Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | tubulin alpha-1 chain | 0.0187 | 0.3745 | 0.3745 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Schistosoma mansoni | tubulin subunit delta | 0.0078 | 0.11 | 0.1084 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin, putative | 0.0101 | 0.1671 | 0.1671 |
Trypanosoma cruzi | tubulin gamma chain | 0.0179 | 0.3551 | 0.3551 |
Plasmodium vivax | delta tubulin, putative | 0.0078 | 0.11 | 0.1028 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0187 | 0.3745 | 0.3745 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0081 | 0.0062 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Leishmania major | delta tubulin, putative | 0.0078 | 0.11 | 0.11 |
Trypanosoma brucei | zeta tubulin | 0.0078 | 0.11 | 0.11 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0187 | 0.3745 | 0.3745 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0081 | 0.0081 |
Plasmodium falciparum | alpha tubulin 2 | 0.0187 | 0.3745 | 0.2972 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.3745 | 0.2972 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0412 | 0.0394 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0101 | 0.1671 | 0.1671 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.3745 | 0.3694 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0187 | 0.3745 | 0.3733 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0078 | 0.11 | 0.11 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0081 | 0.0081 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.3745 | 0.3733 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.11 | 0.11 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0078 | 0.11 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0179 | 0.3551 | 0.3551 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0078 | 0.11 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0078 | 0.11 | 0.1084 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0081 | 0.0062 |
Trypanosoma brucei | beta tubulin | 0.0179 | 0.3551 | 0.3551 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0187 | 0.3745 | 0.3745 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0081 | 0.0081 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0237 | 0.0237 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0179 | 0.3551 | 0.3551 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0187 | 0.3745 | 0.3745 |
Brugia malayi | tubulin alpha-2 chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0109 | 0.1864 | 0.1864 |
Trichomonas vaginalis | tubulin, putative | 0.0101 | 0.1671 | 0.1671 |
Schistosoma mansoni | tubulin subunit gamma | 0.0179 | 0.3551 | 0.3539 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0101 | 0.1671 | 0.1671 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0179 | 0.3551 | 0.3539 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma cruzi | zeta tubulin, putative | 0.0078 | 0.11 | 0.11 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1864 | 0.1849 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0078 | 0.11 | 0.11 |
Echinococcus granulosus | tubulin subunit TubB | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma brucei | epsilon tubulin | 0.0179 | 0.3551 | 0.3551 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0081 | 0.0062 |
Trypanosoma cruzi | tubulin delta chain | 0.0078 | 0.11 | 0.11 |
Echinococcus multilocularis | tubulin alpha | 0.0179 | 0.3551 | 0.3539 |
Leishmania major | epsilon tubulin, putative | 0.0179 | 0.3551 | 0.3551 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.3745 | 0.3733 |
Onchocerca volvulus | 0.0101 | 0.1671 | 1 | |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0179 | 0.3551 | 0.3551 |
Mycobacterium leprae | cell division protein FtsZ | 0.0078 | 0.11 | 1 |
Entamoeba histolytica | tubulin gamma chain | 0.0179 | 0.3551 | 0.3551 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.3745 | 0.3694 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0035 | 0.0016 |
Echinococcus granulosus | tubulin delta chain | 0.0078 | 0.11 | 0.1084 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Brugia malayi | Tubulin gamma chain | 0.0179 | 0.3551 | 0.3539 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.3745 | 0.3733 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0078 | 0.11 | 0.11 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0019 | 0.0019 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0109 | 0.1864 | 0.1849 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0101 | 0.1671 | 0.1671 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0179 | 0.3551 | 0.3539 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.3745 | 0.3733 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.2597 | 0.2583 |
Schistosoma mansoni | tubulin subunit alpha | 0.0078 | 0.11 | 0.1084 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0187 | 0.3745 | 0.3733 |
Brugia malayi | Tubulin alpha chain | 0.0078 | 0.11 | 0.1084 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.3745 | 0.3733 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0179 | 0.3551 | 0.3539 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0412 | 0.0394 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0078 | 0.11 | 0.2195 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0237 | 0.0219 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Brugia malayi | alpha-tubulin | 0.0187 | 0.3745 | 0.3733 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus granulosus | tubulin epsilon chain | 0.0179 | 0.3551 | 0.3539 |
Plasmodium falciparum | tubulin gamma chain | 0.0179 | 0.3551 | 0.2754 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.3745 | 0.2972 |
Brugia malayi | Tubulin beta chain | 0.0101 | 0.1671 | 0.1655 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0081 | 0.0081 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 0.11 | 0.1084 |
Echinococcus multilocularis | hypothetical protein | 0.0187 | 0.3745 | 0.3733 |
Leishmania major | gamma-tubulin | 0.0179 | 0.3551 | 0.3551 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0179 | 0.3551 | 0.3499 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0237 | 0.0219 |
Trichomonas vaginalis | tubulin, putative | 0.0078 | 0.11 | 0.11 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma cruzi | tubulin delta chain | 0.0078 | 0.11 | 0.11 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0086 | 0.1294 | 0.1278 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0081 | 0.0081 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Giardia lamblia | Gamma tubulin | 0.0179 | 0.3551 | 0.2754 |
Echinococcus multilocularis | tubulin delta chain | 0.0078 | 0.11 | 0.1084 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0237 | 0.0237 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0081 | 0.0081 |
Trypanosoma cruzi | zeta tubulin, putative | 0.0078 | 0.11 | 0.11 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0237 | 0.0219 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0086 | 0.1294 | 0.1294 |
Trichomonas vaginalis | tubulin beta-1 chain, putative | 0.0078 | 0.11 | 0.11 |
Plasmodium falciparum | alpha tubulin 1 | 0.0187 | 0.3745 | 0.2972 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0187 | 0.3745 | 0.3745 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0187 | 0.3745 | 0.3733 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0109 | 0.1864 | 0.1849 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.2597 | 0.2583 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.3745 | 0.3745 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0237 | 0.0237 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0179 | 0.3551 | 0.3539 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0412 | 0.0394 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0081 | 0.0062 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Brugia malayi | Tubulin beta chain | 0.0078 | 0.11 | 0.1084 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0081 | 0.0062 |
Trypanosoma brucei | alpha tubulin, putative | 0.0101 | 0.1671 | 0.1671 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0081 | 0.0081 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma brucei | epsilon tubulin | 0.0179 | 0.3551 | 0.3551 |
Brugia malayi | tubulin alpha chain - mouse | 0.0187 | 0.3745 | 0.3733 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.3745 | 0.3733 |
Echinococcus granulosus | alpha tubulin | 0.0187 | 0.3745 | 0.3733 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0179 | 0.3551 | 0.2754 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.11 | 0.11 |
Trypanosoma brucei | tubulin gamma chain | 0.0179 | 0.3551 | 0.3551 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0101 | 0.1671 | 0.1671 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0081 | 0.0062 |
Treponema pallidum | cell division protein FtsZ | 0.0078 | 0.11 | 0.5 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0101 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Echinococcus granulosus | tubulin alpha | 0.0179 | 0.3551 | 0.3539 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0109 | 0.1864 | 0.1849 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.2597 | 0.2583 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0179 | 0.3551 | 0.3539 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0237 | 0.0219 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.4724 | 1 |
Brugia malayi | Cell division protein ftsZ | 0.0078 | 0.11 | 0.1084 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0179 | 0.3551 | 0.3551 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0035 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0035 | 0.0016 |
Brugia malayi | Tubulin alpha chain | 0.0187 | 0.3745 | 0.3733 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1294 | 0.1278 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0078 | 0.11 | 0.11 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0179 | 0.3551 | 0.3551 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0237 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.3745 | 0.3733 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0081 | 0.0081 |
Trypanosoma brucei | epsilon tubulin | 0.0179 | 0.3551 | 0.3551 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0179 | 0.3551 | 0.3499 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.3745 | 0.3733 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0237 | 0.0237 |
Trypanosoma brucei | zeta tubulin, putative | 0.0078 | 0.11 | 0.11 |
Leishmania major | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0081 | 0.0062 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.3745 | 0.3745 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0062 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0179 | 0.3551 | 0.3551 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.3745 | 0.3733 |
Leishmania major | zeta tubulin, putative | 0.0078 | 0.11 | 0.11 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0081 | 0.0062 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.3745 | 0.3733 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.3745 | 0.3733 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0412 | 0.0394 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.3745 | 0.3745 |
Trypanosoma brucei | tubulin delta chain | 0.0078 | 0.11 | 0.11 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0081 | 0.0062 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0081 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human 17beta-HSD1 in human T47D cells assessed as conversion of [3H]E1 to [3H]E2 at 10 uM after 30 mins | ChEMBL. | 23040895 | |
Inhibition (binding) | Inhibition of human 11beta-HSD2 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol at 10 uM after 2 hrs | ChEMBL. | 23040895 | |
Inhibition (binding) | = 48 % | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol at 1 uM after 2 hrs by scintillation counting | ChEMBL. | 23040895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.