Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.4079 | 0.3854 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7075 | 0.506 |
Brugia malayi | Cell division protein ftsZ | 0.0092 | 0.4079 | 0.3854 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0366 | 0.0366 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2161 | 0.1864 |
Trichomonas vaginalis | tubulin, putative | 0.0119 | 0.5456 | 0.5456 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0092 | 0.4079 | 0.3854 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2161 | 0.1864 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.7075 | 0.7075 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7075 | 0.506 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.7075 | 0.7075 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.7075 | 0.7075 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7075 | 0.506 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5456 | 0.5284 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0119 | 0.5456 | 0.5456 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0366 | 0.0366 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0366 | 0.0366 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0119 | 0.5456 | 0.5456 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0366 | 0.0366 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0366 | 0.0366 |
Trichomonas vaginalis | tubulin, putative | 0.0119 | 0.5456 | 0.5456 |
Brugia malayi | Tubulin beta chain | 0.0119 | 0.5456 | 0.5284 |
Echinococcus granulosus | tubulin delta chain | 0.0092 | 0.4079 | 0.4079 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0119 | 0.5456 | 0.5456 |
Loa Loa (eye worm) | tubulin beta chain | 0.0092 | 0.4079 | 0.3854 |
Trichomonas vaginalis | tubulin beta-1 chain, putative | 0.0092 | 0.4079 | 0.4079 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.7075 | 0.7075 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.7075 | 0.7075 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.6087 | 0.5939 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0119 | 0.5456 | 0.5456 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0119 | 0.5456 | 0.5284 |
Brugia malayi | Tubulin beta chain | 0.0092 | 0.4079 | 0.3854 |
Schistosoma mansoni | tubulin subunit delta | 0.0092 | 0.4079 | 0.4079 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.133 | 0.133 |
Trichomonas vaginalis | tubulin, putative | 0.0092 | 0.4079 | 0.4079 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.7075 | 0.506 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0119 | 0.5456 | 0.5284 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.7075 | 0.6964 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0092 | 0.4079 | 0.4079 |
Schistosoma mansoni | tubulin subunit beta | 0.0092 | 0.4079 | 0.4079 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0366 | 0.0366 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.7075 | 0.7075 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.7075 | 0.6964 |
Schistosoma mansoni | tubulin subunit alpha | 0.0092 | 0.4079 | 0.4079 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0366 | 0.0366 |
Mycobacterium leprae | cell division protein FtsZ | 0.0092 | 0.4079 | 1 |
Echinococcus multilocularis | tubulin delta chain | 0.0092 | 0.4079 | 0.4079 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2161 | 0.1864 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0092 | 0.4079 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.6087 | 0.5939 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0092 | 0.4079 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.4079 | 0.4079 |
Brugia malayi | Tubulin alpha chain | 0.0092 | 0.4079 | 0.3854 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0092 | 0.4079 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0119 | 0.5456 | 0.5456 |
Treponema pallidum | cell division protein FtsZ | 0.0092 | 0.4079 | 1 |
Trypanosoma brucei | alpha tubulin, putative | 0.0119 | 0.5456 | 0.2326 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0119 | 0.5456 | 0.5284 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.133 | 0.1001 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0092 | 0.4079 | 0.4079 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0119 | 0.5456 | 0.5456 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2161 | 0.1864 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0092 | 0.4079 | 0.4079 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.133 | 0.1001 |
Onchocerca volvulus | 0.0119 | 0.5456 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.4079 | 0.4079 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.6087 | 0.5939 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0366 | 0.0366 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.029 uM | Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2 | ChEMBL. | 22897496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.