Detailed information for compound 1725473

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 502.954 | Formula: C20H15ClN6O4S2
  • H donors: 2 H acceptors: 7 LogP: 2.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCn1nccc1c1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1
  • InChi: 1S/C20H15ClN6O4S2/c21-14-1-3-19(16(10-14)17-5-6-24-27(17)7-8-28)31-18-4-2-15(9-13(18)11-22)33(29,30)26-20-23-12-25-32-20/h1-6,9-10,12,28H,7-8H2,(H,23,25,26)
  • InChiKey: FOCAMJUMUILVSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0603 0.0958
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.2509 0.3988
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0269 0.0664
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0503 0.3038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0269 0.0427
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0194 0.053
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.067 0.0781
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0269 0.0269
Brugia malayi jmjC domain containing protein 0.0016 0.0157 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0603 0.067
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.067 0.1886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0324 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Leishmania major cathepsin L-like protease 0.0129 0.297 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0269 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Brugia malayi 6-phosphofructokinase 0.011 0.2509 0.3988
Echinococcus multilocularis cathepsin L 0.0017 0.0194 0.0194
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0194 0.084
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0351 0.0692
Plasmodium vivax JmjC domain containing protein 0.0016 0.0157 0.1868
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1295 0.1295
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Toxoplasma gondii ABC1 family protein 0.0037 0.067 0.4512
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Echinococcus multilocularis cpg binding protein 0.003 0.052 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0046
Onchocerca volvulus 0.0034 0.0603 0.149
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0503 0.7343
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.067 0.0801
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0157 0.0249
Brugia malayi jmjC domain containing protein 0.0016 0.0157 0.0249
Schistosoma mansoni intermediate filament proteins 0.0027 0.0442 0.0442
Brugia malayi nuclear hormone receptor 0.002 0.0269 0.0427
Schistosoma mansoni hypothetical protein 0.0342 0.8287 0.8287
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0351 0.171
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0269 0.0427
Trichomonas vaginalis esterase, putative 0.0037 0.067 0.0781
Onchocerca volvulus 0.002 0.0269 0.0664
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0157 0.022
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0503 0.3038
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0039 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0269 0.0269
Loa Loa (eye worm) phosphofructokinase 0.011 0.2509 0.3988
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0194 0.0194
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0351 0.0897
Loa Loa (eye worm) hypothetical protein 0.0023 0.0324 0.0515
Schistosoma mansoni cathepsin s 0.0011 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1295 0.4047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0503 0.3038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0269 0.0427
Brugia malayi Cathepsin L-like precursor 0.0023 0.0324 0.0515
Brugia malayi beta-lactamase 0.0037 0.067 0.1066
Schistosoma mansoni cpg binding protein 0.003 0.052 0.052
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0157 0.0157
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0603 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Mycobacterium tuberculosis Conserved protein 0.0037 0.067 0.0801
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0269 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0194 0.0351
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0269 0.0664
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0194 0.053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0122
Schistosoma mansoni thyroid hormone receptor 0.002 0.0269 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0157 0.0157
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0503 0.7343
Echinococcus multilocularis lamin dm0 0.0027 0.0442 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Schistosoma mansoni coup transcription factor 0.002 0.0269 0.0269
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.2509 0.8425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.5576 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0243 0.0387
Onchocerca volvulus 0.0037 0.067 0.1658
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.067 0.067
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0269 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0269 0.0427
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2509 0.3797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0324 0.0515
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1295 0.1295
Loa Loa (eye worm) ctsf protein 0.0034 0.0603 0.0958
Leishmania major DNA polymerase eta, putative 0.0019 0.0243 0.0308
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.067 0.0801
Brugia malayi jmjC domain containing protein 0.0016 0.0157 0.0249
Brugia malayi steroid hormone receptor 0.002 0.0269 0.0427
Echinococcus granulosus cathepsin l1 0.0023 0.0324 0.0324
Schistosoma mansoni DNA polymerase eta 0.0019 0.0243 0.0243
Onchocerca volvulus 0.0034 0.0603 0.149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0269 0.0427
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0503 0.0701
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Onchocerca volvulus 0.0034 0.0603 0.149
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1862 0.2961
Mycobacterium ulcerans beta-lactamase 0.0037 0.067 0.1886
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0125 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0324 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1295 0.4645
Echinococcus granulosus lamin dm0 0.0027 0.0442 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0269 0.0427
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0194 0.0309
Loa Loa (eye worm) hypothetical protein 0.0016 0.0157 0.0249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1295 0.4645
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0269 0.0427
Leishmania major cathepsin L-like protease 0.0129 0.297 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2509 0.3797
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0269 0.0427
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.1247 0.1247
Echinococcus granulosus phd:f box containing protein 0.0016 0.0157 0.0157
Schistosoma mansoni 6-phosphofructokinase 0.011 0.2509 0.2509
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2509 0.3797
Brugia malayi Cathepsin L-like precursor 0.0011 0.0039 0.0061
Onchocerca volvulus 0.0029 0.0479 0.1184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0269 0.0427
Schistosoma mansoni lamin 0.0027 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0503 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0269 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1295 0.1295
Loa Loa (eye worm) cysteine protease 0.0034 0.0603 0.0958
Entamoeba histolytica hypothetical protein 0.0024 0.0351 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0269 0.0427
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0503 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0269 0.0269
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2509 0.6218
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0351 0.171
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0603 0.149
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.4045 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0157 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.297 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0269 0.0427
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.297 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0243 0.0243
Leishmania major cathepsin L-like protease 0.0034 0.0603 0.1585
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.629 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1285 0.1285
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0157 0.0157
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0157 0.0249
Mycobacterium leprae conserved hypothetical protein 0.0037 0.067 0.1479
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.2509 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Brugia malayi intermediate filament protein 0.0027 0.0442 0.0703
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0603 0.1585
Echinococcus multilocularis lamin 0.0027 0.0442 0.0442
Brugia malayi nuclear receptor RXR 0.0011 0.0029 0.0046
Onchocerca volvulus 0.0027 0.0442 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0324 0.0213
Brugia malayi CXXC zinc finger family protein 0.0029 0.0479 0.0762
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0194 0.053
Echinococcus granulosus cpg binding protein 0.003 0.052 0.052
Echinococcus granulosus FTZ F1 alpha 0.002 0.0269 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Brugia malayi beta-lactamase family protein 0.0037 0.067 0.1066
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.1288 0.1288
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0243 0.0387
Brugia malayi cathepsin L-like precursor 0.0023 0.0324 0.0515
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.067 0.067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0269 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Plasmodium vivax vivapain-2 0.0034 0.0603 0.8927
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0269 0.0427
Leishmania major cathepsin L-like protease 0.0034 0.0603 0.1585
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0269 0.0427
Onchocerca volvulus 0.0037 0.067 0.1658
Loa Loa (eye worm) hypothetical protein 0.0013 0.0089 0.0142
Onchocerca volvulus 0.0023 0.0324 0.0801
Brugia malayi jmjC domain containing protein 0.0061 0.1288 0.2048
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1295 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0027 0.043 0.0683
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.2509 0.2509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0194 0.0194
Echinococcus multilocularis musashi 0.0027 0.0442 0.0442
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.089 0.089
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0351 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Echinococcus multilocularis sodium channel protein 0.0045 0.089 0.089
Onchocerca volvulus 0.0034 0.0603 0.149
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0243 0.0081
Schistosoma mansoni 6-phosphofructokinase 0.011 0.2509 0.2509
Brugia malayi 6-phosphofructokinase 0.011 0.2509 0.3988
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Brugia malayi beta-lactamase family protein 0.0037 0.067 0.1066
Echinococcus granulosus intermediate filament protein 0.0027 0.0442 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.067 0.2155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0269 0.0427
Onchocerca volvulus 0.0034 0.0603 0.149
Echinococcus granulosus lamin 0.0027 0.0442 0.0442
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.4275 0.6695
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0269 0.0269
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0157 0.0157
Brugia malayi hypothetical protein 0.0011 0.0029 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0157 0.0249
Onchocerca volvulus 0.0084 0.1862 0.4605
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0243 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0269 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0603 0.0603
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0269 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0084 0.1862 0.2961
Echinococcus multilocularis cysteine protease 0.0034 0.0603 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.297 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1862 0.1862
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0194 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0269 0.0269
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0243 0.0387
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0603 0.0603
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.089 0.2605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0324 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0603 0.1924
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2509 0.6218
Plasmodium vivax vivapain-3 0.0017 0.0194 0.2461
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0125 0.0199
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0269 0.0427
Echinococcus multilocularis dna polymerase eta 0.0019 0.0243 0.0243
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0503 0.7757
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0351 0.0203
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.2692 0.905
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.067 0.1066
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0603 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0603 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0269 0.0427
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0194 0.0309
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0167 0.3916 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0269 0.0269
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0037 0.067 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1288 0.1288
Echinococcus granulosus geminin 0.0342 0.8287 0.8287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0157 0.0249
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0603 0.149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0039 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0442 0.0703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0046
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Leishmania major cathepsin L-like protease 0.0034 0.0603 0.1585
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Toxoplasma gondii cathepsin CPL 0.0034 0.0603 0.3916
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.067 0.1886
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1122 0.8479
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.1247 0.1247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0603 0.0603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0698
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.067 0.2006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Schistosoma mansoni jumonji domain containing protein 0.006 0.1247 0.1247
Schistosoma mansoni hypothetical protein 0.0342 0.8287 0.8287
Leishmania major hypothetical protein, conserved 0.0037 0.067 0.1826
Onchocerca volvulus 0.0027 0.0442 0.1093
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0269 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.4275 0.6695
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0243 0.0132
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0157 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1288 0.2048
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.2509 0.8395
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0269 0.0664
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.067 0.0801
Brugia malayi jmjC domain containing protein 0.0016 0.0157 0.0249
Leishmania major ATP-dependent phosphofructokinase 0.011 0.2509 0.8359
Echinococcus granulosus cysteine protease 0.0017 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0269 0.0427
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0269 0.0269
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.067 0.0781
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0029 0.0046
Onchocerca volvulus 0.0034 0.0603 0.149
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0603 0.0958
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0061
Loa Loa (eye worm) beta-lactamase 0.0037 0.067 0.1066
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0269 0.0269
Schistosoma mansoni cpg binding protein 0.003 0.052 0.052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1295 0.1973
Brugia malayi nuclear receptor NHR-88 0.002 0.0269 0.0427
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0503 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2509 0.3797
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0157 0.0157
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0351 0.0477
Loa Loa (eye worm) hypothetical protein 0.0016 0.0157 0.0249
Echinococcus granulosus cathepsin l1 0.0034 0.0603 0.0603
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0269 0.0427
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0442 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0194 0.0351
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0603 0.0603
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0269 0.0269
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0503 0.7757
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0243 0.0698
Brugia malayi jmjC domain containing protein 0.006 0.1247 0.1983
Echinococcus granulosus dna polymerase kappa 0.0019 0.0243 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0603 0.1098
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.297 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0324 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0194 0.053
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0603 0.1098
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.2509 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Brugia malayi Cathepsin L-like precursor 0.0023 0.0324 0.0515
Leishmania major DNA polymerase kappa, putative 0.0019 0.0243 0.0308
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0269 0.0269
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0521
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0698
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0157 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.067 0.0781
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0243 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0269 0.0269
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0029 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0046
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.067 0.1066
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0603 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.067 0.067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0698
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.629 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0269 0.0427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0194 0.0194
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0603 1
Echinococcus granulosus cathepsin L 0.0017 0.0194 0.0194
Schistosoma mansoni lamin 0.0027 0.0442 0.0442
Leishmania major cathepsin L-like protease 0.0034 0.0603 0.1585
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0521
Leishmania major cathepsin L-like protease 0.0034 0.0603 0.1585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.2283 0.7656
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0269 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.4045 0.6316
Echinococcus granulosus sodium channel protein 0.0045 0.089 0.089
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1295 0.4645
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0029 0.0046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0243 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Mycobacterium ulcerans hypothetical protein 0.0037 0.067 0.1886
Loa Loa (eye worm) hypothetical protein 0.0027 0.0442 0.0703
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0269 0.0269
Echinococcus multilocularis cysteine protease 0.0034 0.0603 0.0603
Leishmania major cathepsin L-like protease 0.0129 0.297 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.067 0.0801
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1862 0.1862
Loa Loa (eye worm) fibroinase 0.0034 0.0603 0.0958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0039 0.0061
Mycobacterium tuberculosis Conserved protein 0.0037 0.067 0.0801
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2509 0.6218
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0167 0.3916 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0479 0.0762
Schistosoma mansoni cpg binding protein 0.0029 0.0479 0.0479
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0269 0.0269
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Trypanosoma brucei unspecified product 0.0019 0.0243 0.0521
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0603 0.0603
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0029 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1288 0.1288
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0029 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.067 0.0781
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.067 0.0801
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.067 0.0781
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0243 0.0521
Schistosoma mansoni thyroid hormone receptor 0.002 0.0269 0.0269
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0603 0.149
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0194 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0503 0.0506
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0603 0.0603
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.1247 0.1247
Plasmodium vivax vivapain-2 0.0034 0.0603 0.8927
Brugia malayi Cathepsin L-like precursor 0.0034 0.0603 0.0958
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1295 0.1295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Brugia malayi phosphofructokinase 0.011 0.2509 0.3988
Mycobacterium tuberculosis Conserved protein 0.0037 0.067 0.0801
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0269 0.0269
Plasmodium vivax vivapain-1 0.0017 0.0194 0.2461
Mycobacterium leprae Probable lipase LipE 0.0037 0.067 0.1479
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.067 0.0801
Brugia malayi hypothetical protein 0.0011 0.0029 0.0046
Loa Loa (eye worm) hypothetical protein 0.0167 0.3916 0.6226
Loa Loa (eye worm) hypothetical protein 0.002 0.0269 0.0427
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.2509 0.3988
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0029 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0243 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0324 0.0349
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0351 0.4366
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0157 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Loa Loa (eye worm) hypothetical protein 0.0037 0.067 0.1066
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0269 0.0427
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0198 0.0198
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0442 0.0703
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0243 0.0243
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0198 0.0198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0269 0.0269
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0503 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0351 0.0477
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0029 0.0029
Echinococcus multilocularis geminin 0.0342 0.8287 0.8287
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Entamoeba histolytica cysteine protease, putative 0.0034 0.0603 0.1098
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1862 0.1862
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0603 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0503 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0157 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Brugia malayi ecdysteroid receptor 0.002 0.0269 0.0427
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0243 0.0243
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0157 0.0157
Plasmodium vivax unspecified product 0.0017 0.0194 0.2461
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Onchocerca volvulus 0.0037 0.067 0.1658
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0269 0.0427
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.067 0.0801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0603 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.629 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.067 0.2155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.297 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0243 0.0243
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0269 0.0269
Mycobacterium ulcerans lipase LipD 0.0037 0.067 0.1886
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.2509 0.4248
Schistosoma mansoni nuclear hormone receptor 0.002 0.0269 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0269 0.0427
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.2509 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0521
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0351 0.4949
Onchocerca volvulus 0.0034 0.0603 0.149
Echinococcus granulosus 6 phosphofructokinase 0.011 0.2509 0.2509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0603 0.067

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 Inhibition of NaV1.7 ion channel (unknown origin) ChEMBL. 23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.