TDR Targets

Basic information

Technical information

TDR Targets ID: 1723039
Name: N-[[2-(4-butoxypiperidin-1-yl)-6-(trifluorome thyl)pyridin-3-yl]methyl]-2-(3-fluoro-4-metha nesulfonamidophenyl)propanamide
MW: 574.631 | Formula: C26H34F4N4O4S
H donors: 2 H acceptors: 4 LogP: 4.23 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCCCOC1CCN(CC1)c1nc(ccc1CNC(=O)C(c1ccc(c(c1)F)NS(=O)(=O)C)C)C(F)(F)F
InChi: 1S/C26H34F4N4O4S/c1-4-5-14-38-20-10-12-34(13-11-20)24-19(7-9-23(32-24)26(28,29)30)16-31-25(35)17(2)18-6-8-22(21(27)15-18)33-39(3,36)37/h6-9,15,17,20,33H,4-5,10-14,16H2,1-3H3,(H,31,35)
InChiKey: ZYYDQFHTSSUHSN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[[2-(4-butoxy-1-piperidyl)-6-(trifluoromethyl)-3-pyridyl]methyl]-2-(3-fluoro-4-methanesulfonamido-phenyl)propanamide
N-[[2-(4-butoxy-1-piperidinyl)-6-(trifluoromethyl)-3-pyridyl]methyl]-2-(3-fluoro-4-methanesulfonamidophenyl)propanamide
N-[[2-(4-butoxy-1-piperidyl)-6-(trifluoromethyl)-3-pyridyl]methyl]-2-(3-fluoro-4-methanesulfonamido-phenyl)propionamide
N-[[2-(4-butoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0149	0.0149
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0008	0.0008
Echinococcus granulosus	mitogen activated protein kinase	0.01	0.4613	0.4613
Echinococcus granulosus	tyrosine protein kinase HCK	0.0031	0.1218	0.1218
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0008	0.0008
Schistosoma mansoni	tyrosine kinase	0.0044	0.1857	0.192
Brugia malayi	Tensin	0.0007	0.0008	0.0014
Leishmania major	protein kinase, putative	0.0111	0.5136	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	growth factor receptor bound protein 2	0.0013	0.0324	0.0324
Onchocerca volvulus		0.0009	0.0149	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0009	0.0149	0.0149
Echinococcus granulosus	N chimaerin	0.0007	0.0008	0.0008
Brugia malayi	Protein kinase domain containing protein	0.0009	0.0149	0.0259
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0044	0.1857	0.1857
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0044	0.1857	0.1857
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.000000099004	0.000000099004
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0013	0.0324	0.0324
Brugia malayi	Protein kinase domain containing protein	0.0009	0.0149	0.0259
Echinococcus multilocularis	SH2 motif	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0007	0.0008	0.0008
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0007	0.0008	0.0014
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.4613	0.8981
Echinococcus multilocularis		0.0007	0.0008	0.0008
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0007	0.0008	0.0538
Schistosoma mansoni	tyrosine kinase	0.0009	0.0149	0.0154
Trypanosoma brucei	aurora B kinase	0.0111	0.5136	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0013	0.0324	0.0334
Loa Loa (eye worm)	STAT protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Schistosoma mansoni	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	aurora kinase A	0.0111	0.5136	0.5136
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0009	0.0149	0.0149
Schistosoma mansoni	SH2A	0.0007	0.0008	0.0008
Schistosoma mansoni	tyrosine kinase	0.0203	0.9676	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0008	0.0008
Echinococcus granulosus	SH2 motif	0.0007	0.0008	0.0008
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0007	0.0008	0.0008
Echinococcus multilocularis	mitogen activated protein kinase 3	0.01	0.4613	0.4613
Entamoeba histolytica	protein kinase, putative	0.0111	0.5136	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0141	0.0146
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0007	0.0008	0.0008
Schistosoma mansoni	tensin	0.0007	0.0008	0.0008
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.01	0.4613	0.8981
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0013	0.0324	0.0324
Echinococcus granulosus	signal transduction protein lnk realted	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Echinococcus granulosus	tyrosine protein kinase Srms	0.0009	0.0149	0.0149
Schistosoma mansoni	tensin	0.0007	0.0008	0.0008
Loa Loa (eye worm)	AUR protein kinase	0.0111	0.5136	0.5136
Onchocerca volvulus		0.0008	0.0088	0.5918
Schistosoma mansoni	suppressor of cytokine signaling	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3592	0.3592
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.01	0.4613	0.4613
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0007	0.0008	0.0014
Echinococcus granulosus	tyrosine protein kinase shark	0.0009	0.0149	0.0149
Schistosoma mansoni	tensin-related	0.0007	0.0008	0.0008
Entamoeba histolytica	protein kinase , putative	0.0111	0.5136	1
Loa Loa (eye worm)	TK protein kinase	0.0031	0.1218	0.1218
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0008	0.0008
Loa Loa (eye worm)	SRC-1	0.0044	0.1857	0.1857
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0007	0.0008	0.0008
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0007	0.0008	0.0008
Loa Loa (eye worm)	AUR protein kinase	0.0111	0.5136	0.5136
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.5136	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0007	0.0008	0.0008
Giardia lamblia	Aurora kinase	0.0111	0.5136	1
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.5136	1
Schistosoma mansoni	vav2	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0044	0.1857	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	adapter molecule crk	0.0013	0.0324	0.0334
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0007	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	suppressor of cytokine signaling	0.0007	0.0008	0.0008
Entamoeba histolytica	protein kinase, putative	0.0008	0.0096	0.0188
Onchocerca volvulus		0.0007	0.0008	0.0538
Echinococcus multilocularis	aurora kinase A	0.0111	0.5136	0.5136
Schistosoma mansoni	apoptosis stimulating of P53	0.0006	0.000000099004	0.00000010231
Echinococcus granulosus	c src tyrosine kinase	0.0016	0.0465	0.0465
Echinococcus multilocularis	NCK adaptor protein	0.0013	0.0324	0.0324
Brugia malayi	Variant SH3 domain containing protein	0.0013	0.0324	0.0561
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0038	0.1542	0.1542
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0044	0.1857	0.1857
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0038	0.1542	0.1542
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0044	0.1857	0.1857
Onchocerca volvulus		0.0009	0.0149	1
Onchocerca volvulus		0.0009	0.0149	1
Brugia malayi	hypothetical protein	0.0009	0.0149	0.0259
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0009	0.0149	0.0291
Onchocerca volvulus		0.0009	0.0149	1
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.5136	1
Echinococcus granulosus	expressed conserved protein	0.0007	0.0008	0.0008
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0324	0.0324
Echinococcus granulosus	SH2 motif	0.0007	0.0008	0.0008
Schistosoma mansoni	signal transduction protein lnk-related	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0009	0.0149	0.0149
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.01	0.4613	0.8981
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.4613	0.8981
Loa Loa (eye worm)	AUR protein kinase	0.0111	0.5136	0.5136
Schistosoma mansoni	protein kinase	0.0111	0.5136	0.5308
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0111	0.5136	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.4613	0.8981
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Echinococcus granulosus	tyrosine kinase	0.0038	0.1542	0.1542
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Schistosoma mansoni	tyrosine kinase	0.0016	0.0465	0.048
Schistosoma mansoni	nck2/grb4	0.0013	0.0324	0.0334
Schistosoma mansoni	tyrosine kinase	0.0009	0.0149	0.0154
Echinococcus multilocularis	N chimaerin	0.0007	0.0008	0.0008
Brugia malayi	serine/threonine kinase 12	0.0111	0.5136	0.8903
Brugia malayi	SRC-1	0.0044	0.1857	0.322
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0007	0.0008	0.0008
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0007	0.0008	0.0008
Onchocerca volvulus		0.0007	0.0008	0.0538
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0007	0.0008	0.0538
Schistosoma mansoni	tyrosine kinase	0.0044	0.1857	0.192
Echinococcus granulosus	mitogen activated protein kinase 3	0.01	0.4613	0.4613
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0008	0.0008
Echinococcus multilocularis	SH2 motif	0.0007	0.0008	0.0008
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0111	0.5136	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0007	0.0008	0.0008
Echinococcus multilocularis	SH2 domain containing protein 7	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0031	0.1218	0.1218
Echinococcus multilocularis	SH2 motif	0.0007	0.0008	0.0008
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.01	0.4613	0.8981
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.5136	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0111	0.5136	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0008	0.0014
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.01	0.4613	0.8981
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK protein kinase	0.0038	0.1542	0.1542
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0035	0.1401	0.1401
Echinococcus granulosus	NCK adaptor protein	0.0013	0.0324	0.0324
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Brugia malayi	MAP kinase sur-1	0.01	0.4613	0.7996
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0007	0.0008	0.0008
Echinococcus multilocularis	c src tyrosine kinase	0.0016	0.0465	0.0465
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0007	0.0008	0.0008
Schistosoma mansoni	tensin	0.0007	0.0008	0.0008
Brugia malayi	Protein kinase domain containing protein	0.0009	0.0149	0.0259
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.5136	0.5308
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0008	0.0008
Onchocerca volvulus		0.0007	0.0008	0.0538
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0111	0.5136	1
Schistosoma mansoni	tyrosine kinase	0.0016	0.0465	0.048
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.01	0.4613	0.8981
Brugia malayi	RhoGAP domain containing protein	0.0007	0.0008	0.0014
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.000000099004	0.00000017162
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Echinococcus multilocularis	SHC transforming protein 3	0.0007	0.0008	0.0008
Entamoeba histolytica	protein kinase, putative	0.0031	0.1218	0.2372
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0044	0.1857	0.1857
Schistosoma mansoni	growth factor receptor-bound protein	0.0013	0.0324	0.0334
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Echinococcus granulosus	SHC transforming protein 3	0.0007	0.0008	0.0008
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0013	0.0324	0.0324
Brugia malayi	protein-tyrosine kinase	0.0038	0.1542	0.2673
Brugia malayi	SH2 domain containing protein	0.0009	0.0149	0.0259
Echinococcus multilocularis	tyrosine kinase	0.0009	0.0149	0.0149
Brugia malayi	Sex muscle abnormal protein 5	0.0013	0.0324	0.0561
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0035	0.1401	0.1401
Onchocerca volvulus		0.0007	0.0008	0.0538
Echinococcus multilocularis	tensin	0.0007	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Loa Loa (eye worm)	p53BP2	0.0006	0.000000099004	0.000000099004
Brugia malayi	Tyrosine-protein kinase abl-1	0.0092	0.4231	0.7335
Schistosoma mansoni	tensin-related	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.1542	0.1542
Onchocerca volvulus		0.0009	0.0149	1
Echinococcus granulosus	tyrosine kinase	0.0009	0.0149	0.0149
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.4613	0.4767
Echinococcus granulosus	tensin	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.4613	0.8981
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.0465	0.0465
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Brugia malayi	Tyrosine-protein kinase abl-1	0.0124	0.5769	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0044	0.1857	0.1857
Entamoeba histolytica	SH2 domain containing protein	0.0007	0.0008	0.0016
Onchocerca volvulus		0.0007	0.0008	0.0538
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0008	0.0096	0.0188
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0007	0.0008	0.0014
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0016	0.0465	0.048
Trypanosoma brucei	protein kinase, putative	0.01	0.4613	0.8981
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0046	0.1946	0.1946
Brugia malayi	serine/threonine-protein kinase 6	0.0111	0.5136	0.8903
Brugia malayi	serine/threonine protein kinase 6	0.0111	0.5136	0.8903
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0007	0.0008	0.0008
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0111	0.5136	1
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0007	0.0008	0.0008
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0038	0.1542	0.1542
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0016	0.0465	0.0465
Brugia malayi	SH2 domain containing protein	0.0009	0.0149	0.0259
Echinococcus granulosus	SH2 domain containing protein 7	0.0007	0.0008	0.0008
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0007	0.0008	0.0008
Onchocerca volvulus		0.0009	0.0149	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0044	0.1857	0.1857
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.01	0.4613	0.8981
Brugia malayi	Protein kinase domain containing protein	0.0009	0.0149	0.0259
Entamoeba histolytica	protein kinase, putative	0.0111	0.5136	1
Brugia malayi	Variant SH3 domain containing protein	0.0013	0.0324	0.0561
Echinococcus multilocularis	tensin	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	shc transforming protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0092	0.4231	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0008	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.01	0.4613	0.8981
Brugia malayi	SH2 domain containing protein	0.0007	0.0008	0.0014
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0007	0.0008	0.0008
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0111	0.5136	0.5136
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0111	0.5136	0.5136
Brugia malayi	hypothetical protein	0.0007	0.0008	0.0014
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0044	0.1857	0.1857
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0044	0.1857	0.1857
Echinococcus multilocularis	mitogen activated protein kinase	0.01	0.4613	0.4613
Toxoplasma gondii	aurora kinase	0.0111	0.5136	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0044	0.1857	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0013	0.0324	0.0334
Echinococcus granulosus	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0149	0.0149
Echinococcus granulosus	tyrosine protein kinase Blk	0.0038	0.1542	0.1542
Trypanosoma cruzi	aurora B kinase, putative	0.0111	0.5136	1
Onchocerca volvulus		0.0007	0.0008	0.0538
Brugia malayi	Protein kinase domain containing protein	0.0009	0.0149	0.0259
Schistosoma mansoni	GTPase activating protein	0.0007	0.0008	0.0008
Entamoeba histolytica	protein kinase domain containing protein	0.0111	0.5136	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 28.2 nM	Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of pH-induced activity by FLIPR assay	ChEMBL.	22957803
Ki (functional)	= 3.5 nM	Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assay	ChEMBL.	22957803

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177411

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1723039