trichomonas vaginalis tubulin gamma chain, putative 0.0812 0.4723 0.4723
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0626 0.3628 0.3628
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0012 0.0012
Giardia lamblia Alpha-tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis nAChR subunit 0.0013 0.0012 0.0012
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0014 0.0016 0.0016
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0014 0.0016 0.0016
Plasmodium falciparum tubulin delta chain, putative 0.0353 0.2014 0.2014
Brugia malayi alpha-tubulin 0.102 0.5949 0.5949
Brugia malayi hypothetical protein 0.0017 0.0036 0.0036
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Echinococcus multilocularis tubulin alpha 3 chain 0.102 0.5949 0.5949
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0012 0.0012
Echinococcus granulosus tubulin alpha chain 0.102 0.5949 0.5949
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0026 0.0014
Loa Loa (eye worm) tubulin beta chain 0.0353 0.2014 0.2005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.008
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0619 0.0609
Echinococcus multilocularis tubulin alpha chain 0.102 0.5949 0.5949
Echinococcus multilocularis tubulin alpha chain 0.102 0.5949 0.5949
Schistosoma mansoni tubulin subunit epsilon 0.0812 0.4723 0.4723
Leishmania major hypothetical protein, conserved 0.0027 0.0092 0.0092
Echinococcus granulosus nervana 2 0.0021 0.0057 0.0057
Echinococcus granulosus tubulin alpha chain 0.102 0.5949 0.5949
Plasmodium falciparum alpha tubulin 2 0.102 0.5949 0.5949
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.161 0.161
Schistosoma mansoni alpha tubulin 0.102 0.5949 0.5949
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0012 0.0012
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Onchocerca volvulus 0.046 0.2644 1
Trypanosoma brucei epsilon tubulin 0.0812 0.4723 0.4723
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0016 0.0016
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0014 0.0016 0.0016
Trypanosoma brucei epsilon tubulin 0.0812 0.4723 0.4723
Trypanosoma cruzi epsilon tubulin, putative 0.0812 0.4723 0.4723
Echinococcus granulosus nervana 2 0.0021 0.0057 0.0057
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0353 0.2014 0.2014
Echinococcus multilocularis tubulin epsilon chain 0.0812 0.4723 0.4723
Echinococcus multilocularis nervana 2 0.0021 0.0057 0.0057
Loa Loa (eye worm) tubulin alpha-3 chain 0.0561 0.324 0.3232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0221 0.0221
Schistosoma mansoni ATPase 0.0014 0.0016 0.0016
Echinococcus granulosus tubulin delta chain 0.0353 0.2014 0.2014
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0228 0.1282 0.1282
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0012 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0092 0.0076
Brugia malayi Cation transporter family protein 0.0013 0.0012 0.0012
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0353 0.2014 0.2014
Schistosoma mansoni tubulin subunit delta 0.0353 0.2014 0.2014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Brugia malayi tubulin alpha-2 chain 0.102 0.5949 0.5949
Echinococcus granulosus tubulin epsilon chain 0.0812 0.4723 0.4723
Echinococcus granulosus tubulin alpha chain 0.102 0.5949 0.5949
Loa Loa (eye worm) alpha-tubulin 0.102 0.5949 0.5944
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0014 0.0016 0.0016
Brugia malayi Na,K-ATPase alpha subunit 0.0014 0.0016 0.0016
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0021 0.0057 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0026 0.0026
Echinococcus multilocularis tubulin alpha chain 0.102 0.5949 0.5949
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0057 0.0057
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Echinococcus granulosus Tubulin alpha 1 chain 0.102 0.5949 0.5949
Leishmania major epsilon tubulin, putative 0.0812 0.4723 0.4723
Echinococcus multilocularis hypothetical protein 0.102 0.5949 0.5949
Echinococcus granulosus nAChR subunit 0.0013 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0014
Mycobacterium tuberculosis Cell division protein FtsZ 0.0353 0.2014 1
Trypanosoma brucei alpha tubulin 0.102 0.5949 0.5949
Trypanosoma brucei tubulin gamma chain 0.0812 0.4723 0.4723
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0353 0.2014 0.5
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0014 0.0016 0.0016
Toxoplasma gondii alpha-tubulin I, putative 0.102 0.5949 0.5949
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0016 0.0016
Trichomonas vaginalis tubulin epsilon chain, putative 0.102 0.5949 0.5949
Trypanosoma brucei zeta tubulin, putative 0.0353 0.2014 0.2014
Trichomonas vaginalis tubulin alpha chain, putative 0.046 0.2644 0.2644
Echinococcus multilocularis tubulin alpha 1C chain 0.102 0.5949 0.5949
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0016 0.0016
Onchocerca volvulus 0.0021 0.0057 0.0172
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0006 0.0006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0012 0.0012
Brugia malayi hypothetical protein 0.0027 0.0092 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0092 0.0092
Schistosoma mansoni alpha tubulin 0.102 0.5949 0.5949
Trypanosoma cruzi tubulin delta chain 0.0353 0.2014 0.2014
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Trypanosoma cruzi alpha tubulin, putative 0.102 0.5949 0.5949
Loa Loa (eye worm) tubulin alpha-2 chain 0.102 0.5949 0.5944
Plasmodium vivax tubulin alpha chain, putative 0.102 0.5949 0.5943
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0221 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0221 0.021
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0014 0.0016 0.0016
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0016 0.0016
Brugia malayi Cell division protein ftsZ 0.0353 0.2014 0.2014
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0012 0.0012
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0016 0.0016
Echinococcus multilocularis Tubulin alpha 1 chain 0.102 0.5949 0.5949
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0021 0.0057 0.0057
Echinococcus granulosus tubulin alpha 0.0812 0.4723 0.4723
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0014 0.0016 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0012 0.0012
Trichomonas vaginalis tubulin gamma chain, putative 0.0353 0.2014 0.2014
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0012 0.0012
Trypanosoma cruzi tubulin gamma chain 0.0812 0.4723 0.4723
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0026 0.0026
Toxoplasma gondii alpha tubulin TUBA1 0.102 0.5949 0.5949
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0092 0.0092
Giardia lamblia Alpha-tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0006 0.0006
Echinococcus multilocularis nervana 2 0.0021 0.0057 0.0057
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0012 0.0012
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0561 0.324 0.324
Leishmania major gamma-tubulin 0.0812 0.4723 0.4723
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) tubulin alpha 2 0.0668 0.387 0.3863
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0057 0.0057
Echinococcus multilocularis tubulin alpha chain 0.102 0.5949 0.5949
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0014 0.0016 0.0016
Brugia malayi Cation transporter family protein 0.0013 0.0012 0.0012
Schistosoma mansoni alpha tubulin 0.102 0.5949 0.5949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Trypanosoma cruzi zeta tubulin, putative 0.0353 0.2014 0.2014
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0045
Trypanosoma brucei alpha tubulin 0.102 0.5949 0.5949
Echinococcus granulosus nervana 2 0.0021 0.0057 0.0057
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.2644 0.2644
Echinococcus granulosus GPCR family 2 0.0015 0.0026 0.0026
Trichomonas vaginalis tubulin, putative 0.0353 0.2014 0.2014
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0353 0.2014 0.2014
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0668 0.387 0.3863
Loa Loa (eye worm) hypothetical protein 0.0033 0.0131 0.0119
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0026
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0012 0.0012
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.0012 0.0012
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0012 0.0012
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0012 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0026 0.0026
Trypanosoma brucei beta tubulin 0.0812 0.4723 0.4723
Trichomonas vaginalis tubulin gamma chain, putative 0.0812 0.4723 0.4723
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0012 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) tubulin alpha chain 0.102 0.5949 0.5944
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Loa Loa (eye worm) tubulin alpha 2 0.0208 0.1161 0.1151
Schistosoma mansoni transmemberane protein 0.0021 0.0057 0.0057
Echinococcus multilocularis tubulin alpha chain 0.102 0.5949 0.5949
Leishmania major zeta tubulin, putative 0.0353 0.2014 0.2014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0004
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0012 0.0012
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis nervana 2 0.0021 0.0057 0.0057
Loa Loa (eye worm) tubulin alpha 2 0.0668 0.387 0.3863
Echinococcus multilocularis Tubulin alpha 1 chain 0.102 0.5949 0.5949
Leishmania major calcium-translocating P-type ATPase 0.0014 0.0016 0.0016
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0012 0.0012
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0014 0.0016 0.0016
Brugia malayi Tubulin alpha-2 chain 0.102 0.5949 0.5949
Brugia malayi Tubulin alpha chain 0.0353 0.2014 0.2014
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0012 0.0012
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0016 0.0016
Entamoeba histolytica tubulin gamma chain 0.0812 0.4723 0.4715
Leishmania major delta tubulin, putative 0.0353 0.2014 0.2014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0353 0.2014 0.2014
Loa Loa (eye worm) hypothetical protein 0.0265 0.1498 0.1489
Echinococcus granulosus tubulin alpha 1C chain 0.102 0.5949 0.5949
Plasmodium falciparum tubulin gamma chain 0.0812 0.4723 0.4723
Echinococcus multilocularis GPCR, family 2 0.0015 0.0026 0.0026
Giardia lamblia Delta tubulin 0.0353 0.2014 0.2014
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Schistosoma mansoni tubulin subunit beta 0.0353 0.2014 0.2014
Mycobacterium ulcerans cell division protein FtsZ 0.0353 0.2014 1
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0057 0.0057
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0012 0.0012
Entamoeba histolytica tubulin alpha-1 chain 0.102 0.5949 0.5943
Entamoeba histolytica tubulin alpha chain, putative 0.102 0.5949 0.5943
Trypanosoma brucei alpha tubulin 0.102 0.5949 0.5949
Toxoplasma gondii P-type ATPase4, putative 0.0014 0.0016 0.0016
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0016 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0092 0.0092
Trypanosoma cruzi epsilon tubulin, putative 0.0812 0.4723 0.4723
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0812 0.4723 0.4723
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0012 0.0012
Trypanosoma brucei zeta tubulin 0.0353 0.2014 0.2014
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Echinococcus granulosus tubulin gamma 1 chain 0.0812 0.4723 0.4723
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Schistosoma mansoni tubulin subunit alpha 0.0353 0.2014 0.2014
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0014 0.0016 0.0016
Schistosoma mansoni tubulin subunit alpha 0.102 0.5949 0.5949
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.161 0.1597
Plasmodium falciparum alpha tubulin 1 0.102 0.5949 0.5949
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0014 0.0016 0.0004
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0016 0.0016
Trypanosoma brucei tubulin delta chain 0.0353 0.2014 0.2014
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Treponema pallidum cell division protein FtsZ 0.0353 0.2014 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Onchocerca volvulus 0.0014 0.0016 0.0017
Echinococcus granulosus tubulin alpha chain 0.102 0.5949 0.5949
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0012 0.0012
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0016 0.0016
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Loa Loa (eye worm) hypothetical protein 0.0494 0.2845 0.2836
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0012 0.0012
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0012 0.0012
Schistosoma mansoni tubulin subunit gamma 0.0812 0.4723 0.4723
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0026 0.0026
Echinococcus granulosus tubulin alpha chain 0.102 0.5949 0.5949
Onchocerca volvulus 0.0021 0.0057 0.0172
Echinococcus granulosus tubulin subunit TubB 0.102 0.5949 0.5949
Echinococcus granulosus tubulin alpha 1C chain 0.102 0.5949 0.5949
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0014 0.0016 0.0016
Plasmodium vivax tubulin gamma chain, putative 0.0812 0.4723 0.4715
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0014 0.0016 0.0016
Trichomonas vaginalis tubulin alpha chain, putative 0.046 0.2644 0.2644
Echinococcus granulosus peroxisome assembly protein 26 0.102 0.5949 0.5949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0012 0.0012
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0353 0.2014 0.2014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Giardia lamblia Gamma tubulin 0.0812 0.4723 0.4723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0012 0.0012
Brugia malayi Tubulin beta chain 0.0353 0.2014 0.2014
Brugia malayi MH2 domain containing protein 0.0116 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0561 0.324 0.3232
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.046 0.2644 0.2644
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0012 0.0012
Trichomonas vaginalis tubulin epsilon chain, putative 0.102 0.5949 0.5949
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0012 0.0012
Echinococcus granulosus alpha tubulin 0.102 0.5949 0.5949
Schistosoma mansoni tubulin subunit alpha 0.102 0.5949 0.5949
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0016 0.0016
Brugia malayi Tubulin beta chain 0.046 0.2644 0.2644
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0014 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0014 0.0016 0.0016
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.0012 0.0012
Echinococcus multilocularis tubulin subunit TubB 0.102 0.5949 0.5949
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0026
Trypanosoma brucei epsilon tubulin 0.0812 0.4723 0.4723
Echinococcus granulosus nervana 2 0.0021 0.0057 0.0057
Trichomonas vaginalis tubulin alpha chain, putative 0.046 0.2644 0.2644
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Brugia malayi tubulin alpha chain - mouse 0.102 0.5949 0.5949
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0004
Mycobacterium leprae cell division protein FtsZ 0.0353 0.2014 1
Giardia lamblia Epsilon tubulin 0.0353 0.2014 0.2014
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0012 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0012 0.0012
Plasmodium vivax tubulin epsilon chain, putative 0.0812 0.4723 0.4715
Brugia malayi Tubulin gamma chain 0.0812 0.4723 0.4723
Echinococcus multilocularis tubulin alpha 0.0812 0.4723 0.4723
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0092 0.0092
Echinococcus multilocularis peroxisome assembly protein 26 0.102 0.5949 0.5949
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.021
Trichomonas vaginalis tubulin epsilon chain, putative 0.0353 0.2014 0.2014
Echinococcus granulosus tubulin alpha 3 chain 0.102 0.5949 0.5949
Echinococcus multilocularis nervana 2 0.0021 0.0057 0.0057
Loa Loa (eye worm) alpha-tubulin 0.102 0.5949 0.5944
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0012 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0619 0.0609
Echinococcus multilocularis tubulin alpha 1C chain 0.102 0.5949 0.5949
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0012 0.0012
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.102 0.5949 0.5949
Brugia malayi Tubulin alpha chain 0.102 0.5949 0.5949
Schistosoma mansoni hypothetical protein 0.0033 0.0131 0.0131
Leishmania major alpha tubulin 0.102 0.5949 0.5949
Trypanosoma cruzi zeta tubulin, putative 0.0353 0.2014 0.2014
Trichomonas vaginalis tubulin beta chain, putative 0.102 0.5949 0.5949
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0021 0.0057 0.0057
Plasmodium vivax delta tubulin, putative 0.0353 0.2014 0.2001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0026 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) tubulin alpha chain 0.102 0.5949 0.5944
Loa Loa (eye worm) hypothetical protein 0.0668 0.387 0.3863
Echinococcus granulosus Tubulin alpha 1 chain 0.102 0.5949 0.5949
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0092 0.0092
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0026
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0026
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0012 0.0012
Trypanosoma cruzi tubulin delta chain 0.0353 0.2014 0.2014
Trypanosoma brucei alpha tubulin, putative 0.046 0.2644 0.2644
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0132 0.0716 0.0705
Loa Loa (eye worm) tubulin gamma chain 0.0812 0.4723 0.4717
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0012 0.0012
Schistosoma mansoni nAChR subunit 0.0013 0.0012 0.0012
Schistosoma mansoni ATPase 0.0014 0.0016 0.0016
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0026 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.102 0.5949 0.5944
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0012 0.0012
Plasmodium vivax tubulin alpha chain, putative 0.102 0.5949 0.5943
Trichomonas vaginalis tubulin, putative 0.046 0.2644 0.2644
Plasmodium falciparum tubulin epsilon chain, putative 0.0812 0.4723 0.4723
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0668 0.387 0.387
Echinococcus multilocularis tubulin alpha 3 chain 0.102 0.5949 0.5949
Trypanosoma brucei alpha tubulin 0.102 0.5949 0.5949
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0012 0.0012
Trichomonas vaginalis tubulin, putative 0.046 0.2644 0.2644
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0012 0.0012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.161 0.1597
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0016 0.0016
Trichomonas vaginalis tubulin alpha chain, putative 0.0812 0.4723 0.4723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Schistosoma mansoni tubulin subunit alpha 0.102 0.5949 0.5949
Echinococcus multilocularis tubulin gamma 1 chain 0.0812 0.4723 0.4723
Brugia malayi Tubulin alpha-2 chain 0.102 0.5949 0.5949
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0754 0.369
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.161 0.161
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0016 0.0016
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0057 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 50 % Inhibition of recombinant SphK2 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP assessed as residual activity at 10 uM by scintillation counting ChEMBL. 22321213
Activity (binding) = 73 % Inhibition of recombinant SphK1 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP assessed as residual activity at 10 uM by scintillation counting ChEMBL. 22321213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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