Detailed information for compound 1725464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.569 | Formula: C27H24N4O3S
  • H donors: 1 H acceptors: 5 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)CS(=O)(=O)NC(c1ccccc1)C
  • InChi: 1S/C27H24N4O3S/c1-18(20-6-4-3-5-7-20)30-35(33,34)17-19-8-9-21-10-11-26-25(27(32)24(21)12-19)13-22(14-28-26)23-15-29-31(2)16-23/h3-16,18,30H,17H2,1-2H3
  • InChiKey: UVVNHLGXPBGUMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.127 0.4644
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0166 0.0842
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0414 0.066
Echinococcus granulosus dna polymerase eta 0.0021 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.127 0.127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.4257 0.6695
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0128 0.0128
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0241 0.0241
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0241 0.0241
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0128 0.0128
Mycobacterium ulcerans lipase LipD 0.0039 0.0643 0.1885
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Echinococcus granulosus lamin 0.0029 0.0414 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Onchocerca volvulus 0.0039 0.0643 0.1106
Onchocerca volvulus 0.0036 0.0575 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0241 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0241 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0169 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2486 0.3797
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0096
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0128 0.0128
Onchocerca volvulus 0.0031 0.0452 0.0603
Brugia malayi 6-phosphofructokinase 0.0117 0.2486 0.396
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Leishmania major cathepsin L-like protease 0.0036 0.0575 0.1585
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0575 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.2486 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.001 0.0016
Onchocerca volvulus 0.0039 0.0643 0.1106
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0241 0.0383
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0475 0.3038
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.1587 0.1587
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus phd:f box containing protein 0.0017 0.0128 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0241 0.0241
Schistosoma mansoni tyrosine kinase 0.0047 0.0844 0.0844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Brugia malayi nuclear hormone receptor 0.0022 0.0241 0.0383
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.2486 0.2486
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0177 0.3898 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0414 0.066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Mycobacterium tuberculosis Conserved protein 0.0039 0.0643 0.0801
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0241 0.0241
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0166 0.053
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0125 0.267 0.905
Schistosoma mansoni lamin 0.0029 0.0414 0.0414
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0215 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0215 0.0343
Trichomonas vaginalis esterase, putative 0.0039 0.0643 0.0781
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.3165 0.5042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0241 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0241 0.0241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0575 0.0917
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0296 0.0472
Schistosoma mansoni tyrosine kinase 0.0077 0.1544 0.1544
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0241 0.0241
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Schistosoma mansoni hypothetical protein 0.0363 0.828 0.828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0223 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2949 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0241 0.0241
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.2486 0.2486
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.127 0.127
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Schistosoma mansoni cpg binding protein 0.0032 0.0493 0.0493
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.1587 0.1587
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0097 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0698
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0475 0.7754
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.1587 0.1587
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.1263 0.2011
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0643 0.0801
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0215 0.0343
Leishmania major cathepsin L-like protease 0.0136 0.2949 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0215 0.0081
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.127 0.4644
Brugia malayi plexin A 0.0025 0.0313 0.0498
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0241 0.0241
Mycobacterium tuberculosis Conserved protein 0.0039 0.0643 0.0801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0475 0.0828
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0166 0.053
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0012 0.001 0.0016
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0128 0.0128
Leishmania major cathepsin L-like protease 0.0036 0.0575 0.1585
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0241 0.0383
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2486 0.3797
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0475 0.3038
Onchocerca volvulus 0.0029 0.0414 0.0504
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0128 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0241 0.0241
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0643 0.0801
Onchocerca volvulus 0.0089 0.1838 0.4248
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Mycobacterium tuberculosis Conserved protein 0.0039 0.0643 0.0801
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0241 0.0241
Leishmania major cathepsin L-like protease 0.0036 0.0575 0.1585
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0643 0.0801
Mycobacterium ulcerans beta-lactamase 0.0039 0.0643 0.1885
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0166 0.0166
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Schistosoma mansoni intermediate filament proteins 0.0029 0.0414 0.0414
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0215 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0166 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0241 0.0383
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.127 0.4046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1097 0.8484
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.127 0.4644
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.2486 0.396
Onchocerca volvulus 0.0036 0.0575 0.0928
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2486 0.6217
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0575 0.0575
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0643 0.0801
Entamoeba histolytica cysteine protease, putative 0.0036 0.0575 0.1098
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0575 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0296 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0343
Onchocerca volvulus 0.0024 0.0296 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.4257 0.6695
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.3165 0.3165
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Plasmodium vivax vivapain-1 0.0018 0.0166 0.2462
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0643 0.1025
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.226 0.7656
Onchocerca volvulus 0.0036 0.0575 0.0928
Echinococcus multilocularis dna polymerase eta 0.0021 0.0215 0.0215
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0128 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0643 0.2155
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Toxoplasma gondii cathepsin CPL 0.0036 0.0575 0.3918
Schistosoma mansoni DNA polymerase eta 0.0021 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0241 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0575 0.067
Schistosoma mansoni hypothetical protein 0.0363 0.828 0.828
Mycobacterium ulcerans hypothetical protein 0.0039 0.0643 0.1885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0097 0.0154
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2486 0.6217
Leishmania major cathepsin L-like protease 0.0036 0.0575 0.1585
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0061 0.0061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0241 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.126 0.126
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0166 0.0264
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0128 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0215 0.0343
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0575 0.0575
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0414 0.066
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0643 0.0643
Toxoplasma gondii ABC1 family protein 0.0039 0.0643 0.4512
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0241 0.0241
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.3165 0.5042
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0323 0.0896
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.2486 0.396
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.1838 0.2928
Schistosoma mansoni cpg binding protein 0.0031 0.0452 0.0452
Schistosoma mansoni tyrosine kinase 0.0079 0.1587 0.1587
Mycobacterium leprae Probable lipase LipE 0.0039 0.0643 0.1479
Loa Loa (eye worm) hypothetical protein 0.0029 0.0414 0.066
Schistosoma mansoni lamin 0.0029 0.0414 0.0414
Onchocerca volvulus 0.0022 0.0241 0.0047
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.1838 0.1838
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.1221 0.1221
Plasmodium vivax vivapain-2 0.0036 0.0575 0.8929
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0575 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Leishmania major cathepsin L-like protease 0.0136 0.2949 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0643 0.0781
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0241 0.0383
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2486 0.6217
Echinococcus multilocularis plexin a4 0.0025 0.0313 0.0313
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0241 0.0241
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.2486 0.4247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0323 0.4949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0166 0.035
Echinococcus multilocularis cathepsin L 0.0018 0.0166 0.0166
Echinococcus granulosus cpg binding protein 0.0032 0.0493 0.0493
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0166 0.053
Brugia malayi jmjC domain containing protein 0.0063 0.1221 0.1946
Leishmania major cathepsin L-like protease 0.0136 0.2949 1
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0844 0.0844
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0128 0.0402
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0128 0.0128
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.3165 0.3165
Echinococcus multilocularis cpg binding protein 0.0032 0.0493 0.0493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0241 0.0241
Plasmodium vivax unspecified product 0.0018 0.0166 0.2462
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0575 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0475 0.7343
Echinococcus granulosus cathepsin l1 0.0024 0.0296 0.0296
Brugia malayi steroid hormone receptor 0.0022 0.0241 0.0383
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0575 0.0917
Onchocerca volvulus Glucosylceramidase homolog 0.0182 0.4026 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0241 0.0241
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0215 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0241 0.0383
Loa Loa (eye worm) cysteine protease 0.0036 0.0575 0.0917
Echinococcus granulosus geminin 0.0363 0.828 0.828
Echinococcus multilocularis insulin receptor 0.0047 0.0844 0.0844
Onchocerca volvulus 0.0036 0.0575 0.0928
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Echinococcus granulosus plexin a4 0.0025 0.0313 0.0313
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0166 0.0166
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0475 0.0506
Onchocerca volvulus 0.0039 0.0643 0.1106
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0204
Loa Loa (eye worm) hypothetical protein 0.0028 0.0402 0.064
Loa Loa (eye worm) beta-lactamase 0.0039 0.0643 0.1025
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0296 0.0349
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.1221 0.1221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus lamin dm0 0.0029 0.0414 0.0414
Brugia malayi ecdysteroid receptor 0.0022 0.0241 0.0383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus multilocularis cysteine protease 0.0036 0.0575 0.0575
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0575 0.0928
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0698
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0166 0.035
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0204
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0323 0.0477
Schistosoma mansoni tyrosine kinase 0.0146 0.3165 0.3165
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0643 0.0781
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0128 0.0128
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0169 0.0169
Brugia malayi Protein kinase domain containing protein 0.0047 0.0844 0.1345
Schistosoma mansoni jumonji domain containing protein 0.0063 0.1221 0.1221
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.1838 0.1838
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0323 0.0202
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0241 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0643 0.2005
Echinococcus granulosus cathepsin l1 0.0036 0.0575 0.0575
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0215 0.0521
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2949 1
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2486 0.3797
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0241 0.0241
Brugia malayi jmjC domain containing protein 0.0065 0.1263 0.2011
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0575 0.0928
Plasmodium vivax JmjC domain containing protein 0.0017 0.0128 0.1867
Echinococcus multilocularis geminin 0.0363 0.828 0.828
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.2486 0.2486
Echinococcus multilocularis cysteine protease 0.0036 0.0575 0.0575
Leishmania major DNA polymerase eta, putative 0.0021 0.0215 0.0308
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0215 0.0698
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0215 0.0215
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0241 0.0241
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0204
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0241 0.0241
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0128 0.022
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0323 0.0477
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0215 0.0215
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0323 0.4364
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.2486 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0241 0.0383
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.5561 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0643 0.0643
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0521
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.1221 0.1221
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Echinococcus granulosus cathepsin L 0.0018 0.0166 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0204
Loa Loa (eye worm) plexin A 0.0025 0.0313 0.0498
Echinococcus multilocularis 0.0045 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0472
Leishmania major cathepsin L-like protease 0.0036 0.0575 0.1585
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0698
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0215 0.0132
Leishmania major hypothetical protein, conserved 0.0039 0.0643 0.1826
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0475 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0452 0.072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0241 0.0383
Loa Loa (eye worm) ctsf protein 0.0036 0.0575 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0177 0.3898 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.001 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0241 0.0383
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0575 0.1924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0241 0.0241
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0241 0.0241
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0643 0.0801
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0575 0.0575
Echinococcus granulosus intermediate filament protein 0.0029 0.0414 0.0414
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0323 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0296 0.0213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0521
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0166 0.053
Brugia malayi Cathepsin L-like precursor 0.0024 0.0296 0.0472
Plasmodium vivax vivapain-3 0.0018 0.0166 0.2462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0204
Onchocerca volvulus 0.0036 0.0575 0.0928
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0643 0.0801
Brugia malayi beta-lactamase 0.0039 0.0643 0.1025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0241 0.0383
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1263 0.1263
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0241 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.6277 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Echinococcus multilocularis lamin 0.0029 0.0414 0.0414
Trypanosoma brucei unspecified product 0.0021 0.0215 0.0521
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0475 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0475 0.7343
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.2949 1
Loa Loa (eye worm) phosphofructokinase 0.0117 0.2486 0.396
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0575 0.0917
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0241 0.0241
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0241 0.0047
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.127 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.1838 0.1838
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.2486 1
Schistosoma mansoni plexin 0.0021 0.0223 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0575 0.067
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.2486 0.2486
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0128 0.0402
Loa Loa (eye worm) hypothetical protein 0.0089 0.1838 0.2928
Brugia malayi intermediate filament protein 0.0029 0.0414 0.066
Echinococcus granulosus cysteine protease 0.0018 0.0166 0.0166
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0643 0.1479
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Schistosoma mansoni tyrosine kinase 0.0077 0.1544 0.1544
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0241 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Echinococcus multilocularis musashi 0.0029 0.0414 0.0414
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0475 0.3038
Leishmania major DNA polymerase kappa, putative 0.0021 0.0215 0.0308
Schistosoma mansoni tyrosine kinase 0.0047 0.0844 0.0844
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0241 0.0383
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.127 0.127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Brugia malayi beta-lactamase family protein 0.0039 0.0643 0.1025
Loa Loa (eye worm) fibroinase 0.0036 0.0575 0.0917
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0241 0.0241
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1263 0.1263
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0643 0.0781
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2949 1
Onchocerca volvulus 0.0036 0.0575 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0241 0.0383
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0575 0.1098
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0475 1
Schistosoma mansoni cpg binding protein 0.0032 0.0493 0.0493
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0128 0.0128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0643 0.1025
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0475 0.0701
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0241 0.0241
Brugia malayi Cathepsin L-like precursor 0.0036 0.0575 0.0917
Brugia malayi phosphofructokinase 0.0117 0.2486 0.396
Brugia malayi Plexin repeat family protein 0.0021 0.0223 0.0354
Schistosoma mansoni tyrosine kinase 0.0079 0.1587 0.1587
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0241 0.0383
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0475 0.7754
Brugia malayi cathepsin L-like precursor 0.0024 0.0296 0.0472
Brugia malayi beta-lactamase family protein 0.0039 0.0643 0.1025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0241 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0241 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.127 0.127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0241 0.0383
Loa Loa (eye worm) hypothetical protein 0.0177 0.3898 0.6209
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0575 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2486 0.3797
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0643 0.2155
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0323 0.171
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0575 0.0575
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.127 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0241 0.0383
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0521
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.2486 0.8423
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Onchocerca volvulus 0.0029 0.0414 0.0504
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Echinococcus multilocularis lamin dm0 0.0029 0.0414 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Echinococcus granulosus dna polymerase kappa 0.0021 0.0215 0.0215
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0643 0.1885
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0643 0.0781
Schistosoma mansoni cathepsin s 0.0012 0.001 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0166 0.0264
Brugia malayi 6-phosphofructokinase 0.0117 0.2486 0.396
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0475 0.0506
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0241 0.0241
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0166 0.0166
Plasmodium vivax vivapain-2 0.0036 0.0575 0.8929
Entamoeba histolytica hypothetical protein 0.0025 0.0323 0.0422
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0241 0.0047
Onchocerca volvulus 0.0036 0.0575 0.0928
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.6277 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.4026 0.6316
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.6277 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.2486 0.8393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0643 0.1025
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0643 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0166 0.053
Echinococcus granulosus insulin receptor 0.0047 0.0844 0.0844
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0643 0.1885
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0575 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0241 0.0383
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0575 1
Schistosoma mansoni coup transcription factor 0.0022 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0241 0.0383
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0241 0.0383
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0323 0.0692
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0323 0.171
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.1263 0.1263
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0575 0.0575
Brugia malayi Cathepsin L-like precursor 0.0024 0.0296 0.0472
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.2486 0.8357
Schistosoma mansoni tyrosine kinase 0.0077 0.1544 0.1544
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0575 0.0917
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0241 0.0383
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0241 0.0241
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0296 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0643 0.0781
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0844 0.1345
Loa Loa (eye worm) hypothetical protein 0.0022 0.0241 0.0383
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0241 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0521
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0844 0.0844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0575 0.067
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0128 0.0128
Schistosoma mansoni plexin 0.0012 0.0017 0.0017
Brugia malayi CXXC zinc finger family protein 0.0031 0.0452 0.072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0472
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0643 0.0801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2949 1
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0575 0.1585
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0575 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0241 0.0383

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 52 nM Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay ChEMBL. 23379595
Inhibition (ADMET) Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate at 10 uM by LC-MS-MS analysis relative to control ChEMBL. 23379595
TDI (ADMET) Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate at 10 uM preincubated for 30 mins by LC-MS-MS analysis relative to control ChEMBL. 23379595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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