Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase | 0.0109 | 0.3849 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0865 | 0.0865 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1352 | 0.3514 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0109 | 0.3849 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0109 | 0.3849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0865 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1352 | 0.3514 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1352 | 0.1352 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0865 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0865 | 0.0865 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0109 | 0.3849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Onchocerca volvulus | 0.0038 | 0.0865 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0109 | 0.3849 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0865 | 0.2248 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1352 | 0.1352 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0109 | 0.3849 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1352 | 0.3514 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1352 | 0.3514 |
Trypanosoma brucei | protein kinase, putative | 0.0109 | 0.3849 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0865 | 0.0865 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1352 | 0.3514 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1352 | 0.3514 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 0.3849 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0865 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.3849 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0109 | 0.3849 | 0.3849 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0865 | 0.2248 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0865 | 0.5 |
Onchocerca volvulus | 0.0038 | 0.0865 | 0.5 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0865 | 0.2248 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0109 | 0.3849 | 0.3849 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1352 | 0.3514 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0109 | 0.3849 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0109 | 0.3849 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0109 | 0.3849 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.3849 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.9468 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.3849 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0865 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0865 | 0.0865 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0865 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0865 | 0.0865 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0109 | 0.3849 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0109 | 0.3849 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0865 | 0.0865 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.3849 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0109 | 0.3849 | 1 |
Onchocerca volvulus | 0.0038 | 0.0865 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0109 | 0.3849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0865 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0865 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0865 | 0.2248 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0865 | 0.0865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10000 nM | Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay | ChEMBL. | 23470139 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23470139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.