TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1330.49 | Formula: C65H87N17O14
H donors: 17 H acceptors: 14 LogP: -0.93 Rotable bonds: 49
Rule of 5 violations (Lipinski): 4
SMILES: OC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CCCNC(=N)N(C)C)CC(C)C)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CC(=O)N)CC(=O)N
InChi: 1S/C65H87N17O14/c1-36(2)26-47(60(92)75-45(20-13-25-71-65(70)82(3)4)59(91)76-46(56(69)88)28-37-14-7-5-8-15-37)74-55(87)34-73-58(90)48(29-38-16-9-6-10-17-38)78-64(96)52(35-83)81-63(95)51(32-54(68)86)80-61(93)49(30-40-33-72-44-19-12-11-18-42(40)44)79-62(94)50(31-53(67)85)77-57(89)43(66)27-39-21-23-41(84)24-22-39/h5-12,14-19,21-24,33,36,43,45-52,72,83-84H,13,20,25-32,34-35,66H2,1-4H3,(H2,67,85)(H2,68,86)(H2,69,88)(H2,70,71)(H,73,90)(H,74,87)(H,75,92)(H,76,91)(H,77,89)(H,78,96)(H,79,94)(H,80,93)(H,81,95)/t43-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1
InChiKey: OCPWMJLUGMDFNB-NSWSVTGLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	KISS1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0083	0.4483	0.4483
Trichomonas vaginalis	STE family protein kinase	0.0083	0.4483	0.7186
Brugia malayi	larval opioid receptor	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus granulosus	laminin	0.0015	0.0544	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0006	0.0022	0.0022
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0112	0.6218	1
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.0051	0.0046
Onchocerca volvulus		0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Trichomonas vaginalis	STE family protein kinase	0.0083	0.4483	0.7186
Loa Loa (eye worm)	TYRA-2 protein	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0196	0.0281
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.6218	1
Brugia malayi	GnHR receptor homolog	0.0006	0.0022	0.0022
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0196	0.0281
Loa Loa (eye worm)	zinc metalloproteinase toh-2	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0544	0.0544
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0196	0.0281
Schistosoma mansoni	serine/threonine protein kinase	0.0112	0.6218	1
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.6218	1
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0196	0.0281
Brugia malayi	N-terminal motif family protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0013	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0196	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus granulosus	mitogen activated protein kinase	0.0112	0.6218	1
Onchocerca volvulus		0.0006	0.0051	0.0051
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0112	0.6218	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus granulosus	son of sevenless 1	0.0006	0.0051	0.0046
Brugia malayi	Nematode astacin protease protein 30	0.0006	0.0022	0.0022
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	zinc metalloproteinase toh-2 precursor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0458	0.0458
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0196	0.0196
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.0051	0.0046
Brugia malayi	hypothetical protein	0.0009	0.0196	0.0196
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0022	0.0022
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0112	0.6218	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0006	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Onchocerca volvulus		0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0196	0.0196
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0196	0.0196
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.0051	0.0046
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0015	0.0544	0.0578
Onchocerca volvulus		0.0006	0.0022	0.0022
Schistosoma mansoni	dishevelled	0.0009	0.0196	0.0281
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0009	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	Zinc metalloproteinase toh-2 precursor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0015	0.0544	0.0544
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0006	0.0022	0.0022
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0196	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	Nematode astacin protease protein 30	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0196	0.0196
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0015	0.0544	0.0578
Brugia malayi	N-terminal motif family protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0009	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0006	0.0022	0.0022
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.6218	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus granulosus	mitogen activated protein kinase 3	0.0112	0.6218	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0015	0.0544	0.0544
Schistosoma mansoni	egf-like domain protein	0.0013	0.0458	0.0703
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0051	0.0046
Onchocerca volvulus		0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0083	0.4483	0.7199
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0006	0.0022	0.0022
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0112	0.6218	1
Echinococcus multilocularis	son of sevenless 1	0.0006	0.0051	0.0046
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0051	0.0046
Brugia malayi	Dopamine receptor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	DPY-31 protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	melatonin receptor type 1A	0.0006	0.0022	0.0022
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0006	0.0022	0.0022
Loa Loa (eye worm)	AStacin protease	0.0029	0.1347	0.1347
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0112	0.6218	1
Giardia lamblia	Kinase, CMGC MAPK	0.0112	0.6218	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0112	0.6218	1
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0046	0.2341	0.3742
Brugia malayi	follicle stimulating hormone receptor	0.0006	0.0022	0.0022
Brugia malayi	RasGEF domain containing protein	0.0006	0.0051	0.0051
Brugia malayi	Fibulin-1 precursor	0.0015	0.0544	0.0544
Brugia malayi	G-protein coupled receptor	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0083	0.4483	0.7186
Brugia malayi	DIX domain containing protein	0.0009	0.0196	0.0196
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0196	0.0196
Brugia malayi	neuropeptide F receptor	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0196	0.0281
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0112	0.6218	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Brugia malayi	astacin protease protein 30	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Echinococcus multilocularis	fibrillin 1	0.0015	0.0544	0.0842
Brugia malayi	Serotonin receptor	0.0006	0.0022	0.0022
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0196	0.0281
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0112	0.6218	0.6218
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0006	0.0051	0.0051
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0196	0.0281
Brugia malayi	ORL1-like opioid receptor	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Echinococcus granulosus	Protein son of sevenless	0.0006	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	G protein-coupled receptor F59B2.13	0.0006	0.0022	0.0022
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0196	0.0281
Echinococcus granulosus	dual specificity mitogen activated protein	0.0083	0.4483	0.7199
Echinococcus multilocularis	mitogen activated protein kinase	0.0112	0.6218	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0006	0.0022	0.0022
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0022	0.0022
Brugia malayi	Dopamine receptor protein 1	0.0006	0.0022	0.0022
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0196	0.0196
Trichomonas vaginalis	STE family protein kinase	0.0083	0.4483	0.7186
Brugia malayi	G protein-coupled receptor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0083	0.4483	0.4483
Brugia malayi	G-protein coupled receptor	0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus	Arrow homolog	0.0013	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	AKH receptor	0.0006	0.0022	0.0022
Schistosoma mansoni	dep domain containing protein	0.0009	0.0196	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Schistosoma mansoni	dishevelled	0.0009	0.0196	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.6218	1
Onchocerca volvulus		0.0006	0.0022	0.0022
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0051	0.0046
Brugia malayi	Serotonin receptor	0.0006	0.0022	0.0022
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0112	0.6218	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0006	0.0022	0.0022
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	RE15519p	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Echinococcus granulosus	Tolloid protein 1	0.0046	0.2341	0.3742
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0051	0.0046
Brugia malayi	sulfakinin receptor protein	0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0033	0.0017
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	MAP kinase sur-1	0.0112	0.6218	0.6218
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0046	0.2341	0.2341
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.0051	0.0046
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0006	0.0022	0.0022
Echinococcus multilocularis	laminin	0.0015	0.0544	0.0842
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	putative neuropeptide receptor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0051	0.0051
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0006	0.0022	0.0022
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0022	0.0022
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0013	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0769	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Trypanosoma brucei	protein kinase, putative	0.0112	0.6218	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0006	0.0022	0.0022
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0112	0.6218	1
Brugia malayi	Melatonin receptor type 1A	0.0006	0.0022	0.0022
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0083	0.4483	0.7199
Brugia malayi	putative neuropeptide receptor NPR1	0.0006	0.0022	0.0022
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0022	0.0022
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Brugia malayi	Dopamine receptor protein 2	0.0006	0.0022	0.0022
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0196	0.0281
Brugia malayi	RasGEF domain containing protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus multilocularis	Tolloid protein 1	0.0046	0.2341	0.3742
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0051	0.5
Brugia malayi	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0006	0.0022	0.0022
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.0051	0.0046
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.0051	0.0046
Brugia malayi	neuropeptide F receptor	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0196	0.0281
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0196	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0196	0.0196
Onchocerca volvulus		0.0006	0.0022	0.0022
Onchocerca volvulus		0.0006	0.0022	0.0022
Brugia malayi	RasGEF domain containing protein	0.0006	0.0051	0.0051
Onchocerca volvulus		0.0006	0.0022	0.0022

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.039 nM	Agonist activity at human OT7T175 assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL.	22995619
Ratio EC50 (binding)	= 0.61	Ratio of compound EC50 to metastin(residue 45 to 54) EC50 for human OT7T175	ChEMBL.	22995619

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2152056

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1724024