Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0776 | 0.2648 | 0.2523 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0604 | 0.202 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0604 | 0.202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.1033 | 0.5117 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0063 | 0.0048 | 0.024 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1343 | 0.4715 | 0.4625 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1066 | 0.3706 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0063 | 0.0048 | 0.0028 |
Brugia malayi | DNA topoisomerase III | 0.0096 | 0.0168 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.1033 | 0.5117 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0096 | 0.0168 | 0.0633 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0604 | 0.202 | 0.1883 |
Brugia malayi | Probable DNA topoisomerase II | 0.0604 | 0.202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0875 | 0.4334 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0881 | 0.3029 | 0.291 |
Leishmania major | DNA topoisomerase ii | 0.0508 | 0.167 | 0.4244 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1343 | 0.4715 | 0.4625 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.1165 | 0.5769 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0604 | 0.202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0612 | 0.3032 |
Giardia lamblia | DNA topoisomerase II | 0.0562 | 0.1866 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0096 | 0.0168 | 0.0633 |
Brugia malayi | GRF zinc finger family protein | 0.0096 | 0.0168 | 0.0607 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0085 | 0.0129 | 0.0435 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0604 | 0.202 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0063 | 0.0048 | 0.0028 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.0222 | 0.0906 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0508 | 0.167 | 0.4244 |
Schistosoma mansoni | DNA topoisomerase II | 0.0604 | 0.202 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1331 | 0.4672 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0604 | 0.202 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1066 | 0.3706 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0604 | 0.202 | 0.1883 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0604 | 0.202 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0604 | 0.202 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0096 | 0.0168 | 0.0633 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0111 | 0.0222 | 0.0906 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1343 | 0.4715 | 0.4625 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0096 | 0.0168 | 0.0633 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0096 | 0.0168 | 0.0832 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1343 | 0.4715 | 0.4625 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0096 | 0.0168 | 0.0607 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0604 | 0.202 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0462 | 0.1504 | 0.2966 |
Onchocerca volvulus | 0.0333 | 0.1033 | 0.4674 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.0222 | 0.0906 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0096 | 0.0168 | 0.0633 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0604 | 0.202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1127 | 0.5578 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0096 | 0.0168 | 0.0633 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1343 | 0.4715 | 0.4625 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0604 | 0.202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.1033 | 0.5117 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0508 | 0.167 | 0.4244 |
Echinococcus granulosus | protein kinase C gamma type | 0.0085 | 0.0129 | 0.0435 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0111 | 0.0222 | 0.0906 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1066 | 0.3706 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0508 | 0.167 | 0.4244 |
Brugia malayi | Protein kinase c protein 2 | 0.0075 | 0.0093 | 0.0227 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0096 | 0.0168 | 0.0832 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0604 | 0.202 | 0.1883 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0085 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0875 | 0.4334 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0063 | 0.0048 | 0.0028 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.029 | 0.0875 | 0.0719 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1343 | 0.4715 | 0.4625 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0612 | 0.3032 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1066 | 0.3706 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0508 | 0.167 | 0.4244 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 60 nM | Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23398373 |
Ki (binding) | = 722 nM | Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP | ChEMBL. | 23398373 |
Ki (binding) | > 1250 nM | Inhibition of PKC alpha (unknown origin) using RRRRRKGSFKRKA as substrate after 15 mins by spectrophotometry in presence of ATP | ChEMBL. | 23398373 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.