TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.164 | Formula: C12H27BN2O5
H donors: 5 H acceptors: 5 LogP: -3.1 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: OCCN(CC[C@@](C(=O)O)(CCCCB(O)O)N)CC
InChi: 1S/C12H27BN2O5/c1-2-15(9-10-16)8-6-12(14,11(17)18)5-3-4-7-13(19)20/h16,19-20H,2-10,14H2,1H3,(H,17,18)/t12-/m1/s1
InChiKey: FPYITPAXHJSSOY-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arginase 1	Starlite/ChEMBL	References
Homo sapiens	arginase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania infantum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis		Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium falciparum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Entamoeba histolytica	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma mansoni	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania major	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania mexicana	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis	arginase 2, mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma japonicum	ko:K01476 arginase [EC3.5.3.1], putative	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania donovani	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium knowlesi	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium berghei	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium vivax	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania braziliensis	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0032	0.0239	0.0239
Echinococcus multilocularis	endoplasmin	0.0032	0.0239	0.0239
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0034	0.0293	1
Plasmodium vivax	SET domain protein, putative	0.0026	0.0087	0.0087
Echinococcus granulosus	heat shock protein	0.0034	0.0293	0.0293
Trypanosoma brucei	Heat shock protein 83, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	protein kinase	0.0029	0.0161	0.0161
Brugia malayi	Pre-SET motif family protein	0.0026	0.0087	0.0213
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0056	0.0864	0.0864
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0293	0.0293
Leishmania major	extracellular receptor, putative	0.0029	0.0161	0.0161
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0293	0.0896
Onchocerca volvulus		0.0029	0.0161	0.0341
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0034	0.0291	0.0291
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0085	0.1605	0.1605
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0026	0.0073	0.0073
Schistosoma mansoni	heat shock protein	0.0034	0.0293	0.0293
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0085	0.1605	0.1605
Giardia lamblia	Grp94/Hsp90	0.0032	0.0239	0.5748
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0034	0.0291	0.0291
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0029	0.0161	0.0161
Echinococcus multilocularis	glutamate receptor 2	0.0056	0.0864	0.0864
Schistosoma mansoni	glutamate receptor AMPA	0.0056	0.0864	0.0864
Echinococcus granulosus	heat shock protein 90	0.0029	0.0167	0.0167
Loa Loa (eye worm)	glutamate receptor	0.0029	0.0161	0.0304
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Schistosoma mansoni	endoplasmin	0.0034	0.0293	0.0293
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0081	0.1482	0.3646
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0087	0.0087
Brugia malayi	Glutamate receptor 2 precursor	0.0056	0.0864	0.2127
Brugia malayi	heat shock protein 90	0.0034	0.0293	0.072
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Loa Loa (eye worm)	endoplasmin	0.0034	0.0293	0.0554
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0026	0.0087	0.0087
Brugia malayi	Glutamate receptor 1 precursor	0.0056	0.0864	0.2127
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0081	0.1482	0.2806
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0182	0.4065	0.7697
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0026	0.0087	0.0087
Echinococcus granulosus	snurportin 1	0.0229	0.5281	0.5281
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0081	0.1482	0.3646
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0026	0.0073	0.0073
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0034	0.0291	0.0291
Entamoeba histolytica	hypothetical protein	0.0027	0.0105	0.0105
Schistosoma mansoni	glutamate receptor kainate	0.0056	0.0864	0.0864
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0034	0.0291	0.0552
Echinococcus granulosus	nmda type glutamate receptor	0.0201	0.4566	0.4566
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0029	0.0161	0.0304
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0161	0.0161
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus multilocularis	geminin	0.0126	0.2647	0.2647
Echinococcus granulosus	endoplasmin	0.0032	0.0239	0.0239
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0029	0.0161	0.0161
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0029	0.0161	0.0395
Plasmodium falciparum	heat shock protein 90, putative	0.0129	0.2727	0.2688
Echinococcus granulosus	GPCR family 2	0.0026	0.0073	0.0073
Toxoplasma gondii	Hsp90 domain-containing protein	0.0129	0.2727	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0029	0.0161	0.0341
Echinococcus multilocularis	GPCR, family 2	0.0026	0.0073	0.0073
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Brugia malayi	RNA, U transporter 1	0.0061	0.0982	0.2415
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0027	0.0105	0.0105
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0029	0.0161	0.0161
Schistosoma mansoni	glutamate receptor NMDA	0.0056	0.0864	0.0864
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0026	0.0087	0.0318
Schistosoma mansoni	hypothetical protein	0.0026	0.0073	0.0073
Trypanosoma cruzi	agmatinase, putative	0.0151	0.327	1
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0167	0.0114
Schistosoma mansoni	endoplasmin	0.0034	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0145	0.3122	1
Loa Loa (eye worm)	heat shock protein 90	0.0034	0.0293	0.0554
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0293	0.0896
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0034	0.0291	0.0291
Brugia malayi	Receptor family ligand binding region containing protein	0.0029	0.0161	0.0395
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0588	0.1113
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0201	0.4566	0.4566
Echinococcus granulosus	glutamate receptor 2	0.0085	0.1605	0.1605
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0056	0.0864	0.0864
Brugia malayi	latrophilin 2 splice variant baaae	0.0055	0.083	0.2041
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0087	0.0164
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0145	0.3122	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0201	0.4566	0.4566
Schistosoma mansoni	glutamate receptor AMPA	0.0056	0.0864	0.0864
Echinococcus multilocularis	NMDA receptor	0.0056	0.0864	0.0864
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	hypothetical protein	0.0027	0.0105	0.0105
Onchocerca volvulus		0.0029	0.0161	0.0341
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0029	0.0161	0.0304
Schistosoma mansoni	hypothetical protein	0.0056	0.0864	0.0864
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0229	0.5281	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0138
Brugia malayi	hypothetical protein	0.0027	0.0105	0.0259
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Brugia malayi	hypothetical protein	0.0029	0.0161	0.0395
Trypanosoma cruzi	arginase, putative	0.0151	0.327	1
Plasmodium falciparum	heat shock protein 90	0.0034	0.0293	0.0241
Schistosoma mansoni	glutamate receptor kainate	0.0056	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0056	0.0864	0.0864
Trypanosoma cruzi	heat shock protein 90, putative	0.0029	0.0167	0.051
Entamoeba histolytica	hypothetical protein	0.0027	0.0105	0.0105
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0032	0.0239	0.5
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Onchocerca volvulus		0.0026	0.0087	0.0184
Trypanosoma cruzi	agmatinase, putative	0.0151	0.327	1
Echinococcus multilocularis	tyrosine kinase	0.0029	0.0161	0.0161
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0161	0.0161
Chlamydia trachomatis	glutamine binding protein	0.0145	0.3122	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0026	0.0073	0.0138
Echinococcus multilocularis	heat shock protein 90	0.0034	0.0293	0.0293
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0085	0.1605	0.1605
Toxoplasma gondii	heat shock protein 90, putative	0.0034	0.0293	0.1074
Echinococcus multilocularis	heat shock protein 90	0.0029	0.0167	0.0167
Schistosoma mansoni	glutamate receptor NMDA	0.0085	0.1605	0.1605
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0029	0.0161	0.0395
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0026	0.0073	0.0179
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0239	0.0187
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Brugia malayi	Endoplasmin precursor	0.0034	0.0293	0.072
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0056	0.0864	0.0864
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0087	0.0087
Brugia malayi	metabotropic glutamate receptor type 2	0.0029	0.0161	0.0395
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0293	0.0896
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Schistosoma mansoni	hypothetical protein	0.0026	0.0073	0.0073
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0145	0.3122	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0085	0.1605	0.1605
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	hypothetical protein	0.0229	0.5281	0.5281
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0291	0.0291
Entamoeba histolytica	hypothetical protein	0.0027	0.0105	0.0105
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Schistosoma mansoni	tyrosine kinase	0.0029	0.0161	0.0161
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.0087	0.0087
Brugia malayi	Guanylyl cyclase protein 23	0.0029	0.0161	0.0395
Echinococcus granulosus	geminin	0.0126	0.2647	0.2647
Schistosoma mansoni	hypothetical protein	0.0055	0.083	0.083
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0026	0.0073	0.0073
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0293	0.0293
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0085	0.1605	0.1605
Schistosoma mansoni	metabotropic glutamate receptor	0.0029	0.0161	0.0161
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0029	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0293	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Trypanosoma cruzi	Heat shock protein 83, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	hypothetical protein	0.0026	0.0073	0.0073
Entamoeba histolytica	hypothetical protein	0.0027	0.0105	0.0105
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0056	0.0864	0.0864
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0056	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0055	0.083	0.1571
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0034	0.0291	0.0717
Toxoplasma gondii	heat shock protein HSP90	0.0034	0.0293	0.1074
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0087	0.0087
Trichomonas vaginalis	set domain proteins, putative	0.0207	0.4706	0.4678
Echinococcus multilocularis	glutamate receptor 2	0.0085	0.1605	0.1605
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0145	0.3122	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0085	0.1605	0.1605
Leishmania major	agmatinase-like protein	0.0151	0.327	0.327
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0029	0.0161	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1482	0.2806
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0291	0.0291
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0087	0.0087
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	transcription factor LCR-F1	0.0027	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0126	0.2647	0.2647
Plasmodium vivax	heat shock protein 86, putative	0.0034	0.0293	0.0293
Schistosoma mansoni	heat shock protein	0.0034	0.0293	0.0293
Echinococcus multilocularis	heat shock protein	0.0034	0.0293	0.0293
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0032	0.0239	0.5
Schistosoma mansoni	glutamate receptor kainate	0.0056	0.0864	0.0864
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0056	0.0864	0.0864
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0293	0.0241
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Schistosoma mansoni	metabotropic glutamate receptor	0.0029	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Trypanosoma brucei	agmatinase, putative	0.0151	0.327	1
Schistosoma mansoni	tyrosine kinase	0.0029	0.0161	0.0161
Echinococcus multilocularis	nmda type glutamate receptor	0.0029	0.0161	0.0161
Trypanosoma cruzi	heat shock protein 85, putative	0.0029	0.0167	0.051
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0085	0.1605	0.1605
Brugia malayi	Receptor family ligand binding region containing protein	0.0029	0.0161	0.0395
Loa Loa (eye worm)	glutamate receptor 2	0.0056	0.0864	0.1637
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0029	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0056	0.0864	0.0864
Plasmodium vivax	endoplasmin, putative	0.0034	0.0293	0.0293
Trypanosoma cruzi	extracellular receptor, putative	0.0029	0.0161	0.0491
Echinococcus multilocularis	snurportin 1	0.0229	0.5281	0.5281
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0291	0.0291
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Loa Loa (eye worm)	glutamate receptor 1	0.0056	0.0864	0.1637
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0025	0.0062	0.0062
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Echinococcus granulosus	receptor type guanylyl cyclase	0.0029	0.0161	0.0161
Schistosoma mansoni	hypothetical protein	0.0126	0.2647	0.2647
Brugia malayi	Pre-SET motif family protein	0.0182	0.4065	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0161	0.0304
Schistosoma mansoni	hypothetical protein	0.0026	0.0073	0.0073
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0145	0.3122	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0029	0.0161	0.0304
Plasmodium vivax	heat shock protein, putative	0.0129	0.2727	0.2727
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0588	0.1446
Onchocerca volvulus		0.0207	0.4706	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0026	0.0073	0.0073
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0293	0.0896
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0239	0.0187
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0029	0.0161	0.0161
Schistosoma mansoni	ATP-binding cassette transporter	0.0056	0.0864	0.0864
Brugia malayi	Latrophilin receptor protein 2	0.0026	0.0073	0.0179
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0056	0.0864	0.0864
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0027	0.0105	0.0105
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0029	0.0161	0.0161
Trypanosoma cruzi	arginase, putative	0.0151	0.327	1
Echinococcus granulosus	nmda type glutamate receptor	0.0029	0.0161	0.0161
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0029	0.0161	0.0304
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Leishmania major	heat shock protein 83-1	0.0034	0.0293	0.0293
Echinococcus granulosus	heat shock protein 90	0.0034	0.0293	0.0293
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0085	0.1605	0.1605
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0029	0.0161	0.0304
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0029	0.0161	0.0161
Entamoeba histolytica	hypothetical protein	0.0029	0.0161	0.0161
Echinococcus granulosus	tyrosine kinase	0.0029	0.0161	0.0161

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 390 nM	Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	ChEMBL.	23472952
IC50 (binding)	= 550 nM	Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	ChEMBL.	23472952

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326084

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1724543