Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0028 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0028 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0028 | 0.0028 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0028 | 0.0028 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0.0028 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0028 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.9185 | 0.9185 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0028 | 0.0028 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.9185 | 0.9185 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0028 | 0.0028 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0028 | 0.0028 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0028 | 0.0028 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0028 | 0.5 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0028 | 0.0028 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0028 | 0.0028 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0028 | 0.0028 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0028 | 0.5 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0028 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0028 | 0.0028 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0.0028 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.9185 | 0.9185 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of eNOS in rat PMEC assessed as reduction in nitrite level at 100 uM after 48 hrs by Griess method | ChEMBL. | 23123728 | |
Inhibition (binding) | Inhibition of iNOS in LPS-stimulated Wistar rat neutrophils assessed as decrease in total NOS activity at 100 uM after 18 hrs by enzymatic assay | ChEMBL. | 23123728 | |
Inhibition (binding) | Inhibition of iNOS activity in LPS-stimulated Wistar rat neutrophils at 100 uM after 18 hrs by enzymatic assay | ChEMBL. | 23123728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.