TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.381 | Formula: C17H20N6
H donors: 2 H acceptors: 3 LogP: 2.21 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@H]1NCCN(C1)c1cccc(n1)c1n[nH]c2c1cccn2
InChi: 1S/C17H20N6/c1-2-12-11-23(10-9-18-12)15-7-3-6-14(20-15)16-13-5-4-8-19-17(13)22-21-16/h3-8,12,18H,2,9-11H2,1H3,(H,19,21,22)/t12-/m1/s1
InChiKey: GZRXZIIXJPGKRW-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, theta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	alpha tubulin 1	0.0209	0.2076	0.6133
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Schistosoma mansoni	nephrin	0.0144	0.1324	0.423
Giardia lamblia	Beta tubulin	0.0277	0.2857	0.9001
Plasmodium vivax	tubulin epsilon chain, putative	0.015	0.1388	0.3608
Schistosoma mansoni	cell adhesion molecule	0.0148	0.1364	0.4359
Echinococcus multilocularis	tubulin alpha 1C chain	0.0209	0.2076	0.6633
Trypanosoma brucei	alpha tubulin	0.0209	0.2076	0.6133
Plasmodium vivax	tubulin alpha chain, putative	0.0209	0.2076	0.6133
Schistosoma mansoni	tyrosine kinase	0.0041	0.0122	0.0389
Giardia lamblia	Beta tubulin	0.0277	0.2857	0.9001
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0189	0.0603
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Echinococcus granulosus	twitchin	0.0147	0.1358	0.4341
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Loa Loa (eye worm)	AUR protein kinase	0.03	0.3129	0.3117
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1364	0.1349
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0209	0.2076	0.6133
Echinococcus granulosus	beta tubulin	0.0277	0.2857	0.913
Trypanosoma cruzi	epsilon tubulin, putative	0.015	0.1388	0.3608
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Brugia malayi	Tubulin beta chain	0.0085	0.0633	0.0453
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Brugia malayi	Tubulin alpha-2 chain	0.0209	0.2076	0.1923
Echinococcus multilocularis	Tubulin beta 2C chain	0.0277	0.2857	0.913
Echinococcus granulosus	tubulin gamma 1 chain	0.015	0.1388	0.4434
Brugia malayi	alpha-tubulin	0.0209	0.2076	0.1923
Plasmodium vivax	tubulin alpha chain, putative	0.0209	0.2076	0.6133
Giardia lamblia	Aurora kinase	0.03	0.3129	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0132	0.1177	0.3762
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0125	0.1092	0.1077
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0633	0.0839
Schistosoma mansoni	tubulin subunit alpha	0.0209	0.2076	0.6633
Loa Loa (eye worm)	alpha-tubulin	0.0209	0.2076	0.2062
Schistosoma mansoni	tubulin subunit epsilon	0.015	0.1388	0.4434
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0132	0.1177	0.3762
Toxoplasma gondii	aurora kinase	0.03	0.3129	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0209	0.2076	0.3951
Echinococcus granulosus	neuroglian	0.0144	0.1324	0.423
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Trichomonas vaginalis	tubulin, putative	0.0277	0.2857	0.9001
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Echinococcus granulosus	protein kinase c iota type	0.0047	0.0189	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Echinococcus granulosus	Tubulin beta 2C chain	0.0277	0.2857	0.913
Leishmania major	protein kinase, putative	0.03	0.3129	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0209	0.2076	0.6633
Echinococcus multilocularis	tubulin delta chain	0.0065	0.0404	0.1292
Mycobacterium ulcerans	cell division protein FtsZ	0.0065	0.0404	0.5
Echinococcus granulosus	beta tubulin	0.0277	0.2857	0.913
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0085	0.0633	0.0839
Echinococcus multilocularis	tubulin alpha chain	0.0209	0.2076	0.6633
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Brugia malayi	Tubulin gamma chain	0.015	0.1388	0.1222
Entamoeba histolytica	protein kinase domain containing protein	0.03	0.3129	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3512	0.3501
Echinococcus multilocularis	roundabout 2	0.0161	0.151	0.4826
Echinococcus multilocularis	Tubulin beta 2C chain	0.0277	0.2857	0.913
Loa Loa (eye worm)	alpha-tubulin	0.0209	0.2076	0.2062
Trichomonas vaginalis	AGC family protein kinase	0.03	0.3129	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.015	0.1388	0.3608
Echinococcus granulosus	Protein kinase C brain isozyme	0.0047	0.0189	0.0603
Schistosoma mansoni	alpha tubulin	0.0209	0.2076	0.6633
Loa Loa (eye worm)	tubulin alpha chain	0.0209	0.2076	0.2062
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0404	0.1292
Echinococcus granulosus	tubulin alpha chain	0.0209	0.2076	0.6633
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0209	0.2076	0.6133
Echinococcus multilocularis	peroxisome assembly protein 26	0.0209	0.2076	0.6633
Trypanosoma brucei	beta tubulin	0.0277	0.2857	0.9001
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3512	0.3501
Trypanosoma brucei	epsilon tubulin	0.015	0.1388	0.3608
Echinococcus granulosus	tubulin delta chain	0.0065	0.0404	0.1292
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0633	0.0839
Trichomonas vaginalis	AGC family protein kinase	0.03	0.3129	1
Echinococcus multilocularis	beta tubulin	0.0277	0.2857	0.913
Echinococcus granulosus	tubulin epsilon chain	0.015	0.1388	0.4434
Echinococcus granulosus	Tubulin beta 2C chain	0.0277	0.2857	0.913
Loa Loa (eye worm)	tubulin beta chain	0.0277	0.2857	0.2845
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Echinococcus multilocularis	Tubulin beta 2C chain	0.0277	0.2857	0.913
Trypanosoma cruzi	epsilon tubulin, putative	0.015	0.1388	0.3608
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0132	0.1177	0.1008
Trichomonas vaginalis	tubulin beta chain, putative	0.0277	0.2857	0.9001
Echinococcus granulosus	tubulin alpha 3 chain	0.0209	0.2076	0.6633
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Loa Loa (eye worm)	tubulin alpha 2	0.0059	0.0338	0.0321
Echinococcus multilocularis	beta tubulin	0.0277	0.2857	0.913
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Schistosoma mansoni	vesicular amine transporter	0.0132	0.1177	0.3762
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Brugia malayi	Tubulin alpha chain	0.0065	0.0404	0.022
Plasmodium falciparum	tubulin gamma chain	0.015	0.1388	0.3608
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Trichomonas vaginalis	tubulin alpha chain, putative	0.015	0.1388	0.3608
Loa Loa (eye worm)	tubulin beta-2A chain	0.0277	0.2857	0.2845
Trypanosoma brucei	alpha tubulin	0.0209	0.2076	0.6133
Entamoeba histolytica	protein kinase, putative	0.03	0.3129	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1321	0.1306
Entamoeba histolytica	tubulin family protein	0.0277	0.2857	0.8438
Trypanosoma cruzi	alpha tubulin, putative	0.0209	0.2076	0.6133
Leishmania major	gamma-tubulin	0.015	0.1388	0.3608
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Echinococcus granulosus	tubulin beta 4A class IVa	0.0277	0.2857	0.913
Loa Loa (eye worm)	BEN-1 protein	0.0277	0.2857	0.2845
Echinococcus granulosus	tubulin alpha	0.015	0.1388	0.4434
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Onchocerca volvulus		0.0733	0.8147	0.9634
Plasmodium falciparum	tubulin epsilon chain, putative	0.015	0.1388	0.3608
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0277	0.2857	0.9001
Echinococcus multilocularis	aurora kinase A	0.03	0.3129	1
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0189	0.0603
Brugia malayi	Tubulin beta-1 chain	0.0277	0.2857	0.272
Schistosoma mansoni	serine/threonine protein kinase	0.03	0.3129	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0047	0.0189	0.0603
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Entamoeba histolytica	protein kinase, putative	0.03	0.3129	1
Echinococcus granulosus	roundabout 2	0.0161	0.151	0.4826
Giardia lamblia	Alpha-tubulin	0.0209	0.2076	0.6133
Trichomonas vaginalis	tubulin beta chain, putative	0.0085	0.0633	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Schistosoma mansoni	tubulin subunit gamma	0.015	0.1388	0.4434
Trypanosoma brucei	epsilon tubulin	0.015	0.1388	0.3608
Echinococcus granulosus	aurora kinase A	0.03	0.3129	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0148	0.1364	0.4359
Echinococcus multilocularis	tubulin alpha chain	0.0209	0.2076	0.6633
Echinococcus multilocularis	Tubulin beta 2C chain	0.0277	0.2857	0.913
Schistosoma mansoni	atypical protein kinase C	0.0047	0.0189	0.0603
Loa Loa (eye worm)	tubulin beta-4 chain	0.0277	0.2857	0.2845
Brugia malayi	hypothetical protein	0.0132	0.1177	0.1008
Plasmodium falciparum	tubulin beta chain	0.0277	0.2857	0.9001
Brugia malayi	Tubulin alpha chain	0.0209	0.2076	0.1923
Echinococcus granulosus	tubulin alpha chain	0.0209	0.2076	0.6633
Loa Loa (eye worm)	AUR protein kinase	0.03	0.3129	0.3117
Echinococcus granulosus	tubulin alpha 3 chain	0.0209	0.2076	0.6633
Giardia lamblia	Gamma tubulin	0.015	0.1388	0.3608
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0633	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Trypanosoma cruzi	aurora B kinase, putative	0.03	0.3129	1
Echinococcus granulosus	tubulin alpha chain	0.0209	0.2076	0.6633
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Loa Loa (eye worm)	tubulin alpha 2	0.0144	0.1321	0.1306
Echinococcus multilocularis	Immunoglobulin	0.0132	0.1177	0.3762
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Onchocerca volvulus	Tyrosine kinase homolog	0.0758	0.8432	1
Loa Loa (eye worm)	tubulin gamma chain	0.015	0.1388	0.1372
Echinococcus granulosus	Immunoglobulin	0.0132	0.1177	0.3762
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.03	0.3129	1
Echinococcus granulosus	protein kinase c epsilon type	0.0047	0.0189	0.0603
Giardia lamblia	Alpha-tubulin	0.0209	0.2076	0.6133
Trypanosoma brucei	beta tubulin	0.0277	0.2857	0.9001
Echinococcus granulosus	alpha tubulin	0.0209	0.2076	0.6633
Echinococcus multilocularis	protein kinase c iota type	0.0047	0.0189	0.0603
Brugia malayi	Fibronectin type III domain containing protein	0.0132	0.1177	0.1008
Echinococcus multilocularis	tubulin alpha 3 chain	0.0209	0.2076	0.6633
Loa Loa (eye worm)	tubulin alpha 2	0.0144	0.1321	0.1306
Echinococcus multilocularis	tubulin epsilon chain	0.015	0.1388	0.4434
Brugia malayi	Cell division protein ftsZ	0.0065	0.0404	0.022
Trichomonas vaginalis	AGC family protein kinase	0.03	0.3129	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0209	0.2076	0.3951
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Trypanosoma brucei	beta tubulin	0.0277	0.2857	0.9001
Schistosoma mansoni	protein kinase	0.03	0.3129	1
Brugia malayi	tubulin alpha chain - mouse	0.0209	0.2076	0.1923
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0189	0.0603
Echinococcus multilocularis	tubulin alpha chain	0.0209	0.2076	0.6633
Echinococcus multilocularis	tubulin subunit TubB	0.0209	0.2076	0.6633
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1092	0.1077
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Toxoplasma gondii	beta-1 tubulin, putative	0.0277	0.2857	0.9001
Mycobacterium leprae	cell division protein FtsZ	0.0065	0.0404	0.5
Toxoplasma gondii	alpha tubulin TUBA1	0.0209	0.2076	0.6133
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.03	0.3129	1
Plasmodium vivax	tubulin beta chain, putative	0.0277	0.2857	0.9001
Loa Loa (eye worm)	hypothetical protein	0.0161	0.151	0.1495
Leishmania major	epsilon tubulin, putative	0.015	0.1388	0.3608
Echinococcus granulosus	Tubulin beta 2C chain	0.0277	0.2857	0.913
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3512	0.3501
Schistosoma mansoni	tubulin subunit alpha	0.0209	0.2076	0.6633
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Brugia malayi	serine/threonine kinase 12	0.03	0.3129	0.2997
Loa Loa (eye worm)	tubulin alpha chain	0.0209	0.2076	0.2062
Trypanosoma brucei	beta tubulin	0.015	0.1388	0.3608
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.03	0.3129	1
Trichomonas vaginalis	AGC family protein kinase	0.03	0.3129	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Toxoplasma gondii	alpha-tubulin I, putative	0.0209	0.2076	0.6133
Echinococcus granulosus	Tubulin beta 2C chain	0.0277	0.2857	0.913
Trypanosoma brucei	beta tubulin	0.0277	0.2857	0.9001
Loa Loa (eye worm)	hypothetical protein	0.0362	0.384	0.3829
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Schistosoma mansoni	alpha tubulin	0.0209	0.2076	0.6633
Trichomonas vaginalis	tubulin gamma chain, putative	0.0277	0.2857	0.9001
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Schistosoma mansoni	alpha tubulin	0.0209	0.2076	0.6633
Echinococcus granulosus	tubulin alpha chain	0.0209	0.2076	0.6633
Brugia malayi	tubulin alpha-2 chain	0.0209	0.2076	0.1923
Echinococcus multilocularis	tubulin alpha 1C chain	0.0209	0.2076	0.6633
Echinococcus granulosus	tubulin alpha 1C chain	0.0209	0.2076	0.6633
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0047	0.0189	0.0603
Giardia lamblia	Beta tubulin	0.0277	0.2857	0.9001
Trypanosoma brucei	alpha tubulin, putative	0.0085	0.0633	0.0839
Loa Loa (eye worm)	BEN-1 protein	0.0277	0.2857	0.2845
Loa Loa (eye worm)	beta-tubulin	0.0277	0.2857	0.2845
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0065	0.0404	0.5
Plasmodium falciparum	alpha tubulin 2	0.0209	0.2076	0.6133
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Entamoeba histolytica	protein kinase , putative	0.03	0.3129	1
Toxoplasma gondii	beta tubulin	0.0277	0.2857	0.9001
Trichomonas vaginalis	tubulin gamma chain, putative	0.015	0.1388	0.3608
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0144	0.1321	0.3365
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.03	0.3129	1
Loa Loa (eye worm)	AUR protein kinase	0.03	0.3129	0.3117
Trichomonas vaginalis	tubulin beta chain, putative	0.0209	0.2076	0.6133
Treponema pallidum	cell division protein FtsZ	0.0065	0.0404	0.5
Echinococcus multilocularis	tubulin subunit beta	0.0277	0.2857	0.913
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0209	0.2076	0.6133
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.03	0.3129	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0277	0.2857	0.913
Schistosoma mansoni	tubulin subunit delta	0.0065	0.0404	0.1292
Echinococcus multilocularis	neuroglian	0.0144	0.1324	0.423
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Trypanosoma brucei	tubulin gamma chain	0.015	0.1388	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0352	0.3724	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Trypanosoma cruzi	beta tubulin, putative	0.0277	0.2857	0.9001
Echinococcus granulosus	Tubulin beta 2C chain	0.0277	0.2857	0.913
Trichomonas vaginalis	tubulin alpha chain, putative	0.0277	0.2857	0.9001
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Trichomonas vaginalis	tubulin, putative	0.0085	0.0633	0.0839
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Echinococcus multilocularis	tubulin alpha chain	0.0209	0.2076	0.6633
Loa Loa (eye worm)	hypothetical protein	0.0161	0.151	0.1495
Echinococcus multilocularis	Immunoglobulin	0.0132	0.1177	0.3762
Loa Loa (eye worm)	hypothetical protein	0.0209	0.2076	0.2062
Echinococcus granulosus	tubulin subunit beta	0.0277	0.2857	0.913
Echinococcus granulosus	defective proboscis extension response	0.0132	0.1177	0.3762
Trypanosoma brucei	aurora B kinase	0.03	0.3129	1
Trypanosoma cruzi	tubulin gamma chain	0.015	0.1388	0.3608
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0047	0.0189	0.0171
Brugia malayi	beta-tubulin, identical	0.0277	0.2857	0.272
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1177	0.1162
Trypanosoma brucei	alpha tubulin	0.0209	0.2076	0.6133
Schistosoma mansoni	tubulin subunit alpha	0.0065	0.0404	0.1292
Echinococcus granulosus	tubulin alpha chain	0.0209	0.2076	0.6633
Loa Loa (eye worm)	tubulin beta-1 chain	0.0277	0.2857	0.2845
Echinococcus granulosus	tubulin subunit TubB	0.0209	0.2076	0.6633
Entamoeba histolytica	tubulin family protein	0.0277	0.2857	0.8438
Echinococcus multilocularis	hypothetical protein	0.0209	0.2076	0.6633
Brugia malayi	Tubulin alpha-2 chain	0.0209	0.2076	0.1923
Trypanosoma brucei	epsilon tubulin	0.015	0.1388	0.3608
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Brugia malayi	Tubulin beta chain	0.0065	0.0404	0.022
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0144	0.1321	0.1306
Echinococcus multilocularis	tubulin alpha 3 chain	0.0209	0.2076	0.6633
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.03	0.3129	1
Schistosoma mansoni	tubulin subunit alpha	0.0209	0.2076	0.6633
Leishmania major	beta tubulin	0.0277	0.2857	0.9001
Plasmodium vivax	tubulin gamma chain, putative	0.015	0.1388	0.3608
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0209	0.2076	0.2062
Loa Loa (eye worm)	tubulin beta chain	0.0065	0.0404	0.0387
Toxoplasma gondii	beta-tubulin, putative	0.0277	0.2857	0.9001
Trypanosoma brucei	alpha tubulin	0.0209	0.2076	0.6133
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Trichomonas vaginalis	tubulin, putative	0.0085	0.0633	0.0839
Brugia malayi	serine/threonine-protein kinase 6	0.03	0.3129	0.2997
Onchocerca volvulus		0.0333	0.3512	0.3692
Echinococcus multilocularis	tubulin gamma 1 chain	0.015	0.1388	0.4434
Schistosoma mansoni	tubulin subunit beta	0.0277	0.2857	0.913
Echinococcus multilocularis	Tubulin beta 2C chain	0.0277	0.2857	0.913
Plasmodium falciparum	serine/threonine protein kinase, putative	0.03	0.3129	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0209	0.2076	0.6633
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0132	0.1177	0.3762
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0277	0.2857	0.9001
Leishmania major	alpha tubulin	0.0209	0.2076	0.6133
Trichomonas vaginalis	tubulin gamma chain, putative	0.015	0.1388	0.3608
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0277	0.2857	0.913
Echinococcus multilocularis	tubulin alpha	0.015	0.1388	0.4434
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0125	0.1092	0.2525
Echinococcus granulosus	tubulin beta 1 chain	0.0277	0.2857	0.913
Echinococcus multilocularis	tubulin alpha chain	0.0209	0.2076	0.6633
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209	0.2076	0.6633
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0065	0.0404	0.5
Brugia malayi	serine/threonine protein kinase 6	0.03	0.3129	0.2997

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 12 nM	Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP	ChEMBL.	23398373
Ki (binding)	= 81 nM	Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP	ChEMBL.	23398373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326016

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1725657