Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.0078 | 0.0544 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0158 | 0.0421 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0019 | 0.0019 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0078 | 0.0544 | 0.1037 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0433 | 0.3765 | 0.7183 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0019 | 0.0021 |
Leishmania major | cathepsin L-like protease | 0.002 | 0.0019 | 0.0049 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0433 | 0.3765 | 0.3765 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0433 | 0.3765 | 0.7183 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0386 | 0.3339 | 0.6369 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0433 | 0.3765 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0019 | 0.0019 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0019 | 0.0342 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0078 | 0.0544 | 0.0544 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0158 | 0.0158 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0078 | 0.0544 | 0.0544 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0078 | 0.0544 | 0.1444 |
Entamoeba histolytica | hypothetical protein | 0.0474 | 0.4139 | 0.7895 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0078 | 0.0544 | 0.1037 |
Entamoeba histolytica | cysteine protease, putative | 0.002 | 0.0019 | 0.0035 |
Toxoplasma gondii | cathepsin CPL | 0.002 | 0.0019 | 0.0049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Leishmania major | cathepsin L-like protease | 0.002 | 0.0019 | 0.0049 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0078 | 0.0544 | 0.1037 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0596 | 0.5242 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0596 | 0.5242 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0596 | 0.5242 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0578 | 0.5082 | 0.9695 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0158 | 0.0158 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0078 | 0.0544 | 0.1444 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0158 | 0.0158 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0433 | 0.3765 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0019 | 0.0019 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0199 | 0.1647 | 0.3142 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0078 | 0.0544 | 0.1444 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0019 | 0.0079 |
Onchocerca volvulus | 0.0278 | 0.2366 | 1 | |
Leishmania major | cathepsin L-like protease | 0.002 | 0.0019 | 0.0049 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.002 | 0.0019 | 0.0035 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.0019 | 0.0342 |
Trypanosoma brucei | protein kinase, putative | 0.0433 | 0.3765 | 1 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0078 | 0.0544 | 0.1037 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0433 | 0.3765 | 0.7183 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0287 | 0.2447 | 0.6499 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0433 | 0.3765 | 0.7183 |
Onchocerca volvulus | 0.0035 | 0.0158 | 0.0669 | |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0182 | 0.1487 | 0.2837 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0078 | 0.0544 | 0.1037 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0433 | 0.3765 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0078 | 0.0544 | 0.0611 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0199 | 0.1647 | 0.4374 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 0.052 | 0.0993 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0078 | 0.0544 | 0.1037 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0525 | 0.4598 | 0.8772 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0596 | 0.5242 | 1 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0019 | 0.0342 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0433 | 0.3765 | 0.7183 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.052 | 0.1382 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.052 | 0.1382 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0433 | 0.3765 | 0.7183 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.1113 | 0.1251 |
Echinococcus granulosus | phosphatidylinositol 3 kinase catalytic subunit | 0.0078 | 0.0544 | 0.0544 |
Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0019 | 0.0079 |
Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0019 | 0.0035 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0433 | 0.3765 | 0.3765 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0474 | 0.4139 | 0.7895 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0433 | 0.3765 | 0.7183 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0386 | 0.3339 | 0.3339 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0199 | 0.1647 | 0.3142 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0199 | 0.1647 | 0.3142 |
Leishmania major | cysteine peptidase A (CPA) | 0.002 | 0.0019 | 0.0049 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0596 | 0.5242 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0199 | 0.1647 | 0.3142 |
Trichomonas vaginalis | set domain proteins, putative | 0.0278 | 0.2366 | 0.4513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0059 | 0.0375 | 0.0715 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0158 | 0.0158 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0158 | 0.0158 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.052 | 0.1382 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0158 | 0.0302 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Echinococcus multilocularis | Zinc finger, PHD finger | 0.0078 | 0.0544 | 0.0544 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0078 | 0.0544 | 0.0544 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0999 | 0.8897 | 1 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.1743 | 0.1959 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0386 | 0.3339 | 0.3339 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0078 | 0.0544 | 0.1037 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0433 | 0.3765 | 1 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0078 | 0.0544 | 0.1037 |
Leishmania major | cathepsin L-like protease | 0.002 | 0.0019 | 0.0049 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0433 | 0.3765 | 0.3765 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.052 | 0.0993 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0199 | 0.1647 | 0.3142 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0199 | 0.1647 | 0.3142 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0019 | 0.0021 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0019 | 0.0021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0158 | 0.0158 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0433 | 0.3765 | 0.3765 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0158 | 0.2913 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.052 | 0.0993 |
Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0019 | 0.0021 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0596 | 0.5242 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.0147 | 0.0147 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.0019 | 0.0342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0182 | 0.1487 | 0.1672 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.3339 | 0.3753 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Leishmania major | cathepsin L-like protease | 0.002 | 0.0019 | 0.0049 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0433 | 0.3765 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0199 | 0.1647 | 0.3142 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0019 | 0.0019 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0433 | 0.3765 | 0.7183 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0409 | 0.355 | 0.6773 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0018 | 0.000000013333 | 0.000000013333 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.0019 | 0.0342 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Brugia malayi | MAP kinase sur-1 | 0.0433 | 0.3765 | 0.7183 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | fibroinase | 0.002 | 0.0019 | 0.0021 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0019 | 0.0035 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.052 | 0.0993 |
Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0019 | 0.0021 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.1113 | 0.1251 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.1113 | 0.2123 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0199 | 0.1647 | 0.1647 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0409 | 0.355 | 0.6773 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Onchocerca volvulus | 0.002 | 0.0019 | 0.0079 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0433 | 0.3765 | 0.3765 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0264 | 0.2236 | 0.4265 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0068 | 0.0461 | 0.088 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0245 | 0.2059 | 0.2315 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0078 | 0.0544 | 0.1444 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0433 | 0.3765 | 0.4232 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0078 | 0.0544 | 0.1444 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0019 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0019 | 0.0035 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.052 | 0.1382 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0596 | 0.5242 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0019 | 0.0035 |
Giardia lamblia | Phosphoinositide-3-kinase, class 3 | 0.0139 | 0.1103 | 0.293 |
Brugia malayi | Pre-SET motif family protein | 0.0245 | 0.2059 | 0.3928 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0158 | 0.0178 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0078 | 0.0544 | 0.0544 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.0078 | 0.0544 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0019 | 0.0035 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0158 | 0.0158 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.56 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 7 days by resazurin method | ChEMBL. | 24900646 |
Ratio (functional) | = 32 | Ratio of compound MIC to pyridomycin MIC for Mycobacterium tuberculosis H37Rv by resazurin method | ChEMBL. | 24900646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.