TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.353 | Formula: C15H14FN3O3S
H donors: 2 H acceptors: 3 LogP: 1.31 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2ccc(cc2CN1C)NS(=O)(=O)c1ccccc1F
InChi: 1S/C15H14FN3O3S/c1-19-9-10-8-11(6-7-13(10)17-15(19)20)18-23(21,22)14-5-3-2-4-12(14)16/h2-8,18H,9H2,1H3,(H,17,20)
InChiKey: KHRKHFBEJJSXAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain containing 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Neospora caninum	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma japonicum	ko:K08871 bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	bromodomain-containing protein 3 brd3	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Toxoplasma gondii	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Onchocerca volvulus		Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Giardia lamblia	Kinase, putative	Get druggable targets OG5_126719	All targets in OG5_126719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.076	0.7926	0.7926
Schistosoma mansoni	DNA topoisomerase II	0.0194	0.189	0.189
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0194	0.189	0.2127
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0425	0.0425
Brugia malayi	hypothetical protein	0.0038	0.0223	0.0223
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.0733	0.052
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0105	0.0105
Leishmania major	DNA topoisomerase ii	0.0194	0.189	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0391	0.3989	0.3989
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0194	0.189	0.1704
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0259	0.0036
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0194	0.189	0.189
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0194	0.189	0.2127
Mycobacterium ulcerans	two component sensor kinase MprB	0.0194	0.189	0.2127
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0194	0.189	0.2127
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0194	0.189	0.2127
Echinococcus multilocularis	musashi	0.0027	0.0105	0.0105
Echinococcus granulosus	tumor protein p63	0.039	0.3979	0.3979
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.0896	0.0896
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0194	0.189	0.2127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0379	0.0379
Trichomonas vaginalis	sensor histidine kinase, putative	0.0194	0.189	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0194	0.189	0.189
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0194	0.189	0.1704
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0194	0.189	0.2127
Loa Loa (eye worm)	heat shock protein 75	0.0391	0.3989	0.3989
Mycobacterium tuberculosis	Conserved protein	0.0194	0.189	0.2127
Onchocerca volvulus		0.0042	0.0259	0.0398
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0194	0.189	0.2127
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0223	0.0223
Brugia malayi	MH2 domain containing protein	0.0254	0.252	0.252
Onchocerca volvulus		0.0042	0.0259	0.0398
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.0896	0.0896
Leishmania major	mitochondrial DNA topoisomerase II	0.0194	0.189	0.1674
Entamoeba histolytica	bromodomain-containing protein	0.0038	0.0225	0.0001
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.076	0.7926	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0379	0.0379
Trypanosoma brucei	heat shock protein 84, putative	0.0391	0.3989	0.3829
Onchocerca volvulus		0.0057	0.0425	0.0824
Echinococcus granulosus	lamin dm0	0.0027	0.0105	0.0105
Entamoeba histolytica	DNA topoisomerase II, putative	0.0194	0.189	0.1705
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0194	0.189	0.2127
Trichomonas vaginalis	heat shock protein, putative	0.0391	0.3989	0.3851
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Chlamydia trachomatis	DNA gyrase subunit B	0.0194	0.189	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0259	0.0259
Trypanosoma cruzi	heat shock protein, putative	0.0391	0.3989	0.3829
Loa Loa (eye worm)	hypothetical protein	0.0194	0.189	0.189
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0194	0.189	0.2127
Plasmodium vivax	heat shock protein 90, putative	0.0391	0.3989	0.3829
Giardia lamblia	Grp94/Hsp90	0.076	0.7926	0.7878
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0194	0.189	0.189
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0194	0.189	0.2127
Trypanosoma cruzi	heat shock protein 90, putative	0.076	0.7926	0.7871
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Entamoeba histolytica	bromodomain-containing protein	0.0038	0.0225	0.0001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0379	0.0379
Echinococcus granulosus	intermediate filament protein	0.0027	0.0105	0.0105
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0385	0.0165
Plasmodium falciparum	heat shock protein 90, putative	0.0391	0.3989	0.2588
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0194	0.189	0.189
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0194	0.189	0.189
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0391	0.3989	0.3989
Plasmodium vivax	heat shock protein, putative	0.0391	0.3989	0.3829
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0194	0.189	0.2127
Chlamydia trachomatis	DNA gyrase subunit B	0.0194	0.189	0.5
Brugia malayi	beta-lactamase	0.0042	0.0259	0.0259
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0896	0.0896
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0194	0.189	0.1704
Trypanosoma cruzi	heat shock protein 85, putative	0.076	0.7926	0.7871
Echinococcus multilocularis	tumor protein p63	0.039	0.3979	0.3979
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0194	0.189	0.1674
Echinococcus multilocularis	Bromodomain containing protein	0.0038	0.0225	0.0225
Trichomonas vaginalis	heat shock protein, putative	0.076	0.7926	0.7878
Schistosoma mansoni	pyruvate dehydrogenase	0.0194	0.189	0.189
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0425	0.0425
Leishmania major	heat shock protein, putative	0.0391	0.3989	0.3829
Brugia malayi	beta-lactamase family protein	0.0042	0.0259	0.0259
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0194	0.189	0.1704
Trichomonas vaginalis	endoplasmin, putative	0.0586	0.6063	0.5972
Trichomonas vaginalis	receptor histidine kinase, putative	0.0194	0.189	0.1704
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.0733	0.052
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0259	0.0259
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0194	0.189	0.2127
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0259	0.0036
Trichomonas vaginalis	receptor histidine kinase, putative	0.0194	0.189	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Loa Loa (eye worm)	transcription factor SMAD2	0.0254	0.252	0.252
Toxoplasma gondii	heat shock protein 75, putative	0.0391	0.3989	0.3851
Onchocerca volvulus		0.0042	0.0259	0.0398
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0194	0.189	0.2127
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0194	0.189	0.1704
Schistosoma mansoni	hypothetical protein	0.0032	0.0157	0.0157
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0733	0.0733
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0194	0.189	0.1674
Loa Loa (eye worm)	MH2 domain-containing protein	0.0254	0.252	0.252
Mycobacterium leprae	Probable two-component sensor kinase	0.0194	0.189	0.2127
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.0896	0.0896
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0194	0.189	0.2127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0379	0.0379
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0194	0.189	0.2127
Loa Loa (eye worm)	hypothetical protein	0.0027	0.01	0.01
Giardia lamblia	Heat shock protein HSP 90-alpha	0.076	0.7926	0.7878
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0157	0.0157
Brugia malayi	Bromodomain containing protein	0.0086	0.0733	0.0733
Brugia malayi	intermediate filament protein	0.0027	0.0105	0.0105
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0379	0.0379
Plasmodium falciparum	heat shock protein 90, putative	0.0391	0.3989	0.2588
Plasmodium vivax	DNA topoisomerase II, putative	0.0194	0.189	0.1674
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0259	0.0036
Brugia malayi	hypothetical protein	0.0033	0.0164	0.0164
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0379	0.0379
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0259	0.0259
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0194	0.189	0.4596
Schistosoma mansoni	heat shock protein	0.0391	0.3989	0.3989
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0259	0.0259
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0194	0.189	0.2127
Echinococcus granulosus	bromodomain containing 2	0.0086	0.0733	0.0733
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0194	0.189	0.1704
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0194	0.189	0.189
Echinococcus granulosus	heat shock protein 90	0.076	0.7926	0.7926
Plasmodium vivax	hypothetical protein, conserved	0.0194	0.189	0.1674
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0194	0.189	0.2127
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0194	0.189	0.2127
Schistosoma mansoni	lamin	0.0027	0.0105	0.0105
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0259	0.0036
Echinococcus multilocularis	endoplasmin	0.076	0.7926	0.7926
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0194	0.189	0.2127
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0157	0.0157
Echinococcus granulosus	endoplasmin	0.076	0.7926	0.7926
Echinococcus granulosus	lamin	0.0027	0.0105	0.0105
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0157	0.0157
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0259	0.0259
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0194	0.189	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0157	0.0157
Mycobacterium ulcerans	heat shock protein 90	0.076	0.7926	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0391	0.3989	0.3851
Brugia malayi	kinase, mitochondrial precursor	0.0194	0.189	0.189
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0194	0.189	0.2127
Leishmania major	hypothetical protein, conserved	0.0194	0.189	0.1674
Giardia lamblia	Pms1-like protein	0.0194	0.189	0.1704
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0194	0.189	0.2127
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0385	0.0165
Loa Loa (eye worm)	bromodomain containing protein	0.0038	0.0225	0.0225
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0194	0.189	0.1674
Mycobacterium ulcerans	putative regultory protein	0.0194	0.189	0.2127
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0194	0.189	0.1674
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0194	0.189	0.1704
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0194	0.189	0.1674
Toxoplasma gondii	ABC1 family protein	0.0042	0.0259	0.0036
Echinococcus multilocularis	heat shock protein 90	0.076	0.7926	0.7926
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0385	0.0165
Loa Loa (eye worm)	TOPoisomerase family member	0.0194	0.189	0.189
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0194	0.189	0.4596
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0086	0.0733	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0385	0.0165
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0223	0.0223
Echinococcus multilocularis	lamin dm0	0.0027	0.0105	0.0105
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0194	0.189	0.1674
Schistosoma mansoni	hypothetical protein	0.0069	0.0554	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0157
Echinococcus multilocularis	bromodomain containing 2	0.0086	0.0733	0.0733
Plasmodium falciparum	endoplasmin, putative	0.0586	0.6063	0.5145
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0157	0.0157
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0324	0.0102
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0259	0.0036
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0194	0.189	0.1674
Schistosoma mansoni	hypothetical protein	0.0038	0.0223	0.0223
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0194	0.189	0.1674
Brugia malayi	Probable DNA topoisomerase II	0.0194	0.189	0.189
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.076	0.7926	0.7871
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0194	0.189	0.189
Trichomonas vaginalis	esterase, putative	0.0042	0.0259	0.0036
Trypanosoma cruzi	heat shock protein 90, putative	0.0564	0.5827	0.5716
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0194	0.189	0.1704
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0554	0.0554
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0194	0.189	0.1674
Trichomonas vaginalis	heat shock protein, putative	0.076	0.7926	0.7878
Echinococcus granulosus	GPCR family 2	0.0032	0.0157	0.0157
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0259	0.0259
Trichomonas vaginalis	bromodomain containing protein, putative	0.0053	0.0385	0.0165
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0266	0.265	0.3118
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0391	0.3989	1
Brugia malayi	Hsp90 protein	0.0391	0.3989	0.3989
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0259	0.0259
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0194	0.189	0.1704
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0105	0.0105
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0379	0.0379
Schistosoma mansoni	lamin	0.0027	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0032	0.0157	0.0157
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0157	0.0157
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0554	0.0554
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0194	0.189	0.4596
Schistosoma mansoni	hypothetical protein	0.0032	0.0157	0.0157
Trypanosoma brucei	DNA topoisomerase ii	0.0194	0.189	0.1674
Onchocerca volvulus		0.0038	0.0225	0.0308
Trichomonas vaginalis	heat shock protein, putative	0.0586	0.6063	0.5972
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0194	0.189	0.1674
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.076	0.7926	1
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.076	0.7926	1
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0391	0.3989	0.3851
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0194	0.189	0.2127
Mycobacterium ulcerans	DNA gyrase subunit B	0.0194	0.189	0.2127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0379	0.0379
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0194	0.189	0.2127
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0194	0.189	0.1674
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0105	0.0105
Entamoeba histolytica	bromodomain-containing protein	0.0038	0.0225	0.0001
Brugia malayi	Bromodomain containing protein	0.0086	0.0733	0.0733
Echinococcus multilocularis	lamin	0.0027	0.0105	0.0105
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0194	0.189	0.1704
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0223	0.0223
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0194	0.189	0.189
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0194	0.189	0.189
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0194	0.189	0.2127
Trichomonas vaginalis	heat shock protein, putative	0.076	0.7926	0.7878
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0194	0.189	0.2127
Plasmodium vivax	DNA gyrase subunit B, putative	0.0194	0.189	0.1674
Brugia malayi	beta-lactamase family protein	0.0042	0.0259	0.0259
Treponema pallidum	heat shock protein 90	0.076	0.7926	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.36 uM	Inhibition of BRD4 isoform 1 by AlphaScreen assay	ChEMBL.	23095041

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2179388

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1723759