Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0026 | 0.4001 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.3877 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3877 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.4001 | 0.4001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3877 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.4001 | 0.4001 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3843 | 0.3843 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3877 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.3877 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.4001 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0017 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3877 | 0.3877 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.4001 | 0.4001 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4001 | 0.4001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.3877 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3877 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.3877 | 0.3877 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.4001 | 0.4001 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.3877 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.