Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0797 | 0.2029 | 0.0698 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0639 | 0.1431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.23 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1405 | 0.4323 | 0.3375 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0639 | 0.1431 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0413 | 0.0581 | 0.4061 |
Giardia lamblia | DNA topoisomerase II | 0.0594 | 0.1261 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0639 | 0.1431 | 0.5939 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0639 | 0.1431 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0639 | 0.1431 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1405 | 0.4323 | 0.423 |
Schistosoma mansoni | DNA topoisomerase II | 0.0639 | 0.1431 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1387 | 0.4255 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1099 | 0.3169 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1099 | 0.3169 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0639 | 0.1431 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1099 | 0.3169 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0944 | 0.2585 | 0.2463 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1405 | 0.4323 | 0.3375 |
Brugia malayi | Probable DNA topoisomerase II | 0.0639 | 0.1431 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0639 | 0.1431 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0455 | 0.0737 | 0.5148 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1099 | 0.3169 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0639 | 0.1431 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0639 | 0.1431 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0639 | 0.1431 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2676 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.