Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0163 | 0.1049 | 0.1049 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0237 | 0.3296 | 0.3296 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0237 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | fibroinase | 0.0237 | 0.3296 | 0.251 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0179 | 0.1541 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0179 | 0.1541 | 0.1541 |
Onchocerca volvulus | Cathepsin F homolog | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.1049 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0163 | 0.1049 | 0.1049 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0237 | 0.3296 | 0.3296 |
Giardia lamblia | Cathepsin B precursor | 0.0179 | 0.1541 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0163 | 0.1049 | 0.1049 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0179 | 0.1541 | 0.4674 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0237 | 0.3296 | 0.3296 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0163 | 0.1049 | 0.1049 |
Brugia malayi | cathepsin L-like precursor | 0.0163 | 0.1049 | 0.1049 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.1049 | 0.1049 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0237 | 0.3296 | 0.3296 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0179 | 0.1541 | 0.1541 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0237 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0237 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.3296 | 0.251 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0237 | 0.3296 | 0.3296 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0237 | 0.3296 | 0.3296 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0237 | 0.3296 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0237 | 0.3296 | 1 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0237 | 0.3296 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.1049 | 0.1049 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | cysteine protease | 0.0237 | 0.3296 | 0.251 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0237 | 0.3296 | 0.251 |
Plasmodium vivax | vivapain-2 | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0237 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0179 | 0.1541 | 0.4674 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0163 | 0.1049 | 0.3182 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0237 | 0.3296 | 0.3296 |
Leishmania major | cysteine peptidase A (CPA) | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0237 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0237 | 0.3296 | 0.251 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.1049 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0179 | 0.1541 | 0.055 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0237 | 0.3296 | 0.3296 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0237 | 0.3296 | 0.3296 |
Toxoplasma gondii | cathepsin CPL | 0.0237 | 0.3296 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0237 | 0.3296 | 0.3296 |
Plasmodium vivax | vivapain-2 | 0.0237 | 0.3296 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0179 | 0.1541 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Leishmania major | cathepsin L-like protease | 0.0237 | 0.3296 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0237 | 0.3296 | 0.251 |
Onchocerca volvulus | Cathepsin L homolog | 0.0237 | 0.3296 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0237 | 0.3296 | 0.3296 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Onchocerca volvulus | 0.0237 | 0.3296 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0237 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0237 | 0.3296 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0237 | 0.3296 | 0.3296 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0237 | 0.3296 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0237 | 0.3296 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0237 | 0.3296 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 180 uM | Inhibition of human recombinant CDK4/Cyclin D1 using fluoresceinyl-Ahx-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly tracer peptide as substrate after 45 mins by fluorescent polarization binding assay | ChEMBL. | 23323521 |
IC50 (binding) | > 180 uM | Inhibition of human recombinant CDK2/Cyclin A2 using fluoresceinyl-Ahx-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly tracer peptide as substrate after 45 mins by fluorescent polarization binding assay | ChEMBL. | 23323521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.