Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 48 % | Intrinsic agonist activity at human D2 dopamine receptor expressed in CHO cell membrane using cellular CD spectroscopy by Cell-Key assay | ChEMBL. | 23237836 |
IC50 (functional) | = 0.6 uM | Antagonist activity at human D2 dopamine receptor expressed in CHO cell membrane by GTPgammaS-binding assay | ChEMBL. | 23237836 |
IC50 (binding) | = 3.6 uM | Inhibition of human ERG | ChEMBL. | 23237836 |
Ki (binding) | = 75 nM | Displacement of [3H]raclopride from human D2 dopamine receptor expressed in CHO cell membranes | ChEMBL. | 23237836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.