Detailed information for compound 1724622

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.964 | Formula: C23H15ClFN3O4S2
  • H donors: 1 H acceptors: 4 LogP: 5.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cc(ccc1Oc1ccc(c(c1)c1cccc(c1)OC)Cl)S(=O)(=O)Nc1ncc(s1)F
  • InChi: 1S/C23H15ClFN3O4S2/c1-31-16-4-2-3-14(9-16)19-11-17(5-7-20(19)24)32-21-8-6-18(10-15(21)12-26)34(29,30)28-23-27-13-22(25)33-23/h2-11,13H,1H3,(H,27,28)
  • InChiKey: KERXUBXOMSEYNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DnaJ domain-containing protein 0.0059 0.1063 0.1207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0592 0.1643
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.3178 0.3623
Trichomonas vaginalis glutaminase, putative 0.0265 0.5476 0.5451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1076 0.3002
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0592 0.0974
Loa Loa (eye worm) PXA domain-containing protein 0.0012 0.0055 0.0055
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.6072 1
Echinococcus granulosus dna polymerase kappa 0.0037 0.0592 0.1643
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.3178 0.8905
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0617 0.1761
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0165 0.3329 0.5483
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.5869 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0141 0.0377
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0672 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0141 0.0377
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0419 0.1259
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0124 0.2454 0.2796
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.1533 0.4286
Schistosoma mansoni alpha-glucosidase 0.0136 0.2706 0.4936
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0245
Loa Loa (eye worm) hypothetical protein 0.006 0.1076 0.1221
Schistosoma mansoni hypothetical protein 0.0059 0.1063 0.1932
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0502 0.1393
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0069 0.0025
Loa Loa (eye worm) hypothetical protein 0.0145 0.2896 0.3301
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0467 0.077
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0069 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3772 0.3737
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.1122 0.1274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.1533 0.2749
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0549 0.062
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.0014
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0178 0.0196
Mycobacterium ulcerans glutaminase 0.0265 0.5476 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.1107 0.3089
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.1122 0.1847
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1107 0.2012
Echinococcus granulosus expressed protein 0.0032 0.0484 0.134
Schistosoma mansoni phosphoglycerate kinase 0.0165 0.3329 0.6076
Loa Loa (eye worm) hypothetical protein 0.0145 0.2896 0.3301
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0484 0.0431
Brugia malayi Muscleblind-like protein 0.0145 0.2896 0.3301
Trichomonas vaginalis protein kinase inhibitor, putative 0.0059 0.1063 0.1014
Echinococcus granulosus sodium channel protein 0.0045 0.0762 0.2121
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.039 0.1069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Toxoplasma gondii hypothetical protein 0.0047 0.0802 0.2409
Loa Loa (eye worm) RecQ helicase 0.0044 0.0732 0.0829
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0165 0.3329 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0865 0.1425
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0055 0.0088
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0932 0.2599
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0061 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0901 0.1022
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1107 0.2012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.6072 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0038 0.0062
Loa Loa (eye worm) hypothetical protein 0.0134 0.2657 0.3028
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0762 0.2121
Loa Loa (eye worm) glutaminase 0.0265 0.5476 0.6248
Brugia malayi Augmenter of liver regeneration 0.0033 0.0502 0.0567
Echinococcus granulosus bloom syndrome protein 0.0044 0.0732 0.2037
Echinococcus granulosus regulator of G protein signaling 3 0.0012 0.0055 0.0135
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0178 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Leishmania major hypothetical protein, conserved 0.0033 0.0502 0.0827
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3772 0.3737
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0901 0.1022
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.1533 0.4542
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0932 0.1845
Schistosoma mansoni DNA helicase recq5 0.0018 0.0178 0.0314
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.1533 0.2791
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0541 0.0836
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0293 0.0239
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0165 0.3329 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0012 0.0055 0.0088
Brugia malayi regulator of G-protein signaling rgs-7 0.0012 0.0055 0.0055
Schistosoma mansoni phosphoglycerate kinase 0.0165 0.3329 0.6076
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1107 0.3089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Brugia malayi A-kinase anchor protein 10, precursor 0.0012 0.0055 0.0055
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0293 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Loa Loa (eye worm) hypothetical protein 0.0062 0.1122 0.1274
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.1533 0.2749
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Schistosoma mansoni glutaminase 0.0265 0.5476 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0484 0.0545
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0069 0.0071
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0541 0.0489
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0592 0.0974
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Trypanosoma brucei unspecified product 0.0026 0.0342 0.0564
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0541 0.0891
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0178 0.0426
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.1533 0.4604
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0732 0.2037
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1107 0.2012
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0342 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0541 0.0489
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0245
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0069 0.0063
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0541 0.1624
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.876 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.1533 0.4604
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0592 0.1018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0541 0.0611
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0055 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0038 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.5869 1
Echinococcus granulosus expressed protein 0.0012 0.0055 0.0135
Schistosoma mansoni rotamase 0.0032 0.0484 0.0873
Trypanosoma brucei phosphoglycerate kinase 0.0165 0.3329 0.5483
Chlamydia trachomatis phosphoglycerate kinase 0.0165 0.3329 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1076 0.1955
Brugia malayi DnaJ domain containing protein 0.0059 0.1063 0.1207
Toxoplasma gondii hypothetical protein 0.0028 0.039 0.117
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0061 0.01
Giardia lamblia DINP protein human, muc B family 0.0037 0.0592 0.095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.0762 0.1255
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0112 0.2188 0.6125
Brugia malayi Phosphoglycerate kinase 0.0061 0.1088 0.1236
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0055 0.0088
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0541 0.0489
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0055 0.0088
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2762 0.4549
Brugia malayi PXA domain containing protein 0.0012 0.0055 0.0055
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0467 0.077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.1028 0.2869
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0592 0.054
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0484 0.0545
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.5549 0.6331
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0055 0.0135
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0069 0.0113
Echinococcus multilocularis dnaJ subfamily C 6 0.0059 0.1063 0.2967
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0069 0.0113
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0502 0.1393
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.1533 0.4542
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Brugia malayi Phosphoglycerate kinase 0.0165 0.3329 0.3796
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Echinococcus multilocularis regulator of G protein signaling 3 0.0012 0.0055 0.0135
Loa Loa (eye worm) RGS-3 protein 0.0012 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1076 0.1955
Echinococcus multilocularis muscleblind protein 0.0145 0.2896 0.8114
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0541 0.0489
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0732 0.0829
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.3178 0.3623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0012 0.0055 0.0088
Giardia lamblia Phosphoglycerate kinase 0.0165 0.3329 0.5645
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0124 0.2454 0.2796
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0502 0.0827
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0038 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Trypanosoma brucei phosphoglycerate kinase 0.0165 0.3329 0.5483
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0502 0.1411
Echinococcus multilocularis muscleblind protein 1 0.0145 0.2896 0.8114
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0592 0.1643
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.6072 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0541 0.0489
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0178 0.0482
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.2762 0.4549
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0055 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0038 0.0062
Brugia malayi regulator of G-protein signaling egl-10 0.0012 0.0055 0.0055
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0427 0.1181
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0165 0.3329 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0141 0.0377
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0055 0.0135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0141 0.0153
Brugia malayi Regulator of G protein signaling domain containing protein 0.0012 0.0055 0.0055
Schistosoma mansoni DNA polymerase eta 0.0062 0.1122 0.2039
Loa Loa (eye worm) glutaminase 2 0.0265 0.5476 0.6248
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0502 0.1509
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0038 0.0062
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.3178 0.8905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0901 0.1022
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0245
Echinococcus multilocularis phosphoglycerate kinase 1 0.0165 0.3329 0.933
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0932 0.2599
Echinococcus granulosus dnaJ subfamily C 6 0.0059 0.1063 0.2967
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0467 0.077
Echinococcus granulosus Regulator of G protein signaling 20 0.0012 0.0055 0.0135
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0534 0.0964
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.2454 0.4475
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0293 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Brugia malayi polk-prov protein 0.0012 0.0038 0.0036
Leishmania major DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1107 0.1257
Schistosoma mansoni hypothetical protein 0.0176 0.3568 0.6512
Schistosoma mansoni hypothetical protein 0.0035 0.0549 0.0992
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0055 0.0135
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0592 0.1018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0549 0.062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1076 0.1955
Echinococcus multilocularis beta adrenergic receptor kinase 0.0013 0.0061 0.0153
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0112 0.2188 0.2492
Echinococcus granulosus muscleblind protein 0.0145 0.2896 0.8114
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.1533 0.4286
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0541 0.0489
Loa Loa (eye worm) hypothetical protein 0.0016 0.0141 0.0153
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0055 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.5549 0.6331
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0055 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0038 0.0062
Schistosoma mansoni alpha glucosidase 0.0035 0.0541 0.0977
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.2759 0.806
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0165 0.3329 0.3293
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0038 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1076 0.1955
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0178 0.0482
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0932 0.1243
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0502 0.0567
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0502 0.1411
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0541 0.0891
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.0014
Brugia malayi glutaminase DH11.1 0.0265 0.5476 0.6248
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0672 0.1107
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0038 0.0062
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0672 0.1107
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0178 0.0535
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.0014
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0012 0.0055 0.0088
Trypanosoma brucei unspecified product 0.0037 0.0592 0.0974
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.5869 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.6072 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0592 0.107
Onchocerca volvulus 0.006 0.1076 0.107
Schistosoma mansoni hypothetical protein 0.0176 0.3568 0.6512
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0592 0.1643
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1107 0.1257
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1107 0.2012
Plasmodium vivax phosphoglycerate kinase, putative 0.0165 0.3329 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0502 0.0827
Trichomonas vaginalis rotamase, putative 0.0032 0.0484 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0932 0.1243
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0467 0.071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1076 0.3002
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0541 0.0891
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0293 0.0482
Echinococcus granulosus phosphoglycerate kinase 1 0.0165 0.3329 0.933
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.1533 0.2086
Echinococcus multilocularis Regulator of G protein signaling 20 0.0012 0.0055 0.0135
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0165 0.3329 0.3293
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0112 0.2188 0.6125
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0541 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0342 0.0564
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0069 0.0113
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0178 0.024
Leishmania major phosphoglycerate kinase B, cytosolic 0.0165 0.3329 0.5483
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.2759 0.5004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0178 0.0196
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0069 0.0014
Echinococcus multilocularis regulator of G protein signaling 0.0012 0.0055 0.0135
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0592 0.0669
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.1533 0.3889
Loa Loa (eye worm) RNA binding protein 0.0061 0.1107 0.1257
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0141 0.0377
Echinococcus multilocularis expressed protein 0.0012 0.0055 0.0135
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0541 0.0489
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0055 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0165 0.3329 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.1088 0.1793
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1107 0.2012
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0038 0.0058
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0541 0.1501
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0592 0.107
Echinococcus granulosus GPCR family 2 0.0016 0.0141 0.0377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1076 0.3002
Echinococcus multilocularis sodium channel protein 0.0045 0.0762 0.2121
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0502 0.0827
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0141 0.0377
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0038 0.0062
Echinococcus granulosus beta-adrenergic receptor kinase 0.0013 0.0061 0.0153
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0055 0.0135
Loa Loa (eye worm) hypothetical protein 0.0081 0.1533 0.1744
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0165 0.3329 0.5483
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0568 0.0935
Echinococcus multilocularis dna polymerase eta 0.0062 0.1122 0.3131
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0541 0.0489
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0069 0.0014
Echinococcus multilocularis regulator of G protein signaling 3 0.0012 0.0055 0.0135
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.3568 0.3564
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.1122 0.1847
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0178 0.0196
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0055 0.0088
Echinococcus granulosus regulator of G protein signaling 3 0.0012 0.0055 0.0135
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0038 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0592 0.0974
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.2759 0.7916
Brugia malayi Pre-SET motif family protein 0.0418 0.876 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0165 0.3329 0.5632
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Brugia malayi hypothetical protein 0.0012 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0165 0.3329 0.3796
Leishmania major phosphoglycerate kinase C, glycosomal 0.0165 0.3329 0.5483
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0038 0.0114
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0732 0.0681
Brugia malayi TAR-binding protein 0.0061 0.1107 0.1257
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0592 0.0974
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0178 0.0482
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0038 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.3098 0.9156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0541 0.0836
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0055 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0038 0.0062
Trypanosoma brucei glucosidase, putative 0.0035 0.0541 0.0891
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0012 0.0055 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0069 0.0014
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0055 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0592 0.0669
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0178 0.0482
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0502 0.0827
Brugia malayi Regulator of G protein signaling domain containing protein 0.0012 0.0055 0.0055
Brugia malayi Pre-SET motif family protein 0.006 0.1076 0.1221
Echinococcus multilocularis expressed protein 0.0032 0.0484 0.134
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0568 0.1706
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0069 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0055
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0592 0.0924
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.1088 0.1793
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5549 0.5524
Leishmania major DNA polymerase eta, putative 0.0062 0.1122 0.1847
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0342 0.0564
Brugia malayi Probable ClpP-like protease 0.0081 0.1533 0.1744
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0293 0.0482
Brugia malayi PXA domain containing protein 0.0012 0.0055 0.0055
Schistosoma mansoni DNA helicase recq1 0.0018 0.0178 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3568 0.3533
Plasmodium falciparum phosphoglycerate kinase 0.0165 0.3329 1
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0245
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0541 0.0611
Leishmania major DNA polymerase eta, putative 0.0036 0.0568 0.0935
Schistosoma mansoni z-protein (S1r protein) 0.0012 0.0055 0.0088
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0112 0.2188 0.2492
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.3178 0.8905
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0165 0.3329 1
Echinococcus multilocularis geminin 0.0176 0.3568 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Leishmania major DNA damage repair protein, putative 0.0012 0.0038 0.0062
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0012 0.0055 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5869 0.5846
Echinococcus granulosus geminin 0.0176 0.3568 1
Brugia malayi hypothetical protein 0.0012 0.0055 0.0055
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0502 0.1509
Trichomonas vaginalis rotamase, putative 0.0032 0.0467 0.0415
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0141 0.0153
Schistosoma mansoni alpha-glucosidase 0.0136 0.2706 0.4936
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0013 0.0061 0.0062
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.5869 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1076 0.323
Plasmodium vivax SET domain protein, putative 0.006 0.1076 0.3152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0071
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1107 0.1257
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0672 0.1107
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0467 0.077
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0732 0.0681
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0178 0.0535
Trypanosoma brucei unspecified product 0.0026 0.0342 0.0564
Brugia malayi RNA binding protein 0.0061 0.1107 0.1257
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0141 0.0153
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0112 0.2188 0.2492
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0592 0.0974
Echinococcus granulosus dna polymerase eta 0.0062 0.1122 0.3131
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0592 0.054
Onchocerca volvulus 0.0091 0.1749 0.1744
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0012 0.0055 0.0135
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0467 0.1403
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2762 0.4549
Leishmania major DNA polymerase kappa, putative 0.0012 0.0038 0.0062
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.1533 0.4604
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0541 0.1501
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.1088 0.1793
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.039 0.1069
Mycobacterium ulcerans hypothetical protein 0.0154 0.3098 0.5628
Mycobacterium ulcerans phosphoglycerate kinase 0.0165 0.3329 0.6053
Treponema pallidum phosphoglycerate kinase 0.0165 0.3329 0.5365
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0901 0.1022

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.9586 Inhibition of NaV1.7 ion channel (unknown origin) ChEMBL. 23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.