Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.6012 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.6012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.021 | 0.2385 | 0.2385 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0211 | 0.2408 | 0.2408 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0169 | 0.1552 | 0.0868 |
Schistosoma mansoni | plexin | 0.0282 | 0.3837 | 0.4724 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 0.7402 |
Echinococcus multilocularis | semaphorin 5B | 0.0211 | 0.2408 | 0.2408 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.2408 | 0.2964 |
Brugia malayi | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.6012 | 0.6012 |
Brugia malayi | Plexin repeat family protein | 0.0493 | 0.8122 | 0.8122 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.6012 | 0.7067 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.6012 | 0.6012 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.8122 | 0.8122 |
Schistosoma mansoni | plexin | 0.0493 | 0.8122 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.3837 | 0.4724 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0211 | 0.2408 | 0.2408 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0121 | 0.0576 | 1 |
Onchocerca volvulus | 0.0493 | 0.8122 | 1 | |
Schistosoma mansoni | semaphorin 5-related | 0.0211 | 0.2408 | 0.2964 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0121 | 0.0576 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.6012 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.0211 | 0.2408 | 0.2408 |
Brugia malayi | hypothetical protein | 0.0185 | 0.1876 | 0.1876 |
Brugia malayi | thymidylate synthase | 0.0389 | 0.6012 | 0.6012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.1876 | 1 |
Brugia malayi | Sema domain containing protein | 0.0211 | 0.2408 | 0.2408 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.021 | 0.2385 | 0.2385 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.2408 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.6012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Echinococcus granulosus | semaphorin 5B | 0.0211 | 0.2408 | 0.2408 |
Brugia malayi | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 0.5 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0582 | 0.9919 | 0.9919 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3837 | 0.3837 |
Onchocerca volvulus | 0.0211 | 0.2408 | 0.2057 | |
Brugia malayi | Sema domain containing protein | 0.0211 | 0.2408 | 0.2408 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.6012 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.6012 | 0.6012 |
Echinococcus multilocularis | hypothetical protein | 0.0211 | 0.2408 | 0.2408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.